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Identifier: 15835088

GI number: 15835088

Start: 570066

End: 571088

Strand: Direct

Name: Not Available

Synonym: TC0470

Alternate gene names: 15835088

Gene position: 570066-571088 (Clockwise)

Preceding gene: 15835087

Following gene: 15835089

Centisome position: 53.13

GC content: 43.79

Gene sequence:

>1023_bases
ATGCTAACACTAGGCTTAGAAAGCTCTTGCGATGAAACCTCTTGTGCTCTTGTCGAGAATGGAAAAATCCTTGCAAATAG
GATAGCATCTCAGGACATTCATGCGGCTTATGGAGGCGTAATCCCTGAGCTAGCTTCCCGTGCACATCTACAAATATTCC
CAAAACTTTTGGCCGCTGTAGCTCAAGATGCCGAAGTTTCTTTAGAAGATGTCGAATTAATTTCTGTAGCCAATACCCCC
GGCCTTATTGGCGCGCTTTCTGTTGGCGTTAACTTCGCAAAGGGACTAGCTAGCGGGTTAAAAAAAACTCTTATAGGAGT
CAACCATGTAGAGGCACATTTATATGCTGCCTGCTTGGAAGAACCTTCCATTCGCTTCCCCGCTCTAGGCCTAGCTATTT
CGGGAGCACACACTTCTTTATTCTTAATGCCTAATGCCACAACCTTCCTTTTAATAGGCAAAACTCGAGATGATGCTATA
GGAGAAACTTTTGATAAAGTAGCTCGATTCCTTGGGCTCCCCTATCCAGGAGGACAAAAATTAGAGGAATTGGCTCAAGA
TGGCGATGAAGAAGCTTACCCCTTTTCACGAGCCAAAGTTTCTGGAAACGATTTCTCTTTTAGTGGATTAAAAACCGCCG
TATTATATGCCTTGAAAGGTAACAATAGCTCGGCCAAAGCACCTTTCCCAGAAGTCTCTGAAACGCAAAAACGAAACATC
GCTGCATCTTTCCAAAAAGCAGCTTTCATGACTATTGCTCAAAAACTTCCTGATATTGTAAAAGCGTTTTCTTGCGAGTC
TTTGATTGTTGGTGGGGGCGTAGCAAACAACCGTTACTTCCGTCGCCTGCTGAATCAAACGTGCTCTCTTCCTACATATT
TCCCTTCTTCGCAGTTGTGCTCTGATAATGCTGCAATGATAGCTGGATTAGGAGAGAGACTGTTTTGCAATCAGACATAT
GTTTCTAAGGAGGTTATTCCATGCGCAAGGTATCAGTGGGAATCTGCTTGCTTATCGCATTAG

Upstream 100 bases:

>100_bases
ATCAATCTCAAGACCTGCATATCATTTATTATTAACACCTTGCTTGATTAACAATCTCATGATACGATCCTTCTCTTTGC
CTTCTTTTTAAGTTTTTGCC

Downstream 100 bases:

>100_bases
CAACAGCAATTACCGGCTGCTCCAAATCCTCCTCAAACAAATCAAATCACTCCTCCTCTAATCAAAGCGTATCTGTGAGC
ATGAAGGACGATCCTCGCAC

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLTLGLESSCDETSCALVENGKILANRIASQDIHAAYGGVIPELASRAHLQIFPKLLAAVAQDAEVSLEDVELISVANTP
GLIGALSVGVNFAKGLASGLKKTLIGVNHVEAHLYAACLEEPSIRFPALGLAISGAHTSLFLMPNATTFLLIGKTRDDAI
GETFDKVARFLGLPYPGGQKLEELAQDGDEEAYPFSRAKVSGNDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNI
AASFQKAAFMTIAQKLPDIVKAFSCESLIVGGGVANNRYFRRLLNQTCSLPTYFPSSQLCSDNAAMIAGLGERLFCNQTY
VSKEVIPCARYQWESACLSH

Sequences:

>Translated_340_residues
MLTLGLESSCDETSCALVENGKILANRIASQDIHAAYGGVIPELASRAHLQIFPKLLAAVAQDAEVSLEDVELISVANTP
GLIGALSVGVNFAKGLASGLKKTLIGVNHVEAHLYAACLEEPSIRFPALGLAISGAHTSLFLMPNATTFLLIGKTRDDAI
GETFDKVARFLGLPYPGGQKLEELAQDGDEEAYPFSRAKVSGNDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNI
AASFQKAAFMTIAQKLPDIVKAFSCESLIVGGGVANNRYFRRLLNQTCSLPTYFPSSQLCSDNAAMIAGLGERLFCNQTY
VSKEVIPCARYQWESACLSH
>Mature_340_residues
MLTLGLESSCDETSCALVENGKILANRIASQDIHAAYGGVIPELASRAHLQIFPKLLAAVAQDAEVSLEDVELISVANTP
GLIGALSVGVNFAKGLASGLKKTLIGVNHVEAHLYAACLEEPSIRFPALGLAISGAHTSLFLMPNATTFLLIGKTRDDAI
GETFDKVARFLGLPYPGGQKLEELAQDGDEEAYPFSRAKVSGNDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNI
AASFQKAAFMTIAQKLPDIVKAFSCESLIVGGGVANNRYFRRLLNQTCSLPTYFPSSQLCSDNAAMIAGLGERLFCNQTY
VSKEVIPCARYQWESACLSH

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=342, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI8923380, Length=324, Percent_Identity=25.6172839506173, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789445, Length=315, Percent_Identity=36.1904761904762, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17557464, Length=338, Percent_Identity=30.4733727810651, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71995670, Length=327, Percent_Identity=26.2996941896024, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320099, Length=366, Percent_Identity=29.5081967213115, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322891, Length=292, Percent_Identity=24.6575342465753, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129063, Length=359, Percent_Identity=30.3621169916435, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21357207, Length=326, Percent_Identity=24.8466257668712, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_CHLMU (Q9PKJ5)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296847.1
- ProteinModelPortal:   Q9PKJ5
- SMR:   Q9PKJ5
- MEROPS:   M22.001
- GeneID:   1245825
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0470
- TIGR:   TC_0470
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   CMUR243161:TC_0470-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36331; Mature: 36331

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLGLESSCDETSCALVENGKILANRIASQDIHAAYGGVIPELASRAHLQIFPKLLAAV
CEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AQDAEVSLEDVELISVANTPGLIGALSVGVNFAKGLASGLKKTLIGVNHVEAHLYAACLE
HCCCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
EPSIRFPALGLAISGAHTSLFLMPNATTFLLIGKTRDDAIGETFDKVARFLGLPYPGGQK
CCCCCCCEEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHH
LEELAQDGDEEAYPFSRAKVSGNDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNI
HHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
AASFQKAAFMTIAQKLPDIVKAFSCESLIVGGGVANNRYFRRLLNQTCSLPTYFPSSQLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHC
SDNAAMIAGLGERLFCNQTYVSKEVIPCARYQWESACLSH
CCCCHHHHCCCCHHEECCHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLTLGLESSCDETSCALVENGKILANRIASQDIHAAYGGVIPELASRAHLQIFPKLLAAV
CEEECCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AQDAEVSLEDVELISVANTPGLIGALSVGVNFAKGLASGLKKTLIGVNHVEAHLYAACLE
HCCCCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
EPSIRFPALGLAISGAHTSLFLMPNATTFLLIGKTRDDAIGETFDKVARFLGLPYPGGQK
CCCCCCCEEEEEEECCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHH
LEELAQDGDEEAYPFSRAKVSGNDFSFSGLKTAVLYALKGNNSSAKAPFPEVSETQKRNI
HHHHHHCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHH
AASFQKAAFMTIAQKLPDIVKAFSCESLIVGGGVANNRYFRRLLNQTCSLPTYFPSSQLC
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHC
SDNAAMIAGLGERLFCNQTYVSKEVIPCARYQWESACLSH
CCCCHHHHCCCCHHEECCHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935