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The map label for this gene is acsA [H]

Identifier: 158422173

GI number: 158422173

Start: 606988

End: 608592

Strand: Reverse

Name: acsA [H]

Synonym: AZC_0549

Alternate gene names: 158422173

Gene position: 608592-606988 (Counterclockwise)

Preceding gene: 158422174

Following gene: 158422170

Centisome position: 11.33

GC content: 69.28

Gene sequence:

>1605_bases
ATGCTCGCGAACCTCGGCGATTTCGACCGGCTGCGCGCTGCCTTCCAGTGGCGCATCCCCGCCCGCTACAACATGGCCAC
CCACGCCTGCGACGGCTGGGCGGCGCGCGATCCCTCTCGCCCCGCGCTCTATGTGCCGCAGGGCGCGGACTTCGTGCCGG
TGAGCTACGGCCACCTCGCGGAAGCCTCCAACCGCTTCGCAAATGCGCTTGCCGCCAAGGGCATCACGCGCGGCGACCGG
GTGGCGATCCTGCTGCCGCAGAGCATCGAGGTGCTGGTCACCCACCTTGCGGTCTACAAGCTCGGCGCCATCGCCGTGCC
GCTGGCCTCTGCCTTCGGCGTCGAGGCCCTCACCTTCCGCCTGAACGATTCCGGCGCGCGGGCTCTGGTGGCCGACGCCG
CTGGTCTCGCCAAGCTCGCCGAACGGCCGGAGTGGCTCGACCTCATCGTCTCCCGTGACGGCCCCGCCCCCGGCATCGAG
GGCTTCGACGATCTCGTGTCGCGCGCCAGCGCCACCGCTCCCGGCATCATCACGGGGCCCGACGATCCGGCGCTGATGAT
CTACACCTCCGGCACCACCGGCGCGCCCAAGGGCGCCCTGCACGGCCACCGGGTGCTGATCGGCCATGTGACGGGACAGC
ACTTCACCCACGATTCCATGCCCGCCCCCGGCGACCGCATGTGGACGCCCTCCGACTGGGCCTGGGCCGGCGGCCTGCTC
AATACCGTCCTGTCGGCGCTCGCCCATGGCGTGCCCGTGGTGGTGCAGCCGCCCGGCCGGTTCGACCCGGAATCGGCCTT
TCGCCTCATGAAGACGGCGGGCGTGCGCAATGTCTTCATCCCACCAACCGCGCTCAAGATGATGCGCGCCGTGGAGAAGC
CGAAGGAACGCTTCGGCTTCAACCTGCGCACCGTGGGCACGGCGGGCGAGGCGCTGGGTGCGGAGACCTTCGAATGGGGC
CGCGCAGCGCTGGGGGTCGCCGTGAACGAATTCTACGGCCAGACCGAATGCAATTATGTCATCGGCTCCAACGCCCGCCT
CGGTGTCGCCCGCGCGGGCGCCACGGGCAAGGCGATTCCCGGCCATGACGTGCGCATCATCCGCACCGACGGCAGCCTCT
GCGACATCGGCGAGATGGGGCAGATCGCCATCCGCGCGCCGGACCCGGTGATGTTCCTGCGCTACTGGAACCAGCCGGAG
GCGACCGCCCGCAAGTATCTGGGCGACCTGTTCGTGACCGGCGACCTCGCACGGCTCGATGCGGACGGCTACATCCATTT
CCAGGGGCGGGACGACGACGTCATCACCTCATCGGGCTATCGCATCGGCCCGAGCGAGATCGAGGACTGCCTGCTGCGCC
ATCCCGCCGTACAGATCGCTGCTGTGGTCGGCAAGCCGGACCCGGTGCGCACGGAGATCGTGAAGGCCGTGCTGGTGCTG
CGGCCGGGCTACAAGCCGGGGCCGGAGCTGGTGAAGGAGATCCAGGACTTCGTGCGCACGCGCCTTGCGGCCTACGAATA
TCCGCGCGAGATCGTCTTCATGGACGAACTGCCGCTCACCACCACCGGCAAGGTCATCCGCCGCCTGTTACGCGACCAGA
CCTGA

