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Identifier: 15836140

GI number: 15836140

Start: 698334

End: 698966

Strand: Reverse

Name: Not Available

Synonym: CPj0608

Alternate gene names: 15836140

Gene position: 698966-698334 (Counterclockwise)

Preceding gene: 15836142

Following gene: 15836139

Centisome position: 56.99

GC content: 41.39

Gene sequence:

>633_bases
ATGATGAACTACGAAGATGCAAAATTACGCGGTCAAGCTGTAGCAATTCTATACCAAATCGGAGCTATAAAGTTCGGAAA
ACATATTCTCGCTAGCGGAGAAGAAACTCCTCTGTATGTAGATATGCGTCTTGTGATCTCCTCTCCAGAAGTTCTCCAGA
CAGTGGCAACTCTTATTTGGCAGCTCCGCCCCTCATTCAATAGTAGCTTACTCTGCGGAGTCCCTTATACTGCTCTAACC
CTAGCAACCTCGATCTCTTTAAAATATAACATCCCTATGGTATTGCGAAGGAAGGAATTACAGAATGTAGACCCCTCGGA
CGCTATTAAAGTAGAAGGGTTATTTACTCCAGGACAAACTTGTTTAGTCATCAATGATATGGTTTCCTCAGGAAAATCTA
TAATAGAGACAGCAGTCGCACTGGAAGAAAATGGTCTGGTAGTTCGTGAAGCATTGGTATTCTTAGATCGTAGAAAAGAA
GCGTGTCAACCACTTGGTCCACAGGGAATAAAAGTCAGTTCGGTATTTACTGTACCCACTCTGATAAAAGCTTTGATCGC
TTATGGGAAGCTAAGCAGTGGTGATCTAACCCTGGCAAACAAAATTTCCGAAATTCTAGAAATTGAATCTTAA

Upstream 100 bases:

>100_bases
CCTTTGGGAAGAGAAATTCCAAGAAACAGGCGTATTAGCATGTTTTCCCTTATAAGTGAGTTTTTTGTATTTTGTCAAAA
ACGGTCGGAGGCTCTGGAGA

Downstream 100 bases:

>100_bases
TTTCTAGAACCTATTTATTAAAAAGAATTTAATTATTTAACAAAATTTATTTGTTTTGTTGTGTTGGCCTTTTTATTTGT
TTCTAATTTAAAATTAAATT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWQLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES

Sequences:

>Translated_210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWQLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES
>Mature_210_residues
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIWQLRPSFNSSLLCGVPYTALT
LATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQTCLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKE
ACQPLGPQGIKVSSVFTVPTLIKALIAYGKLSSGDLTLANKISEILEIES

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=177, Percent_Identity=41.8079096045198, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17508631, Length=178, Percent_Identity=35.3932584269663, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17554964, Length=172, Percent_Identity=29.0697674418605, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17933654, Length=212, Percent_Identity=34.4339622641509, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22867; Mature: 22867

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIW
CCCCCCHHHCCHHEEEEHHHHHHHHCCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
QLRPSFNSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQT
HHCCCCCCCEEECCCHHHHHHHHHEEEEECCHHEEEHHHHCCCCCCCCEEEEEEECCCCE
CLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPT
EEEEEHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHEECHHH
LIKALIAYGKLSSGDLTLANKISEILEIES
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNYEDAKLRGQAVAILYQIGAIKFGKHILASGEETPLYVDMRLVISSPEVLQTVATLIW
CCCCCCHHHCCHHEEEEHHHHHHHHCCHHHCCCCCCCEEEEEEEEECCHHHHHHHHHHHH
QLRPSFNSSLLCGVPYTALTLATSISLKYNIPMVLRRKELQNVDPSDAIKVEGLFTPGQT
HHCCCCCCCEEECCCHHHHHHHHHEEEEECCHHEEEHHHHCCCCCCCCEEEEEEECCCCE
CLVINDMVSSGKSIIETAVALEENGLVVREALVFLDRRKEACQPLGPQGIKVSSVFTVPT
EEEEEHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEHEECHHH
LIKALIAYGKLSSGDLTLANKISEILEIES
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]