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Identifier: 15836487

GI number: 15836487

Start: 1087635

End: 1088060

Strand: Direct

Name: Not Available

Synonym: CPj0954

Alternate gene names: 15836487

Gene position: 1087635-1088060 (Clockwise)

Preceding gene: 15836486

Following gene: 15836488

Centisome position: 88.67

GC content: 39.91

Gene sequence:

>426_bases
ATGCAATACTTTTCTCCCGCAAAGTTAAACCTTTTTTTAAAAATATGGGGAAAGCGTTTCGATAATTTTCACGAGCTCAC
AACCCTTTATCAAGCTATAGATTTTGGAGACACACTTTCTTTAAAGAATAGCATGAAGGATAGTTTGAGCAGTAATGTTA
ACGAATTGCTTTCCCCCTCGAATCTCATCTGGAAAAGCCTCGAAATTTTCAGAAGAGAAACACAAATTCACCAACCAGTT
TCTTGGCACCTCAATAAATCTATTCCCCTCCAGTCTGGCTTAGGAGGAGGCAGTAGTAATGCAGCCACAGCCCTCTACGC
TCTTAACGAGCATTTCCAAACCCATATTCCTATAACAACATTGCAACTTTGGGCTCGAGAAATCGGAAGCGATGTTCCTT
TTTTTTTTCTTCAGGAACAGCATTAG

Upstream 100 bases:

>100_bases
TCTGACAATGAATACGTCACTGTTTTGGCTCAAGGAAAACAAACTGAGGAAAATCAAGAAGGCTAATACGTAGGGTAGAA
AAGTTTGTTATAAGGATATC

Downstream 100 bases:

>100_bases
GGAAAGGTCGGGGAGAACACCTCTTCTCTATAAAAAAACTCAACCATAAACATAAATATGTTCTCTATCTCGATCATCAA
GGAATACCCACAGAAAAGGC

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MQYFSPAKLNLFLKIWGKRFDNFHELTTLYQAIDFGDTLSLKNSMKDSLSSNVNELLSPSNLIWKSLEIFRRETQIHQPV
SWHLNKSIPLQSGLGGGSSNAATALYALNEHFQTHIPITTLQLWAREIGSDVPFFFLQEQH

Sequences:

>Translated_141_residues
MQYFSPAKLNLFLKIWGKRFDNFHELTTLYQAIDFGDTLSLKNSMKDSLSSNVNELLSPSNLIWKSLEIFRRETQIHQPV
SWHLNKSIPLQSGLGGGSSNAATALYALNEHFQTHIPITTLQLWAREIGSDVPFFFLQEQH
>Mature_141_residues
MQYFSPAKLNLFLKIWGKRFDNFHELTTLYQAIDFGDTLSLKNSMKDSLSSNVNELLSPSNLIWKSLEIFRRETQIHQPV
SWHLNKSIPLQSGLGGGSSNAATALYALNEHFQTHIPITTLQLWAREIGSDVPFFFLQEQH

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [H]

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787459, Length=143, Percent_Identity=37.7622377622378, Blast_Score=77, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.148 [H]

Molecular weight: Translated: 16165; Mature: 16165

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYFSPAKLNLFLKIWGKRFDNFHELTTLYQAIDFGDTLSLKNSMKDSLSSNVNELLSPS
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCH
NLIWKSLEIFRRETQIHQPVSWHLNKSIPLQSGLGGGSSNAATALYALNEHFQTHIPITT
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
LQLWAREIGSDVPFFFLQEQH
HHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MQYFSPAKLNLFLKIWGKRFDNFHELTTLYQAIDFGDTLSLKNSMKDSLSSNVNELLSPS
CCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCH
NLIWKSLEIFRRETQIHQPVSWHLNKSIPLQSGLGGGSSNAATALYALNEHFQTHIPITT
HHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
LQLWAREIGSDVPFFFLQEQH
HHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA