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The map label for this gene is ldh

Identifier: 15836452

GI number: 15836452

Start: 1048726

End: 1049781

Strand: Direct

Name: ldh

Synonym: CPj0919

Alternate gene names: 15836452

Gene position: 1048726-1049781 (Clockwise)

Preceding gene: 15836450

Following gene: 15836454

Centisome position: 85.5

GC content: 42.71

Gene sequence:

>1056_bases
ATGAAATACTCACTGAACTTTAAAGAGATCAAAATAGATGATTATGAGCGTGTTATTGAAGTCACATGTTCAAAAGTTCG
TCTTCATGCAATTATTGCTATTCATCAAACGGCAGTAGGACCCGCCTTAGGTGGAGTGCGAGCCTCTCTATATTCTTCTT
TTGAGGATGCGTGCACAGACGCTCTTCGCTTGGCTCGGGGGATGACCTACAAGGCAATCATTAGTAATACAGGAACAGGC
GGGGGGAAAAGTGTTATTATTCTTCCCCAGGATGCTCCTTCCCTCACTGAAGACATGCTGAGGGCTTTTGGCCAGGCTGT
GAATGCTTTAGAGGGGACCTACATCTGTGCTGAAGATCTTGGTGTATCTATAAATGATATTTCTATCGTTGCTGAAGAAA
CTCCTTATGTGTGTGGGATCGCTGATGTTAGTGGAGATCCTTCTATATACACCGCACATGGCGGATTTTTATGCATAAAA
GAAACCGCTAAGTATCTTTGGGGATCTTCCTCTCTTAGAGGGAAAAAAATTGCGATTCAGGGAATAGGCTCTGTAGGACG
ACGTCTATTACAATCGTTGTTTTTTGAAGGCGCCGAACTTTATGTTGCTGATGTTTTAGAAAGAGCCGTTCAGGATGCTG
CAAGGCTCTATGGGGCTACGATTGTTCCTACAGAAGAGATTCATGCATTGGAATGTGATATTTTCTCTCCTTGTGCTCGT
GGGAACGTGATTCGTAAAGATAATCTTGCAGATTTAAATTGTAAGGCGATTGTAGGTGTCGCAAATAACCAACTTGAAGA
TAGCTCAGCTGGAATGATGCTCCACGAACGGGGAATTCTTTATGGTCCCGACTATTTAGTGAATGCTGGGGGATTGCTTA
ATGTGGCCGCAGCAATAGAAGGAAGAGTCTATGCTCCTAAAGAAGTGCTTCTTAAAGTAGAAGAGCTTCCTATAGTTCTA
AGTAAGCTATACAATCAAAGTAAAACTACAGGAAAAGACCTTGTAGCTTTATCAGATTCCTTCGTGGAAGACAAGCTCTT
GGCCTATACGTCATAG

Upstream 100 bases:

>100_bases
AACACGGAGAAAGTTTTAAGAGAAGTGTCTGCTCAGGCCTAATTGACTTTTAATTAAAAGTAGTCAATAATTTTATTTTC
TAATTAAACCTCACTAATTT

Downstream 100 bases:

>100_bases
AGCAATAAGCTTATCCGTGGGGACAACATTGAGTTGGTTTTGTAACGCTGCTAATGTTGTCTCATGGGTTTCCTGGTCTC
CAGAAGCAAGAATCACTGCG

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKYSLNFKEIKIDDYERVIEVTCSKVRLHAIIAIHQTAVGPALGGVRASLYSSFEDACTDALRLARGMTYKAIISNTGTG
GGKSVIILPQDAPSLTEDMLRAFGQAVNALEGTYICAEDLGVSINDISIVAEETPYVCGIADVSGDPSIYTAHGGFLCIK
ETAKYLWGSSSLRGKKIAIQGIGSVGRRLLQSLFFEGAELYVADVLERAVQDAARLYGATIVPTEEIHALECDIFSPCAR
GNVIRKDNLADLNCKAIVGVANNQLEDSSAGMMLHERGILYGPDYLVNAGGLLNVAAAIEGRVYAPKEVLLKVEELPIVL
SKLYNQSKTTGKDLVALSDSFVEDKLLAYTS

Sequences:

>Translated_351_residues
MKYSLNFKEIKIDDYERVIEVTCSKVRLHAIIAIHQTAVGPALGGVRASLYSSFEDACTDALRLARGMTYKAIISNTGTG
GGKSVIILPQDAPSLTEDMLRAFGQAVNALEGTYICAEDLGVSINDISIVAEETPYVCGIADVSGDPSIYTAHGGFLCIK
ETAKYLWGSSSLRGKKIAIQGIGSVGRRLLQSLFFEGAELYVADVLERAVQDAARLYGATIVPTEEIHALECDIFSPCAR
GNVIRKDNLADLNCKAIVGVANNQLEDSSAGMMLHERGILYGPDYLVNAGGLLNVAAAIEGRVYAPKEVLLKVEELPIVL
SKLYNQSKTTGKDLVALSDSFVEDKLLAYTS
>Mature_351_residues
MKYSLNFKEIKIDDYERVIEVTCSKVRLHAIIAIHQTAVGPALGGVRASLYSSFEDACTDALRLARGMTYKAIISNTGTG
GGKSVIILPQDAPSLTEDMLRAFGQAVNALEGTYICAEDLGVSINDISIVAEETPYVCGIADVSGDPSIYTAHGGFLCIK
ETAKYLWGSSSLRGKKIAIQGIGSVGRRLLQSLFFEGAELYVADVLERAVQDAARLYGATIVPTEEIHALECDIFSPCAR
GNVIRKDNLADLNCKAIVGVANNQLEDSSAGMMLHERGILYGPDYLVNAGGLLNVAAAIEGRVYAPKEVLLKVEELPIVL
SKLYNQSKTTGKDLVALSDSFVEDKLLAYTS

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 37693; Mature: 37693

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYSLNFKEIKIDDYERVIEVTCSKVRLHAIIAIHQTAVGPALGGVRASLYSSFEDACTD
CCCCCCCEEEEECHHHHHHHHHHHHHEEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHH
ALRLARGMTYKAIISNTGTGGGKSVIILPQDAPSLTEDMLRAFGQAVNALEGTYICAEDL
HHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEHHHC
GVSINDISIVAEETPYVCGIADVSGDPSIYTAHGGFLCIKETAKYLWGSSSLRGKKIAIQ
CCEEEEEEEEEECCCCEEEEECCCCCCCEEEECCCEEEHHHHHHHHCCCCCCCCCEEEEE
GIGSVGRRLLQSLFFEGAELYVADVLERAVQDAARLYGATIVPTEEIHALECDIFSPCAR
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEECCCCCHHHC
GNVIRKDNLADLNCKAIVGVANNQLEDSSAGMMLHERGILYGPDYLVNAGGLLNVAAAIE
CCEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEECCCCEECCCCHHEEHHHHC
GRVYAPKEVLLKVEELPIVLSKLYNQSKTTGKDLVALSDSFVEDKLLAYTS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHEECC
>Mature Secondary Structure
MKYSLNFKEIKIDDYERVIEVTCSKVRLHAIIAIHQTAVGPALGGVRASLYSSFEDACTD
CCCCCCCEEEEECHHHHHHHHHHHHHEEEEEEEEHHHHCCHHHHHHHHHHHHHHHHHHHH
ALRLARGMTYKAIISNTGTGGGKSVIILPQDAPSLTEDMLRAFGQAVNALEGTYICAEDL
HHHHHHCCEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCEEEHHHC
GVSINDISIVAEETPYVCGIADVSGDPSIYTAHGGFLCIKETAKYLWGSSSLRGKKIAIQ
CCEEEEEEEEEECCCCEEEEECCCCCCCEEEECCCEEEHHHHHHHHCCCCCCCCCEEEEE
GIGSVGRRLLQSLFFEGAELYVADVLERAVQDAARLYGATIVPTEEIHALECDIFSPCAR
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEECCCCCHHHC
GNVIRKDNLADLNCKAIVGVANNQLEDSSAGMMLHERGILYGPDYLVNAGGLLNVAAAIE
CCEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEECCCCEECCCCEECCCCHHEEHHHHC
GRVYAPKEVLLKVEELPIVLSKLYNQSKTTGKDLVALSDSFVEDKLLAYTS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]