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The map label for this gene is adk

Identifier: 15835023

GI number: 15835023

Start: 464046

End: 464807

Strand: Reverse

Name: adk

Synonym: TC0404

Alternate gene names: 15835023

Gene position: 464807-464046 (Counterclockwise)

Preceding gene: 15835026

Following gene: 15835022

Centisome position: 43.32

GC content: 40.42

Gene sequence:

>762_bases
ATGGATCGATCCCCCCTCTTTCTTATCATCATGGGAGCCCCGGGATCCGGAAAAGGCACCCAGTCAAAGTTATTAGCATC
TCAATTGTCTCTCCAGCATATCAGCTCCGGGGACTTACTCAGAAATGCGGTTTCCCAAAACACACCACTTGGCCAAGAAA
TCAAATCCTACTTAGATCAGGGCAAATTGTTACCAGATCAATTAGTCTGGAAGTTAGTCCATGAAAAACTTGATGAGTTA
CAACAAGATACTTTATTACGAAAACTTTCCTTTTTATCTCGTTCAGAAAATGGCGCCATTTTAGATGGCTTCCCAAGAAC
AGTCGCTCAAGCCAAACTGTTGAATGAGTTTCTCTGCTCCTATTTCCCTGATTATAAAATCATCCTTTTAGATATTTCTG
ATGAAGAAGTCCTCAATCGCTTAACTTCTCGCTACATCTGTCCGTCTTGTCAGGGTATTTATAACAAACAACAAGGATTC
TCTCGATGTCCTAAATGTTTAGTAGAGCTAACTCGTAGATCTGATGACACTCCAGAAGTGATTCTTGATAGAATTCAGAC
CTATAAACAAGAAACACAGCCTGTTTTGGATTATTATGCAGCTCTGCAAAGACTCATCACTATTGATGCTAATGCTCCCA
CCCAGCAGGTGTTTAAGAACATTTTAGATGCTCTTCCTGAATCTAACTATACCATTCATAAGAAAAGTTGTTGCGATTGT
TGTGACTGTGACTGCTATGATGGTTGTGACTGCGAAGAGTAG

Upstream 100 bases:

>100_bases
AGATTTTTTACACAACTTATGTTTCAGAAAAATAAAAACTCGTGTACATTTTACAAGGCCCCTAAATTCTTTGTATCGGG
CTTTAAGGTATTGTATTAGT

Downstream 100 bases:

>100_bases
CGTACGAAAATTTTTTTTGATATAGTTCGGGGGAAGTAGATCGCTTATCTACAGTCTTCTTGCGAATTTTCTGCTAAGGT
GGTCCTGTGTTCTATGCCTT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLQHISSGDLLRNAVSQNTPLGQEIKSYLDQGKLLPDQLVWKLVHEKLDEL
QQDTLLRKLSFLSRSENGAILDGFPRTVAQAKLLNEFLCSYFPDYKIILLDISDEEVLNRLTSRYICPSCQGIYNKQQGF
SRCPKCLVELTRRSDDTPEVILDRIQTYKQETQPVLDYYAALQRLITIDANAPTQQVFKNILDALPESNYTIHKKSCCDC
CDCDCYDGCDCEE

Sequences:

>Translated_253_residues
MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLQHISSGDLLRNAVSQNTPLGQEIKSYLDQGKLLPDQLVWKLVHEKLDEL
QQDTLLRKLSFLSRSENGAILDGFPRTVAQAKLLNEFLCSYFPDYKIILLDISDEEVLNRLTSRYICPSCQGIYNKQQGF
SRCPKCLVELTRRSDDTPEVILDRIQTYKQETQPVLDYYAALQRLITIDANAPTQQVFKNILDALPESNYTIHKKSCCDC
CDCDCYDGCDCEE
>Mature_253_residues
MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLQHISSGDLLRNAVSQNTPLGQEIKSYLDQGKLLPDQLVWKLVHEKLDEL
QQDTLLRKLSFLSRSENGAILDGFPRTVAQAKLLNEFLCSYFPDYKIILLDISDEEVLNRLTSRYICPSCQGIYNKQQGF
SRCPKCLVELTRRSDDTPEVILDRIQTYKQETQPVLDYYAALQRLITIDANAPTQQVFKNILDALPESNYTIHKKSCCDC
CDCDCYDGCDCEE

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=37.8787878787879, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI4502013, Length=226, Percent_Identity=32.7433628318584, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI7524346, Length=222, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=31.6831683168317, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=31.6831683168317, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=31.6831683168317, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=31.6831683168317, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=26.027397260274, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=26.5765765765766, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI28144899, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144897, Length=242, Percent_Identity=26.4462809917355, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=148, Percent_Identity=31.7567567567568, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1786680, Length=221, Percent_Identity=32.579185520362, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17552384, Length=221, Percent_Identity=33.4841628959276, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17567503, Length=226, Percent_Identity=28.7610619469027, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17537943, Length=230, Percent_Identity=24.7826086956522, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=223, Percent_Identity=32.7354260089686, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321018, Length=215, Percent_Identity=36.2790697674419, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=223, Percent_Identity=26.9058295964126, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI22026816, Length=220, Percent_Identity=34.0909090909091, Blast_Score=124, Evalue=6e-29,
Organism=Drosophila melanogaster, GI17737899, Length=198, Percent_Identity=34.3434343434343, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645822, Length=198, Percent_Identity=34.3434343434343, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24663208, Length=219, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647141, Length=219, Percent_Identity=24.2009132420091, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221459597, Length=227, Percent_Identity=23.3480176211454, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356893, Length=227, Percent_Identity=23.3480176211454, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CHLMU (Q9PKR0)

Other databases:

- EMBL:   AE002160
- PIR:   B81706
- RefSeq:   NP_296782.1
- ProteinModelPortal:   Q9PKR0
- SMR:   Q9PKR0
- GeneID:   1245756
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0404
- TIGR:   TC_0404
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   CMUR243161:TC_0404-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 28598; Mature: 28598

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLQHISSGDLLRNAVSQNTPLGQEIKSYLDQ
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHC
GKLLPDQLVWKLVHEKLDELQQDTLLRKLSFLSRSENGAILDGFPRTVAQAKLLNEFLCS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHH
YFPDYKIILLDISDEEVLNRLTSRYICPSCQGIYNKQQGFSRCPKCLVELTRRSDDTPEV
HCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ILDRIQTYKQETQPVLDYYAALQRLITIDANAPTQQVFKNILDALPESNYTIHKKSCCDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
CDCDCYDGCDCEE
CCCCCCCCCCCCC
>Mature Secondary Structure
MDRSPLFLIIMGAPGSGKGTQSKLLASQLSLQHISSGDLLRNAVSQNTPLGQEIKSYLDQ
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHC
GKLLPDQLVWKLVHEKLDELQQDTLLRKLSFLSRSENGAILDGFPRTVAQAKLLNEFLCS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHH
YFPDYKIILLDISDEEVLNRLTSRYICPSCQGIYNKQQGFSRCPKCLVELTRRSDDTPEV
HCCCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ILDRIQTYKQETQPVLDYYAALQRLITIDANAPTQQVFKNILDALPESNYTIHKKSCCDC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
CDCDCYDGCDCEE
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935