Upstream 100 bases:

>100_bases
TGAGGCGCCGCTCCGCCTGCCGGAGCGGCAGATACCGCACTGCGGCATTTTTTTCGCAGACGCACTGGAAGTTTGGCTGC
CCAAGGCTTAATCACTTGGG

Downstream 100 bases:

>100_bases
ACGGCCGCCGGAGCCCGCTGCGACTCAGGCCGTTGCAGGCTGCTGCCACATGGGCATACGGGCTATGAGCGCCTTGTAGG
GGCCGAGGAATACAAGGATC

Product: fatty-acid-CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MLANLGDFDRLRAAFQWRIPARYNMATHACDGWAARDPSRPALYVPQGADFVPVSYGHLAEASNRFANALAAKGITRGDR
VAILLPQSIEVLVTHLAVYKLGAIAVPLASAFGVEALTFRLNDSGARALVADAAGLAKLAERPEWLDLIVSRDGPAPGIE
GFDDLVSRASATAPGIITGPDDPALMIYTSGTTGAPKGALHGHRVLIGHVTGQHFTHDSMPAPGDRMWTPSDWAWAGGLL
NTVLSALAHGVPVVVQPPGRFDPESAFRLMKTAGVRNVFIPPTALKMMRAVEKPKERFGFNLRTVGTAGEALGAETFEWG
RAALGVAVNEFYGQTECNYVIGSNARLGVARAGATGKAIPGHDVRIIRTDGSLCDIGEMGQIAIRAPDPVMFLRYWNQPE
ATARKYLGDLFVTGDLARLDADGYIHFQGRDDDVITSSGYRIGPSEIEDCLLRHPAVQIAAVVGKPDPVRTEIVKAVLVL
RPGYKPGPELVKEIQDFVRTRLAAYEYPREIVFMDELPLTTTGKVIRRLLRDQT

Sequences:

>Translated_534_residues
MLANLGDFDRLRAAFQWRIPARYNMATHACDGWAARDPSRPALYVPQGADFVPVSYGHLAEASNRFANALAAKGITRGDR
VAILLPQSIEVLVTHLAVYKLGAIAVPLASAFGVEALTFRLNDSGARALVADAAGLAKLAERPEWLDLIVSRDGPAPGIE
GFDDLVSRASATAPGIITGPDDPALMIYTSGTTGAPKGALHGHRVLIGHVTGQHFTHDSMPAPGDRMWTPSDWAWAGGLL
NTVLSALAHGVPVVVQPPGRFDPESAFRLMKTAGVRNVFIPPTALKMMRAVEKPKERFGFNLRTVGTAGEALGAETFEWG
RAALGVAVNEFYGQTECNYVIGSNARLGVARAGATGKAIPGHDVRIIRTDGSLCDIGEMGQIAIRAPDPVMFLRYWNQPE
ATARKYLGDLFVTGDLARLDADGYIHFQGRDDDVITSSGYRIGPSEIEDCLLRHPAVQIAAVVGKPDPVRTEIVKAVLVL
RPGYKPGPELVKEIQDFVRTRLAAYEYPREIVFMDELPLTTTGKVIRRLLRDQT
>Mature_534_residues
MLANLGDFDRLRAAFQWRIPARYNMATHACDGWAARDPSRPALYVPQGADFVPVSYGHLAEASNRFANALAAKGITRGDR
VAILLPQSIEVLVTHLAVYKLGAIAVPLASAFGVEALTFRLNDSGARALVADAAGLAKLAERPEWLDLIVSRDGPAPGIE
GFDDLVSRASATAPGIITGPDDPALMIYTSGTTGAPKGALHGHRVLIGHVTGQHFTHDSMPAPGDRMWTPSDWAWAGGLL
NTVLSALAHGVPVVVQPPGRFDPESAFRLMKTAGVRNVFIPPTALKMMRAVEKPKERFGFNLRTVGTAGEALGAETFEWG
RAALGVAVNEFYGQTECNYVIGSNARLGVARAGATGKAIPGHDVRIIRTDGSLCDIGEMGQIAIRAPDPVMFLRYWNQPE
ATARKYLGDLFVTGDLARLDADGYIHFQGRDDDVITSSGYRIGPSEIEDCLLRHPAVQIAAVVGKPDPVRTEIVKAVLVL
RPGYKPGPELVKEIQDFVRTRLAAYEYPREIVFMDELPLTTTGKVIRRLLRDQT

