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The map label for this gene is nth

Identifier: 15836370

GI number: 15836370

Start: 946463

End: 947092

Strand: Reverse

Name: nth

Synonym: CPj0837

Alternate gene names: 15836370

Gene position: 947092-946463 (Counterclockwise)

Preceding gene: 15836371

Following gene: 15836369

Centisome position: 77.21

GC content: 42.22

Gene sequence:

>630_bases
ATGAAGCAATTTATTCTCAGAACACTCAACGCGCTATTTCCCAATCCAAAACCATCTTTAGAAGGGTGGTCCTCTCCCTT
TCAACTACTTATTGCTATTCTCTTATCTGGGAATTCTACGGACAAAGCAGTAAATTCCGTGACACCACAACTCTTTGCAA
AAGCCCCAGACGCCCAATCTATTTTAGATTTGCCTCCAGGGAAGCTATACCAGCTCATTGCCCCTTGTGGCCTTGGAGAG
AGAAAGTCCGCCTATATTTATCAATTATCTCAAATTTTAGTGCGTGATTTTCATGGAGAACCCCCTAATGACATGGCTCT
TCTCACACAACTTCCGGGAGTTGGCAGAAAAACCGCTTCTGTTTTTCTTGGGATAGCCTATGGAAAACCTACATTCCCTG
TAGACACTCATATTTTGCGTTTAGCGCAGCGATGGAAAATTTCTGAAAAAAAAAGCCCCTCCGCTGCTGAAAAGGATCTG
GCTCGCTTTTTTGGCCATGAGAACACACCGAAATTGCACTTGCAACTCATCTATTATGCACGACAGTATTGTCCTGCTTT
ACATCATAAAATTGACAATTGCCCTATATGTTCATATCTTGCAAAAGAAGCAAATAGTACCCGTACTTAG

Upstream 100 bases:

>100_bases
AGAGGCACTTCACTCGATTGGGATGCTTTCTGGCAAAGAAGTTACTGAAAGTATTTTAGGGGAAATTTTTAGTAAATTTT
GCATTGGAAAATAGCTCACC

Downstream 100 bases:

>100_bases
AAAATCGCTTTGTTATAAAAAAAACTGTATAAATTTAGAGTTGTTAGCTTTTTAAGAATTCGTAACTCTACCTTTTGTCC
CACAGTACAATAAAAACTAA

Product: endonuclease III

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MKQFILRTLNALFPNPKPSLEGWSSPFQLLIAILLSGNSTDKAVNSVTPQLFAKAPDAQSILDLPPGKLYQLIAPCGLGE
RKSAYIYQLSQILVRDFHGEPPNDMALLTQLPGVGRKTASVFLGIAYGKPTFPVDTHILRLAQRWKISEKKSPSAAEKDL
ARFFGHENTPKLHLQLIYYARQYCPALHHKIDNCPICSYLAKEANSTRT

Sequences:

>Translated_209_residues
MKQFILRTLNALFPNPKPSLEGWSSPFQLLIAILLSGNSTDKAVNSVTPQLFAKAPDAQSILDLPPGKLYQLIAPCGLGE
RKSAYIYQLSQILVRDFHGEPPNDMALLTQLPGVGRKTASVFLGIAYGKPTFPVDTHILRLAQRWKISEKKSPSAAEKDL
ARFFGHENTPKLHLQLIYYARQYCPALHHKIDNCPICSYLAKEANSTRT
>Mature_209_residues
MKQFILRTLNALFPNPKPSLEGWSSPFQLLIAILLSGNSTDKAVNSVTPQLFAKAPDAQSILDLPPGKLYQLIAPCGLGE
RKSAYIYQLSQILVRDFHGEPPNDMALLTQLPGVGRKTASVFLGIAYGKPTFPVDTHILRLAQRWKISEKKSPSAAEKDL
ARFFGHENTPKLHLQLIYYARQYCPALHHKIDNCPICSYLAKEANSTRT

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=171, Percent_Identity=30.9941520467836, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1787920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17554540, Length=175, Percent_Identity=29.1428571428571, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45550361, Length=141, Percent_Identity=27.6595744680851, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 23271; Mature: 23271

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFILRTLNALFPNPKPSLEGWSSPFQLLIAILLSGNSTDKAVNSVTPQLFAKAPDAQS
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCCHHH
ILDLPPGKLYQLIAPCGLGERKSAYIYQLSQILVRDFHGEPPNDMALLTQLPGVGRKTAS
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHH
VFLGIAYGKPTFPVDTHILRLAQRWKISEKKSPSAAEKDLARFFGHENTPKLHLQLIYYA
HEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
RQYCPALHHKIDNCPICSYLAKEANSTRT
HHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKQFILRTLNALFPNPKPSLEGWSSPFQLLIAILLSGNSTDKAVNSVTPQLFAKAPDAQS
CHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHCCCCHHH
ILDLPPGKLYQLIAPCGLGERKSAYIYQLSQILVRDFHGEPPNDMALLTQLPGVGRKTAS
HHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHH
VFLGIAYGKPTFPVDTHILRLAQRWKISEKKSPSAAEKDLARFFGHENTPKLHLQLIYYA
HEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHH
RQYCPALHHKIDNCPICSYLAKEANSTRT
HHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704260; 8760912; 9384377 [H]