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The map label for this gene is argG [H]

Identifier: 158422369

GI number: 158422369

Start: 841394

End: 842620

Strand: Reverse

Name: argG [H]

Synonym: AZC_0745

Alternate gene names: 158422369

Gene position: 842620-841394 (Counterclockwise)

Preceding gene: 158422370

Following gene: 158422368

Centisome position: 15.69

GC content: 65.61

Gene sequence:

>1227_bases
ATGTCGCGCGACGTGAAGAAGGTTGTGCTCGCTTATTCCGGCGGGCTCGACACCTCGGTGATCCTGAAGTGGCTCCAGAC
CACCTACCGGTGCGAGGTGGTGACCTTCACCGCCGACCTCGGCCAGGGCGAGGAACTGGAGCCGGCGCGCAAGAAGGCGG
AACTGCTGGGCATCAAGCCCGAGAACATCTTCATCGAGGACGTGCGCGAGGAATTCGTGCGCGACTATGTCTTCCCGATG
TTCCGCGCCAATGCGGTCTATGAGGGCCAGTATCTGCTGGGCACCTCCATCGCCCGCCCGCTGATCGCCAAGAAGCAGAT
CGAGATCGCCCGCAAGGTCGGCGCCGACGCCGTCTCCCACGGCGCCACCGGCAAGGGCAACGACCAGGTGCGCTTCGAGC
TCGGCTATTACGCGCTGGAGCCGGAAATCACCGTCATCGCCCCGTGGCGCGAGTGGGACCTGACCTCCCGCACCAAGCTG
CTGGAATTCGCCGAGACCCACCAGATCCCGATCGCCAAGGACAAGCGCGGCGAAGCTCCCTTCTCGGTGGACGCGAACCT
CCTGCACTCCTCCTCCGAGGGCAAGGTTCTGGAAGACCCGGCCGAGGACGCGCCGGAATATGTCTACCAGCGCACCATCT
CGCCGGAGGCGGCGCCCGACGTGGCCACCGTCATCACCATCGGCTTCGAGAAGGGTGACGCAGTCTCCATCAATGGCGAG
GCCCTGAGCCCGGCCACCCTGCTGGCGAAGCTCAACGAGCTCGGCAAGGCCAACGGCATCGGCCGCCTCGACCTCGTGGA
GAACCGCTTCGTCGGCATGAAGTCGCGCGGCGTCTACGAGACCCCCGGCGGCACCATCCTGCTCGCCGCCCACCGCGGCA
TCGAGAGCATCACGCTCGACCGCGGCGCCGCCCACCTCAAGGACGAGCTGATGCCGCGCTATGCGGAGCTCATCTACAAC
GGCTTCTGGTTCTCCCCCGAGCGCGAGATGCTCCAGGCGGCCATCGACCACTCGCAGGCCTATGTCACCGGCGAAGTGAC
CGTCAAGCTCTACAAGGGCAATGCCACGGTCATCGGCCGCAAGAGCCCGTACTCGCTCTACAATCAGGAGCTTGTCACGT
TCGAGGAAGGCGCCGTCGCCTACGACCATCGCGACGCTGCCGGCTTCATCAAGCTCAATGCCTTGCGCCTGCGGACGACC
GCCGCCCGCGCACGCAAGGCTCAATAA

Upstream 100 bases:

>100_bases
GCGCGGATTTTCGCCCCTCGCCCCGGATGGCGCGGGTGGCCTTCGACCCAACCGCAGCGGGCGCCCTTGCCGGGCTCCGC
TCAAGCCTTCGAGTGATTAG

Downstream 100 bases:

>100_bases
AGCTCGGGCCGCTATATCCATCCTTCCAGGGGGAGGTATCCCCGTGAAGAAGGGCGGATGTCATGGCGGTGACCTCCAGC
GTCGCTTCGCTGAGGGAGTA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSRDVKKVVLAYSGGLDTSVILKWLQTTYRCEVVTFTADLGQGEELEPARKKAELLGIKPENIFIEDVREEFVRDYVFPM
FRANAVYEGQYLLGTSIARPLIAKKQIEIARKVGADAVSHGATGKGNDQVRFELGYYALEPEITVIAPWREWDLTSRTKL
LEFAETHQIPIAKDKRGEAPFSVDANLLHSSSEGKVLEDPAEDAPEYVYQRTISPEAAPDVATVITIGFEKGDAVSINGE
ALSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLDRGAAHLKDELMPRYAELIYN
GFWFSPEREMLQAAIDHSQAYVTGEVTVKLYKGNATVIGRKSPYSLYNQELVTFEEGAVAYDHRDAAGFIKLNALRLRTT
AARARKAQ

Sequences:

>Translated_408_residues
MSRDVKKVVLAYSGGLDTSVILKWLQTTYRCEVVTFTADLGQGEELEPARKKAELLGIKPENIFIEDVREEFVRDYVFPM
FRANAVYEGQYLLGTSIARPLIAKKQIEIARKVGADAVSHGATGKGNDQVRFELGYYALEPEITVIAPWREWDLTSRTKL
LEFAETHQIPIAKDKRGEAPFSVDANLLHSSSEGKVLEDPAEDAPEYVYQRTISPEAAPDVATVITIGFEKGDAVSINGE
ALSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLDRGAAHLKDELMPRYAELIYN
GFWFSPEREMLQAAIDHSQAYVTGEVTVKLYKGNATVIGRKSPYSLYNQELVTFEEGAVAYDHRDAAGFIKLNALRLRTT
AARARKAQ
>Mature_407_residues
SRDVKKVVLAYSGGLDTSVILKWLQTTYRCEVVTFTADLGQGEELEPARKKAELLGIKPENIFIEDVREEFVRDYVFPMF
RANAVYEGQYLLGTSIARPLIAKKQIEIARKVGADAVSHGATGKGNDQVRFELGYYALEPEITVIAPWREWDLTSRTKLL
EFAETHQIPIAKDKRGEAPFSVDANLLHSSSEGKVLEDPAEDAPEYVYQRTISPEAAPDVATVITIGFEKGDAVSINGEA
LSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLDRGAAHLKDELMPRYAELIYNG
FWFSPEREMLQAAIDHSQAYVTGEVTVKLYKGNATVIGRKSPYSLYNQELVTFEEGAVAYDHRDAAGFIKLNALRLRTTA
ARARKAQ

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=400, Percent_Identity=49, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI16950633, Length=400, Percent_Identity=49, Blast_Score=362, Evalue=1e-100,
Organism=Escherichia coli, GI1789563, Length=415, Percent_Identity=26.9879518072289, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324514, Length=408, Percent_Identity=42.8921568627451, Blast_Score=316, Evalue=4e-87,
Organism=Drosophila melanogaster, GI21358151, Length=404, Percent_Identity=46.039603960396, Blast_Score=338, Evalue=5e-93,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 45143; Mature: 45012

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRDVKKVVLAYSGGLDTSVILKWLQTTYRCEVVTFTADLGQGEELEPARKKAELLGIKP
CCCCCEEEEEEECCCCCHHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHCCCCC
ENIFIEDVREEFVRDYVFPMFRANAVYEGQYLLGTSIARPLIAKKQIEIARKVGADAVSH
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHC
GATGKGNDQVRFELGYYALEPEITVIAPWREWDLTSRTKLLEFAETHQIPIAKDKRGEAP
CCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
FSVDANLLHSSSEGKVLEDPAEDAPEYVYQRTISPEAAPDVATVITIGFEKGDAVSINGE
CEECHHHEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCC
ALSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLD
CCCHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCEECCCCEEEEEECCCCCEEEEC
RGAAHLKDELMPRYAELIYNGFWFSPEREMLQAAIDHSQAYVTGEVTVKLYKGNATVIGR
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEEC
KSPYSLYNQELVTFEEGAVAYDHRDAAGFIKLNALRLRTTAARARKAQ
CCCCHHHCCEEEEEECCCEEECCCCCCCEEEEEEEEEEHHHHHHHCCC
>Mature Secondary Structure 
SRDVKKVVLAYSGGLDTSVILKWLQTTYRCEVVTFTADLGQGEELEPARKKAELLGIKP
CCCCEEEEEEECCCCCHHHHHHHHHHHEEEEEEEEEECCCCCCCCCHHHHHHHHCCCCC
ENIFIEDVREEFVRDYVFPMFRANAVYEGQYLLGTSIARPLIAKKQIEIARKVGADAVSH
CCCHHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHHCCHHHHC
GATGKGNDQVRFELGYYALEPEITVIAPWREWDLTSRTKLLEFAETHQIPIAKDKRGEAP
CCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
FSVDANLLHSSSEGKVLEDPAEDAPEYVYQRTISPEAAPDVATVITIGFEKGDAVSINGE
CEECHHHEECCCCCCEECCCHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCEEEECCC
ALSPATLLAKLNELGKANGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRGIESITLD
CCCHHHHHHHHHHHHCCCCCCEEEEHHCCCCCCCCCCCEECCCCEEEEEECCCCCEEEEC
RGAAHLKDELMPRYAELIYNGFWFSPEREMLQAAIDHSQAYVTGEVTVKLYKGNATVIGR
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEEECCEEEEEC
KSPYSLYNQELVTFEEGAVAYDHRDAAGFIKLNALRLRTTAARARKAQ
CCCCHHHCCEEEEEECCCEEECCCCCCCEEEEEEEEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA