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Identifier: 15835233

GI number: 15835233

Start: 741584

End: 743620

Strand: Reverse

Name: Not Available

Synonym: TC0618

Alternate gene names: 15835233

Gene position: 743620-741584 (Counterclockwise)

Preceding gene: 15835234

Following gene: 15835231

Centisome position: 69.31

GC content: 43.4

Gene sequence:

>2037_bases
GTGAGACACTCCATATATCAATTAGATTCTGCTGTTGAGAATGTATTTAGGTTGGCATGGACTTTAAGATTCTCTGAGCG
GAAGATGTTGTTGTTATCTCGTCAAAGTGGTTCGGGCGGCTCCTTTCAACTATCTTGCGCTGGTCATGAGCTTGCAGGCG
TTGTGGCGGCAAAGAGTTTGATTCCAGGCAAGGACTGGGCATTTCCTTACTATCGGGACCAAGGATTCCCTCTAGGGTTA
GGATGTGATCTTTCTGAGATTTTTGCTTCTTTTTTAGCTCGAACGACACAAAATCATTCTGATGGCAGAATGATGCCCTA
CCATTATTCTCATAAAAAACTTCGTATATGTTGCCAGTCTAGTGTAGTTGGGACACAGTTTTTGCAAGCAGCTGGGCGTG
CCTGGGCGGTTAAAAATTCTGGGAAAAATGAAGTCGTTTATGTATCGGGAGGGGACGGATCTACTTCGCAAGGGGAATTC
CATGAGATGTTAAATTTTGCATCTTTGCATCAGCTCCCGCTTGTGATTGTTATACAAAATAATCAATGGGCGATTTCAGT
TCCTTTTGCTGATCAATGTGGAGCAGATTTGGTAGCGCTTGGGAAGAGCTATTCTGGCCTTGCGACATACAAAGTAGATG
GGGGGGATCTGTCTGCGTTGACACAAACTTTTGATTGCGCAGTTTCTGATGCAAGACATCACCATATTCCCGCCTTAGTA
ATCGTCGATGTTGTGCGGTTGGAGTCTCATAGCAATTCAGATAACCAGACTAAATATCGTTCTGAAGAAGAATTGCTGTA
CTGTCAAGAACAAGATCCTTTGGTTCGTTTAGAAAAATCTCTGATTGATGATTTTGGAGTTGCTCAAGAGACTATTGAGC
AAATTAAGGAAGAGCTTCAAGAAACGATTAGCAAGGCTTGTGAGCTTGCTGAGTCTACGCCTTTCCATTGTAAAGGGGCT
ACCAAACATGAGGTTTTTGCTCCCTATAATGTTTCCTTGATCGACTATGAAAATTCCTTAGAGTCCGCTTCTTTACAGGG
ATCAGAGCCTCGGGTTATGCGTGATGCGATAACCGAGGCTTTGGTTGAAGAGATGCATAGAGATCCCGGTGTTGTTGTTT
TTGGTGAAGATGTTGCTGGGAATAAAGGAGGGGTTTTTGGGGTTACAAGAACTCTGACGGAGCGATTTGGAAGAAATCGT
TGTTTCAATACACCTTTGGCGGAAGCTACCATTATTGGAACTGCGATTGGAATGGCTTTTGATGGCTTCCATAAGCCTGT
TGCAGAGATTCAATTTGCTGATTATATCTGGCCAGGTATCAACCAGTTGTTTTCTGAGGCAGCGAGTATCTATTATCGCT
CCGCAGGAGAGTGGGAGATGCCTATTGTGATAAGAACTCCTTGCGGAGGGTATATTCAAGGGGGGCCTTATCATTCTCAG
AATATAGAAGCTTTTCTTGCCCATTGCCCAGGATTAAAGGTAGCATATCCTTCAAATGCTGCTGATGCGAAAGCTTTATT
GAAAGCAGCTATTCGTGATCCTAATCCTGTAGTGTTTTTGGAACACAAGGCCTTGTATCAGCGACGGGCATTTAGTACAA
CGCCTGTATTTTCTTCTGATTATGTTCTTCCTTTTGGTAAAGCTCGTATTGTGCACTCAGGAACGGATTTAACGATTGTT
TCTTGGGGAATGTCCCTAGTTATGAGTGTAGAGGTTGCGAAGGATCTTTTAGGATTAGGGGTCTCTGTCGAGGTGATTGA
TTTACGAACAATCGTTCCCTGTGATTTTGCTACCGTGTGTGAATCTGTGAAAAAGACAGGGAAATTGCTGGTTGTTCACG
AAGCTTCAGAGTTTTGTGGCTTTGGTAGCGAGCTTGTGGCTTTGGTAGCGGAAAGAGCTTATAGATATCTAGATGCTCCG
ATCAAACGTATAGGAGGGCGGCATTCCCCTATTCCTTATTCCAAGGTGTTAGAGAATGAAGTTCTTCCACAGAAAGAAAT
GATCTTTCAAGAAGCGAAATCATTGGCAGAGTTTTAG

