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The map label for this gene is tlyC_2

Identifier: 15836041

GI number: 15836041

Start: 590133

End: 591296

Strand: Direct

Name: tlyC_2

Synonym: CPj0510

Alternate gene names: 15836041

Gene position: 590133-591296 (Clockwise)

Preceding gene: 15836040

Following gene: 15836042

Centisome position: 48.11

GC content: 43.99

Gene sequence:

>1164_bases
ATGCTCCATATTCTTTTAGCCATATTCTGTATTCTTCTATTCCTAGCCTTCGGGCTTACGCAACCGTCCTGTCACGGATC
CTCAAAATTCCTAAAAACCCTAAACCAACGCTTCTTCAAAGATAAAGGAAGAGAGTATCCCCCCTTCCCCAGTGCTCCTA
CAATTCTCGCCACGCTGCTCTGCATCCTCTATGGAGCTCTCGGGACAAAACTCTATACCCTCCTCCCTCCAAAAACAGCT
CACAAAGATCTCCTATTCTGGCCCCTATACTCTCTAAGCGCCCTGATAGCTTACGGATTCCTCCCCCCATGGATCTCTAC
AAAAGTCCCTAAAGAAACCACCGCCCACCTCCGTTTTCTAGCTTCGGTATTCCAACTCGGTCTCTTCCCACTGCAACTGC
TCTTTTACAGACGCCGCCCTAACCAACAAGTACGATCTTCAACATCATTTCAAAGCCAGCTCTCCGAAGCCCTCTCCGCT
TTTGATAACCTCATTGTCCGTGAAGTCATGATCCCAAAAGTAGATATTTTCGCACTTCCCGAAGAAACTACACTACAAGA
AGCTCTGGTTCTCGTAAGCGAAGAAGGCTACAGTCGCGTTCCCGTTTATAAAAAAAACTTAGACAACATCACAGGAATCC
TTCTTGTTAAAGATCTCTTACTGCTCTATACAAGCAGCCACGACCTCAGCCAACCCATATCCTCAGTAGCAAAACCCCCA
TTCTATGCCCCAGAAATAAAAAAAGCCTCCTCTCTTCTCCAAGAGTTCCGACAAAAACATCGCCATCTAGCCATCATAGT
CAATGAATACGGATTCACAGAAGGCATCGCTACCATGGAAGATATTATCGAAGAAATTATAGGAGAGATCGCAGACGAGC
ACGACGTACAAGAAAATACTCCTTATAAGAAAATCGGAAGCTCTTGGATTGTAGATGGAAGAATGAATATCTCCGACGCT
GAAGAGTACTTCAATTTGAAAATCGATCATGAAAATAGCTACGATACACTAGGAGGACATGTCTTCCATAAAGTGGGTGC
TGTTCCCCAAAAAGGAATGCGTATCCATCACGAAAACTTCGATATAGAAATCATTACCTGCACAGAACGAAATGTCGGAA
AACTAAAAATCACACCAAGAAAACGTAAATTCAATATCTCCTAA

Upstream 100 bases:

>100_bases
TACGACGACACCTCATCAGAAGAAAAGAGAAAAATGAGAGTTAAAGAAAATCAAATCCTGTGTATGTTAAGAAAAAAACA
TGCTTTGCTAACAGCTTAAC

Downstream 100 bases:

>100_bases
GAATGTAAACATCCTAGGACCGATTTCCTTGCACTCCACGATCCCATCCTGCCTCCCCCCAATCGAAATTCTCAAACATC
ACCAATAAAAATCTCTTTGC

Product: CBS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MLHILLAIFCILLFLAFGLTQPSCHGSSKFLKTLNQRFFKDKGREYPPFPSAPTILATLLCILYGALGTKLYTLLPPKTA
HKDLLFWPLYSLSALIAYGFLPPWISTKVPKETTAHLRFLASVFQLGLFPLQLLFYRRRPNQQVRSSTSFQSQLSEALSA
FDNLIVREVMIPKVDIFALPEETTLQEALVLVSEEGYSRVPVYKKNLDNITGILLVKDLLLLYTSSHDLSQPISSVAKPP
FYAPEIKKASSLLQEFRQKHRHLAIIVNEYGFTEGIATMEDIIEEIIGEIADEHDVQENTPYKKIGSSWIVDGRMNISDA
EEYFNLKIDHENSYDTLGGHVFHKVGAVPQKGMRIHHENFDIEIITCTERNVGKLKITPRKRKFNIS

Sequences:

>Translated_387_residues
MLHILLAIFCILLFLAFGLTQPSCHGSSKFLKTLNQRFFKDKGREYPPFPSAPTILATLLCILYGALGTKLYTLLPPKTA
HKDLLFWPLYSLSALIAYGFLPPWISTKVPKETTAHLRFLASVFQLGLFPLQLLFYRRRPNQQVRSSTSFQSQLSEALSA
FDNLIVREVMIPKVDIFALPEETTLQEALVLVSEEGYSRVPVYKKNLDNITGILLVKDLLLLYTSSHDLSQPISSVAKPP
FYAPEIKKASSLLQEFRQKHRHLAIIVNEYGFTEGIATMEDIIEEIIGEIADEHDVQENTPYKKIGSSWIVDGRMNISDA
EEYFNLKIDHENSYDTLGGHVFHKVGAVPQKGMRIHHENFDIEIITCTERNVGKLKITPRKRKFNIS
>Mature_387_residues
MLHILLAIFCILLFLAFGLTQPSCHGSSKFLKTLNQRFFKDKGREYPPFPSAPTILATLLCILYGALGTKLYTLLPPKTA
HKDLLFWPLYSLSALIAYGFLPPWISTKVPKETTAHLRFLASVFQLGLFPLQLLFYRRRPNQQVRSSTSFQSQLSEALSA
FDNLIVREVMIPKVDIFALPEETTLQEALVLVSEEGYSRVPVYKKNLDNITGILLVKDLLLLYTSSHDLSQPISSVAKPP
FYAPEIKKASSLLQEFRQKHRHLAIIVNEYGFTEGIATMEDIIEEIIGEIADEHDVQENTPYKKIGSSWIVDGRMNISDA
EEYFNLKIDHENSYDTLGGHVFHKVGAVPQKGMRIHHENFDIEIITCTERNVGKLKITPRKRKFNIS

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=196, Percent_Identity=32.1428571428571, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI40068055, Length=284, Percent_Identity=27.112676056338, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI40068053, Length=284, Percent_Identity=27.112676056338, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI94681046, Length=153, Percent_Identity=32.6797385620915, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40068049, Length=153, Percent_Identity=33.9869281045752, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786879, Length=208, Percent_Identity=32.6923076923077, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI145693175, Length=243, Percent_Identity=25.1028806584362, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87082033, Length=254, Percent_Identity=24.4094488188976, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790664, Length=188, Percent_Identity=21.8085106382979, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788119, Length=217, Percent_Identity=23.963133640553, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539402, Length=313, Percent_Identity=27.4760383386581, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 43981; Mature: 43981

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHILLAIFCILLFLAFGLTQPSCHGSSKFLKTLNQRFFKDKGREYPPFPSAPTILATLL
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
CILYGALGTKLYTLLPPKTAHKDLLFWPLYSLSALIAYGFLPPWISTKVPKETTAHLRFL
HHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ASVFQLGLFPLQLLFYRRRPNQQVRSSTSFQSQLSEALSAFDNLIVREVMIPKVDIFALP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
EETTLQEALVLVSEEGYSRVPVYKKNLDNITGILLVKDLLLLYTSSHDLSQPISSVAKPP
CHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
FYAPEIKKASSLLQEFRQKHRHLAIIVNEYGFTEGIATMEDIIEEIIGEIADEHDVQENT
CCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PYKKIGSSWIVDGRMNISDAEEYFNLKIDHENSYDTLGGHVFHKVGAVPQKGMRIHHENF
CHHHCCCCEEECCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
DIEIITCTERNVGKLKITPRKRKFNIS
CEEEEEECCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MLHILLAIFCILLFLAFGLTQPSCHGSSKFLKTLNQRFFKDKGREYPPFPSAPTILATLL
CHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
CILYGALGTKLYTLLPPKTAHKDLLFWPLYSLSALIAYGFLPPWISTKVPKETTAHLRFL
HHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ASVFQLGLFPLQLLFYRRRPNQQVRSSTSFQSQLSEALSAFDNLIVREVMIPKVDIFALP
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
EETTLQEALVLVSEEGYSRVPVYKKNLDNITGILLVKDLLLLYTSSHDLSQPISSVAKPP
CHHHHHHHHHHHCCCCCCCCCCHHHCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
FYAPEIKKASSLLQEFRQKHRHLAIIVNEYGFTEGIATMEDIIEEIIGEIADEHDVQENT
CCCHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PYKKIGSSWIVDGRMNISDAEEYFNLKIDHENSYDTLGGHVFHKVGAVPQKGMRIHHENF
CHHHCCCCEEECCCCCCCCHHHHEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
DIEIITCTERNVGKLKITPRKRKFNIS
CEEEEEECCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]