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The map label for this gene is hemC [H]

Identifier: 158421885

GI number: 158421885

Start: 306100

End: 307041

Strand: Reverse

Name: hemC [H]

Synonym: AZC_0261

Alternate gene names: 158421885

Gene position: 307041-306100 (Counterclockwise)

Preceding gene: 158421888

Following gene: 158421884

Centisome position: 5.72

GC content: 73.78

Gene sequence:

>942_bases
ATGCCCGATCCGAACGCTCCCTTCGCCCCGCGCCTCGCCATCGGCACCCGCGGCAGCCCGCTCGCGCTCTGGCAGGCCCA
TGCGGTGCGCGACGCCCTCGCCGCCGCGCTGGCGCGTCCCGTGGAGAGCATCTCCATCACGGTCATCCGCACCTCGGGCG
ACAGCATTCAGGACCGCGCCCTGTCAGAAGCCGGCGGCAAGGGCCTGTTCACCAAGGAGATCGAGGAGCAGCTCCTCGAC
GGGCGCATCGACCTCGCGGTCCATTCCGCCAAGGACATGGCCACCGCTTTGCCCGACGGCCTGTTCCTCTCCGGCTTCCT
GCCGCGCGCCGATGTGCGCGACGCTTTGATCCTGCGCGAGGGCAAGAGCCTCGCGGACCTGCCCGCCGGCGCGCGCATCG
GCACCGCCTCGCTCCGGCGCGAAGCCCAGTTGCGGCGGCTGCGGCCGGACCTCGACGTGTCGCTGCTACGGGGCAATGTC
CACACGCGCCTCGCCAAGGTGCGCGAAGGCACGTTCGATGGCACGCTGCTGGCGCTCGCCGGCCTCACCCGCCTCGGCCT
CGCCCATGAGGCGAGCGCGGTTCTGGACACGGACGCTTTCCTGCCCGCCGTGGGCCAAGGGGCGGTGGCCATCGAGAGCC
GTGTCGGGGATGAGGCCACCAACGGCGCCATTGCCGCCATCGCCTGCCGGGCCACCGGCATCGCGCTCGCGGCCGAGCGG
GCGCTGCTGACCGCGCTGGATGGCTCCTGCCGCACGCCCATCGGCGGGCTCGCCACCGTGGAAGGCGACATGGTGCGCCT
GCGCGGCCTCATTCTCTCGCCCGATGGGCGGGATGCCGCCGAGGCGGACGAGACGGCCCCGGTCTCTGACGCCGCCCGGC
TGGGCGCGGACATGGGCGCGCGGTTGCGCGCGACGGCTCCCGCCCGCGCGCTGGGGCTCTAG

Upstream 100 bases:

>100_bases
CTGCGCGTGCAAGCAAGGCGCCGGAACGCCGCGCTATCTTGTTGCGATTCCGGCTATCATTGTACGCGCCCCCGACACAA
GACGCGATGCCGCAAGCCTG

Downstream 100 bases:

>100_bases
GGCGTGCGCCTGCTCGTGACCCGCCCGCAACCGGGCGCCGGCGACACCGCCCGGCGTCTTGCGGCGCTGGGTCACGATGC
GATCGTGGACCCCATGCTGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MPDPNAPFAPRLAIGTRGSPLALWQAHAVRDALAAALARPVESISITVIRTSGDSIQDRALSEAGGKGLFTKEIEEQLLD
GRIDLAVHSAKDMATALPDGLFLSGFLPRADVRDALILREGKSLADLPAGARIGTASLRREAQLRRLRPDLDVSLLRGNV
HTRLAKVREGTFDGTLLALAGLTRLGLAHEASAVLDTDAFLPAVGQGAVAIESRVGDEATNGAIAAIACRATGIALAAER
ALLTALDGSCRTPIGGLATVEGDMVRLRGLILSPDGRDAAEADETAPVSDAARLGADMGARLRATAPARALGL

Sequences:

>Translated_313_residues
MPDPNAPFAPRLAIGTRGSPLALWQAHAVRDALAAALARPVESISITVIRTSGDSIQDRALSEAGGKGLFTKEIEEQLLD
GRIDLAVHSAKDMATALPDGLFLSGFLPRADVRDALILREGKSLADLPAGARIGTASLRREAQLRRLRPDLDVSLLRGNV
HTRLAKVREGTFDGTLLALAGLTRLGLAHEASAVLDTDAFLPAVGQGAVAIESRVGDEATNGAIAAIACRATGIALAAER
ALLTALDGSCRTPIGGLATVEGDMVRLRGLILSPDGRDAAEADETAPVSDAARLGADMGARLRATAPARALGL
>Mature_312_residues
PDPNAPFAPRLAIGTRGSPLALWQAHAVRDALAAALARPVESISITVIRTSGDSIQDRALSEAGGKGLFTKEIEEQLLDG
RIDLAVHSAKDMATALPDGLFLSGFLPRADVRDALILREGKSLADLPAGARIGTASLRREAQLRRLRPDLDVSLLRGNVH
TRLAKVREGTFDGTLLALAGLTRLGLAHEASAVLDTDAFLPAVGQGAVAIESRVGDEATNGAIAAIACRATGIALAAERA
LLTALDGSCRTPIGGLATVEGDMVRLRGLILSPDGRDAAEADETAPVSDAARLGADMGARLRATAPARALGL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=295, Percent_Identity=35.9322033898305, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI66933009, Length=284, Percent_Identity=36.6197183098592, Blast_Score=164, Evalue=9e-41,
Organism=Escherichia coli, GI48994974, Length=291, Percent_Identity=45.0171821305842, Blast_Score=225, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319996, Length=281, Percent_Identity=37.3665480427046, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI20130425, Length=255, Percent_Identity=41.1764705882353, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32369; Mature: 32238

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDPNAPFAPRLAIGTRGSPLALWQAHAVRDALAAALARPVESISITVIRTSGDSIQDRA
CCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LSEAGGKGLFTKEIEEQLLDGRIDLAVHSAKDMATALPDGLFLSGFLPRADVRDALILRE
HHHCCCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCEECCCCCCCCHHHHHHHHC
GKSLADLPAGARIGTASLRREAQLRRLRPDLDVSLLRGNVHTRLAKVREGTFDGTLLALA
CCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHCCHHHHHHHHHCCCCCHHHHHHH
GLTRLGLAHEASAVLDTDAFLPAVGQGAVAIESRVGDEATNGAIAAIACRATGIALAAER
HHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHCCCCCCCCCEEEEEEHHHHHHHHHHH
ALLTALDGSCRTPIGGLATVEGDMVRLRGLILSPDGRDAAEADETAPVSDAARLGADMGA
HHHHHCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
RLRATAPARALGL
CEECCCCHHHHCC
>Mature Secondary Structure 
PDPNAPFAPRLAIGTRGSPLALWQAHAVRDALAAALARPVESISITVIRTSGDSIQDRA
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHH
LSEAGGKGLFTKEIEEQLLDGRIDLAVHSAKDMATALPDGLFLSGFLPRADVRDALILRE
HHHCCCCCCCHHHHHHHHHCCCEEEEEECHHHHHHHCCCCCEECCCCCCCCHHHHHHHHC
GKSLADLPAGARIGTASLRREAQLRRLRPDLDVSLLRGNVHTRLAKVREGTFDGTLLALA
CCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEHHCCHHHHHHHHHCCCCCHHHHHHH
GLTRLGLAHEASAVLDTDAFLPAVGQGAVAIESRVGDEATNGAIAAIACRATGIALAAER
HHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHCCCCCCCCCEEEEEEHHHHHHHHHHH
ALLTALDGSCRTPIGGLATVEGDMVRLRGLILSPDGRDAAEADETAPVSDAARLGADMGA
HHHHHCCCCCCCCCCCEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCC
RLRATAPARALGL
CEECCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA