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The map label for this gene is ldc [H]

Identifier: 158421957

GI number: 158421957

Start: 384008

End: 385138

Strand: Reverse

Name: ldc [H]

Synonym: AZC_0333

Alternate gene names: 158421957

Gene position: 385138-384008 (Counterclockwise)

Preceding gene: 158421961

Following gene: 158421956

Centisome position: 7.17

GC content: 65.96

Gene sequence:

>1131_bases
ATGACCGATCGCATCCGCGAATTCCTTCGGAACCGACGTGAGGATGGTCCCTGCGTCGTCGTTGACCTCGATGTGGTGCG
CGCGAACTATACTGCGTTCGCCCGTGCGCTGCCTGACACCCGTGTCTTCTACGCGGTGAAGGCCAATCCCGACGCGGCCA
TCCTGAAGGCCCTCGCCGAGCTGGGCTCGTGCTTCGACTGCGCCTCGGTGCAGGAGATCGAGATGGCGCTGTTCGCCGGC
GCCACCCCCGACCGCATCTCCTTCGGCAACACGATCAAGAAGGAGCGCGACATCGAGCGCGCCTACAAGATCGGCGTGCG
CCTGTTCGCGGTCGACTGCTACGAGGAAGTCGAGAAGATCGCCCGCGTTGCCCCCGGCGCGCGCGTGTTCTGCCGCATCC
TCTGCGACGGCGCGGGCGCCGAATGGCCGCTCTCGCGCAAGTTCGGCTGCGTCCCGGAGATGGCGCCGGACGTGCTGGAG
CATGCCTTCCGCCTCGGCCTCTCGCCCTATGGCGTGTCCTTCCATGTGGGCTCGCAGCAGAAGAACGTGCATGCCTGGGA
TCAGGCGCTCGGCTCTGCGGCCTATATCTTCCGCGAGTGCGCCGTGCGCGGCATCTCGCTCTCCATGGTGAACCTCGGCG
GCGGCTTCCCGACGAAGTATCTTCAGGATGTTCCCAAGGCGCAGGCCTATGGCGAGGCGATCTTCGATTCGCTGCGCCGC
CATTTCGGCAACGCCATCCCCGAGACCATCATGGAGCCCGGTCGCGGCATGGTCGGCAATGCCGGCATCATCGAGACCGA
GGTGGTGCTGATCTCCAAGAAGGCCGAGAGCGACACCATGCGCTGGGTCTATCTGGACATCGGCAAGTTCGGCGGGCTCG
CCGAGACCATGGACGAGGCGATCCGCTACCCGCTGCGCACGCCGCGCGACGGGGACGACACCGCCCCGTGCGTCCTCGCC
GGCCCGACCTGCGATTCGGCCGACGTGCTCTATGAGAAGACACCGGTGGAACTGCCCCTGTCGCTGTCCATCGGCGACAA
GGTGCTCATCGAGGCCTGCGGCGCCTACACCACCACCTATTCGGCGGTGGCGTTCAATGGCTTCCCGCCGCTGAAGTCCT
ACGTGATCTGA

Upstream 100 bases:

>100_bases
CGTGCCCCGGATTGGCGGCGGTGAACGTCGCGATCCGCCTGACTGTCGTCGCGCGGCGAAGGCCGCGCTTCACGAGGCTT
CTAGGTCACGGGAGGTTGCC

Downstream 100 bases:

>100_bases
TCGCAGCCGGCGGCAGCAACGCCGCCGGCTCCGGGCGAGGCGCCAACGGCGCGCGGCTTCCGCCGCGCCGCGCGGGTGGC
CTCGCCCGTGCTTTCCCGAG

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTDRIREFLRNRREDGPCVVVDLDVVRANYTAFARALPDTRVFYAVKANPDAAILKALAELGSCFDCASVQEIEMALFAG
ATPDRISFGNTIKKERDIERAYKIGVRLFAVDCYEEVEKIARVAPGARVFCRILCDGAGAEWPLSRKFGCVPEMAPDVLE
HAFRLGLSPYGVSFHVGSQQKNVHAWDQALGSAAYIFRECAVRGISLSMVNLGGGFPTKYLQDVPKAQAYGEAIFDSLRR
HFGNAIPETIMEPGRGMVGNAGIIETEVVLISKKAESDTMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLA
GPTCDSADVLYEKTPVELPLSLSIGDKVLIEACGAYTTTYSAVAFNGFPPLKSYVI

Sequences:

