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The map label for this gene is pntAA [H]

Identifier: 158422054

GI number: 158422054

Start: 483883

End: 485034

Strand: Direct

Name: pntAA [H]

Synonym: AZC_0430

Alternate gene names: 158422054

Gene position: 483883-485034 (Clockwise)

Preceding gene: 158422053

Following gene: 158422055

Centisome position: 9.01

GC content: 69.01

Gene sequence:

>1152_bases
ATGAAAATCGCTGTACCCGCCGAGGTTGATCTCGGCGAGCCGAGGGTTGCTGCGACCCCGGATACGGTCAAGCGCCTGAT
CGGCCTTGGCGCGGAGGTGGCTGTCCAGTCGGGCGCCGGCCTCGCCTCGGGTATTCCCGATGCCGATTATCAGGCCGTTG
GCGCGACCATTGCCGCCACCGCCGGCGACGCGGTGAGCGGCGCTGACGTTGTGCTCAAGGTGCGCCGTCCCACGGTGGAA
GAGATCGCCGGCTACAAGAGCGGCGCCCTCGTCATCGGCATCATGGATCCCTATGGCAATGAGGCGGCTCTGGCCGAGCT
CGCCAAGGCCGGTCTGTCCACCTTCGCCATGGAGCTGATGCCGCGCATCACCCGCGCGCAGGTGATGGACGTGCTGTCCT
CGCAGGCGAACCTCGCCGGCTATCGCGCCGTGATCGACGCCTCGGCCGAGTTCGGCCGCGCCCTGCCCATGATGATGACC
GCCGCCGGCACCGTTCCGGCCGCCAAGGTCTTCGTGATGGGCGCCGGCGTCGCCGGCCTTCAGGCCATCGCGACCGCCCG
CCGCCTCGGCGCGGTCGTCACCGCCACCGACGTGCGTCCCGCCGCCAAGGAGCAGGTGGAATCCCTCGGCGCCAAGTTCG
TCGCGGTGGAGGACGAGGAGTTCAAGCAGGCCGAGACGGCGGCGGGCTACGCCAAGCCCATGTCCGCCGAATATCAGGCC
AAGCAGGCGGCCCTCGTCGCCGAGCACATCAAGAAGCAGGACATCGTCATCACCACGGCGCTGATCCCCGGCCGGCCTGC
GCCGCGCCTGGTCTCCGCCGCCATGGTGGCCTCCATGAAGCCCGGCTCCGTGATCGTCGACCTCGCGGTCGAGCGCGGCG
GCAACGTGGAAGGCGCGGTGCCCGGCGAGGTCGCGGACGTGAACGGCGTGAAGATCGTCGGCCACCTCAACGTGCCCGGC
CGCCTCGCTGCCTCGTCCTCGCAGCTTTATGCCAAGAACCTCTTCGCCTTCCTCGAGACCCTCGTGGACAAGCAGGCGAA
GGCGCTGGCGGTGAAGTGGGACGACGAGCTGGTCAAGGCCACCCTGCTCACCCGCGACGGCGCCGTGGTGCATCCGAATT
TCGCCCCCAAGGTTGAGGGAGCTGCCCAATGA

Upstream 100 bases:

>100_bases
CCGCGCTGACCAAATGGGGCACGGTCGCCGTCGCCGCCCTGATGGTCATCATGTGGTTCACTCTCCTCTGAGCGCTGCTC
GGAACTCGTAGAGGTTTCAG

Downstream 100 bases:

>100_bases
ACCCCATCACCGCTCAGGCCGCGGCTGATTCCGCCGCCCAGGCGAAGGCTGCCGCCGAGATCGCCCGGCAGGCCGCGGAC
GCCGCCCAGCTCTATGCCGA

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MKIAVPAEVDLGEPRVAATPDTVKRLIGLGAEVAVQSGAGLASGIPDADYQAVGATIAATAGDAVSGADVVLKVRRPTVE
EIAGYKSGALVIGIMDPYGNEAALAELAKAGLSTFAMELMPRITRAQVMDVLSSQANLAGYRAVIDASAEFGRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVESLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLVSAAMVASMKPGSVIVDLAVERGGNVEGAVPGEVADVNGVKIVGHLNVPG
RLAASSSQLYAKNLFAFLETLVDKQAKALAVKWDDELVKATLLTRDGAVVHPNFAPKVEGAAQ

Sequences:

>Translated_383_residues
MKIAVPAEVDLGEPRVAATPDTVKRLIGLGAEVAVQSGAGLASGIPDADYQAVGATIAATAGDAVSGADVVLKVRRPTVE
EIAGYKSGALVIGIMDPYGNEAALAELAKAGLSTFAMELMPRITRAQVMDVLSSQANLAGYRAVIDASAEFGRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVESLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLVSAAMVASMKPGSVIVDLAVERGGNVEGAVPGEVADVNGVKIVGHLNVPG
RLAASSSQLYAKNLFAFLETLVDKQAKALAVKWDDELVKATLLTRDGAVVHPNFAPKVEGAAQ
>Mature_383_residues
MKIAVPAEVDLGEPRVAATPDTVKRLIGLGAEVAVQSGAGLASGIPDADYQAVGATIAATAGDAVSGADVVLKVRRPTVE
EIAGYKSGALVIGIMDPYGNEAALAELAKAGLSTFAMELMPRITRAQVMDVLSSQANLAGYRAVIDASAEFGRALPMMMT
AAGTVPAAKVFVMGAGVAGLQAIATARRLGAVVTATDVRPAAKEQVESLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLVSAAMVASMKPGSVIVDLAVERGGNVEGAVPGEVADVNGVKIVGHLNVPG
RLAASSSQLYAKNLFAFLETLVDKQAKALAVKWDDELVKATLLTRDGAVVHPNFAPKVEGAAQ

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=390, Percent_Identity=39.7435897435897, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI122939153, Length=390, Percent_Identity=39.7435897435897, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI1787887, Length=380, Percent_Identity=45.2631578947368, Blast_Score=312, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17550456, Length=367, Percent_Identity=46.3215258855586, Blast_Score=305, Evalue=2e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39301; Mature: 39301

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVPAEVDLGEPRVAATPDTVKRLIGLGAEVAVQSGAGLASGIPDADYQAVGATIAAT
CEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHEEECCCCCCCCCCCCCHHHHCCEEEEC
AGDAVSGADVVLKVRRPTVEEIAGYKSGALVIGIMDPYGNEAALAELAKAGLSTFAMELM
CCCCCCCCEEEEEECCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVIDASAEFGRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHCCCCCHHHHEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVESLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHH
KQAALVAEHIKKQDIVITTALIPGRPAPRLVSAAMVASMKPGSVIVDLAVERGGNVEGAV
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PGEVADVNGVKIVGHLNVPGRLAASSSQLYAKNLFAFLETLVDKQAKALAVKWDDELVKA
CCCEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEECCHHHHHH
TLLTRDGAVVHPNFAPKVEGAAQ
HHEECCCCEECCCCCCCCCCCCC
>Mature Secondary Structure
MKIAVPAEVDLGEPRVAATPDTVKRLIGLGAEVAVQSGAGLASGIPDADYQAVGATIAAT
CEEECCCCCCCCCCCCCCCHHHHHHHHCCCHHHEEECCCCCCCCCCCCCHHHHCCEEEEC
AGDAVSGADVVLKVRRPTVEEIAGYKSGALVIGIMDPYGNEAALAELAKAGLSTFAMELM
CCCCCCCCEEEEEECCCCHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVIDASAEFGRALPMMMTAAGTVPAAKVFVMGAGVAGL
HHHHHHHHHHHHHHCCCCCHHHHEEECCHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHH
QAIATARRLGAVVTATDVRPAAKEQVESLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHH
KQAALVAEHIKKQDIVITTALIPGRPAPRLVSAAMVASMKPGSVIVDLAVERGGNVEGAV
HHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PGEVADVNGVKIVGHLNVPGRLAASSSQLYAKNLFAFLETLVDKQAKALAVKWDDELVKA
CCCEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEECCHHHHHH
TLLTRDGAVVHPNFAPKVEGAAQ
HHEECCCCEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]