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=548, Percent_Identity=32.6642335766423, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI122937307, Length=548, Percent_Identity=35.036496350365, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI38505220, Length=534, Percent_Identity=34.2696629213483, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI157311624, Length=545, Percent_Identity=33.9449541284404, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI157311622, Length=545, Percent_Identity=33.9449541284404, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI58082049, Length=545, Percent_Identity=34.3119266055046, Blast_Score=265, Evalue=1e-70,
Organism=Homo sapiens, GI115511026, Length=535, Percent_Identity=31.588785046729, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI13375727, Length=517, Percent_Identity=28.6266924564797, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI28416953, Length=572, Percent_Identity=27.4475524475524, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI8923896, Length=537, Percent_Identity=26.2569832402235, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI253970489, Length=550, Percent_Identity=25.2727272727273, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI156151445, Length=539, Percent_Identity=25.974025974026, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI42544134, Length=377, Percent_Identity=26.790450928382, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI187761345, Length=524, Percent_Identity=26.3358778625954, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI187761343, Length=524, Percent_Identity=26.3358778625954, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI195947378, Length=448, Percent_Identity=25.6696428571429, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI31982927, Length=558, Percent_Identity=25.089605734767, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI38524616, Length=515, Percent_Identity=26.4077669902913, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=556, Percent_Identity=28.4172661870504, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=26.7504488330341, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI145693145, Length=516, Percent_Identity=28.4883720930233, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1786529, Length=560, Percent_Identity=26.0714285714286, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1786810, Length=508, Percent_Identity=25.1968503937008, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786801, Length=451, Percent_Identity=24.8337028824834, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789201, Length=501, Percent_Identity=23.9520958083832, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI221142682, Length=157, Percent_Identity=31.2101910828025, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32563687, Length=497, Percent_Identity=28.169014084507, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=27.7207392197125, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI71983001, Length=571, Percent_Identity=26.0945709281961, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71982997, Length=571, Percent_Identity=26.0945709281961, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17557194, Length=504, Percent_Identity=26.3888888888889, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=520, Percent_Identity=23.0769230769231, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=499, Percent_Identity=27.0541082164329, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71994703, Length=527, Percent_Identity=24.6679316888046, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71994694, Length=527, Percent_Identity=24.6679316888046, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71994690, Length=527, Percent_Identity=24.6679316888046, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17559526, Length=505, Percent_Identity=25.5445544554455, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=501, Percent_Identity=23.5528942115768, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI115534440, Length=558, Percent_Identity=24.1935483870968, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=364, Percent_Identity=26.9230769230769, Blast_Score=92, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6319264, Length=568, Percent_Identity=26.9366197183099, Blast_Score=170, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6323182, Length=563, Percent_Identity=26.8206039076377, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319699, Length=488, Percent_Identity=26.2295081967213, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21355225, Length=526, Percent_Identity=28.1368821292776, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24667955, Length=527, Percent_Identity=28.2732447817837, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI62472339, Length=527, Percent_Identity=28.2732447817837, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24667959, Length=496, Percent_Identity=27.0161290322581, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18859661, Length=512, Percent_Identity=27.34375, Blast_Score=128, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24581924, Length=506, Percent_Identity=23.7154150197628, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19922652, Length=497, Percent_Identity=24.9496981891348, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656500, Length=516, Percent_Identity=24.8062015503876, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21356947, Length=501, Percent_Identity=23.75249500998, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24648260, Length=367, Percent_Identity=26.4305177111717, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653035, Length=495, Percent_Identity=23.4343434343434, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI161076582, Length=501, Percent_Identity=22.9540918163673, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355181, Length=498, Percent_Identity=24.2971887550201, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45550496, Length=550, Percent_Identity=25.0909090909091, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45552801, Length=550, Percent_Identity=25.2727272727273, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20130357, Length=494, Percent_Identity=22.6720647773279, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648253, Length=489, Percent_Identity=22.4948875255624, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648255, Length=489, Percent_Identity=22.0858895705521, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281365686, Length=330, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356441, Length=450, Percent_Identity=22.4444444444444, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21358303, Length=457, Percent_Identity=22.9759299781182, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 57668; Mature: 57668

