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The map label for this gene is pepA [H]

Identifier: 158421904

GI number: 158421904

Start: 326144

End: 327499

Strand: Reverse

Name: pepA [H]

Synonym: AZC_0280

Alternate gene names: 158421904

Gene position: 327499-326144 (Counterclockwise)

Preceding gene: 158421905

Following gene: 158421903

Centisome position: 6.1

GC content: 71.83

Gene sequence:

>1356_bases
ATGTCGTCCTGTTTCGCCGCGGCCGATGCGCCGAACCTGCCCATCTGGTGCGTGACCCCCGACAGCTTCGCGGCCGCCGC
CATTCCGGAGAGCGCGCGCCGTTTCGCCACCGGCACCGGCTTCACCGGCGAGGCGGGCAAGCTCGTGGCCGTGCCCGGCG
CCGAAGGGGCGCTCGCGGGCTATCTCTTCGGCTTCGGGCCGGACAGCGATCCCTTCGCCGCCGGCAGCCTGCCGGGCCAG
CTCGCCGCCGGCACCTATCGCTTCGAGGGCGCCGTACCGGCCCTCGCGCCCCTCGCCTTCGGCCTCGGCACCTATCGCTT
CGAGCGCTACCGCAGCCGCGCCGCCCGCGCCGTCTCCCTCGTGCCCCCTGCCGGCGCCGACGTCGCCGCGCTGACCCGCA
CGCTGGAGGCGGTGACGCTGGTGCGCGACCTTGTGAACACCCCGGCCAATGATCTTGGCCCGGCCGAAATCGAGGACGCC
GCGCGTGCGCTGGCCGCCCGTTTCGACGCCGCGCTCAACGTGGTGGTGGGCGAGACGCTGCTGGAAGAGAATTTCCCGAT
GATCCACGCGGTGGGCCGCGCCGCCACCCGTGCGCCGCGCCTCATCGACCTCACCTGGGGGCCGGAGGACGCGCCGAAGG
TGACGCTGGTGGGCAAGGGCGTCGCCTTCGACACCGGCGGCCTCGACATCAAGACATCCGCCGGCATGCTCCTCATGAAG
AAGGACATGGGCGGCGCCGCCTCGGCGCTGGGCCTTGCCCAGATGATCATGGGGCGCGGCCTCAAGGTGCGCCTGCGCGT
GCTCATCCCGGCGGTGGAGAATGCCATTGCCGGCAACGCCTTCCGCCCCGGTGACGTGCTGAAGAGCCGCAAGGGCCTCT
CGGTGGAGATCGGCAACACCGACGCCGAGGGCCGCCTGGTGCTCGCCGACGCGCTGACACTGGCCGATGCCGAAGCGCCT
GACCTCCTCATCGATTTCGCCACCCTCACCGGTGCGGCCCGCGTCGCCCTCGGCCCGCAACTGCCGCCGGCCTATACGGA
CGACGAGGGGCTCGCTGCCGACCTCGCCCGCCATGCGCAGGCCGAGCACGATCCGCTGTGGCGCATGCCGCTCTGGGCGC
CTTACGCCGCCATGCTCGACAGCAAGATCGCGGACATCAACAACGCCGGCTCCGGCGGCTTTGCCGGCTCGATCACCGCG
GCCCTGTTCCTGAAGCGCTTCGTGGGCGTGGCGAAATCCTGGCTGCACCTCGACATCTATGCCTGGAACCCCTCCACCCG
CCCCGGCCGGCCGGAAGGCGGCGAGGCGCAGACCATCCGCGCCCTCGATGCGCTGCTGACCGAACGCTATGGCTGA

Upstream 100 bases:

>100_bases
CTGGCCGCGGCCATGAATCAACCCGCTTTTGCGCGCTTTTCGGGGCGCACCGCCGGGCGCGATTCGTCGTGGCTGGCGCC
AGTTCGTTCGGAGTGAAGCA

Downstream 100 bases:

>100_bases
GCTGGACCGCCGCCTCACCCCCGCGCGGCCGGACCTTGCCGCATCGAGTCTCAAGGGCGTGGTGGATGCCTCGCGCTTTG
TGGAGGGCGAGGTGCGCCGT

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSSCFAAADAPNLPIWCVTPDSFAAAAIPESARRFATGTGFTGEAGKLVAVPGAEGALAGYLFGFGPDSDPFAAGSLPGQ
LAAGTYRFEGAVPALAPLAFGLGTYRFERYRSRAARAVSLVPPAGADVAALTRTLEAVTLVRDLVNTPANDLGPAEIEDA
ARALAARFDAALNVVVGETLLEENFPMIHAVGRAATRAPRLIDLTWGPEDAPKVTLVGKGVAFDTGGLDIKTSAGMLLMK
KDMGGAASALGLAQMIMGRGLKVRLRVLIPAVENAIAGNAFRPGDVLKSRKGLSVEIGNTDAEGRLVLADALTLADAEAP
DLLIDFATLTGAARVALGPQLPPAYTDDEGLAADLARHAQAEHDPLWRMPLWAPYAAMLDSKIADINNAGSGGFAGSITA
ALFLKRFVGVAKSWLHLDIYAWNPSTRPGRPEGGEAQTIRALDALLTERYG

Sequences:

>Translated_451_residues
MSSCFAAADAPNLPIWCVTPDSFAAAAIPESARRFATGTGFTGEAGKLVAVPGAEGALAGYLFGFGPDSDPFAAGSLPGQ
LAAGTYRFEGAVPALAPLAFGLGTYRFERYRSRAARAVSLVPPAGADVAALTRTLEAVTLVRDLVNTPANDLGPAEIEDA
ARALAARFDAALNVVVGETLLEENFPMIHAVGRAATRAPRLIDLTWGPEDAPKVTLVGKGVAFDTGGLDIKTSAGMLLMK
KDMGGAASALGLAQMIMGRGLKVRLRVLIPAVENAIAGNAFRPGDVLKSRKGLSVEIGNTDAEGRLVLADALTLADAEAP
DLLIDFATLTGAARVALGPQLPPAYTDDEGLAADLARHAQAEHDPLWRMPLWAPYAAMLDSKIADINNAGSGGFAGSITA
ALFLKRFVGVAKSWLHLDIYAWNPSTRPGRPEGGEAQTIRALDALLTERYG
>Mature_450_residues
SSCFAAADAPNLPIWCVTPDSFAAAAIPESARRFATGTGFTGEAGKLVAVPGAEGALAGYLFGFGPDSDPFAAGSLPGQL
AAGTYRFEGAVPALAPLAFGLGTYRFERYRSRAARAVSLVPPAGADVAALTRTLEAVTLVRDLVNTPANDLGPAEIEDAA
RALAARFDAALNVVVGETLLEENFPMIHAVGRAATRAPRLIDLTWGPEDAPKVTLVGKGVAFDTGGLDIKTSAGMLLMKK
DMGGAASALGLAQMIMGRGLKVRLRVLIPAVENAIAGNAFRPGDVLKSRKGLSVEIGNTDAEGRLVLADALTLADAEAPD
LLIDFATLTGAARVALGPQLPPAYTDDEGLAADLARHAQAEHDPLWRMPLWAPYAAMLDSKIADINNAGSGGFAGSITAA
LFLKRFVGVAKSWLHLDIYAWNPSTRPGRPEGGEAQTIRALDALLTERYG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=329, Percent_Identity=34.3465045592705, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI47155554, Length=340, Percent_Identity=31.4705882352941, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI87082123, Length=300, Percent_Identity=42, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1790710, Length=316, Percent_Identity=37.9746835443038, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=303, Percent_Identity=37.953795379538, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17565172, Length=247, Percent_Identity=31.1740890688259, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24661038, Length=286, Percent_Identity=33.5664335664336, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21355725, Length=286, Percent_Identity=32.8671328671329, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI221379063, Length=309, Percent_Identity=34.9514563106796, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221379062, Length=309, Percent_Identity=34.9514563106796, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21357381, Length=309, Percent_Identity=34.9514563106796, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21355645, Length=329, Percent_Identity=26.4437689969605, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24662223, Length=329, Percent_Identity=26.4437689969605, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24662227, Length=288, Percent_Identity=26.7361111111111, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI20129969, Length=288, Percent_Identity=28.125, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI161077148, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20130057, Length=289, Percent_Identity=29.0657439446367, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922386, Length=313, Percent_Identity=26.517571884984, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129963, Length=354, Percent_Identity=26.8361581920904, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24646701, Length=223, Percent_Identity=33.1838565022422, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646703, Length=223, Percent_Identity=33.1838565022422, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358201, Length=223, Percent_Identity=33.1838565022422, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 46882; Mature: 46751

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSCFAAADAPNLPIWCVTPDSFAAAAIPESARRFATGTGFTGEAGKLVAVPGAEGALAG
CCCCCCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHCCCCCCCCCCCEEEECCCCCCHHH
YLFGFGPDSDPFAAGSLPGQLAAGTYRFEGAVPALAPLAFGLGTYRFERYRSRAARAVSL
EEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VPPAGADVAALTRTLEAVTLVRDLVNTPANDLGPAEIEDAARALAARFDAALNVVVGETL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEENFPMIHAVGRAATRAPRLIDLTWGPEDAPKVTLVGKGVAFDTGGLDIKTSAGMLLMK
HHCCCCCEEHHHHHHHCCCCEEEEECCCCCCCEEEEEECCEEECCCCEEEECCCCEEEEE
KDMGGAASALGLAQMIMGRGLKVRLRVLIPAVENAIAGNAFRPGDVLKSRKGLSVEIGNT
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCCCCHHHHHCCCCCEEEECCC
DAEGRLVLADALTLADAEAPDLLIDFATLTGAARVALGPQLPPAYTDDEGLAADLARHAQ
CCCCCEEEEEHHHHCCCCCCCCEEEHHHHCCCHHEEECCCCCCCCCCCCCHHHHHHHHHC
AEHDPLWRMPLWAPYAAMLDSKIADINNAGSGGFAGSITAALFLKRFVGVAKSWLHLDIY
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEE
AWNPSTRPGRPEGGEAQTIRALDALLTERYG
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSCFAAADAPNLPIWCVTPDSFAAAAIPESARRFATGTGFTGEAGKLVAVPGAEGALAG
CCCCCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHCCCCCCCCCCCEEEECCCCCCHHH
YLFGFGPDSDPFAAGSLPGQLAAGTYRFEGAVPALAPLAFGLGTYRFERYRSRAARAVSL
EEEECCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
VPPAGADVAALTRTLEAVTLVRDLVNTPANDLGPAEIEDAARALAARFDAALNVVVGETL
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEENFPMIHAVGRAATRAPRLIDLTWGPEDAPKVTLVGKGVAFDTGGLDIKTSAGMLLMK
HHCCCCCEEHHHHHHHCCCCEEEEECCCCCCCEEEEEECCEEECCCCEEEECCCCEEEEE
KDMGGAASALGLAQMIMGRGLKVRLRVLIPAVENAIAGNAFRPGDVLKSRKGLSVEIGNT
CCCCCHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHCCCCCCCHHHHHCCCCCEEEECCC
DAEGRLVLADALTLADAEAPDLLIDFATLTGAARVALGPQLPPAYTDDEGLAADLARHAQ
CCCCCEEEEEHHHHCCCCCCCCEEEHHHHCCCHHEEECCCCCCCCCCCCCHHHHHHHHHC
AEHDPLWRMPLWAPYAAMLDSKIADINNAGSGGFAGSITAALFLKRFVGVAKSWLHLDIY
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEE
AWNPSTRPGRPEGGEAQTIRALDALLTERYG
EECCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA