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The map label for this gene is bioA [C]

Identifier: 158422353

GI number: 158422353

Start: 820117

End: 821520

Strand: Reverse

Name: bioA [C]

Synonym: AZC_0729

Alternate gene names: 158422353

Gene position: 821520-820117 (Counterclockwise)

Preceding gene: 158422358

Following gene: 158422350

Centisome position: 15.3

GC content: 66.45

Gene sequence:

>1404_bases
TTGTGCTCAGGCCAATTTCGCTGCGGCGGACGCGCGACCTTTCAGGAGAGAACAATGGATCAGGTGACCGACACCGGCGC
GCTCGCGCGTCAGCTCAATGTGGATCCCTACTGGGCGCCGTTTACCTCCAACCGCCGCTTCAAGGCCGACCCGTCCGACC
GCACGATGATCTCGGCGGAAGGCTGCTACTTCACCAATGCCAATGGCGTGAAGCTGTTCGACGGCTCCTCGGGCCTGTGG
TGCACGCCGCTCGGCCATTCCCACCCGCGCATCGTCGAAGCGGTGACCAAGCAGGTCCGCTCGCTCGACTACGCCCCGTC
CTTCCAGGTGGCGAGCGCCACCACCATCCAGCTCGCCGAGCGCGTGGCCGAGATGGCGCCCGAGGGCCTCAACCGCGTGT
TCTTTGCCAATTCCGGCTCGGAAGCGGTGGATACGGCGCTGAAGATCGCCATGGGTTATCACCGGCTTACGGGGAACGCC
ACGCGCACCCGCTTCATCGGCCGTGAAAAGGGCTATCACGGCGTCGGCTTCGGCGGCATGTCGGTGGGCGGCATCGTCGC
CAACCGCAAGATGTTTGCCCCCGGCATGGTGAACGGCGTCGATCACCTGCCCCACACCTATGACCAGTCGAAGATGGCCT
TCTCCAAGGGTCAGCCGGCCTGGGGCGCGCATCTCGCCGACGAACTGGAGCGCATCGTTGCGCTGCACGACGCCTCCACC
ATCGCCGCCGTGATCGTGGAGCCCATGCAGGGCTCGGCCGGCGTCATCGTGCCGCCAATCGGCTATCTCGAGCGCCTGCG
CGAAATCTGCACCAAGCACGGCATCCTGCTGATCTTCGACGAAGTGATCACCGGCTTCGGCCGCACCGGCTGGGCGTTTG
CCGCCCAGCGCCTCGGCGTCGTCCCGGACATGATCACCTTCGCCAAGGCGATCACCAACGGCATCATCCCCATGGGCGGC
GTGATCGCCCGCCAGGAGATCTACGAGGCCTTCATGAGCGGCCCGCCGGCTGCCATCGAGTTCTGCCACGGCTACACCTA
TTCGGGTCACCCGATGGCCGCCGCCGCCGCCCACGCCACCCTCGACGTGTATGAGGAAGAGGATCTGTTCGGCCGCGTGC
GGGCGCTGGAGCCCCTCATGGAAGCCGAGTTCCACAGCCTCAAGGGCGAGCCCAACGTGGTGGACGTGCGCAACTTCGGC
CTCACCGCCGCGGTCGAGCTCTCGCCCTCCGCTGCCGGCCCGAGCATGCGGGCGCTCAGCATCTTCGAGGCCGGTCTCAA
GCAGGGCCTCTACATGCGCTACACCGGCGAGAGCCTCGCGTTCTCGCCGCCCTTCATCTCCACCGAGCAGCAGATCAAGG
ACATGGTGGCGATCCTGCGCAAGCTCATCCGCGACGCGGCCTGA

Upstream 100 bases:

>100_bases
GACGACGCTGGCCGCCCCTTCACTGTATCGGTCAGGCGACCATAACAGCTTCAGCAGGCGGTCGCGCATCTGTATATATA
CAAAAGCGCCGCGGGGTCTA

Downstream 100 bases:

>100_bases
GCCCTTTCGGACCCTTCACCAGACGCGCGGCAGTCGCCTGCCGCGCGTTTTTTTTGCGTCCGTTCAGCCGCGTACCGGCG
GCAATGTCTCCTCCGCCACC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MCSGQFRCGGRATFQERTMDQVTDTGALARQLNVDPYWAPFTSNRRFKADPSDRTMISAEGCYFTNANGVKLFDGSSGLW
CTPLGHSHPRIVEAVTKQVRSLDYAPSFQVASATTIQLAERVAEMAPEGLNRVFFANSGSEAVDTALKIAMGYHRLTGNA
TRTRFIGREKGYHGVGFGGMSVGGIVANRKMFAPGMVNGVDHLPHTYDQSKMAFSKGQPAWGAHLADELERIVALHDAST
IAAVIVEPMQGSAGVIVPPIGYLERLREICTKHGILLIFDEVITGFGRTGWAFAAQRLGVVPDMITFAKAITNGIIPMGG
VIARQEIYEAFMSGPPAAIEFCHGYTYSGHPMAAAAAHATLDVYEEEDLFGRVRALEPLMEAEFHSLKGEPNVVDVRNFG
LTAAVELSPSAAGPSMRALSIFEAGLKQGLYMRYTGESLAFSPPFISTEQQIKDMVAILRKLIRDAA

Sequences:

>Translated_467_residues
MCSGQFRCGGRATFQERTMDQVTDTGALARQLNVDPYWAPFTSNRRFKADPSDRTMISAEGCYFTNANGVKLFDGSSGLW
CTPLGHSHPRIVEAVTKQVRSLDYAPSFQVASATTIQLAERVAEMAPEGLNRVFFANSGSEAVDTALKIAMGYHRLTGNA
TRTRFIGREKGYHGVGFGGMSVGGIVANRKMFAPGMVNGVDHLPHTYDQSKMAFSKGQPAWGAHLADELERIVALHDAST
IAAVIVEPMQGSAGVIVPPIGYLERLREICTKHGILLIFDEVITGFGRTGWAFAAQRLGVVPDMITFAKAITNGIIPMGG
VIARQEIYEAFMSGPPAAIEFCHGYTYSGHPMAAAAAHATLDVYEEEDLFGRVRALEPLMEAEFHSLKGEPNVVDVRNFG
LTAAVELSPSAAGPSMRALSIFEAGLKQGLYMRYTGESLAFSPPFISTEQQIKDMVAILRKLIRDAA
>Mature_467_residues
MCSGQFRCGGRATFQERTMDQVTDTGALARQLNVDPYWAPFTSNRRFKADPSDRTMISAEGCYFTNANGVKLFDGSSGLW
CTPLGHSHPRIVEAVTKQVRSLDYAPSFQVASATTIQLAERVAEMAPEGLNRVFFANSGSEAVDTALKIAMGYHRLTGNA
TRTRFIGREKGYHGVGFGGMSVGGIVANRKMFAPGMVNGVDHLPHTYDQSKMAFSKGQPAWGAHLADELERIVALHDAST
IAAVIVEPMQGSAGVIVPPIGYLERLREICTKHGILLIFDEVITGFGRTGWAFAAQRLGVVPDMITFAKAITNGIIPMGG
VIARQEIYEAFMSGPPAAIEFCHGYTYSGHPMAAAAAHATLDVYEEEDLFGRVRALEPLMEAEFHSLKGEPNVVDVRNFG
LTAAVELSPSAAGPSMRALSIFEAGLKQGLYMRYTGESLAFSPPFISTEQQIKDMVAILRKLIRDAA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=29.7297297297297, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI37574042, Length=450, Percent_Identity=28, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=29.040404040404, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI24119277, Length=431, Percent_Identity=29.0023201856148, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=26.8965517241379, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI13994255, Length=364, Percent_Identity=30.7692307692308, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=30.6060606060606, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI188536080, Length=341, Percent_Identity=22.8739002932551, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI38679950, Length=341, Percent_Identity=22.8739002932551, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI38679946, Length=341, Percent_Identity=22.8739002932551, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1786991, Length=429, Percent_Identity=32.6340326340326, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI145693181, Length=401, Percent_Identity=30.1745635910224, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789759, Length=408, Percent_Identity=29.656862745098, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789016, Length=359, Percent_Identity=32.3119777158774, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788044, Length=404, Percent_Identity=28.960396039604, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1787560, Length=437, Percent_Identity=30.6636155606407, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786349, Length=339, Percent_Identity=29.2035398230088, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=445, Percent_Identity=30.7865168539326, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=26.1501210653753, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=26.4775413711584, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=30.8016877637131, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17541228, Length=441, Percent_Identity=25.3968253968254, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=28.7769784172662, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=490, Percent_Identity=26.3265306122449, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=26.3681592039801, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=279, Percent_Identity=23.6559139784946, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21357415, Length=422, Percent_Identity=28.436018957346, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI21356575, Length=372, Percent_Identity=30.6451612903226, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=29.7674418604651, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=28.735632183908, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281366494, Length=436, Percent_Identity=23.6238532110092, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667139, Length=436, Percent_Identity=23.6238532110092, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24667143, Length=436, Percent_Identity=23.6238532110092, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 50581; Mature: 50581

