Click here to switch to the map view.

The map label for this gene is argS

Identifier: 15835354

GI number: 15835354

Start: 880230

End: 881921

Strand: Direct

Name: argS

Synonym: TC0739

Alternate gene names: 15835354

Gene position: 880230-881921 (Clockwise)

Preceding gene: 15835353

Following gene: 15835356

Centisome position: 82.04

GC content: 40.6

Gene sequence:

>1692_bases
ATGACAACACTTCTCTCTTTTCTGACTTCGCTATGTTCTTCAGCGATTCGTCAAGCTTTCCCTGAATTGGAAGAGCTTAC
CCTAGATATCACTCCATCCACTAAAGAGCATTTTGGACATTACCAATGCAATGATGCGATGAAACTTGCTCGCGCATTAC
GAAAATCTCCCCGAGCAATCGCAGAAGAAATCGTTGCACACATTCCAGCTACTCCTTTTTCTTCTATAGAAATTGCTGGA
GCAGGATTTATTAACTTCACTTTCTCAAAAGAATTCCTAGCTAATCAGCTCCAAATCTTTTCTCAAGAATTAGCGAAAGG
GTTTCCTGTTTCCTCACCACAAAAAGTGATCATTGACTTCTCCTCTCCTAATATCGCTAAGGACATGCATGTTGGGCATC
TTCGCTCCACTATCATAGGAGATTGTCTGGCTCGATGTTTTTCTTTTGTGGGCCATGATGTCTTACGTTTGAACCACATT
GGAGATTGGGGAACAGCTTTTGGCATGCTTATCACCTATCTACAAGAAACAGCACAAACTGACATTCATCAGCTGGAAAA
TCTCACAGAATTATATAAAAAAGCCCACGTACGTTTTGCTGAAGACCCAGAATTTAAAAAACGCTCTCAATATAATGTCG
TAGCCTTACAATCTGGAGATCCTCAAGCTCTTGCATTATGGAAACAGATTTGCGCTGTTTCAGAAAAATCTTTTCAAAAG
ATTTATTCTATCTTAGATGTTGAACTTCATACTCGTGGAGAGTCTTTTTATAACCCCTTTTTGGCAGATGTGGTTTCAGA
TCTGGAATCCAAAAACCTTGTTACTCTCTCTGATGGGGCAAAATGTGTATTCCACGAAGAGTTTTCCATCCCTCTAATGA
TTCAAAAAAGTGATGGTGGATACAACTATGCAACGACAGATGTTGCAGCCATGCGCTACCGTATACAGCAAGACCATGCT
GACAGAATTCTTATCGTCACAGACTCTGGGCAATCCTTGCACTTCCAATTATTGGAAGCTACGTGCTTAGCAGCCGGATA
TCTTCCCCATAAAGGAATCTTCTCTCATGTAGGATTCGGACTAGTTTTAGACACTCAAGGGAGAAAATTCAAAACGCGCT
CAGGAGAAAATATCAAACTTCAAGAGCTGCTAGATACTGCTATTGAAAAAGCTAAGGAATCCTTAAGAGAACATCGCCCA
GAAATTTCCGAAGAAGAGCTAGCTTATCAGGGTCCTATCCTCGGCATCAATGCGATTAAATACGCAGATCTTTCCGCACA
TAGAATCAATGACTACGTGTTCTCTTTTGAGAAAATGCTACGTTTTGAAGGAAACACAGCGATGTCCCTTCTGTATGCTT
ACGTACGAATTCAAGGAATCAAACGTAGAATGAAGCTAGATACTCTTCCTCAAAAAGGACCTCTATCTATTCATGAACCC
GCGGAAGAAACATTAGCTCTTACTTTACTGCGCTTCCCCGAAGTTTTAGATTTAACTTTAAGAGAACTCTGTCCACATTT
TCTGACAGATTACCTCTACGTGCTTACAAATAAGTTTAATGCTTTCTTCCGTGATTGTCATATAGAAGGGTCTGATTATC
AACAAGAGCGTCTTTATCTCTGCGGTCTGACAGAAAAAACCTTGGAAACAGGCATGCACCTATTAGGTCTGAAGACTCTA
GATCACCTGTAA

Upstream 100 bases:

>100_bases
ATCAATTAGCGACCGAACGCATCATGGCCAAGATTGCAAAACTTCGTACTTGGTTCCAGCAAGGATGCATCGGAGAAATT
CCTTAGTTTTGTAGATTCTT

Downstream 100 bases:

>100_bases
AAACAATCTAAGGGAAGGTCTAAAATCCTTCCCTTAGACACATCTTGTTTTCTCTGTGAGTATTTTGGCTCCTAGTCTTT
CTAAATTCCCTAGCCAGTCT

Product: arginyl-tRNA synthetase

Products: NA

Alternate protein names: Arginine--tRNA ligase; ArgRS

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MTTLLSFLTSLCSSAIRQAFPELEELTLDITPSTKEHFGHYQCNDAMKLARALRKSPRAIAEEIVAHIPATPFSSIEIAG
AGFINFTFSKEFLANQLQIFSQELAKGFPVSSPQKVIIDFSSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHI
GDWGTAFGMLITYLQETAQTDIHQLENLTELYKKAHVRFAEDPEFKKRSQYNVVALQSGDPQALALWKQICAVSEKSFQK
IYSILDVELHTRGESFYNPFLADVVSDLESKNLVTLSDGAKCVFHEEFSIPLMIQKSDGGYNYATTDVAAMRYRIQQDHA
DRILIVTDSGQSLHFQLLEATCLAAGYLPHKGIFSHVGFGLVLDTQGRKFKTRSGENIKLQELLDTAIEKAKESLREHRP
EISEEELAYQGPILGINAIKYADLSAHRINDYVFSFEKMLRFEGNTAMSLLYAYVRIQGIKRRMKLDTLPQKGPLSIHEP
AEETLALTLLRFPEVLDLTLRELCPHFLTDYLYVLTNKFNAFFRDCHIEGSDYQQERLYLCGLTEKTLETGMHLLGLKTL
DHL

Sequences:

>Translated_563_residues
MTTLLSFLTSLCSSAIRQAFPELEELTLDITPSTKEHFGHYQCNDAMKLARALRKSPRAIAEEIVAHIPATPFSSIEIAG
AGFINFTFSKEFLANQLQIFSQELAKGFPVSSPQKVIIDFSSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHI
GDWGTAFGMLITYLQETAQTDIHQLENLTELYKKAHVRFAEDPEFKKRSQYNVVALQSGDPQALALWKQICAVSEKSFQK
IYSILDVELHTRGESFYNPFLADVVSDLESKNLVTLSDGAKCVFHEEFSIPLMIQKSDGGYNYATTDVAAMRYRIQQDHA
DRILIVTDSGQSLHFQLLEATCLAAGYLPHKGIFSHVGFGLVLDTQGRKFKTRSGENIKLQELLDTAIEKAKESLREHRP
EISEEELAYQGPILGINAIKYADLSAHRINDYVFSFEKMLRFEGNTAMSLLYAYVRIQGIKRRMKLDTLPQKGPLSIHEP
AEETLALTLLRFPEVLDLTLRELCPHFLTDYLYVLTNKFNAFFRDCHIEGSDYQQERLYLCGLTEKTLETGMHLLGLKTL
DHL
>Mature_562_residues
TTLLSFLTSLCSSAIRQAFPELEELTLDITPSTKEHFGHYQCNDAMKLARALRKSPRAIAEEIVAHIPATPFSSIEIAGA
GFINFTFSKEFLANQLQIFSQELAKGFPVSSPQKVIIDFSSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHIG
DWGTAFGMLITYLQETAQTDIHQLENLTELYKKAHVRFAEDPEFKKRSQYNVVALQSGDPQALALWKQICAVSEKSFQKI
YSILDVELHTRGESFYNPFLADVVSDLESKNLVTLSDGAKCVFHEEFSIPLMIQKSDGGYNYATTDVAAMRYRIQQDHAD
RILIVTDSGQSLHFQLLEATCLAAGYLPHKGIFSHVGFGLVLDTQGRKFKTRSGENIKLQELLDTAIEKAKESLREHRPE
ISEEELAYQGPILGINAIKYADLSAHRINDYVFSFEKMLRFEGNTAMSLLYAYVRIQGIKRRMKLDTLPQKGPLSIHEPA
EETLALTLLRFPEVLDLTLRELCPHFLTDYLYVLTNKFNAFFRDCHIEGSDYQQERLYLCGLTEKTLETGMHLLGLKTLD
HL

Specific function: Unknown

COG id: COG0018

COG function: function code J; Arginyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15149476, Length=589, Percent_Identity=42.4448217317487, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI197100773, Length=509, Percent_Identity=30.6483300589391, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1788184, Length=579, Percent_Identity=40.4145077720207, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI71985061, Length=590, Percent_Identity=39.6610169491525, Blast_Score=396, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71985068, Length=549, Percent_Identity=40.4371584699454, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17532153, Length=386, Percent_Identity=26.1658031088083, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320548, Length=540, Percent_Identity=29.4444444444444, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321883, Length=472, Percent_Identity=28.8135593220339, Blast_Score=187, Evalue=4e-48,
Organism=Drosophila melanogaster, GI18859963, Length=592, Percent_Identity=40.5405405405405, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI28571570, Length=505, Percent_Identity=29.7029702970297, Blast_Score=172, Evalue=8e-43,

Paralogues:

None

Copy number: 789 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYR_CHLMU (Q9PJT8)

Other databases:

- EMBL:   AE002160
- PIR:   F81670
- RefSeq:   NP_297113.1
- ProteinModelPortal:   Q9PJT8
- SMR:   Q9PJT8
- GeneID:   1246102
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0739
- TIGR:   TC_0739
- HOGENOM:   HBG695395
- OMA:   HMGFGTM
- PhylomeDB:   Q9PJT8
- ProtClustDB:   PRK01611
- BioCyc:   CMUR243161:TC_0739-MONOMER
- BRENDA:   6.1.1.19
- GO:   GO:0005737
- HAMAP:   MF_00123
- InterPro:   IPR001412
- InterPro:   IPR001278
- InterPro:   IPR015945
- InterPro:   IPR005148
- InterPro:   IPR008909
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.30.1360.70
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11956
- PRINTS:   PR01038
- SMART:   SM00836
- TIGRFAMs:   TIGR00456

Pfam domain/function: PF03485 Arg_tRNA_synt_N; PF05746 DALR_1; PF00750 tRNA-synt_1d; SSF55190 Arg-tRNA-synth_Ic_N; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.19

Molecular weight: Translated: 63660; Mature: 63529

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLSFLTSLCSSAIRQAFPELEELTLDITPSTKEHFGHYQCNDAMKLARALRKSPRAI
CHHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHCCCCCCCHHHHHHHHHHHCHHHH
AEEIVAHIPATPFSSIEIAGAGFINFTFSKEFLANQLQIFSQELAKGFPVSSPQKVIIDF
HHHHHHHCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
SSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHIGDWGTAFGMLITYLQETAQT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHH
DIHQLENLTELYKKAHVRFAEDPEFKKRSQYNVVALQSGDPQALALWKQICAVSEKSFQK
HHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IYSILDVELHTRGESFYNPFLADVVSDLESKNLVTLSDGAKCVFHEEFSIPLMIQKSDGG
HHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCEEEEEECCCC
YNYATTDVAAMRYRIQQDHADRILIVTDSGQSLHFQLLEATCLAAGYLPHKGIFSHVGFG
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCE
LVLDTQGRKFKTRSGENIKLQELLDTAIEKAKESLREHRPEISEEELAYQGPILGINAIK
EEEECCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEECCCEE
YADLSAHRINDYVFSFEKMLRFEGNTAMSLLYAYVRIQGIKRRMKLDTLPQKGPLSIHEP
ECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AEETLALTLLRFPEVLDLTLRELCPHFLTDYLYVLTNKFNAFFRDCHIEGSDYQQERLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
CGLTEKTLETGMHLLGLKTLDHL
ECCCHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTLLSFLTSLCSSAIRQAFPELEELTLDITPSTKEHFGHYQCNDAMKLARALRKSPRAI
HHHHHHHHHHHHHHHHHHCCCHHHEEEECCCCHHHHCCCCCCCHHHHHHHHHHHCHHHH
AEEIVAHIPATPFSSIEIAGAGFINFTFSKEFLANQLQIFSQELAKGFPVSSPQKVIIDF
HHHHHHHCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEC
SSPNIAKDMHVGHLRSTIIGDCLARCFSFVGHDVLRLNHIGDWGTAFGMLITYLQETAQT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEECCCCHHHHHHHHHHHHHHHHHH
DIHQLENLTELYKKAHVRFAEDPEFKKRSQYNVVALQSGDPQALALWKQICAVSEKSFQK
HHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IYSILDVELHTRGESFYNPFLADVVSDLESKNLVTLSDGAKCVFHEEFSIPLMIQKSDGG
HHHHHHHHEECCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCEEEEEECCCC
YNYATTDVAAMRYRIQQDHADRILIVTDSGQSLHFQLLEATCLAAGYLPHKGIFSHVGFG
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCE
LVLDTQGRKFKTRSGENIKLQELLDTAIEKAKESLREHRPEISEEELAYQGPILGINAIK
EEEECCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCEEECCCEE
YADLSAHRINDYVFSFEKMLRFEGNTAMSLLYAYVRIQGIKRRMKLDTLPQKGPLSIHEP
ECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AEETLALTLLRFPEVLDLTLRELCPHFLTDYLYVLTNKFNAFFRDCHIEGSDYQQERLYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
CGLTEKTLETGMHLLGLKTLDHL
ECCCHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935