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANLGDFDRLRAAFQWRIPARYNMATHACDGWAARDPSRPALYVPQGADFVPVSYGHLA
CCCCCCCHHHHHHHHEEECCCCCCCHHHCCCCCCCCCCCCCEEECCCCCCEEECCCHHHH
EASNRFANALAAKGITRGDRVAILLPQSIEVLVTHLAVYKLGAIAVPLASAFGVEALTFR
HHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
LNDSGARALVADAAGLAKLAERPEWLDLIVSRDGPAPGIEGFDDLVSRASATAPGIITGP
ECCCCCEEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEECC
DDPALMIYTSGTTGAPKGALHGHRVLIGHVTGQHFTHDSMPAPGDRMWTPSDWAWAGGLL
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
NTVLSALAHGVPVVVQPPGRFDPESAFRLMKTAGVRNVFIPPTALKMMRAVEKPKERFGF
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCHHHHHCC
NLRTVGTAGEALGAETFEWGRAALGVAVNEFYGQTECNYVIGSNARLGVARAGATGKAIP
CEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCC
GHDVRIIRTDGSLCDIGEMGQIAIRAPDPVMFLRYWNQPEATARKYLGDLFVTGDLARLD
CCCEEEEECCCCEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHEEEECCCEEEC
ADGYIHFQGRDDDVITSSGYRIGPSEIEDCLLRHPAVQIAAVVGKPDPVRTEIVKAVLVL
CCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHC
RPGYKPGPELVKEIQDFVRTRLAAYEYPREIVFMDELPLTTTGKVIRRLLRDQT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLANLGDFDRLRAAFQWRIPARYNMATHACDGWAARDPSRPALYVPQGADFVPVSYGHLA
CCCCCCCHHHHHHHHEEECCCCCCCHHHCCCCCCCCCCCCCEEECCCCCCEEECCCHHHH
EASNRFANALAAKGITRGDRVAILLPQSIEVLVTHLAVYKLGAIAVPLASAFGVEALTFR
HHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
LNDSGARALVADAAGLAKLAERPEWLDLIVSRDGPAPGIEGFDDLVSRASATAPGIITGP
ECCCCCEEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCCEEECC
DDPALMIYTSGTTGAPKGALHGHRVLIGHVTGQHFTHDSMPAPGDRMWTPSDWAWAGGLL
CCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
NTVLSALAHGVPVVVQPPGRFDPESAFRLMKTAGVRNVFIPPTALKMMRAVEKPKERFGF
HHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHCHHHHHCC
NLRTVGTAGEALGAETFEWGRAALGVAVNEFYGQTECNYVIGSNARLGVARAGATGKAIP
CEEEECCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCC
GHDVRIIRTDGSLCDIGEMGQIAIRAPDPVMFLRYWNQPEATARKYLGDLFVTGDLARLD
CCCEEEEECCCCEECCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHEEEECCCEEEC
ADGYIHFQGRDDDVITSSGYRIGPSEIEDCLLRHPAVQIAAVVGKPDPVRTEIVKAVLVL
CCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHEEEEEECCCCCHHHHHHHHHHHC
RPGYKPGPELVKEIQDFVRTRLAAYEYPREIVFMDELPLTTTGKVIRRLLRDQT
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]