>Translated_376_residues
MTDRIREFLRNRREDGPCVVVDLDVVRANYTAFARALPDTRVFYAVKANPDAAILKALAELGSCFDCASVQEIEMALFAG
ATPDRISFGNTIKKERDIERAYKIGVRLFAVDCYEEVEKIARVAPGARVFCRILCDGAGAEWPLSRKFGCVPEMAPDVLE
HAFRLGLSPYGVSFHVGSQQKNVHAWDQALGSAAYIFRECAVRGISLSMVNLGGGFPTKYLQDVPKAQAYGEAIFDSLRR
HFGNAIPETIMEPGRGMVGNAGIIETEVVLISKKAESDTMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLA
GPTCDSADVLYEKTPVELPLSLSIGDKVLIEACGAYTTTYSAVAFNGFPPLKSYVI
>Mature_375_residues
TDRIREFLRNRREDGPCVVVDLDVVRANYTAFARALPDTRVFYAVKANPDAAILKALAELGSCFDCASVQEIEMALFAGA
TPDRISFGNTIKKERDIERAYKIGVRLFAVDCYEEVEKIARVAPGARVFCRILCDGAGAEWPLSRKFGCVPEMAPDVLEH
AFRLGLSPYGVSFHVGSQQKNVHAWDQALGSAAYIFRECAVRGISLSMVNLGGGFPTKYLQDVPKAQAYGEAIFDSLRRH
FGNAIPETIMEPGRGMVGNAGIIETEVVLISKKAESDTMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLAG
PTCDSADVLYEKTPVELPLSLSIGDKVLIEACGAYTTTYSAVAFNGFPPLKSYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=374, Percent_Identity=33.6898395721925, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI16506287, Length=355, Percent_Identity=29.2957746478873, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI22538418, Length=367, Percent_Identity=28.3378746594005, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI21361583, Length=367, Percent_Identity=28.3378746594005, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1789203, Length=383, Percent_Identity=26.6318537859008, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562780, Length=381, Percent_Identity=31.758530183727, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322664, Length=385, Percent_Identity=29.8701298701299, Blast_Score=143, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24586472, Length=373, Percent_Identity=31.0991957104558, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24586474, Length=357, Percent_Identity=30.5322128851541, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41136; Mature: 41004

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRIREFLRNRREDGPCVVVDLDVVRANYTAFARALPDTRVFYAVKANPDAAILKALAE
CCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LGSCFDCASVQEIEMALFAGATPDRISFGNTIKKERDIERAYKIGVRLFAVDCYEEVEKI
HCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
ARVAPGARVFCRILCDGAGAEWPLSRKFGCVPEMAPDVLEHAFRLGLSPYGVSFHVGSQQ
HHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCC
KNVHAWDQALGSAAYIFRECAVRGISLSMVNLGGGFPTKYLQDVPKAQAYGEAIFDSLRR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHHH
HFGNAIPETIMEPGRGMVGNAGIIETEVVLISKKAESDTMRWVYLDIGKFGGLAETMDEA
HHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHH
IRYPLRTPRDGDDTAPCVLAGPTCDSADVLYEKTPVELPLSLSIGDKVLIEACGAYTTTY
HHCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHCCHHHCC
SAVAFNGFPPLKSYVI
CEEEECCCCCHHHHCC
>Mature Secondary Structure 
TDRIREFLRNRREDGPCVVVDLDVVRANYTAFARALPDTRVFYAVKANPDAAILKALAE
CHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LGSCFDCASVQEIEMALFAGATPDRISFGNTIKKERDIERAYKIGVRLFAVDCYEEVEKI
HCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
ARVAPGARVFCRILCDGAGAEWPLSRKFGCVPEMAPDVLEHAFRLGLSPYGVSFHVGSQQ
HHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCC
KNVHAWDQALGSAAYIFRECAVRGISLSMVNLGGGFPTKYLQDVPKAQAYGEAIFDSLRR
CCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCHHHHHHHHHHHHHHHH
HFGNAIPETIMEPGRGMVGNAGIIETEVVLISKKAESDTMRWVYLDIGKFGGLAETMDEA
HHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHH
IRYPLRTPRDGDDTAPCVLAGPTCDSADVLYEKTPVELPLSLSIGDKVLIEACGAYTTTY
HHCCCCCCCCCCCCCCEEEECCCCCCCCCEEECCCCCEEEEECCCHHHHHHHHCCHHHCC
SAVAFNGFPPLKSYVI
CEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]