Click here to switch to the map view.

The map label for this gene is murB

Identifier: 15836519

GI number: 15836519

Start: 1134477

End: 1135391

Strand: Reverse

Name: murB

Synonym: CPj0988

Alternate gene names: 15836519

Gene position: 1135391-1134477 (Counterclockwise)

Preceding gene: 15836520

Following gene: 15836514

Centisome position: 92.57

GC content: 44.48

Gene sequence:

>915_bases
ATGAAAGAAGCTGCGCCTATGCATTTTCCTTTTCCTGTTCGTCGTAGTGTGTGGCTGAATAGGTATTCCACTTTCCGCAT
TGGAGGACCTGCAAATTACTTTAAAGCCATCCATACTATTGAGGAGGCTCGTGAAGTTATCCGTTTCCTACATTCAATCA
ACTATCCCTTCCTCATCATAGGGAAAGGCTCTAATTGTTTATTTGATGACCGTGGTTTTGATGGCTTTGTACTCTACAAT
GCAATCTATGGTAAACAGTTCCTAGAGGATGCTCGTATTAAAGCGTATTCGGGTCTTTCCTTTGCAGCTTTAGGTAAAGC
GACTGCCTATAATGGATATTCGGGACTTGAGTTTGCTGCGGGCATCCCTGGGTCGGTTGGCGGGGCCATTTTTATGAATG
CAGGTACAAATGAAAGCGACATATCTTCCGTGGTGAGAAATGTTGAGACAATCAACTCTGAAGGAGAGCTTTGTTCCTAT
TCTGTAGAAGAATTAGAGCTGAGCTATCGCTCCTCGCGCTTCCATAGACAACAAGAGTTTATTTTATCAGCGACCCTCCA
GCTTTCAAAAAAGCAAGTTTCTGCCGACCACTCGAAATCCATTCTGCAACATCGGCTCATGACGCAGCCCTATACGCAGC
CTTCTGCTGGCTGTATTTTCCGTAATCCTGAAGGAACTTCTGCTGGCAAGCTTATTGACGCAGCTGGGTTGAAGGGATTA
GCAATCGGAGGGGCACAAATTTCTCCGTTGCATGCAAACTTCATTATCAATACTGGCAAGGCCACTTCTGATGAGGTCAA
GCAACTCATAGCTATCATCCAATCAACGTTAAAAACGCAAGGCATTGATCTGGAACACGAGATTCGCATTATCCCTTATC
AACCGAAGATTCACTCCCCTGTCTCTGAAAAATAA

Upstream 100 bases:

>100_bases
GTCCTTTCATTCAGGCGATTTTGAATGACATTTTCACAGATTCATCTCTAAATGAAAATTCTTTATCAATCTGATTAATT
TAGACCAAGGGATTCTAAAA

Downstream 100 bases:

>100_bases
AAAGTCTAGGGGCTCGACACCGATTCGCTACATAAAATGAGCTCACGCACCATTCCTTAGGATGTAACCGTTGTGCTAGG
CTCTCGACACTATGTGTTTC

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLIIGKGSNCLFDDRGFDGFVLYN
AIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAAGIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSY
SVEELELSYRSSRFHRQQEFILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGL
AIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSPVSEK

Sequences:

>Translated_304_residues
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLIIGKGSNCLFDDRGFDGFVLYN
AIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAAGIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSY
SVEELELSYRSSRFHRQQEFILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGL
AIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSPVSEK
>Mature_304_residues
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLIIGKGSNCLFDDRGFDGFVLYN
AIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAAGIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSY
SVEELELSYRSSRFHRQQEFILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGL
AIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSPVSEK

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_CHLPN (Q9Z6S1)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A86614
- PIR:   C81530
- PIR:   E72010
- RefSeq:   NP_225182.1
- RefSeq:   NP_301043.1
- RefSeq:   NP_445405.1
- RefSeq:   NP_877297.1
- ProteinModelPortal:   Q9Z6S1
- GeneID:   1467704
- GeneID:   895599
- GeneID:   919755
- GeneID:   963318
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0867
- KEGG:   cpn:CPn0988
- KEGG:   cpt:CpB1024
- TIGR:   CP_0867
- HOGENOM:   HBG686573
- OMA:   ISERHAN
- PhylomeDB:   Q9Z6S1
- ProtClustDB:   PRK13905
- BioCyc:   CPNE115711:CP_0867-MONOMER
- BioCyc:   CPNE115713:CPN0988-MONOMER
- BioCyc:   CPNE138677:CPJ0988-MONOMER
- BioCyc:   CPNE182082:CPB1024-MONOMER
- BRENDA:   1.1.1.158
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 33456; Mature: 33456

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 170-170 ACT_SITE 218-218 ACT_SITE 287-287

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLII
CCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GKGSNCLFDDRGFDGFVLYNAIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAA
ECCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHCCCCCCCCCCCC
GIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSYSVEELELSYRSSRFHRQQEF
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
ILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGL
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEHHCCCCEE
AIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSP
EECCCEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
VSEK
CCCC
>Mature Secondary Structure
MKEAAPMHFPFPVRRSVWLNRYSTFRIGGPANYFKAIHTIEEAREVIRFLHSINYPFLII
CCCCCCCCCCCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GKGSNCLFDDRGFDGFVLYNAIYGKQFLEDARIKAYSGLSFAALGKATAYNGYSGLEFAA
ECCCCCEEECCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHCCCCCCCCCCCC
GIPGSVGGAIFMNAGTNESDISSVVRNVETINSEGELCSYSVEELELSYRSSRFHRQQEF
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHH
ILSATLQLSKKQVSADHSKSILQHRLMTQPYTQPSAGCIFRNPEGTSAGKLIDAAGLKGL
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEHHCCCCEE
AIGGAQISPLHANFIINTGKATSDEVKQLIAIIQSTLKTQGIDLEHEIRIIPYQPKIHSP
EECCCEECCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
VSEK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362