Upstream 100 bases:

>100_bases
AATTTCCCTAAAAAACGTAGTTTCTTAGACAAAATTAAAGGTTTTTTTTCTGACTTTGCTGTATAGAAAGAAGGATCTTT
TTACCTAAGAGGGAGCTGCT

Downstream 100 bases:

>100_bases
ATTTCTTGAGTACTTCCTTTAGAGTAGCGCTCCCTCTCATGGGAGCGCTTTTTTTTGGAGTGATTCAGATGATAATCGAG
TGGTTTACAGATGGGTTAGA

Product: 2-oxoisovalerate dehydrogenase, E1 component, alpha and beta subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MRHSIYQLDSAVENVFRLAWTLRFSERKMLLLSRQSGSGGSFQLSCAGHELAGVVAAKSLIPGKDWAFPYYRDQGFPLGL
GCDLSEIFASFLARTTQNHSDGRMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKNSGKNEVVYVSGGDGSTSQGEF
HEMLNFASLHQLPLVIVIQNNQWAISVPFADQCGADLVALGKSYSGLATYKVDGGDLSALTQTFDCAVSDARHHHIPALV
IVDVVRLESHSNSDNQTKYRSEEELLYCQEQDPLVRLEKSLIDDFGVAQETIEQIKEELQETISKACELAESTPFHCKGA
TKHEVFAPYNVSLIDYENSLESASLQGSEPRVMRDAITEALVEEMHRDPGVVVFGEDVAGNKGGVFGVTRTLTERFGRNR
CFNTPLAEATIIGTAIGMAFDGFHKPVAEIQFADYIWPGINQLFSEAASIYYRSAGEWEMPIVIRTPCGGYIQGGPYHSQ
NIEAFLAHCPGLKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRAFSTTPVFSSDYVLPFGKARIVHSGTDLTIV
SWGMSLVMSVEVAKDLLGLGVSVEVIDLRTIVPCDFATVCESVKKTGKLLVVHEASEFCGFGSELVALVAERAYRYLDAP
IKRIGGRHSPIPYSKVLENEVLPQKEMIFQEAKSLAEF

Sequences:

>Translated_678_residues
MRHSIYQLDSAVENVFRLAWTLRFSERKMLLLSRQSGSGGSFQLSCAGHELAGVVAAKSLIPGKDWAFPYYRDQGFPLGL
GCDLSEIFASFLARTTQNHSDGRMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKNSGKNEVVYVSGGDGSTSQGEF
HEMLNFASLHQLPLVIVIQNNQWAISVPFADQCGADLVALGKSYSGLATYKVDGGDLSALTQTFDCAVSDARHHHIPALV
IVDVVRLESHSNSDNQTKYRSEEELLYCQEQDPLVRLEKSLIDDFGVAQETIEQIKEELQETISKACELAESTPFHCKGA
TKHEVFAPYNVSLIDYENSLESASLQGSEPRVMRDAITEALVEEMHRDPGVVVFGEDVAGNKGGVFGVTRTLTERFGRNR
CFNTPLAEATIIGTAIGMAFDGFHKPVAEIQFADYIWPGINQLFSEAASIYYRSAGEWEMPIVIRTPCGGYIQGGPYHSQ
NIEAFLAHCPGLKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRAFSTTPVFSSDYVLPFGKARIVHSGTDLTIV
SWGMSLVMSVEVAKDLLGLGVSVEVIDLRTIVPCDFATVCESVKKTGKLLVVHEASEFCGFGSELVALVAERAYRYLDAP
IKRIGGRHSPIPYSKVLENEVLPQKEMIFQEAKSLAEF
>Mature_678_residues
MRHSIYQLDSAVENVFRLAWTLRFSERKMLLLSRQSGSGGSFQLSCAGHELAGVVAAKSLIPGKDWAFPYYRDQGFPLGL
GCDLSEIFASFLARTTQNHSDGRMMPYHYSHKKLRICCQSSVVGTQFLQAAGRAWAVKNSGKNEVVYVSGGDGSTSQGEF
HEMLNFASLHQLPLVIVIQNNQWAISVPFADQCGADLVALGKSYSGLATYKVDGGDLSALTQTFDCAVSDARHHHIPALV
IVDVVRLESHSNSDNQTKYRSEEELLYCQEQDPLVRLEKSLIDDFGVAQETIEQIKEELQETISKACELAESTPFHCKGA
TKHEVFAPYNVSLIDYENSLESASLQGSEPRVMRDAITEALVEEMHRDPGVVVFGEDVAGNKGGVFGVTRTLTERFGRNR
CFNTPLAEATIIGTAIGMAFDGFHKPVAEIQFADYIWPGINQLFSEAASIYYRSAGEWEMPIVIRTPCGGYIQGGPYHSQ
NIEAFLAHCPGLKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRAFSTTPVFSSDYVLPFGKARIVHSGTDLTIV
SWGMSLVMSVEVAKDLLGLGVSVEVIDLRTIVPCDFATVCESVKKTGKLLVVHEASEFCGFGSELVALVAERAYRYLDAP
IKRIGGRHSPIPYSKVLENEVLPQKEMIFQEAKSLAEF

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=43.0769230769231, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=43.0769230769231, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI156564403, Length=325, Percent_Identity=39.6923076923077, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI291084858, Length=326, Percent_Identity=38.0368098159509, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI258645172, Length=314, Percent_Identity=31.8471337579618, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI11386135, Length=314, Percent_Identity=31.2101910828025, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI4505685, Length=301, Percent_Identity=27.2425249169435, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI291084742, Length=301, Percent_Identity=27.2425249169435, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI291084744, Length=307, Percent_Identity=26.7100977198697, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI4885543, Length=301, Percent_Identity=27.2425249169435, Blast_Score=95, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17538422, Length=335, Percent_Identity=41.1940298507463, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17506935, Length=353, Percent_Identity=41.0764872521246, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI86563357, Length=345, Percent_Identity=29.5652173913043, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI86563355, Length=345, Percent_Identity=29.5652173913043, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17536047, Length=270, Percent_Identity=26.2962962962963, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32564172, Length=270, Percent_Identity=26.2962962962963, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=39.0029325513196, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6321026, Length=268, Percent_Identity=25.3731343283582, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI160714828, Length=328, Percent_Identity=40.8536585365854, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI160714832, Length=328, Percent_Identity=40.8536585365854, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI21358145, Length=313, Percent_Identity=39.297124600639, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24650940, Length=313, Percent_Identity=39.297124600639, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21355903, Length=300, Percent_Identity=28.3333333333333, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24639746, Length=195, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24639740, Length=195, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639744, Length=195, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571106, Length=195, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639748, Length=261, Percent_Identity=27.2030651340996, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 74610; Mature: 74610

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHSIYQLDSAVENVFRLAWTLRFSERKMLLLSRQSGSGGSFQLSCAGHELAGVVAAKSL
CCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHC
IPGKDWAFPYYRDQGFPLGLGCDLSEIFASFLARTTQNHSDGRMMPYHYSHKKLRICCQS
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEHHC
SVVGTQFLQAAGRAWAVKNSGKNEVVYVSGGDGSTSQGEFHEMLNFASLHQLPLVIVIQN
CHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
NQWAISVPFADQCGADLVALGKSYSGLATYKVDGGDLSALTQTFDCAVSDARHHHIPALV
CCEEEECCCHHHCCCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHCCCHHH
IVDVVRLESHSNSDNQTKYRSEEELLYCQEQDPLVRLEKSLIDDFGVAQETIEQIKEELQ
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ETISKACELAESTPFHCKGATKHEVFAPYNVSLIDYENSLESASLQGSEPRVMRDAITEA
HHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
LVEEMHRDPGVVVFGEDVAGNKGGVFGVTRTLTERFGRNRCFNTPLAEATIIGTAIGMAF
HHHHHCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
DGFHKPVAEIQFADYIWPGINQLFSEAASIYYRSAGEWEMPIVIRTPCGGYIQGGPYHSQ
HHHCCHHHHEEHHHHHHHHHHHHHHHHHHHEECCCCCEECCEEEECCCCCCCCCCCCCCC
NIEAFLAHCPGLKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRAFSTTPVFSSD
CHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCC
YVLPFGKARIVHSGTDLTIVSWGMSLVMSVEVAKDLLGLGVSVEVIDLRTIVPCDFATVC
CCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHH
ESVKKTGKLLVVHEASEFCGFGSELVALVAERAYRYLDAPIKRIGGRHSPIPYSKVLENE
HHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VLPQKEMIFQEAKSLAEF
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRHSIYQLDSAVENVFRLAWTLRFSERKMLLLSRQSGSGGSFQLSCAGHELAGVVAAKSL
CCCHHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHC
IPGKDWAFPYYRDQGFPLGLGCDLSEIFASFLARTTQNHSDGRMMPYHYSHKKLRICCQS
CCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEHHC
SVVGTQFLQAAGRAWAVKNSGKNEVVYVSGGDGSTSQGEFHEMLNFASLHQLPLVIVIQN
CHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
NQWAISVPFADQCGADLVALGKSYSGLATYKVDGGDLSALTQTFDCAVSDARHHHIPALV
CCEEEECCCHHHCCCCHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHCCCHHH
IVDVVRLESHSNSDNQTKYRSEEELLYCQEQDPLVRLEKSLIDDFGVAQETIEQIKEELQ
HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ETISKACELAESTPFHCKGATKHEVFAPYNVSLIDYENSLESASLQGSEPRVMRDAITEA
HHHHHHHHHHHCCCCCCCCCCCCCEECCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
LVEEMHRDPGVVVFGEDVAGNKGGVFGVTRTLTERFGRNRCFNTPLAEATIIGTAIGMAF
HHHHHCCCCCEEEECCCCCCCCCCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
DGFHKPVAEIQFADYIWPGINQLFSEAASIYYRSAGEWEMPIVIRTPCGGYIQGGPYHSQ
HHHCCHHHHEEHHHHHHHHHHHHHHHHHHHEECCCCCEECCEEEECCCCCCCCCCCCCCC
NIEAFLAHCPGLKVAYPSNAADAKALLKAAIRDPNPVVFLEHKALYQRRAFSTTPVFSSD
CHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCC
YVLPFGKARIVHSGTDLTIVSWGMSLVMSVEVAKDLLGLGVSVEVIDLRTIVPCDFATVC
CCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCHHHHH
ESVKKTGKLLVVHEASEFCGFGSELVALVAERAYRYLDAPIKRIGGRHSPIPYSKVLENE
HHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
VLPQKEMIFQEAKSLAEF
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]