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The map label for this gene is mutY

Identifier: 15835935

GI number: 15835935

Start: 447594

End: 448703

Strand: Reverse

Name: mutY

Synonym: CPj0402

Alternate gene names: 15835935

Gene position: 448703-447594 (Counterclockwise)

Preceding gene: 15835937

Following gene: 15835934

Centisome position: 36.58

GC content: 40.81

Gene sequence:

>1110_bases
ATGACAAAGATAGCTTTTTCTGAAAAGGCAAAGAATTTTCCTGTAGAGGCATTAAAAAAATGGTTTGAAAAAAATAAACG
ATCTCTTCCTTGGAGAGATAACCCGACTCCCTATAGTGTGTGGGTTTCCGAAGTTATGCTACAGCAAACGCGAGCTGAAG
TTGTTATAGATTATTTTAATCAGTGGATGGAGAGATTTCCTACCATAGAGTCTTTAGCTGCAGCAAAAGAAGAAGATGTC
ATTAAGTTATGGGAGGGATTGGGTTATTATTCTCGAGCGCGCCATCTTTTAGAGGGAGCTCGCATGGTTATGGAGGAGTT
TCATGGAAAGATCCCTGATGATGCCATTTCCTTAGCTCAAATTCGTGGAGTTGGTCCTTATACGGTTCATGCTATTCTAG
CCTTTGCTTTTAAGAGGCGTGCTGCTGCTGTGGATGGCAATGTCTTGCGTGTTCTTAGCCGGATATTTTTGATAGAAACT
TCTATAGACTTAGAATCAACTCGTACTTGGGTTTCTAGGATTGCTCAAGCGCTTCTTCCTCATAAGAGTCCCGAGGTTAT
AGCTGAGGCTCTGATAGAGTTGGGAGCTTGTATCTGTAAAAAAGTTCCTCAATGTCATCGTTGTCCTGTCCGTCAAGCAT
GTGGAGCTTGGAGGGAGAACAAACAGTTCGTATTGCCGGTACGTCATGCCAGAAAAAAGGTCATCTTTTTGCATCGTTTG
GTAGCGATTGTATTGTACGATGGCTCTTTGGTTGTCGAGAAGAGACGTCCTAAAGAAATGATGGCAGGCTTATATGAATT
TCCTTATATTGAAGTTGAACCAGAGGAAGGTCTTCAAGATATAGAAGGATTTACTAAGAAGATGGAGCTTTCTTTAGAAA
GCCCTTTGGAATTCTTAGGTAACCTTAAAGAACAGCGGCATGCGTTTACTAATCATAAGGTTCATTTGTGTCCTATAATT
TTTAAAGCCACTTCTCTGCCTCAGTTCGGGGAATTGCATCTTTTGAGTGATATAGATCACTTAGCTTTTTCTTCAGGACA
CAAAAAGATTAAAGATGCTTTGCTAATCTACCTCGGGGATGTCAGGTCTAGAGAATCAATAGGAGTATAG

Upstream 100 bases:

>100_bases
CTTGAGACTTGTGTGGCAAGCCAGGAAAAATTTTCCATAAAATATTGTAAAGCAGCCCTTTTATCATTTGATAATTGCAT
AAAATTTTAAGAGATTTTGT

Downstream 100 bases:

>100_bases
ATGCGAGATCACGCTTTTTCTAAATTGATAGGGACTGTCCGTGCCATGGTAGTTGAAGGACGTTGTCCTTGGTCACTTCA
GCAATCCCTAGTCTCTATGG

Product: adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTKIAFSEKAKNFPVEALKKWFEKNKRSLPWRDNPTPYSVWVSEVMLQQTRAEVVIDYFNQWMERFPTIESLAAAKEEDV
IKLWEGLGYYSRARHLLEGARMVMEEFHGKIPDDAISLAQIRGVGPYTVHAILAFAFKRRAAAVDGNVLRVLSRIFLIET
SIDLESTRTWVSRIAQALLPHKSPEVIAEALIELGACICKKVPQCHRCPVRQACGAWRENKQFVLPVRHARKKVIFLHRL
VAIVLYDGSLVVEKRRPKEMMAGLYEFPYIEVEPEEGLQDIEGFTKKMELSLESPLEFLGNLKEQRHAFTNHKVHLCPII
FKATSLPQFGELHLLSDIDHLAFSSGHKKIKDALLIYLGDVRSRESIGV

