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The map label for this gene is hemA [H]

Identifier: 158421958

GI number: 158421958

Start: 386047

End: 387324

Strand: Direct

Name: hemA [H]

Synonym: AZC_0334

Alternate gene names: 158421958

Gene position: 386047-387324 (Clockwise)

Preceding gene: 158421955

Following gene: 158421959

Centisome position: 7.19

GC content: 68.62

Gene sequence:

>1278_bases
ATGAGCTACGATCACTTCTTCGCCGACGCTGTCGATGCGCTTCGCCGCGAGCGTCGTTACCGCACCTTCGCCGATGTCGA
GCGGGACGCCACGCGCTTCCCCCGTGCCACGTGGCACTCGCCCGGCGGCCCGCGGGAAATCGTCGTGTGGTGCTCCAACG
ACTATCTGGGCATGGGCAGCCACCCCGCCGTGGTGGAAGCCATGCGCGAGACCGCGCTGCGCCGGGGGGCAGGCGCGGGC
GGCACGCGCAACATCTCGGGCAACAGCCACGAGATCGTCCTGCTGGAGCGTGAACTGGCCGACCTGCACGGCAAGGAGCA
GGGCCTCGTCTTCACCTCGGGCTATGTGTCGAACGCCACGGGCATCTCGACCATCGCCAAGCTGATCCCCGACTGCGTGG
TGATCTCGGACGAGCTGAACCACAATTCCATGATCGAGGGCGTCCGCCAGGGCGGCCGGCAGAAGTTCATCTTCCGCCAT
AACGACCTCGCCCATCTGGAAGAGATCCTCCAGGCGGTCGCGGACCGGCCGAAGCTGATCGTCTTCGAGAGCGTCTATTC
CATGGATGGCGACATCGCGCCCATGGCCGCCATCTGCGATCTGGCCGAGCGCTACGGCGCCATGACGTATCTCGATGAGG
TCCACGCGGTGGGCATGTATGGCCCGCGCGGCGGCGGCGTTGCCGAGCGCGACGGCGTCATGGACCGCATCGACGTGATC
GAGGGCACGCTGGGCAAGGCCTTCGGCGTGGTGGGCGGCTATCTCACCGGCAAGCGGGTGGTGATGGACGCCGTGCGCTC
CTATGCCCCGGGCTTCATCTTCACCACGGCCCTGCCGCCGGCGGTTGCCGCCGCCGCCACGGCCTCCATCCGGCATCTGA
AGGCCTCGAACGCCGAGCGCGACGGCCAGCGCCGTCAGGTCGCCAAGGTCAAGGCGGCGCTCGCCGCCGCCGGCCTGCCG
CAGATGGAAACCCCCACCCACATCGTTCCCGTGATGGTGGGCGACGCGAAGGCCTGCAAGGCCGCCAGCGACGTGCTCCT
CAACGAGCACAACATCTACATCCAGCCCATCAACTATCCCACCGTGCCGCGCGGCACGGAGCGCCTGCGCATCACGCCGA
CGCCCTTCCATAACGACAAGCTCATCGCGCACCTCGCCGATGCGCTGAACGACGTGTGGAATCGCCTCGACCTGCCGCGC
GTGCGCGACACCGGCAGCGAGCGCCGCCTCGTGGCGGCCGGCGCGGCATCGCTCGCCATGCCTACCGCCGGCGGCTGA

Upstream 100 bases:

>100_bases
CCCTGCGGCTTTCCCGCACTTGATCGAGCGCAAGGGAGGGCGCAAGGTGCCAGCATAAGATTAGAAAAGTTCGCGTCCAC
GTTCCGCCCCCGGATATCGA

Downstream 100 bases:

>100_bases
GCGCACAGACAGAAATCTTGTCCTTTCCAAAGCCCGGCCGTCGTGCCGGGCTTTTTGCTGTGGGGGAGCGTCTCTGCCGC
AGCCGGCGGTCGATCGCTTG

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSYDHFFADAVDALRRERRYRTFADVERDATRFPRATWHSPGGPREIVVWCSNDYLGMGSHPAVVEAMRETALRRGAGAG
GTRNISGNSHEIVLLERELADLHGKEQGLVFTSGYVSNATGISTIAKLIPDCVVISDELNHNSMIEGVRQGGRQKFIFRH
NDLAHLEEILQAVADRPKLIVFESVYSMDGDIAPMAAICDLAERYGAMTYLDEVHAVGMYGPRGGGVAERDGVMDRIDVI
EGTLGKAFGVVGGYLTGKRVVMDAVRSYAPGFIFTTALPPAVAAAATASIRHLKASNAERDGQRRQVAKVKAALAAAGLP
QMETPTHIVPVMVGDAKACKAASDVLLNEHNIYIQPINYPTVPRGTERLRITPTPFHNDKLIAHLADALNDVWNRLDLPR
VRDTGSERRLVAAGAASLAMPTAGG

Sequences:

