Click here to switch to the map view.

The map label for this gene is sucC

Identifier: 15836505

GI number: 15836505

Start: 1114070

End: 1115230

Strand: Direct

Name: sucC

Synonym: CPj0972

Alternate gene names: 15836505

Gene position: 1114070-1115230 (Clockwise)

Preceding gene: 15836503

Following gene: 15836506

Centisome position: 90.83

GC content: 43.93

Gene sequence:

>1161_bases
ATGCATCTTCATGAGTACCAAGCTAAAGATCTCTTAGCTTCTTACGATGTGCCTATTCCCCCCTATTGGGTAGTGTCTTC
AGAGGAAGAAGGGGAACTTCTTATCACAAAGTCGGGATTAGATTCCGCCGTGGTTAAAGTACAGGTTCATGCTGGAGGTC
GAGGGAAACATGGTGGTGTCATTGTTGCAAAATCCTCAGCAGGCATTTTGCAAGCCGTAGCTAAGCTCTTAGGAATGCAT
TTTACTAGTAATCAAACTGCCGACGGATTTCTCCCCGTAGAGAAAGTCTTGATTTCACCACTTGTTGCTATACAAAGGGA
ATATTATGTCGCAGTGATTATGGATCGAAAACACCGATGCCCAGTTCTTATGCTTTCAAAAGCAGGAGGTATGGATATCG
AAGAGGTCGCACACTCTTCCCCAGAACAGATCCTGACATTACCACTGACCTCTTATGGGCATATCTATAGTTATCAACTT
CGTCAAGCCACTAAGTTCATGGAGTGGGAAGGAGAAGTGATGCACCAAGGTGTCCAATTGATCAAAAAGCTTGCGAAGTG
CTTTTATGAAAATGATGTCTCTTTATTAGAGATCAATCCTTTGGTGTTGACTTTAGAGGGTGAGCTACTTGTCCTCGATT
CTAAGATTACGATCGATGACAATGCCCTATACCGTCATCCCAACTTAGAAGTATTGTATGACCCCTCTCAAGAGAATGTT
CGGGATGTCCTAGCAAAGCAAATCGGATTGTCCTACATCGCTCTAAGCGGAAATATCGGTTGCATTGTGAATGGCGCCGG
ACTTGCCATGAGTACCTTAGATATTTTAAAGCTCCATGGTGGGAATGCTGCGAATTTCTTAGATGTCGGAGGAGGGGCTT
CTCAAAAGCAAATCCAAGAAGCTGTATCTTTAGTATTGTCCGATGAGAGCGTGAAAGTGCTTTTTATCAATATCTTCGGG
GGGATTATGGACTGTTCTGTAGTTGCCTCCGGGCTCGTTGCAGTTATGGAAACAAGAGATCAAGTGGTTCCTACAGTCAT
TCGTCTCGAAGGAACAAATGTAGAATTGGGAAAAGAAATTGTTCAGCAATCTGGGATTCCTTGCCAATTTGTCTCTTCTA
TGGAAGAGGGCGCTAGACGCGCTGTAGAACTGAGTATGTAG

Upstream 100 bases:

>100_bases
TTGAAGCTTGTTTCTAAAGAATTTGAACATTGCTAATAGCAAAGTTAGTTGAAGTAAAAGAAATGATACAAGATAAGAAG
GAAAAAGCAAAGAGTTATTT

Downstream 100 bases:

>100_bases
ATTTAGGAGATACATGTTCCACTCACTAAGTAAAAATACTCCCATCATCACACAGGGAATTACAGGGAAAGCAGGTTCAT
TTCATACTGAGCAGTGCCTC

Product: succinyl-CoA synthetase subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit beta; SCS-beta

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGLDSAVVKVQVHAGGRGKHGGVIVAKSSAGILQAVAKLLGMH
FTSNQTADGFLPVEKVLISPLVAIQREYYVAVIMDRKHRCPVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQL
RQATKFMEWEGEVMHQGVQLIKKLAKCFYENDVSLLEINPLVLTLEGELLVLDSKITIDDNALYRHPNLEVLYDPSQENV
RDVLAKQIGLSYIALSGNIGCIVNGAGLAMSTLDILKLHGGNAANFLDVGGGASQKQIQEAVSLVLSDESVKVLFINIFG
GIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEIVQQSGIPCQFVSSMEEGARRAVELSM

Sequences:

>Translated_386_residues
MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGLDSAVVKVQVHAGGRGKHGGVIVAKSSAGILQAVAKLLGMH
FTSNQTADGFLPVEKVLISPLVAIQREYYVAVIMDRKHRCPVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQL
RQATKFMEWEGEVMHQGVQLIKKLAKCFYENDVSLLEINPLVLTLEGELLVLDSKITIDDNALYRHPNLEVLYDPSQENV
RDVLAKQIGLSYIALSGNIGCIVNGAGLAMSTLDILKLHGGNAANFLDVGGGASQKQIQEAVSLVLSDESVKVLFINIFG
GIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEIVQQSGIPCQFVSSMEEGARRAVELSM
>Mature_386_residues
MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGLDSAVVKVQVHAGGRGKHGGVIVAKSSAGILQAVAKLLGMH
FTSNQTADGFLPVEKVLISPLVAIQREYYVAVIMDRKHRCPVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQL
RQATKFMEWEGEVMHQGVQLIKKLAKCFYENDVSLLEINPLVLTLEGELLVLDSKITIDDNALYRHPNLEVLYDPSQENV
RDVLAKQIGLSYIALSGNIGCIVNGAGLAMSTLDILKLHGGNAANFLDVGGGASQKQIQEAVSLVLSDESVKVLFINIFG
GIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEIVQQSGIPCQFVSSMEEGARRAVELSM

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain

Homologues:

Organism=Homo sapiens, GI11321583, Length=392, Percent_Identity=39.030612244898, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI157779135, Length=383, Percent_Identity=36.0313315926893, Blast_Score=258, Evalue=9e-69,
Organism=Homo sapiens, GI294862256, Length=362, Percent_Identity=36.4640883977901, Blast_Score=244, Evalue=8e-65,
Organism=Escherichia coli, GI1786948, Length=382, Percent_Identity=42.9319371727749, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17539378, Length=391, Percent_Identity=38.8746803069054, Blast_Score=290, Evalue=8e-79,
Organism=Caenorhabditis elegans, GI17567829, Length=396, Percent_Identity=35.8585858585859, Blast_Score=264, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6321683, Length=395, Percent_Identity=34.4303797468354, Blast_Score=250, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21356231, Length=390, Percent_Identity=39.4871794871795, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI161078106, Length=392, Percent_Identity=37.5, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24645208, Length=392, Percent_Identity=37.5, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI281361397, Length=393, Percent_Identity=37.6590330788804, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI281361395, Length=393, Percent_Identity=37.6590330788804, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SUCC_CHLPN (Q9Z6T6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86612
- PIR:   C72013
- RefSeq:   NP_225167.1
- RefSeq:   NP_301029.1
- RefSeq:   NP_445424.1
- RefSeq:   NP_877281.1
- ProteinModelPortal:   Q9Z6T6
- SMR:   Q9Z6T6
- PHCI-2DPAGE:   Q9Z6T6
- GeneID:   1467688
- GeneID:   895617
- GeneID:   919739
- GeneID:   963340
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0886
- KEGG:   cpn:CPn0973
- KEGG:   cpt:CpB1009
- TIGR:   CP_0886
- HOGENOM:   HBG315432
- OMA:   NPLIVMK
- PhylomeDB:   Q9Z6T6
- ProtClustDB:   PRK00696
- BioCyc:   CPNE115711:CP_0886-MONOMER
- BioCyc:   CPNE115713:CPN0973-MONOMER
- BioCyc:   CPNE138677:CPJ0972-MONOMER
- BioCyc:   CPNE182082:CPB1009-MONOMER
- BRENDA:   6.2.1.5
- HAMAP:   MF_00558
- InterPro:   IPR011761
- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.261
- PANTHER:   PTHR11815
- TIGRFAMs:   TIGR01016

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 41926; Mature: 41926

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50975 ATP_GRASP; PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGLDSAVVKVQVHAGGRGKHGGV
CCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCE
IVAKSSAGILQAVAKLLGMHFTSNQTADGFLPVEKVLISPLVAIQREYYVAVIMDRKHRC
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCC
PVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQLRQATKFMEWEGEVMHQGVQL
CEEEEECCCCCCHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHH
IKKLAKCFYENDVSLLEINPLVLTLEGELLVLDSKITIDDNALYRHPNLEVLYDPSQENV
HHHHHHHHHCCCCEEEEECEEEEEEECCEEEEECEEEECCCCEEECCCCEEEECCCHHHH
RDVLAKQIGLSYIALSGNIGCIVNGAGLAMSTLDILKLHGGNAANFLDVGGGASQKQIQE
HHHHHHHHCCEEEEEECCEEEEEECCCCHHHHEEEEEECCCCCCCEEECCCCCCHHHHHH
AVSLVLSDESVKVLFINIFGGIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEI
HHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
VQQSGIPCQFVSSMEEGARRAVELSM
HHHCCCCHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure
MHLHEYQAKDLLASYDVPIPPYWVVSSEEEGELLITKSGLDSAVVKVQVHAGGRGKHGGV
CCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEEEEEEEECCCCCCCCCE
IVAKSSAGILQAVAKLLGMHFTSNQTADGFLPVEKVLISPLVAIQREYYVAVIMDRKHRC
EEEECCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCC
PVLMLSKAGGMDIEEVAHSSPEQILTLPLTSYGHIYSYQLRQATKFMEWEGEVMHQGVQL
CEEEEECCCCCCHHHHHCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHH
IKKLAKCFYENDVSLLEINPLVLTLEGELLVLDSKITIDDNALYRHPNLEVLYDPSQENV
HHHHHHHHHCCCCEEEEECEEEEEEECCEEEEECEEEECCCCEEECCCCEEEECCCHHHH
RDVLAKQIGLSYIALSGNIGCIVNGAGLAMSTLDILKLHGGNAANFLDVGGGASQKQIQE
HHHHHHHHCCEEEEEECCEEEEEECCCCHHHHEEEEEECCCCCCCEEECCCCCCHHHHHH
AVSLVLSDESVKVLFINIFGGIMDCSVVASGLVAVMETRDQVVPTVIRLEGTNVELGKEI
HHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
VQQSGIPCQFVSSMEEGARRAVELSM
HHHCCCCHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362