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The map label for this gene is fabH

Identifier: 15835833

GI number: 15835833

Start: 335336

End: 336343

Strand: Reverse

Name: fabH

Synonym: CPj0298

Alternate gene names: 15835833

Gene position: 336343-335336 (Counterclockwise)

Preceding gene: 15835838

Following gene: 15835832

Centisome position: 27.42

GC content: 42.16

Gene sequence:

>1008_bases
ATGTGGTTCTCTGTGAATAAAAACAAAAAAGCAGCAATTTGGGCAACGGGTTCCTATTTGCCTGAGAAAGTTCTTTCAAA
CGCAGATTTAGAAAAAATGGTAGATACCTCTGATGAGTGGATCGTGACCAGAACGGGGATCAAAGAGCGTCGTATTGCTG
GACCTCAGGAGTACACTTCTCTTATGGGAGCCATCGCTGCAGAGAAAGCTATAGCAAATGCGGGTTTAAGCAAGGATCAG
ATTGACTGTATCATTTTCTCGACAGCAGCACCAGATTATATTTTCCCATCAAGCGGAGCTCTTGCTCAAGCACATTTAGG
CATTGAGGATGTCCCTACATTTGATTGCCAGGCGGCTTGTACTGGGTATTTGTATGGTTTGTCTGTAGCTAAGGCTTATG
TAGAATCAGGTACATATAACCATGTATTGTTAATTGCTGCTGATAAGTTGTCTTCTTTTGTAGATTATACAGATCGGAAT
ACCTGTGTGTTGTTTGGAGATGGAGGAGCTGCTTGTGTCATAGGGGAGAGTCGGCCAGGATCTTTAGAGATTAATAGGTT
GTCTTTAGGCGCAGATGGTAAGCTAGGAGAGTTATTAAGCCTTCCTGCTGGAGGTAGTCGTTGTCCTGCTTCTAAAGAGA
CTTTACAATCAGGCAAACATTTTATTGCTATGGAGGGAAAAGAAGTTTTTAAGCATGCTGTGAGACGTATGGAAACGGCA
GCTAAACATTCGATAGCCCTGGCAGGCATTCAGGAAGAGGATATAGATTGGTTTGTACCTCATCAAGCTAATGAAAGAAT
AATAGATGCTTTAGCGAAGCGTTTTGAGATTGATGAGTCTAGAGTGTTTAAGAGTGTACATAAGTATGGAAATACTGCGG
CCTCGTCTGTGGGCATTGCTTTGGATGAATTAGTTCATACAGAATCCATTAAGCTTGATGATTATTTACTTTTAGTTGCC
TTTGGGGGCGGTTTGTCTTGGGGCGCAGTAGTTTTAAAGCAGGTCTAA

Upstream 100 bases:

>100_bases
TGTCATAGTGATGTGAATTTTATTTTTACATTCGGGTCTGGGGCCTAAATTAAGGTTAGAGTATAAACTCTCTGAATAGT
ATACTAGCTTTTTTCTTTAT

Downstream 100 bases:

>100_bases
TAAGGACGATAATTTCATGAAAAAACGTTATGCTTTTTTGTTCCCAGGACAAGGGAGCCAATATGTAGGTATGGGACAAG
ACCTATATATGGAGTATCCT

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MWFSVNKNKKAAIWATGSYLPEKVLSNADLEKMVDTSDEWIVTRTGIKERRIAGPQEYTSLMGAIAAEKAIANAGLSKDQ
IDCIIFSTAAPDYIFPSSGALAQAHLGIEDVPTFDCQAACTGYLYGLSVAKAYVESGTYNHVLLIAADKLSSFVDYTDRN
TCVLFGDGGAACVIGESRPGSLEINRLSLGADGKLGELLSLPAGGSRCPASKETLQSGKHFIAMEGKEVFKHAVRRMETA
AKHSIALAGIQEEDIDWFVPHQANERIIDALAKRFEIDESRVFKSVHKYGNTAASSVGIALDELVHTESIKLDDYLLLVA
FGGGLSWGAVVLKQV

Sequences:

>Translated_335_residues
MWFSVNKNKKAAIWATGSYLPEKVLSNADLEKMVDTSDEWIVTRTGIKERRIAGPQEYTSLMGAIAAEKAIANAGLSKDQ
IDCIIFSTAAPDYIFPSSGALAQAHLGIEDVPTFDCQAACTGYLYGLSVAKAYVESGTYNHVLLIAADKLSSFVDYTDRN
TCVLFGDGGAACVIGESRPGSLEINRLSLGADGKLGELLSLPAGGSRCPASKETLQSGKHFIAMEGKEVFKHAVRRMETA
AKHSIALAGIQEEDIDWFVPHQANERIIDALAKRFEIDESRVFKSVHKYGNTAASSVGIALDELVHTESIKLDDYLLLVA
FGGGLSWGAVVLKQV
>Mature_335_residues
MWFSVNKNKKAAIWATGSYLPEKVLSNADLEKMVDTSDEWIVTRTGIKERRIAGPQEYTSLMGAIAAEKAIANAGLSKDQ
IDCIIFSTAAPDYIFPSSGALAQAHLGIEDVPTFDCQAACTGYLYGLSVAKAYVESGTYNHVLLIAADKLSSFVDYTDRN
TCVLFGDGGAACVIGESRPGSLEINRLSLGADGKLGELLSLPAGGSRCPASKETLQSGKHFIAMEGKEVFKHAVRRMETA
AKHSIALAGIQEEDIDWFVPHQANERIIDALAKRFEIDESRVFKSVHKYGNTAASSVGIALDELVHTESIKLDDYLLLVA
FGGGLSWGAVVLKQV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=322, Percent_Identity=46.2732919254658, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_CHLPN (Q9Z8P0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B86528
- PIR:   F72096
- RefSeq:   NP_224503.1
- RefSeq:   NP_300357.1
- RefSeq:   NP_445008.1
- RefSeq:   NP_876583.1
- ProteinModelPortal:   Q9Z8P0
- SMR:   Q9Z8P0
- PHCI-2DPAGE:   Q9Z8P0
- GeneID:   1466990
- GeneID:   895109
- GeneID:   919081
- GeneID:   963748
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0460
- KEGG:   cpn:CPn0298
- KEGG:   cpt:CpB0307
- TIGR:   CP_0460
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q9Z8P0
- ProtClustDB:   PRK09352
- BioCyc:   CPNE115711:CP_0460-MONOMER
- BioCyc:   CPNE115713:CPN0298-MONOMER
- BioCyc:   CPNE138677:CPJ0298-MONOMER
- BioCyc:   CPNE182082:CPB0307-MONOMER
- BRENDA:   2.3.1.180
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 36081; Mature: 36081

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: ACT_SITE 120-120 ACT_SITE 261-261 ACT_SITE 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFSVNKNKKAAIWATGSYLPEKVLSNADLEKMVDTSDEWIVTRTGIKERRIAGPQEYTS
CCEECCCCCCEEEEEECCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCHHHCCCHHHHHH
LMGAIAAEKAIANAGLSKDQIDCIIFSTAAPDYIFPSSGALAQAHLGIEDVPTFDCQAAC
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCEEECCCCCCCCCCCHHHHH
TGYLYGLSVAKAYVESGTYNHVLLIAADKLSSFVDYTDRNTCVLFGDGGAACVIGESRPG
HHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCC
SLEINRLSLGADGKLGELLSLPAGGSRCPASKETLQSGKHFIAMEGKEVFKHAVRRMETA
CEEEEEEEECCCCCCHHHEECCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHH
AKHSIALAGIQEEDIDWFVPHQANERIIDALAKRFEIDESRVFKSVHKYGNTAASSVGIA
HHHCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHH
LDELVHTESIKLDDYLLLVAFGGGLSWGAVVLKQV
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MWFSVNKNKKAAIWATGSYLPEKVLSNADLEKMVDTSDEWIVTRTGIKERRIAGPQEYTS
CCEECCCCCCEEEEEECCCCHHHHHCCCCHHHHHCCCCCEEEEECCCCHHHCCCHHHHHH
LMGAIAAEKAIANAGLSKDQIDCIIFSTAAPDYIFPSSGALAQAHLGIEDVPTFDCQAAC
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEECCCCCCEEECCCCCCCCCCCHHHHH
TGYLYGLSVAKAYVESGTYNHVLLIAADKLSSFVDYTDRNTCVLFGDGGAACVIGESRPG
HHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHCCCCCCEEEEEECCCEEEEEECCCCC
SLEINRLSLGADGKLGELLSLPAGGSRCPASKETLQSGKHFIAMEGKEVFKHAVRRMETA
CEEEEEEEECCCCCCHHHEECCCCCCCCCCCHHHHHCCCEEEEECCHHHHHHHHHHHHHH
AKHSIALAGIQEEDIDWFVPHQANERIIDALAKRFEIDESRVFKSVHKYGNTAASSVGIA
HHHCEEEECCCCCCCCEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHH
LDELVHTESIKLDDYLLLVAFGGGLSWGAVVLKQV
HHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362