>Translated_425_residues
MSYDHFFADAVDALRRERRYRTFADVERDATRFPRATWHSPGGPREIVVWCSNDYLGMGSHPAVVEAMRETALRRGAGAG
GTRNISGNSHEIVLLERELADLHGKEQGLVFTSGYVSNATGISTIAKLIPDCVVISDELNHNSMIEGVRQGGRQKFIFRH
NDLAHLEEILQAVADRPKLIVFESVYSMDGDIAPMAAICDLAERYGAMTYLDEVHAVGMYGPRGGGVAERDGVMDRIDVI
EGTLGKAFGVVGGYLTGKRVVMDAVRSYAPGFIFTTALPPAVAAAATASIRHLKASNAERDGQRRQVAKVKAALAAAGLP
QMETPTHIVPVMVGDAKACKAASDVLLNEHNIYIQPINYPTVPRGTERLRITPTPFHNDKLIAHLADALNDVWNRLDLPR
VRDTGSERRLVAAGAASLAMPTAGG
>Mature_424_residues
SYDHFFADAVDALRRERRYRTFADVERDATRFPRATWHSPGGPREIVVWCSNDYLGMGSHPAVVEAMRETALRRGAGAGG
TRNISGNSHEIVLLERELADLHGKEQGLVFTSGYVSNATGISTIAKLIPDCVVISDELNHNSMIEGVRQGGRQKFIFRHN
DLAHLEEILQAVADRPKLIVFESVYSMDGDIAPMAAICDLAERYGAMTYLDEVHAVGMYGPRGGGVAERDGVMDRIDVIE
GTLGKAFGVVGGYLTGKRVVMDAVRSYAPGFIFTTALPPAVAAAATASIRHLKASNAERDGQRRQVAKVKAALAAAGLPQ
METPTHIVPVMVGDAKACKAASDVLLNEHNIYIQPINYPTVPRGTERLRITPTPFHNDKLIAHLADALNDVWNRLDLPRV
RDTGSERRLVAAGAASLAMPTAGG

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI83977442, Length=404, Percent_Identity=48.2673267326733, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI83977440, Length=404, Percent_Identity=48.2673267326733, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI83977444, Length=404, Percent_Identity=48.2673267326733, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI4502025, Length=403, Percent_Identity=49.1315136476427, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI40316939, Length=403, Percent_Identity=49.1315136476427, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI7657118, Length=349, Percent_Identity=37.5358166189112, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI284448556, Length=349, Percent_Identity=37.5358166189112, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4758668, Length=372, Percent_Identity=28.494623655914, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI119220554, Length=383, Percent_Identity=26.6318537859008, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI5454084, Length=249, Percent_Identity=27.710843373494, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=32.4858757062147, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI1786993, Length=351, Percent_Identity=31.9088319088319, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=361, Percent_Identity=34.9030470914127, Blast_Score=215, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=375, Percent_Identity=28, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17560914, Length=373, Percent_Identity=26.5415549597855, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17560912, Length=281, Percent_Identity=30.2491103202847, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982617, Length=291, Percent_Identity=26.1168384879725, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=291, Percent_Identity=26.1168384879725, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=441, Percent_Identity=47.8458049886621, Blast_Score=418, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=28.2608695652174, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=260, Percent_Identity=25, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17137420, Length=401, Percent_Identity=47.1321695760599, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24662918, Length=375, Percent_Identity=34.9333333333333, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=27.7628032345013, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24653280, Length=251, Percent_Identity=25.8964143426295, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24653276, Length=251, Percent_Identity=25.8964143426295, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24653278, Length=251, Percent_Identity=25.8964143426295, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 46045; Mature: 45914

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDHFFADAVDALRRERRYRTFADVERDATRFPRATWHSPGGPREIVVWCSNDYLGMGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCC
HPAVVEAMRETALRRGAGAGGTRNISGNSHEIVLLERELADLHGKEQGLVFTSGYVSNAT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCEEEECCCCCCCH
GISTIAKLIPDCVVISDELNHNSMIEGVRQGGRQKFIFRHNDLAHLEEILQAVADRPKLI
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCCEE
VFESVYSMDGDIAPMAAICDLAERYGAMTYLDEVHAVGMYGPRGGGVAERDGVMDRIDVI
EEEHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EGTLGKAFGVVGGYLTGKRVVMDAVRSYAPGFIFTTALPPAVAAAATASIRHLKASNAER
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DGQRRQVAKVKAALAAAGLPQMETPTHIVPVMVGDAKACKAASDVLLNEHNIYIQPINYP
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCEEEEECCCC
TVPRGTERLRITPTPFHNDKLIAHLADALNDVWNRLDLPRVRDTGSERRLVAAGAASLAM
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHCC
PTAGG
CCCCC
>Mature Secondary Structure 
SYDHFFADAVDALRRERRYRTFADVERDATRFPRATWHSPGGPREIVVWCSNDYLGMGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCC
HPAVVEAMRETALRRGAGAGGTRNISGNSHEIVLLERELADLHGKEQGLVFTSGYVSNAT
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCEEEECCCCCCCH
GISTIAKLIPDCVVISDELNHNSMIEGVRQGGRQKFIFRHNDLAHLEEILQAVADRPKLI
HHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHCCCCEE
VFESVYSMDGDIAPMAAICDLAERYGAMTYLDEVHAVGMYGPRGGGVAERDGVMDRIDVI
EEEHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
EGTLGKAFGVVGGYLTGKRVVMDAVRSYAPGFIFTTALPPAVAAAATASIRHLKASNAER
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCC
DGQRRQVAKVKAALAAAGLPQMETPTHIVPVMVGDAKACKAASDVLLNEHNIYIQPINYP
CHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHEECCCCEEEEECCCC
TVPRGTERLRITPTPFHNDKLIAHLADALNDVWNRLDLPRVRDTGSERRLVAAGAASLAM
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHCC
PTAGG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]