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The map label for this gene is carE [H]

Identifier: 158422006

GI number: 158422006

Start: 436592

End: 437701

Strand: Reverse

Name: carE [H]

Synonym: AZC_0382

Alternate gene names: 158422006

Gene position: 437701-436592 (Counterclockwise)

Preceding gene: 158422011

Following gene: 158422001

Centisome position: 8.15

GC content: 66.94

Gene sequence:

>1110_bases
GTGAATATTCCTGCGTTGACCGGCGCCCGGTTTTTCGCAGCCGCCGCGATTGTGCTGTATCACTCGCAATTGCCACCCTT
CTTTCCCGCCGATGCGTTCTGGCCGCTGGATCCGAGCGGCGGCGTGCCGTTCTTCTTCGTGCTGTCCGGCTTCGTCCTCA
CGCTGCACGCGGAGAAATACCGCTCGCATCTGCAGTTCATGATCGCCCGCCTGGCGCGCATCTGGCCGGCCTATCTGGCG
GCGGTGGCCTTCTGGTTTGCGCTGTTCTGGCCGTACAGCCGGATGCTGATCGAGAGCAGCGGCACGCAAGTGGCAATCCT
GGTCGCCAACCTCGCCATGGTGCAGGCCTGGGTGCCCGACAGGATCGTCTATTGGTCGATCAATGCGCCGTCCTGGTCCG
TATCGGCGGAGATGTTCTTCTATGCCGTCTTCCCCGCCGTGCTGTGGCGGATGCGCCGGCACGGGCTCGTCTGGCTGGCG
CTGCTGACCCTCGCGGTGATTGCCGCACAGATGGCGGTGTGGACATTGTTTCCCGGCGTGGATGTGCTCTGGCTCGGCCG
GTACAATCCCGTGATCTACCTGCCGGCCTTCGCCGCCGGAGTCCTGGCGGGACATTGGTTCAAGGCCACCGGGCGCAGCC
CGCGCGAGGGCACGCGCATCCAGTGGGGCGCACTGGCGCTGATGCTGGCGGCCAACATGCTGTTCAAGGTGGAATGGCTG
GGGGCCCTGCCGCTGCCGCTGGCGATGGCCATCGCCGCCACCGGCGCCGCACCCGCCTATGCGGCGCTGATCCTGGCGCT
GGGGCGCTATGACGGCGGCCCCAGCCGCTGGCTCTCGCGCCCGTCCATCGTGTTCCTCGGGGAGATCAGCTATGGGCTGT
ATCTCTTCCATCAGCTCATTATCCGCTGGCATACGGACCACCTGGCCGCGTTCTCGGGCGTGCCGGTCTGGGGGCAATAT
GCCGGCATCTGGATCGCCGCGCTGCTGATCTCCGCTGTGTGCTACCTGCTGATCGAGCGGCCCGGCCGCCGCGGCATCGT
CGCCCTGGGCGCGTCCGCACGGGCGGCCTTGGCGCAGAAGCGGTCAGGGCCAATCAGTGATCGGCCCTGA

Upstream 100 bases:

>100_bases
CAGAAGGCCACACCTTGCAAACGGACAGGCGGCTCGGCATAAGCAACGCGGCGCCTACCAAAGCACCGTACCGTTAACAG
GCCTGAGGGGTGGGCTCCTC

Downstream 100 bases:

>100_bases
TGGGGGGCGCCGTCAGCGGGTGAGCTTCTTCTCCACCAGCCAGTTCTGGATCACGCCCGCCACCTCGTCGCTGTTGCGGT
CCATCATGATGAGGTGGCTG

Product: acyltransferase 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNIPALTGARFFAAAAIVLYHSQLPPFFPADAFWPLDPSGGVPFFFVLSGFVLTLHAEKYRSHLQFMIARLARIWPAYLA
AVAFWFALFWPYSRMLIESSGTQVAILVANLAMVQAWVPDRIVYWSINAPSWSVSAEMFFYAVFPAVLWRMRRHGLVWLA
LLTLAVIAAQMAVWTLFPGVDVLWLGRYNPVIYLPAFAAGVLAGHWFKATGRSPREGTRIQWGALALMLAANMLFKVEWL
GALPLPLAMAIAATGAAPAYAALILALGRYDGGPSRWLSRPSIVFLGEISYGLYLFHQLIIRWHTDHLAAFSGVPVWGQY
AGIWIAALLISAVCYLLIERPGRRGIVALGASARAALAQKRSGPISDRP

Sequences:

>Translated_369_residues
MNIPALTGARFFAAAAIVLYHSQLPPFFPADAFWPLDPSGGVPFFFVLSGFVLTLHAEKYRSHLQFMIARLARIWPAYLA
AVAFWFALFWPYSRMLIESSGTQVAILVANLAMVQAWVPDRIVYWSINAPSWSVSAEMFFYAVFPAVLWRMRRHGLVWLA
LLTLAVIAAQMAVWTLFPGVDVLWLGRYNPVIYLPAFAAGVLAGHWFKATGRSPREGTRIQWGALALMLAANMLFKVEWL
GALPLPLAMAIAATGAAPAYAALILALGRYDGGPSRWLSRPSIVFLGEISYGLYLFHQLIIRWHTDHLAAFSGVPVWGQY
AGIWIAALLISAVCYLLIERPGRRGIVALGASARAALAQKRSGPISDRP
>Mature_369_residues
MNIPALTGARFFAAAAIVLYHSQLPPFFPADAFWPLDPSGGVPFFFVLSGFVLTLHAEKYRSHLQFMIARLARIWPAYLA
AVAFWFALFWPYSRMLIESSGTQVAILVANLAMVQAWVPDRIVYWSINAPSWSVSAEMFFYAVFPAVLWRMRRHGLVWLA
LLTLAVIAAQMAVWTLFPGVDVLWLGRYNPVIYLPAFAAGVLAGHWFKATGRSPREGTRIQWGALALMLAANMLFKVEWL
GALPLPLAMAIAATGAAPAYAALILALGRYDGGPSRWLSRPSIVFLGEISYGLYLFHQLIIRWHTDHLAAFSGVPVWGQY
AGIWIAALLISAVCYLLIERPGRRGIVALGASARAALAQKRSGPISDRP

Specific function: Catalyzes the acylation of the mycaminose sugar during carbomycin biosynthesis. Recombinant strains containing care can use spiramycin as a substrate and convert it to the hybrid antibiotic, isovaleryl spiramycin [H]

COG id: COG1835

COG function: function code I; Predicted acyltransferases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002656 [H]

Pfam domain/function: PF01757 Acyl_transf_3 [H]

EC number: NA

Molecular weight: Translated: 40745; Mature: 40745

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPALTGARFFAAAAIVLYHSQLPPFFPADAFWPLDPSGGVPFFFVLSGFVLTLHAEKY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHH
RSHLQFMIARLARIWPAYLAAVAFWFALFWPYSRMLIESSGTQVAILVANLAMVQAWVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCCC
RIVYWSINAPSWSVSAEMFFYAVFPAVLWRMRRHGLVWLALLTLAVIAAQMAVWTLFPGV
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
DVLWLGRYNPVIYLPAFAAGVLAGHWFKATGRSPREGTRIQWGALALMLAANMLFKVEWL
CEEEECCCCCEEEEHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEHHC
GALPLPLAMAIAATGAAPAYAALILALGRYDGGPSRWLSRPSIVFLGEISYGLYLFHQLI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHH
IRWHTDHLAAFSGVPVWGQYAGIWIAALLISAVCYLLIERPGRRGIVALGASARAALAQK
HHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
RSGPISDRP
CCCCCCCCC
>Mature Secondary Structure
MNIPALTGARFFAAAAIVLYHSQLPPFFPADAFWPLDPSGGVPFFFVLSGFVLTLHAEKY
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEHHHH
RSHLQFMIARLARIWPAYLAAVAFWFALFWPYSRMLIESSGTQVAILVANLAMVQAWVPD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHCCCC
RIVYWSINAPSWSVSAEMFFYAVFPAVLWRMRRHGLVWLALLTLAVIAAQMAVWTLFPGV
EEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
DVLWLGRYNPVIYLPAFAAGVLAGHWFKATGRSPREGTRIQWGALALMLAANMLFKVEWL
CEEEECCCCCEEEEHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEHHC
GALPLPLAMAIAATGAAPAYAALILALGRYDGGPSRWLSRPSIVFLGEISYGLYLFHQLI
CCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECHHHHHHHHHHHH
IRWHTDHLAAFSGVPVWGQYAGIWIAALLISAVCYLLIERPGRRGIVALGASARAALAQK
HHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHH
RSGPISDRP
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2628170; 7764361 [H]