Sequences:

>Translated_369_residues
MTKIAFSEKAKNFPVEALKKWFEKNKRSLPWRDNPTPYSVWVSEVMLQQTRAEVVIDYFNQWMERFPTIESLAAAKEEDV
IKLWEGLGYYSRARHLLEGARMVMEEFHGKIPDDAISLAQIRGVGPYTVHAILAFAFKRRAAAVDGNVLRVLSRIFLIET
SIDLESTRTWVSRIAQALLPHKSPEVIAEALIELGACICKKVPQCHRCPVRQACGAWRENKQFVLPVRHARKKVIFLHRL
VAIVLYDGSLVVEKRRPKEMMAGLYEFPYIEVEPEEGLQDIEGFTKKMELSLESPLEFLGNLKEQRHAFTNHKVHLCPII
FKATSLPQFGELHLLSDIDHLAFSSGHKKIKDALLIYLGDVRSRESIGV
>Mature_368_residues
TKIAFSEKAKNFPVEALKKWFEKNKRSLPWRDNPTPYSVWVSEVMLQQTRAEVVIDYFNQWMERFPTIESLAAAKEEDVI
KLWEGLGYYSRARHLLEGARMVMEEFHGKIPDDAISLAQIRGVGPYTVHAILAFAFKRRAAAVDGNVLRVLSRIFLIETS
IDLESTRTWVSRIAQALLPHKSPEVIAEALIELGACICKKVPQCHRCPVRQACGAWRENKQFVLPVRHARKKVIFLHRLV
AIVLYDGSLVVEKRRPKEMMAGLYEFPYIEVEPEEGLQDIEGFTKKMELSLESPLEFLGNLKEQRHAFTNHKVHLCPIIF
KATSLPQFGELHLLSDIDHLAFSSGHKKIKDALLIYLGDVRSRESIGV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI6912520, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI115298650, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI190358497, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI115298654, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI115298652, Length=355, Percent_Identity=34.6478873239437, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1789331, Length=320, Percent_Identity=30.9375, Blast_Score=171, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42273; Mature: 42142

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAFSEKAKNFPVEALKKWFEKNKRSLPWRDNPTPYSVWVSEVMLQQTRAEVVIDYFN
CCCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QWMERFPTIESLAAAKEEDVIKLWEGLGYYSRARHLLEGARMVMEEFHGKIPDDAISLAQ
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IRGVGPYTVHAILAFAFKRRAAAVDGNVLRVLSRIFLIETSIDLESTRTWVSRIAQALLP
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HKSPEVIAEALIELGACICKKVPQCHRCPVRQACGAWRENKQFVLPVRHARKKVIFLHRL
CCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCHHCCCCEEEEHHHHHHHHHHHHHH
VAIVLYDGSLVVEKRRPKEMMAGLYEFPYIEVEPEEGLQDIEGFTKKMELSLESPLEFLG
HHHHHCCCCEEEECCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCHHHHHHHHH
NLKEQRHAFTNHKVHLCPIIFKATSLPQFGELHLLSDIDHLAFSSGHKKIKDALLIYLGD
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VRSRESIGV
CCCCCCCCC
>Mature Secondary Structure 
TKIAFSEKAKNFPVEALKKWFEKNKRSLPWRDNPTPYSVWVSEVMLQQTRAEVVIDYFN
CCCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QWMERFPTIESLAAAKEEDVIKLWEGLGYYSRARHLLEGARMVMEEFHGKIPDDAISLAQ
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
IRGVGPYTVHAILAFAFKRRAAAVDGNVLRVLSRIFLIETSIDLESTRTWVSRIAQALLP
HCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
HKSPEVIAEALIELGACICKKVPQCHRCPVRQACGAWRENKQFVLPVRHARKKVIFLHRL
CCCHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCHHCCCCEEEEHHHHHHHHHHHHHH
VAIVLYDGSLVVEKRRPKEMMAGLYEFPYIEVEPEEGLQDIEGFTKKMELSLESPLEFLG
HHHHHCCCCEEEECCCCHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCHHHHHHHHH
NLKEQRHAFTNHKVHLCPIIFKATSLPQFGELHLLSDIDHLAFSSGHKKIKDALLIYLGD
HHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
VRSRESIGV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]