Click here to switch to the map view.

The map label for this gene is adhA [H]

Identifier: 158421944

GI number: 158421944

Start: 367658

End: 368683

Strand: Reverse

Name: adhA [H]

Synonym: AZC_0320

Alternate gene names: 158421944

Gene position: 368683-367658 (Counterclockwise)

Preceding gene: 158421946

Following gene: 158421943

Centisome position: 6.87

GC content: 66.28

Gene sequence:

>1026_bases
ATGACCAACATGATGAAAGCCGCCGTCGTCCACCAGCTGGGCCAGCCCCTCGTGATCGAGCAGGTGCCCGTGCCAGAGCC
AGGCCCCGAGCAGATTCTCGTGCGCATCGCCGCCACCGGCGTGTGCCACACCGATCTGCATGCGGTGAAGGGCGACTGGC
CGGTGAAGCCGAAGCCGCCGTTCATTCCCGGCCATGAGGGCGTCGGCACCGTGGTCGGCGTCGGCAGCCGGGTGAAGCGC
GTGAAGGAAGGCGACCGCGTGGGCATTCCGTGGCTGCACACCGCCTGCGGCTATTGTCCCCACTGCCGCACGGGGTGGGA
AACGCTTTGCGCCGACCAGCAGAACACCGGCTATTCCGTCAACGGCAGCTTTGCCGAATATGCGGTGGCTGACCCCAATT
ACGTGGGCCGCCTGCCCGACAAGCTGGACTGGGGTCCGGCCGCGCCCGTGCTGTGCGCCGGCGTGACGGTTTACAAGGGC
CTGAAGGAAACCGAGGTGAAGCCGGGCGAATGGGTCGCCATTTCGGGCATCGGCGGGCTCGGCCACATGGCCGTGCAGTA
TGCCAAGGCCATGGGCATGCATGTGGTGGCCATCGACGTGCACCCCGACAAGCTGGAACTGGCGAAGAAGCTGGGTGCCG
AACTGGTCGTGAACGCCCGTGAGGAAGATCCGGGTGCCGTGGTGCAGAAGGCCATCGGCGGCGTCCACGGTGTGCTCGTC
ACGGCCGTCTCGCCCAAGGCGTTCGAACAGGCGTTCAACGTGCTGCGCGCCCACGGCACCATGGCCCTGTGCGGCCTGCC
TCCGGGCATGTTCGCCATGCCCATCTTCGACACGGTGCTGAAGCGCATCACCGTGCGCGGCTCCATCGTGGGCACCCGCC
AGGATCTGGAGGAGGCCCTCGAGTTCGCCGGCAACGGTCAGGTGGCCGCCCACTTCTCGTGGGACAAGCTCGAGAACATC
AACGAGATCTTCCACCGCATGGAAGAAGGCGGCATCGACGGGCGCATCGTCCTCAACATGAACTGA

Upstream 100 bases:

>100_bases
GCCCGCCGGAGTGAACGCTCCGTCACTGGCAGGAGCTTGATGCGGATCAAGGTGCGCCCCGGCGGCCTGCGGTCTTCTCC
GCGGCAGAAGGAGACCGGCC

Downstream 100 bases:

>100_bases
GGGACGCCGGGCGGCAGTGCCCGGCCCCTCGATAGCGCCGAGGCCGCATCTCCTGTGGCTTCCGGCCCTCCGGCCCCGCG
CCCGTCGGCGCGGGGTTCGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTNMMKAAVVHQLGQPLVIEQVPVPEPGPEQILVRIAATGVCHTDLHAVKGDWPVKPKPPFIPGHEGVGTVVGVGSRVKR
VKEGDRVGIPWLHTACGYCPHCRTGWETLCADQQNTGYSVNGSFAEYAVADPNYVGRLPDKLDWGPAAPVLCAGVTVYKG
LKETEVKPGEWVAISGIGGLGHMAVQYAKAMGMHVVAIDVHPDKLELAKKLGAELVVNAREEDPGAVVQKAIGGVHGVLV
TAVSPKAFEQAFNVLRAHGTMALCGLPPGMFAMPIFDTVLKRITVRGSIVGTRQDLEEALEFAGNGQVAAHFSWDKLENI
NEIFHRMEEGGIDGRIVLNMN

Sequences:

>Translated_341_residues
MTNMMKAAVVHQLGQPLVIEQVPVPEPGPEQILVRIAATGVCHTDLHAVKGDWPVKPKPPFIPGHEGVGTVVGVGSRVKR
VKEGDRVGIPWLHTACGYCPHCRTGWETLCADQQNTGYSVNGSFAEYAVADPNYVGRLPDKLDWGPAAPVLCAGVTVYKG
LKETEVKPGEWVAISGIGGLGHMAVQYAKAMGMHVVAIDVHPDKLELAKKLGAELVVNAREEDPGAVVQKAIGGVHGVLV
TAVSPKAFEQAFNVLRAHGTMALCGLPPGMFAMPIFDTVLKRITVRGSIVGTRQDLEEALEFAGNGQVAAHFSWDKLENI
NEIFHRMEEGGIDGRIVLNMN
>Mature_340_residues
TNMMKAAVVHQLGQPLVIEQVPVPEPGPEQILVRIAATGVCHTDLHAVKGDWPVKPKPPFIPGHEGVGTVVGVGSRVKRV
KEGDRVGIPWLHTACGYCPHCRTGWETLCADQQNTGYSVNGSFAEYAVADPNYVGRLPDKLDWGPAAPVLCAGVTVYKGL
KETEVKPGEWVAISGIGGLGHMAVQYAKAMGMHVVAIDVHPDKLELAKKLGAELVVNAREEDPGAVVQKAIGGVHGVLVT
AVSPKAFEQAFNVLRAHGTMALCGLPPGMFAMPIFDTVLKRITVRGSIVGTRQDLEEALEFAGNGQVAAHFSWDKLENIN
EIFHRMEEGGIDGRIVLNMN