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCSGQFRCGGRATFQERTMDQVTDTGALARQLNVDPYWAPFTSNRRFKADPSDRTMISAE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEC
GCYFTNANGVKLFDGSSGLWCTPLGHSHPRIVEAVTKQVRSLDYAPSFQVASATTIQLAE
CEEEECCCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RVAEMAPEGLNRVFFANSGSEAVDTALKIAMGYHRLTGNATRTRFIGREKGYHGVGFGGM
HHHHHCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
SVGGIVANRKMFAPGMVNGVDHLPHTYDQSKMAFSKGQPAWGAHLADELERIVALHDAST
CCCCEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
IAAVIVEPMQGSAGVIVPPIGYLERLREICTKHGILLIFDEVITGFGRTGWAFAAQRLGV
EEEHEEECCCCCCCEEECCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHHHHHHHHHCC
VPDMITFAKAITNGIIPMGGVIARQEIYEAFMSGPPAAIEFCHGYTYSGHPMAAAAAHAT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LDVYEEEDLFGRVRALEPLMEAEFHSLKGEPNVVDVRNFGLTAAVELSPSAAGPSMRALS
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHH
IFEAGLKQGLYMRYTGESLAFSPPFISTEQQIKDMVAILRKLIRDAA
HHHHHHHCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MCSGQFRCGGRATFQERTMDQVTDTGALARQLNVDPYWAPFTSNRRFKADPSDRTMISAE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEC
GCYFTNANGVKLFDGSSGLWCTPLGHSHPRIVEAVTKQVRSLDYAPSFQVASATTIQLAE
CEEEECCCCEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
RVAEMAPEGLNRVFFANSGSEAVDTALKIAMGYHRLTGNATRTRFIGREKGYHGVGFGGM
HHHHHCHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCC
SVGGIVANRKMFAPGMVNGVDHLPHTYDQSKMAFSKGQPAWGAHLADELERIVALHDAST
CCCCEEECCCCCCCCCCCCHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHH
IAAVIVEPMQGSAGVIVPPIGYLERLREICTKHGILLIFDEVITGFGRTGWAFAAQRLGV
EEEHEEECCCCCCCEEECCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCHHHHHHHHHCC
VPDMITFAKAITNGIIPMGGVIARQEIYEAFMSGPPAAIEFCHGYTYSGHPMAAAAAHAT
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHH
LDVYEEEDLFGRVRALEPLMEAEFHSLKGEPNVVDVRNFGLTAAVELSPSAAGPSMRALS
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHH
IFEAGLKQGLYMRYTGESLAFSPPFISTEQQIKDMVAILRKLIRDAA
HHHHHHHCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]