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The map label for this gene is pgi

Identifier: 15836556

GI number: 15836556

Start: 1173708

End: 1175288

Strand: Direct

Name: pgi

Synonym: CPj1025

Alternate gene names: 15836556

Gene position: 1173708-1175288 (Clockwise)

Preceding gene: 15836554

Following gene: 15836557

Centisome position: 95.69

GC content: 44.02

Gene sequence:

>1581_bases
ATGGAAAGAAAAAGATTTATAGATTGCGATTCAACAAAGATACTCCAAGAGCTTGCTTTAAATCCCCTAGACCTAACAGC
TCCCGGGGTTTTATCTGCAGAGAGGATCAAGAAGTTTTCTTTGCTAGGAGGGGGATTTACCTTTAGCTTTGCTACCGAGC
GTTTGGACGATGCTATTTTAGCTGCATTGATCTCATTAGCAGAAGAAAGGGGATTGCATGAGTCTATGTTAGCGATGCAG
CAGGGGCAGGTCGTGAACTATATTGAAGGGTTTCCAAGTGAAATGCGACCTGCTCTGCACACTGCAACTCGGGCATGGGT
AACCGACAGTTCATTTACAGGAGAAGCTGAAGATATCGCCGTAAGATCTCGGGTGGAGGCGCAACGGCTTAAGGATTTTT
TAACCAAAGTGCGCAGCCAGTTCACGACCATAGTGCAGATAGGAATCGGAGGGTCGGAGCTAGGCCCTAAGGCACTCTAT
CGGGCCCTTCGTGCGTACTGCCCTACAGATAAGCACGTACATTTCATATCCAATATAGATCCTGACAATGGCGCCGAGGT
GTTAGATACCATAGATTGTGCTAAGGCTTTGGTAGTTGTAGTATCGAAGTCAGGGACTACAATAGAGACTGCAGTGAATG
AGGCCTTTTTTGCAGATTATTTCGCGAAGAAGGGCTTGTCATTTAAGGATCATTTTATAGCAGTCACTTGTGAAGGCAGT
CCTATGGATGATACGGGTAAGTATCTAGAGGTCTTTCACCTTTGGGAGAGCATCGGAGGAAGATTTTCCTCTACCTCTAT
GGTTGGAGGTGTTGTTTTAGGTTTTGCTTATGGCTTTGAGGTTTTTTTGCAATTACTTCAAGGAGCCTCAGCTATGGATC
AAATTGCTTTGCAACCGAACGCTAGGGAGAATCTCCCTATGCTTTCAGCTTTGATTAGCATTTGGAATCGAAATTTCTTA
GGCTATCCCACAGAAGCTGTCATTCCTTATTCTTCAGGTTTGGAGTTTTTCCCAGCGCATTTGCAGCAGTGTTGCATGGA
ATCTAACGGGAAAAGCATTGTCCAAGATGGTAGAAGGGTAGGATTTTCTACGAGCCCTGTCATTTGGGGTGAGCCGGGAA
CCAACGGACAGCATTCTTTTTTCCAATGCCTTCATCAGGGTACAGACATTATTCCTGTAGAGTTTATAGGTTTTGAAAAG
AGCCAAAAGGGTGAGGATATCTCATTTCAAGGAACTACATCTTCACAAAAGCTTTTTGCCAATATGATTGCTCAGGCGAT
TGCCTTAGCATGTGGCTCTGAAAATACAAATCCGAATAAGAATTTTGATGGAAACCGTCCTTCTTCGGTTTTAGTGTCTA
GCCAGCTGAATCCGTATTCTCTTGGGGAATTACTTTCTTACTATGAGAATAAAATCGTATTTCAAGGGTTCTGTTGGGGG
ATTAATTCTTTTGATCAGGAAGGGGTCTCCTTGGGTAAGGCATTGGCAAACCGTGTTTTAGAGTTGCTTGAGGGGGCGGA
TGCTTCCAATTTCCCTGAAGCTGCATCGTTGTTAACGCTTTTTAACATCAAGTTTAGGTAA

Upstream 100 bases:

>100_bases
ATCGTTGTGTGAAACTGAGTCGAGGGCATAGTCATACTCGCTAACGAATGTAACTTTAGTATAGGGAGCGGAGCAATTTT
CAAGCTACAGAGAGAAAACC

Downstream 100 bases:

>100_bases
AAATTACACTATCCTTTCATAAGTCTACCTCAGAGAGAGGTTTTTCTTAAGGTTCTTTATTGTCCGTCTGTGATATAATG
CTCCTTTGGATTTGGAAAAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MERKRFIDCDSTKILQELALNPLDLTAPGVLSAERIKKFSLLGGGFTFSFATERLDDAILAALISLAEERGLHESMLAMQ
QGQVVNYIEGFPSEMRPALHTATRAWVTDSSFTGEAEDIAVRSRVEAQRLKDFLTKVRSQFTTIVQIGIGGSELGPKALY
RALRAYCPTDKHVHFISNIDPDNGAEVLDTIDCAKALVVVVSKSGTTIETAVNEAFFADYFAKKGLSFKDHFIAVTCEGS
PMDDTGKYLEVFHLWESIGGRFSSTSMVGGVVLGFAYGFEVFLQLLQGASAMDQIALQPNARENLPMLSALISIWNRNFL
GYPTEAVIPYSSGLEFFPAHLQQCCMESNGKSIVQDGRRVGFSTSPVIWGEPGTNGQHSFFQCLHQGTDIIPVEFIGFEK
SQKGEDISFQGTTSSQKLFANMIAQAIALACGSENTNPNKNFDGNRPSSVLVSSQLNPYSLGELLSYYENKIVFQGFCWG
INSFDQEGVSLGKALANRVLELLEGADASNFPEAASLLTLFNIKFR

Sequences:

>Translated_526_residues
MERKRFIDCDSTKILQELALNPLDLTAPGVLSAERIKKFSLLGGGFTFSFATERLDDAILAALISLAEERGLHESMLAMQ
QGQVVNYIEGFPSEMRPALHTATRAWVTDSSFTGEAEDIAVRSRVEAQRLKDFLTKVRSQFTTIVQIGIGGSELGPKALY
RALRAYCPTDKHVHFISNIDPDNGAEVLDTIDCAKALVVVVSKSGTTIETAVNEAFFADYFAKKGLSFKDHFIAVTCEGS
PMDDTGKYLEVFHLWESIGGRFSSTSMVGGVVLGFAYGFEVFLQLLQGASAMDQIALQPNARENLPMLSALISIWNRNFL
GYPTEAVIPYSSGLEFFPAHLQQCCMESNGKSIVQDGRRVGFSTSPVIWGEPGTNGQHSFFQCLHQGTDIIPVEFIGFEK
SQKGEDISFQGTTSSQKLFANMIAQAIALACGSENTNPNKNFDGNRPSSVLVSSQLNPYSLGELLSYYENKIVFQGFCWG
INSFDQEGVSLGKALANRVLELLEGADASNFPEAASLLTLFNIKFR
>Mature_526_residues
MERKRFIDCDSTKILQELALNPLDLTAPGVLSAERIKKFSLLGGGFTFSFATERLDDAILAALISLAEERGLHESMLAMQ
QGQVVNYIEGFPSEMRPALHTATRAWVTDSSFTGEAEDIAVRSRVEAQRLKDFLTKVRSQFTTIVQIGIGGSELGPKALY
RALRAYCPTDKHVHFISNIDPDNGAEVLDTIDCAKALVVVVSKSGTTIETAVNEAFFADYFAKKGLSFKDHFIAVTCEGS
PMDDTGKYLEVFHLWESIGGRFSSTSMVGGVVLGFAYGFEVFLQLLQGASAMDQIALQPNARENLPMLSALISIWNRNFL
GYPTEAVIPYSSGLEFFPAHLQQCCMESNGKSIVQDGRRVGFSTSPVIWGEPGTNGQHSFFQCLHQGTDIIPVEFIGFEK
SQKGEDISFQGTTSSQKLFANMIAQAIALACGSENTNPNKNFDGNRPSSVLVSSQLNPYSLGELLSYYENKIVFQGFCWG
INSFDQEGVSLGKALANRVLELLEGADASNFPEAASLLTLFNIKFR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=511, Percent_Identity=34.2465753424658, Blast_Score=285, Evalue=6e-77,
Organism=Homo sapiens, GI296080693, Length=502, Percent_Identity=32.6693227091633, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI1790457, Length=504, Percent_Identity=35.515873015873, Blast_Score=282, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71996708, Length=518, Percent_Identity=33.7837837837838, Blast_Score=277, Evalue=8e-75,
Organism=Caenorhabditis elegans, GI71996703, Length=518, Percent_Identity=33.7837837837838, Blast_Score=277, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6319673, Length=515, Percent_Identity=33.5922330097087, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24651916, Length=507, Percent_Identity=36.094674556213, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24651914, Length=507, Percent_Identity=36.094674556213, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI17737445, Length=507, Percent_Identity=36.094674556213, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CHLPN (Q9Z6N4)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B81533
- PIR:   C72005
- PIR:   F86618
- RefSeq:   NP_225219.1
- RefSeq:   NP_301080.1
- RefSeq:   NP_445366.1
- RefSeq:   NP_877336.1
- ProteinModelPortal:   Q9Z6N4
- GeneID:   1467743
- GeneID:   895490
- GeneID:   918954
- GeneID:   962825
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0827
- KEGG:   cpn:CPn1025
- KEGG:   cpt:CpB1064
- TIGR:   CP_0827
- HOGENOM:   HBG352954
- OMA:   RTSITSA
- PhylomeDB:   Q9Z6N4
- ProtClustDB:   PRK14095
- BioCyc:   CPNE115711:CP_0827-MONOMER
- BioCyc:   CPNE115713:CPN1025-MONOMER
- BioCyc:   CPNE138677:CPJ1025-MONOMER
- BioCyc:   CPNE182082:CPB1064-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57597; Mature: 57597

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 347-347 ACT_SITE 378-378 ACT_SITE 493-493

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKRFIDCDSTKILQELALNPLDLTAPGVLSAERIKKFSLLGGGFTFSFATERLDDAIL
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AALISLAEERGLHESMLAMQQGQVVNYIEGFPSEMRPALHTATRAWVTDSSFTGEAEDIA
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHHHH
VRSRVEAQRLKDFLTKVRSQFTTIVQIGIGGSELGPKALYRALRAYCPTDKHVHFISNID
HHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCC
PDNGAEVLDTIDCAKALVVVVSKSGTTIETAVNEAFFADYFAKKGLSFKDHFIAVTCEGS
CCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
PMDDTGKYLEVFHLWESIGGRFSSTSMVGGVVLGFAYGFEVFLQLLQGASAMDQIALQPN
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCC
ARENLPMLSALISIWNRNFLGYPTEAVIPYSSGLEFFPAHLQQCCMESNGKSIVQDGRRV
CCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCHHC
GFSTSPVIWGEPGTNGQHSFFQCLHQGTDIIPVEFIGFEKSQKGEDISFQGTTSSQKLFA
CCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHH
NMIAQAIALACGSENTNPNKNFDGNRPSSVLVSSQLNPYSLGELLSYYENKIVFQGFCWG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCEEEEEEECC
INSFDQEGVSLGKALANRVLELLEGADASNFPEAASLLTLFNIKFR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEECC
>Mature Secondary Structure
MERKRFIDCDSTKILQELALNPLDLTAPGVLSAERIKKFSLLGGGFTFSFATERLDDAIL
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHH
AALISLAEERGLHESMLAMQQGQVVNYIEGFPSEMRPALHTATRAWVTDSSFTGEAEDIA
HHHHHHHHHCCHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHEEECCCCCCCHHHHH
VRSRVEAQRLKDFLTKVRSQFTTIVQIGIGGSELGPKALYRALRAYCPTDKHVHFISNID
HHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEECCCC
PDNGAEVLDTIDCAKALVVVVSKSGTTIETAVNEAFFADYFAKKGLSFKDHFIAVTCEGS
CCCCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCC
PMDDTGKYLEVFHLWESIGGRFSSTSMVGGVVLGFAYGFEVFLQLLQGASAMDQIALQPN
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCC
ARENLPMLSALISIWNRNFLGYPTEAVIPYSSGLEFFPAHLQQCCMESNGKSIVQDGRRV
CCCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCCHHC
GFSTSPVIWGEPGTNGQHSFFQCLHQGTDIIPVEFIGFEKSQKGEDISFQGTTSSQKLFA
CCCCCCEEECCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCHHHHHHH
NMIAQAIALACGSENTNPNKNFDGNRPSSVLVSSQLNPYSLGELLSYYENKIVFQGFCWG
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCEEEEEEECC
INSFDQEGVSLGKALANRVLELLEGADASNFPEAASLLTLFNIKFR
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362