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The map label for this gene is mutY [H]

Identifier: 158422080

GI number: 158422080

Start: 508045

End: 509166

Strand: Reverse

Name: mutY [H]

Synonym: AZC_0456

Alternate gene names: 158422080

Gene position: 509166-508045 (Counterclockwise)

Preceding gene: 158422083

Following gene: 158422079

Centisome position: 9.48

GC content: 72.37

Gene sequence:

>1122_bases
ATGACCGCCCGCGCCACCGCCGCCAAGCCGACCGCCCCGACGCCCGCCGCCACGAAACGGCAGGCCCCCAGGTCCAGCAC
CGCCCCCGCCCCCTCGGCCCTGTTGGCCTGGTACGACCGGCACCGGCGCCGCCTGCCCTGGCGGGCGGAAGCGGGACGCA
CCGCCGATCCCTACCACGTCTTCCTGTCGGAGATCATGCTCCAGCAGACGACGGTGAAGGCGGTCGGGCCCTATTTCACC
GATTTCCTGCGCCGCTGGCCCACCGTGCGGCATCTGGCGGAGGCGCCGCTGGAAGAGGTGCTCTCGGCCTGGGCGGGGCT
CGGTTATTACGCGCGCGCCCGCAACCTGCACGCCTGCGCCAAGGCGGTGGTGGCGCGCCACGGCGGACACTTCCCGGCCG
ACGAGGCAGCCTTGCTCGACCTGCCGGGCATCGGCCCCTATACGGCCGCAGCGATCTCCGCCATCGCCTTCGATCTGAAA
GCGAGCCCGGTGGACGGCAATATCGAGCGGGTGGTGAGCCGCCTGTATGCGGTGGACGAGCCGCTGCCCAAATCGAAGCC
CCGCATCAAGGCGCTGGCCGCGGCGCTGACGCCGGAGCGGCGGCCCGGCGATTTCGCGCAGGCCATGATGGACCTCGGCG
CCACCATCTGCACGCCACGCAGCCCCGCCTGCCCGCTCTGTCCCTGGATGGAGCCCTGCACCGCACGGGCGGAGGGCGAT
CCCGCCCGTTACCCGGTGAAGGCGCCGAAGGGCGAGAAGCCAAAGCGTGAGGGCATCGCCTTCCTGATCGTTCGGGCGGA
CGGCGCCGTGCTCCTGCGCACCCGCCCCGACAAGGGACTGCTGGCCAAGATGACCGAGGTGCCCTCAACCCCTTGGGGCG
CCAGACCCGAAACCCCGGCGACCCACGCTCCGCTGGCGGCACGGTGGCGGCCGCTGCCCGGCGCGGTGGAGCATGTCTTC
ACCCACTTCGCCCTCACCCTGTCCGTGCTGCGGGCCGATGTGCCGGCGCGCACACCGGCGCCCGATGGCCATCGCTGGGT
GCACCCTTCCGGATTTGACCGCGAGGCCCTGCCCTCCGTCATGCGCAAAGTGCTGGCGCACGGGCGGATCGGCGAGGGCT
GA

Upstream 100 bases:

>100_bases
GATGGGCCTGCTTCGGCTTGCGCATGACGAACCGCTGTTCTCCAAAACCACCCACGGGAAGGGCCTTGCCCCGGCCCGCG
GCAGACGGCACGGTGCCGCC

Downstream 100 bases:

>100_bases
AGGAGCTTAAACGCCGCAGAACGGATCTGGATTACTGCTCGATCCGGGATAATGAGTTTCGCAAACGGCCGATTATCCGC
AGGACCGAAAGGGCTATCTC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTARATAAKPTAPTPAATKRQAPRSSTAPAPSALLAWYDRHRRRLPWRAEAGRTADPYHVFLSEIMLQQTTVKAVGPYFT
DFLRRWPTVRHLAEAPLEEVLSAWAGLGYYARARNLHACAKAVVARHGGHFPADEAALLDLPGIGPYTAAAISAIAFDLK
ASPVDGNIERVVSRLYAVDEPLPKSKPRIKALAAALTPERRPGDFAQAMMDLGATICTPRSPACPLCPWMEPCTARAEGD
PARYPVKAPKGEKPKREGIAFLIVRADGAVLLRTRPDKGLLAKMTEVPSTPWGARPETPATHAPLAARWRPLPGAVEHVF
THFALTLSVLRADVPARTPAPDGHRWVHPSGFDREALPSVMRKVLAHGRIGEG

Sequences:

>Translated_373_residues
MTARATAAKPTAPTPAATKRQAPRSSTAPAPSALLAWYDRHRRRLPWRAEAGRTADPYHVFLSEIMLQQTTVKAVGPYFT
DFLRRWPTVRHLAEAPLEEVLSAWAGLGYYARARNLHACAKAVVARHGGHFPADEAALLDLPGIGPYTAAAISAIAFDLK
ASPVDGNIERVVSRLYAVDEPLPKSKPRIKALAAALTPERRPGDFAQAMMDLGATICTPRSPACPLCPWMEPCTARAEGD
PARYPVKAPKGEKPKREGIAFLIVRADGAVLLRTRPDKGLLAKMTEVPSTPWGARPETPATHAPLAARWRPLPGAVEHVF
THFALTLSVLRADVPARTPAPDGHRWVHPSGFDREALPSVMRKVLAHGRIGEG
>Mature_372_residues
TARATAAKPTAPTPAATKRQAPRSSTAPAPSALLAWYDRHRRRLPWRAEAGRTADPYHVFLSEIMLQQTTVKAVGPYFTD
FLRRWPTVRHLAEAPLEEVLSAWAGLGYYARARNLHACAKAVVARHGGHFPADEAALLDLPGIGPYTAAAISAIAFDLKA
SPVDGNIERVVSRLYAVDEPLPKSKPRIKALAAALTPERRPGDFAQAMMDLGATICTPRSPACPLCPWMEPCTARAEGDP
ARYPVKAPKGEKPKREGIAFLIVRADGAVLLRTRPDKGLLAKMTEVPSTPWGARPETPATHAPLAARWRPLPGAVEHVFT
HFALTLSVLRADVPARTPAPDGHRWVHPSGFDREALPSVMRKVLAHGRIGEG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI190358497, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI115298648, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI6912520, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI115298654, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI115298652, Length=399, Percent_Identity=36.8421052631579, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789331, Length=312, Percent_Identity=41.3461538461538, Blast_Score=212, Evalue=4e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40449; Mature: 40318

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARATAAKPTAPTPAATKRQAPRSSTAPAPSALLAWYDRHRRRLPWRAEAGRTADPYHV
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FLSEIMLQQTTVKAVGPYFTDFLRRWPTVRHLAEAPLEEVLSAWAGLGYYARARNLHACA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
KAVVARHGGHFPADEAALLDLPGIGPYTAAAISAIAFDLKASPVDGNIERVVSRLYAVDE
HHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PLPKSKPRIKALAAALTPERRPGDFAQAMMDLGATICTPRSPACPLCPWMEPCTARAEGD
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCC
PARYPVKAPKGEKPKREGIAFLIVRADGAVLLRTRPDKGLLAKMTEVPSTPWGARPETPA
CCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCC
THAPLAARWRPLPGAVEHVFTHFALTLSVLRADVPARTPAPDGHRWVHPSGFDREALPSV
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHH
MRKVLAHGRIGEG
HHHHHHCCCCCCC
>Mature Secondary Structure 
TARATAAKPTAPTPAATKRQAPRSSTAPAPSALLAWYDRHRRRLPWRAEAGRTADPYHV
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FLSEIMLQQTTVKAVGPYFTDFLRRWPTVRHLAEAPLEEVLSAWAGLGYYARARNLHACA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
KAVVARHGGHFPADEAALLDLPGIGPYTAAAISAIAFDLKASPVDGNIERVVSRLYAVDE
HHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
PLPKSKPRIKALAAALTPERRPGDFAQAMMDLGATICTPRSPACPLCPWMEPCTARAEGD
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCC
PARYPVKAPKGEKPKREGIAFLIVRADGAVLLRTRPDKGLLAKMTEVPSTPWGARPETPA
CCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCC
THAPLAARWRPLPGAVEHVFTHFALTLSVLRADVPARTPAPDGHRWVHPSGFDREALPSV
CCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHH
MRKVLAHGRIGEG
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]