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=360, Percent_Identity=29.4444444444444, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI71743840, Length=359, Percent_Identity=28.4122562674095, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI262073058, Length=359, Percent_Identity=28.4122562674095, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=29.4444444444444, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=26.5753424657534, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4501929, Length=362, Percent_Identity=29.5580110497238, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156627571, Length=298, Percent_Identity=29.5302013422819, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI71565154, Length=240, Percent_Identity=30.4166666666667, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI194239674, Length=352, Percent_Identity=25.2840909090909, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI13236495, Length=352, Percent_Identity=25.2840909090909, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI156523966, Length=238, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501939, Length=238, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI194239676, Length=224, Percent_Identity=29.0178571428571, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=44.6945337620579, Blast_Score=246, Evalue=1e-66,
Organism=Escherichia coli, GI1786518, Length=345, Percent_Identity=34.7826086956522, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI87082401, Length=342, Percent_Identity=30.7017543859649, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=34.6020761245675, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788073, Length=292, Percent_Identity=30.4794520547945, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082125, Length=204, Percent_Identity=32.843137254902, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI226510992, Length=309, Percent_Identity=30.0970873786408, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788075, Length=305, Percent_Identity=28.8524590163934, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786552, Length=241, Percent_Identity=33.195020746888, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790718, Length=315, Percent_Identity=28.8888888888889, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1786825, Length=263, Percent_Identity=30.7984790874525, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788407, Length=268, Percent_Identity=31.7164179104478, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1790485, Length=303, Percent_Identity=29.3729372937294, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=25.1851851851852, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=40.8823529411765, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=37.9411764705882, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17562582, Length=347, Percent_Identity=39.4812680115274, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=30.3571428571429, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=30.2395209580838, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25146526, Length=243, Percent_Identity=31.2757201646091, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=245, Percent_Identity=31.0204081632653, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17507255, Length=218, Percent_Identity=31.1926605504587, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17536829, Length=206, Percent_Identity=29.126213592233, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17565904, Length=218, Percent_Identity=28.4403669724771, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=43.5294117647059, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6319621, Length=340, Percent_Identity=42.9411764705882, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=42.3529411764706, Blast_Score=267, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323729, Length=340, Percent_Identity=42.0588235294118, Blast_Score=264, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319949, Length=330, Percent_Identity=30.9090909090909, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=325, Percent_Identity=28.9230769230769, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=320, Percent_Identity=28.75, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322619, Length=320, Percent_Identity=28.75, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=243, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=350, Percent_Identity=25.1428571428571, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=369, Percent_Identity=25.2032520325203, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=246, Percent_Identity=31.7073170731707, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137530, Length=316, Percent_Identity=27.2151898734177, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737897, Length=316, Percent_Identity=27.5316455696203, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36519; Mature: 36387

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNMMKAAVVHQLGQPLVIEQVPVPEPGPEQILVRIAATGVCHTDLHAVKGDWPVKPKPP
CCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCC
FIPGHEGVGTVVGVGSRVKRVKEGDRVGIPWLHTACGYCPHCRTGWETLCADQQNTGYSV
CCCCCCCCCCEECCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCCCCEEE
NGSFAEYAVADPNYVGRLPDKLDWGPAAPVLCAGVTVYKGLKETEVKPGEWVAISGIGGL
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEECCCCH
GHMAVQYAKAMGMHVVAIDVHPDKLELAKKLGAELVVNAREEDPGAVVQKAIGGVHGVLV
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHEEEE
TAVSPKAFEQAFNVLRAHGTMALCGLPPGMFAMPIFDTVLKRITVRGSIVGTRQDLEEAL
EECCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHH
EFAGNGQVAAHFSWDKLENINEIFHRMEEGGIDGRIVLNMN
HHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
TNMMKAAVVHQLGQPLVIEQVPVPEPGPEQILVRIAATGVCHTDLHAVKGDWPVKPKPP
CHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCC
FIPGHEGVGTVVGVGSRVKRVKEGDRVGIPWLHTACGYCPHCRTGWETLCADQQNTGYSV
CCCCCCCCCCEECCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHCCCCCCCEEE
NGSFAEYAVADPNYVGRLPDKLDWGPAAPVLCAGVTVYKGLKETEVKPGEWVAISGIGGL
CCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCEEEEECCCCH
GHMAVQYAKAMGMHVVAIDVHPDKLELAKKLGAELVVNAREEDPGAVVQKAIGGVHGVLV
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHEEEE
TAVSPKAFEQAFNVLRAHGTMALCGLPPGMFAMPIFDTVLKRITVRGSIVGTRQDLEEAL
EECCHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHH
EFAGNGQVAAHFSWDKLENINEIFHRMEEGGIDGRIVLNMN
HHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]