Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 158422200

GI number: 158422200

Start: 639143

End: 640285

Strand: Direct

Name: acdA [H]

Synonym: AZC_0576

Alternate gene names: 158422200

Gene position: 639143-640285 (Clockwise)

Preceding gene: 158422199

Following gene: 158422201

Centisome position: 11.9

GC content: 67.45

Gene sequence:

>1143_bases
ATGTTCGAGCTGACGGAAGACCAGATCGCCATCCGCGACATGGCGCGCGCCTTTGCACGCGAGGAAATCGCGCCTCATGC
GCTGGAATGGGACGAGGCGCACCATTTCCCCATTCCGACGCTGAAGGCCGCCGCCGCGCTCGGCATGGCCGGCATCTATG
TGCGCGACGACGTGGGCGGCTCGGCTCTCTCGCGTCTTGATGCGACGCTCATTTTCGAGGCGCTGGCGGAAGGCTGCCCC
GCCACCTCCGCCTATCTCTCCATCCACAACATGGTCGCCTGGATGATCGACCGCTTCGGTGCGCCGGAGCAGCGCACCAG
GTGGCTGCCGAAGCTCTGTGCCATGGACATCGTGGCGAGCTACTGCCTCACCGAGCCTGGCTCGGGATCCGATGCTGCCG
CGCTCAAGACGCGGGCGGCTCGGGACGGCGACCATTATGTGCTGCACGGGGAGAAGCAGTTCATCTCCGGTGCCGGCGCG
TCCGATCTTTATGCGGTGATGGCGCGCACGGGGGGCGAGGGGCCGGGCGGCGTCTCCACCATTCTCGTGGAAGCGGGCAC
GCCGGGCCTGTCCTTCGGGGCCAATGAGAAGAAGATGGGCTGGCGCGTGCAGCCCACACGCGCCGTCATCTTCGACGGCG
TGCGTGTGCCGGTGGAGAACCGCATCGGCGCGGAGGGCGATGGCTTCAAGTTCGCCATGGCGGGGCTCGATGGCGGGCGG
CTCAACATCGCCGCCTGCTCGCTCGGCGGCGCGCAGGCGGCTCTCGACAAGGCGCTGGCCTATACGGCCGAGCGCAAGGC
CTTCGGCAAGGCCATCAACCAGTTTCAGGCGCTGCAATTCCGCCTTGCGGACATGGAGACGGAACTGGAGGTGGCCCGCA
CCTTCCTGTGGCGGGCCGCGAGCGCCCTCGACCGGAGCGATCCGAAGGCCACGCGCCTGTGCGCCATGGCCAAGCGCTTC
GTCACCGACGCCGGGTTCGAGGTGGCCAACGAGGCGCTCCAGCTTCACGGCGGCTATGGCTATCTGGCCGACTACGGGGT
GGAGAAGATCGTTCGCGACCTGCGCGTCCACCAGATCCTCGAAGGCACCAACGAGATCATGCGCGTCATCATTGCGCGCG
GATTGGTGGCGCGGGGCAACTGA

Upstream 100 bases:

>100_bases
ATGAATTGACGCTCGGCCTCCCGGCGTGGACGCTGCCGTCCGCGCCGGGGCATGACATGGCGGGTCAACCGCCAGCGTGC
GTTTCAGACGGGAGGACCTC

Downstream 100 bases:

>100_bases
AGCCCGCCGCGCCCATCCAACAGAACACTGCATCCTTAAGGGAGGACACCATGGCCGTCATCGCCTTCATCGGGCTCGGC
AACATGGGCGGGCCGATGGC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MFELTEDQIAIRDMARAFAREEIAPHALEWDEAHHFPIPTLKAAAALGMAGIYVRDDVGGSALSRLDATLIFEALAEGCP
ATSAYLSIHNMVAWMIDRFGAPEQRTRWLPKLCAMDIVASYCLTEPGSGSDAAALKTRAARDGDHYVLHGEKQFISGAGA
SDLYAVMARTGGEGPGGVSTILVEAGTPGLSFGANEKKMGWRVQPTRAVIFDGVRVPVENRIGAEGDGFKFAMAGLDGGR
LNIAACSLGGAQAALDKALAYTAERKAFGKAINQFQALQFRLADMETELEVARTFLWRAASALDRSDPKATRLCAMAKRF
VTDAGFEVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRVIIARGLVARGN

Sequences:

>Translated_380_residues
MFELTEDQIAIRDMARAFAREEIAPHALEWDEAHHFPIPTLKAAAALGMAGIYVRDDVGGSALSRLDATLIFEALAEGCP
ATSAYLSIHNMVAWMIDRFGAPEQRTRWLPKLCAMDIVASYCLTEPGSGSDAAALKTRAARDGDHYVLHGEKQFISGAGA
SDLYAVMARTGGEGPGGVSTILVEAGTPGLSFGANEKKMGWRVQPTRAVIFDGVRVPVENRIGAEGDGFKFAMAGLDGGR
LNIAACSLGGAQAALDKALAYTAERKAFGKAINQFQALQFRLADMETELEVARTFLWRAASALDRSDPKATRLCAMAKRF
VTDAGFEVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRVIIARGLVARGN
>Mature_380_residues
MFELTEDQIAIRDMARAFAREEIAPHALEWDEAHHFPIPTLKAAAALGMAGIYVRDDVGGSALSRLDATLIFEALAEGCP
ATSAYLSIHNMVAWMIDRFGAPEQRTRWLPKLCAMDIVASYCLTEPGSGSDAAALKTRAARDGDHYVLHGEKQFISGAGA
SDLYAVMARTGGEGPGGVSTILVEAGTPGLSFGANEKKMGWRVQPTRAVIFDGVRVPVENRIGAEGDGFKFAMAGLDGGR
LNIAACSLGGAQAALDKALAYTAERKAFGKAINQFQALQFRLADMETELEVARTFLWRAASALDRSDPKATRLCAMAKRF
VTDAGFEVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRVIIARGLVARGN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=57.9088471849866, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=38.563829787234, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=38.8297872340425, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=37.7659574468085, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=36.0742705570292, Blast_Score=238, Evalue=5e-63,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=33.4231805929919, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI76496475, Length=402, Percent_Identity=32.089552238806, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4557235, Length=402, Percent_Identity=32.089552238806, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=32.1052631578947, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI21361497, Length=364, Percent_Identity=33.7912087912088, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=32.3529411764706, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=29.3650793650794, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI7669494, Length=349, Percent_Identity=29.7994269340974, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=28.7671232876712, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI48976061, Length=287, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI211971008, Length=287, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=30.2872062663185, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=27.3684210526316, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87082384, Length=264, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=48.2758620689655, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=37.7308707124011, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=39.1534391534392, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=35.4330708661417, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=34.4086021505376, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=34.0482573726542, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=34.0369393139842, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=32.2946175637394, Blast_Score=200, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=37.1841155234657, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=259, Percent_Identity=36.2934362934363, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=32.5088339222615, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.2116788321168, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=29.2225201072386, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17505929, Length=358, Percent_Identity=30.4469273743017, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=25.9946949602122, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=252, Percent_Identity=30.952380952381, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=28.75, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI86563381, Length=332, Percent_Identity=26.8072289156627, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=332, Percent_Identity=26.8072289156627, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=39.1534391534392, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=36.5591397849462, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=35.9580052493438, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=35.3099730458221, Blast_Score=231, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=35.3723404255319, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI281363737, Length=340, Percent_Identity=34.4117647058824, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=27.9683377308707, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24652780, Length=277, Percent_Identity=23.1046931407942, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40881; Mature: 40881

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFELTEDQIAIRDMARAFAREEIAPHALEWDEAHHFPIPTLKAAAALGMAGIYVRDDVGG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCH
SALSRLDATLIFEALAEGCPATSAYLSIHNMVAWMIDRFGAPEQRTRWLPKLCAMDIVAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YCLTEPGSGSDAAALKTRAARDGDHYVLHGEKQFISGAGASDLYAVMARTGGEGPGGVST
HHHCCCCCCCCHHHHHHHHCCCCCEEEEECCHHHHCCCCHHHHHHHHHHCCCCCCCCCEE
ILVEAGTPGLSFGANEKKMGWRVQPTRAVIFDGVRVPVENRIGAEGDGFKFAMAGLDGGR
EEEECCCCCCCCCCCCCCCCCEECCCCEEEECCEECCCCCCCCCCCCCCEEEEECCCCCC
LNIAACSLGGAQAALDKALAYTAERKAFGKAINQFQALQFRLADMETELEVARTFLWRAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALDRSDPKATRLCAMAKRFVTDAGFEVANEALQLHGGYGYLADYGVEKIVRDLRVHQIL
HHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EGTNEIMRVIIARGLVARGN
HHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure
MFELTEDQIAIRDMARAFAREEIAPHALEWDEAHHFPIPTLKAAAALGMAGIYVRDDVGG
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCH
SALSRLDATLIFEALAEGCPATSAYLSIHNMVAWMIDRFGAPEQRTRWLPKLCAMDIVAS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
YCLTEPGSGSDAAALKTRAARDGDHYVLHGEKQFISGAGASDLYAVMARTGGEGPGGVST
HHHCCCCCCCCHHHHHHHHCCCCCEEEEECCHHHHCCCCHHHHHHHHHHCCCCCCCCCEE
ILVEAGTPGLSFGANEKKMGWRVQPTRAVIFDGVRVPVENRIGAEGDGFKFAMAGLDGGR
EEEECCCCCCCCCCCCCCCCCEECCCCEEEECCEECCCCCCCCCCCCCCEEEEECCCCCC
LNIAACSLGGAQAALDKALAYTAERKAFGKAINQFQALQFRLADMETELEVARTFLWRAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SALDRSDPKATRLCAMAKRFVTDAGFEVANEALQLHGGYGYLADYGVEKIVRDLRVHQIL
HHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
EGTNEIMRVIIARGLVARGN
HHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]