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The map label for this gene is hemH

Identifier: 15835386

GI number: 15835386

Start: 914023

End: 914976

Strand: Reverse

Name: hemH

Synonym: TC0772

Alternate gene names: 15835386

Gene position: 914976-914023 (Counterclockwise)

Preceding gene: 15835387

Following gene: 15835385

Centisome position: 85.28

GC content: 40.99

Gene sequence:

>954_bases
GTGACAGTTTATCTACTAGCAAATTTTGGTGGCCCAAGAATATCTCAAGAGATTCCCAGCTTTCTGCATGCTTTATTGAC
AGATCAGGATGTTACCGGGGGAAGGATTCCTCCTTGGTTGCATAGACCTCTCTTCTCTTACATAGCGAAGCGTAGAGCTC
ATCGTGTAGCAGAACAATATGCTTATTTAGGAGGCAGATCTCCTATTTTTCAAGATACAGAGAAGCTCGCCCAAAATCTT
TCTCAAGAACTACAAGCTCCTGTGATTTCCTTTCACAGATATTTAACAGAAACTCACCAGGATACTCTTGCTGCTTTGCG
AGAGAGCGCAGGCGACATCATTGGAATTCCCTTATTTCCTCATTATACCTTTGCTGTAACAGGTAGTATAATCCGCTTTT
TTTTAGAACGGATTCCAGAAAAACCTATGGCCTGGATTACTCATTTTGGAGTACATCCACAGTTTATTTCATGCATGCGA
GAGCACATACAAGATTGCTTAATCGCTCAAGGGATCGTTGCAGAGGATTGCTTTTTTCTTTTTTCTGTACATGGTCTCCC
TATGCGACATATTCGCTTGGGAGATCCTTATGCTAAACAGTGTCAAGACTCTTTCAATGCTTTGATAGGAGAATCAGAAG
GCGTTCTTTCCTTTCAATCTAAGTTTGGTATTGGAGAATGGTTGGTCCCTTCTACAAAGGAGATTTGTCAGTCTTTATGT
ACTAAAAAGCGTTACATTGTGGTGGTTCCTTTTGGGTTTGTTTCAGATCATATTGAGACTTTGTATGAAATAGATCATCT
TTATGTCCCGATGTTATTACAACGGGGGTATCGTGTAGTACGTGTGCCAGCTATTAATACCTCTGATCGATGGGTATCAG
CCCTAGCATCTATAGTGAAAAGTTCTCCACATGAGACTATTTTAGAGCCACTTTTGATGCCTAAGCGACGATAG

Upstream 100 bases:

>100_bases
TTAATGCGGGGTTGGCAAAAACCCGTCGATCCGGAAGATATAAAGCAATTAAAATGCAGTCACGTCTTCCCTAAAGCAGA
AAAATTCTATAAGAAAGATA

Downstream 100 bases:

>100_bases
CTTTTGAACTTCTCAAGAAAATGCCTGTTGGGTATTGTCTCTAGGAATACAGTCTTAAAGAATTTTTTCTTCGCAGGGCT
TTCTTTATAGGGGAGAGAAG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MTVYLLANFGGPRISQEIPSFLHALLTDQDVTGGRIPPWLHRPLFSYIAKRRAHRVAEQYAYLGGRSPIFQDTEKLAQNL
SQELQAPVISFHRYLTETHQDTLAALRESAGDIIGIPLFPHYTFAVTGSIIRFFLERIPEKPMAWITHFGVHPQFISCMR
EHIQDCLIAQGIVAEDCFFLFSVHGLPMRHIRLGDPYAKQCQDSFNALIGESEGVLSFQSKFGIGEWLVPSTKEICQSLC
TKKRYIVVVPFGFVSDHIETLYEIDHLYVPMLLQRGYRVVRVPAINTSDRWVSALASIVKSSPHETILEPLLMPKRR

Sequences:

>Translated_317_residues
MTVYLLANFGGPRISQEIPSFLHALLTDQDVTGGRIPPWLHRPLFSYIAKRRAHRVAEQYAYLGGRSPIFQDTEKLAQNL
SQELQAPVISFHRYLTETHQDTLAALRESAGDIIGIPLFPHYTFAVTGSIIRFFLERIPEKPMAWITHFGVHPQFISCMR
EHIQDCLIAQGIVAEDCFFLFSVHGLPMRHIRLGDPYAKQCQDSFNALIGESEGVLSFQSKFGIGEWLVPSTKEICQSLC
TKKRYIVVVPFGFVSDHIETLYEIDHLYVPMLLQRGYRVVRVPAINTSDRWVSALASIVKSSPHETILEPLLMPKRR
>Mature_316_residues
TVYLLANFGGPRISQEIPSFLHALLTDQDVTGGRIPPWLHRPLFSYIAKRRAHRVAEQYAYLGGRSPIFQDTEKLAQNLS
QELQAPVISFHRYLTETHQDTLAALRESAGDIIGIPLFPHYTFAVTGSIIRFFLERIPEKPMAWITHFGVHPQFISCMRE
HIQDCLIAQGIVAEDCFFLFSVHGLPMRHIRLGDPYAKQCQDSFNALIGESEGVLSFQSKFGIGEWLVPSTKEICQSLCT
KKRYIVVVPFGFVSDHIETLYEIDHLYVPMLLQRGYRVVRVPAINTSDRWVSALASIVKSSPHETILEPLLMPKRR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=324, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI60499021, Length=324, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1786681, Length=321, Percent_Identity=27.1028037383178, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324750, Length=320, Percent_Identity=28.125, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17864156, Length=325, Percent_Identity=27.6923076923077, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=27.2373540856031, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=30.0613496932515, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_CHLMU (Q9PJQ6)

Other databases:

- EMBL:   AE002160
- PIR:   B81667
- RefSeq:   NP_297145.1
- ProteinModelPortal:   Q9PJQ6
- SMR:   Q9PJQ6
- GeneID:   1246137
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0772
- TIGR:   TC_0772
- HOGENOM:   HBG697135
- OMA:   RLPNIET
- PhylomeDB:   Q9PJQ6
- ProtClustDB:   PRK00035
- BioCyc:   CMUR243161:TC_0772-MONOMER
- BRENDA:   4.99.1.1
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36090; Mature: 35959

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVYLLANFGGPRISQEIPSFLHALLTDQDVTGGRIPPWLHRPLFSYIAKRRAHRVAEQY
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AYLGGRSPIFQDTEKLAQNLSQELQAPVISFHRYLTETHQDTLAALRESAGDIIGIPLFP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
HYTFAVTGSIIRFFLERIPEKPMAWITHFGVHPQFISCMREHIQDCLIAQGIVAEDCFFL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FSVHGLPMRHIRLGDPYAKQCQDSFNALIGESEGVLSFQSKFGIGEWLVPSTKEICQSLC
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHH
TKKRYIVVVPFGFVSDHIETLYEIDHLYVPMLLQRGYRVVRVPAINTSDRWVSALASIVK
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
SSPHETILEPLLMPKRR
CCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
TVYLLANFGGPRISQEIPSFLHALLTDQDVTGGRIPPWLHRPLFSYIAKRRAHRVAEQY
EEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AYLGGRSPIFQDTEKLAQNLSQELQAPVISFHRYLTETHQDTLAALRESAGDIIGIPLFP
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
HYTFAVTGSIIRFFLERIPEKPMAWITHFGVHPQFISCMREHIQDCLIAQGIVAEDCFFL
CHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHH
FSVHGLPMRHIRLGDPYAKQCQDSFNALIGESEGVLSFQSKFGIGEWLVPSTKEICQSLC
HHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEHHHHCCCCCCCCCCHHHHHHHHH
TKKRYIVVVPFGFVSDHIETLYEIDHLYVPMLLQRGYRVVRVPAINTSDRWVSALASIVK
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHH
SSPHETILEPLLMPKRR
CCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935