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The map label for this gene is xerC

Identifier: 15835241

GI number: 15835241

Start: 750364

End: 751311

Strand: Direct

Name: xerC

Synonym: TC0626

Alternate gene names: 15835241

Gene position: 750364-751311 (Clockwise)

Preceding gene: 15835240

Following gene: 15835242

Centisome position: 69.93

GC content: 39.87

Gene sequence:

>948_bases
ATGATCGCATCCTTTTATGCATTTTTAGATTATCTAAAAAACATGAAAGCAGCTTCTCCTCATACACTAAGAAATTATAG
CATAGATCTTAGCTCTCTAAAATGTTTTTTAGAAAAAAAAGGGGAGCTAACCCCAACCCCTCCACTATCTCTTCAGGAAG
ATTCCCGCTCCTCTAGCCAACTTTCTTTTTCCCTATTTACCAAAGAAAACATCCGTCTTTATCTCTTAGAACAAATCCAA
ACTACTCATTCAAAGCGCACCGTGCGTCGTCGATTATCTGCGATTAAAAGCTTTGCGAAATTTTGTGTAAAAAACCAATG
GATACCAGAGAATCCTGCAGAAATGATTCGCGGCCCTCGCCTCCCTAAAGAACTCCCTTCTCCACTCACCTATGAGCAAG
TTCTGGCCCTAATGTCTGCTCCAGATTTAGATAAAGTTACTGGATTTCGAGACCGTTGCTTACTCGAACTTTTTTATAGT
TCTGGCCTAAGAATTAGCGAGATTACAGCTCTAAATCGTTCTGATATTGATTTTCAATCCAACCTTTTACGCATCTGCGG
GAAAGGCAAAAAGGAACGCATAGTCCCTATGACGAAAGTAGCAGTCCAATGGTTACAAGCCTATCTAGATCACCCAGACA
GAGCTGCTGTTGAACAAGATCATCAAGCTTGTTTTTTAAATCGATTTGGGAAGCGCCTATCTACTCGCTCTATAGACCGA
AAATTTCAACAATATCTTCTCAAAACAGGCCTATCCGGAACGATTACCCCTCATACCATCCGCCACACCATTGCAACGCA
TTGGTTGGAACGAGGAATGGATTTAAAAACCATTCAACTATTATTAGGCCATACTTCATTAGAAACTACAACTATTTATA
CCCATGTTTCTATGAAGTTGAAAAAACAAATCCATGATGAGGCCCATCCTCATAACTTAGAGGATTAA

Upstream 100 bases:

>100_bases
AATTTTGCAGCTACGAGTTTCCTAAAAACGCGAATTAACGCATATACTACAGAAACAACCCAAAAGCTTTCCTAGCTTGT
GTGAATATAGTAGGTCTGGA

Downstream 100 bases:

>100_bases
TTATACAGGCAAACTTCTTGTACTCTAAGAAGTTCTTTGTTATCCTCTCAGCCATGAGTATTGTTCTTGATAAAATCGGC
AAAACATTAGGGACACGAGT

Product: site-specific tyrosine recombinase XerC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIASFYAFLDYLKNMKAASPHTLRNYSIDLSSLKCFLEKKGELTPTPPLSLQEDSRSSSQLSFSLFTKENIRLYLLEQIQ
TTHSKRTVRRRLSAIKSFAKFCVKNQWIPENPAEMIRGPRLPKELPSPLTYEQVLALMSAPDLDKVTGFRDRCLLELFYS
SGLRISEITALNRSDIDFQSNLLRICGKGKKERIVPMTKVAVQWLQAYLDHPDRAAVEQDHQACFLNRFGKRLSTRSIDR
KFQQYLLKTGLSGTITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKLKKQIHDEAHPHNLED

Sequences:

>Translated_315_residues
MIASFYAFLDYLKNMKAASPHTLRNYSIDLSSLKCFLEKKGELTPTPPLSLQEDSRSSSQLSFSLFTKENIRLYLLEQIQ
TTHSKRTVRRRLSAIKSFAKFCVKNQWIPENPAEMIRGPRLPKELPSPLTYEQVLALMSAPDLDKVTGFRDRCLLELFYS
SGLRISEITALNRSDIDFQSNLLRICGKGKKERIVPMTKVAVQWLQAYLDHPDRAAVEQDHQACFLNRFGKRLSTRSIDR
KFQQYLLKTGLSGTITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKLKKQIHDEAHPHNLED
>Mature_315_residues
MIASFYAFLDYLKNMKAASPHTLRNYSIDLSSLKCFLEKKGELTPTPPLSLQEDSRSSSQLSFSLFTKENIRLYLLEQIQ
TTHSKRTVRRRLSAIKSFAKFCVKNQWIPENPAEMIRGPRLPKELPSPLTYEQVLALMSAPDLDKVTGFRDRCLLELFYS
SGLRISEITALNRSDIDFQSNLLRICGKGKKERIVPMTKVAVQWLQAYLDHPDRAAVEQDHQACFLNRFGKRLSTRSIDR
KFQQYLLKTGLSGTITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKLKKQIHDEAHPHNLED

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=303, Percent_Identity=33.3333333333333, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789261, Length=313, Percent_Identity=31.3099041533546, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1790768, Length=175, Percent_Identity=33.1428571428571, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_CHLMU (Q9PK47)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_297000.1
- ProteinModelPortal:   Q9PK47
- SMR:   Q9PK47
- GeneID:   1245986
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0626
- TIGR:   TC_0626
- HOGENOM:   HBG727654
- OMA:   PHTLRNY
- PhylomeDB:   Q9PK47
- ProtClustDB:   PRK00236
- BioCyc:   CMUR243161:TC_0626-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 36271; Mature: 36271

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: ACT_SITE 164-164 ACT_SITE 188-188 ACT_SITE 258-258 ACT_SITE 261-261 ACT_SITE 284-284 ACT_SITE 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASFYAFLDYLKNMKAASPHTLRNYSIDLSSLKCFLEKKGELTPTPPLSLQEDSRSSSQ
CCHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LSFSLFTKENIRLYLLEQIQTTHSKRTVRRRLSAIKSFAKFCVKNQWIPENPAEMIRGPR
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
LPKELPSPLTYEQVLALMSAPDLDKVTGFRDRCLLELFYSSGLRISEITALNRSDIDFQS
CCHHCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCHHH
NLLRICGKGKKERIVPMTKVAVQWLQAYLDHPDRAAVEQDHQACFLNRFGKRLSTRSIDR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFQQYLLKTGLSGTITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHH
KKQIHDEAHPHNLED
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MIASFYAFLDYLKNMKAASPHTLRNYSIDLSSLKCFLEKKGELTPTPPLSLQEDSRSSSQ
CCHHHHHHHHHHHHCCCCCCCCHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
LSFSLFTKENIRLYLLEQIQTTHSKRTVRRRLSAIKSFAKFCVKNQWIPENPAEMIRGPR
EEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
LPKELPSPLTYEQVLALMSAPDLDKVTGFRDRCLLELFYSSGLRISEITALNRSDIDFQS
CCHHCCCCCCHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCHHH
NLLRICGKGKKERIVPMTKVAVQWLQAYLDHPDRAAVEQDHQACFLNRFGKRLSTRSIDR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFQQYLLKTGLSGTITPHTIRHTIATHWLERGMDLKTIQLLLGHTSLETTTIYTHVSMKL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEHHHHHHH
KKQIHDEAHPHNLED
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935