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The map label for this gene is dxr

Identifier: 15834962

GI number: 15834962

Start: 404923

End: 406062

Strand: Direct

Name: dxr

Synonym: TC0343

Alternate gene names: 15834962

Gene position: 404923-406062 (Clockwise)

Preceding gene: 15834961

Following gene: 15834963

Centisome position: 37.74

GC content: 38.81

Gene sequence:

>1140_bases
TTGAAGCGATTAGCTTTAATTGGCTCAACAGGAAGCATAGGAAAGCAAGTTTTACAGGTAATTCGGGAAATTCCAGACGC
TTTTGTCATAGAAACGCTTGCTGCATATGGACGTAATAGAGAAAGTTTGATTTCTCAGATTAGAGAATTTTCGCCGCGAG
TAGTAGCTGTTCGTGATGAGACTACTTATAAGGAATTGCGGAAGTTATTTCCTCATATTGAAATCCTTTCAGGAGAAGAA
GGACTGATTGCTGTCGCTACTGCGGCTTCTGTAGATATGACTATTGTAGCTTCTTCTGGAATAGATGCTTTGCCTGCAGT
AATGGCTTCTATTCAAGAGAGAAAGACGATCGCTTTAGCTAATAAAGAGTCTCTAGTAGCTGCTGGAGAGTTAGTTACTA
CTTTGGCTAAAAAGAATCATGTACAAATTCTTCCCATTGACAGCGAACATAATGCTCTTTTCCAATGTTTGGAAGGTCGA
GATCCTTCTACAATAAAAAAATTAATATTAACGGCGTCAGGCGGTCCATTAAGAAATAAATCAAAAGAGGAGTTGCAAAA
GGTTACTTTACAAGAGGTCTTAAAGCATCCTATTTGGGATATGGGGCCTAAAATTACGGTAGATTCTTCTACTTTAGTGA
ATAAAGGATTAGAGATTATAGAGGCTTTTTGGTTGTTTGGATTACAGGCTGTTGAAATTGAAGCTGTGATACATCCCCAA
AGCCTTATTCATGGCATGGTGGAGTTTTGTGATGGGACAATCCTTTCAGTGATGAATCCTCCTAGTATGCTTTTCCCGAT
ACAACATGTTTTAACTTTTCCAGATCGATATCCCTCGATAATCTCAGGATTAAATTTTCTTACAAATCAAACTTTAGAAT
TTCTCCCTATTGATGAYGAAAGATTCCCTAGCATTCGGCTAGCAAAGGATGTGCTTCGTGAGGGTGGCTCTATGGGATGT
TTTTTCAATGGAGCTAATGAGGCTTTAGTTCAACGATTTCTATCTGGAGAGATTGCTTGGTATCAAATTGTCTCTAAATT
ACAGACTCTTATGGATAAATATGTGGTGCGATCCTGTCTATCTTTAGAGGATATCTTGCAGGTAGACTCAGAAGCTAGAG
CTCTTGCTAGCGAGTGCTAA

Upstream 100 bases:

>100_bases
TTACTTGTTTTTTACATAGGGACGCTTGCAACTGTTTTTGTCAGAAGGCATATTTTACTTCAATCGAAAAATTGACCAAC
AAAAGATGTAAGAGGGTGTT

Downstream 100 bases:

>100_bases
CTATTTCTATGTTCGTAGGATGCTAGCCTTTTTCGATAGTGGTGCGGAAAAAAACGATTCGTGTAGTATAGGGGGCGACT
CTTCATTTTGCTGAGCGTCT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MKRLALIGSTGSIGKQVLQVIREIPDAFVIETLAAYGRNRESLISQIREFSPRVVAVRDETTYKELRKLFPHIEILSGEE
GLIAVATAASVDMTIVASSGIDALPAVMASIQERKTIALANKESLVAAGELVTTLAKKNHVQILPIDSEHNALFQCLEGR
DPSTIKKLILTASGGPLRNKSKEELQKVTLQEVLKHPIWDMGPKITVDSSTLVNKGLEIIEAFWLFGLQAVEIEAVIHPQ
SLIHGMVEFCDGTILSVMNPPSMLFPIQHVLTFPDRYPSIISGLNFLTNQTLEFLPIDDERFPSIRLAKDVLREGGSMGC
FFNGANEALVQRFLSGEIAWYQIVSKLQTLMDKYVVRSCLSLEDILQVDSEARALASEC

Sequences:

>Translated_379_residues
MKRLALIGSTGSIGKQVLQVIREIPDAFVIETLAAYGRNRESLISQIREFSPRVVAVRDETTYKELRKLFPHIEILSGEE
GLIAVATAASVDMTIVASSGIDALPAVMASIQERKTIALANKESLVAAGELVTTLAKKNHVQILPIDSEHNALFQCLEGR
DPSTIKKLILTASGGPLRNKSKEELQKVTLQEVLKHPIWDMGPKITVDSSTLVNKGLEIIEAFWLFGLQAVEIEAVIHPQ
SLIHGMVEFCDGTILSVMNPPSMLFPIQHVLTFPDRYPSIISGLNFLTNQTLEFLPIDDERFPSIRLAKDVLREGGSMGC
FFNGANEALVQRFLSGEIAWYQIVSKLQTLMDKYVVRSCLSLEDILQVDSEARALASEC
>Mature_379_residues
MKRLALIGSTGSIGKQVLQVIREIPDAFVIETLAAYGRNRESLISQIREFSPRVVAVRDETTYKELRKLFPHIEILSGEE
GLIAVATAASVDMTIVASSGIDALPAVMASIQERKTIALANKESLVAAGELVTTLAKKNHVQILPIDSEHNALFQCLEGR
DPSTIKKLILTASGGPLRNKSKEELQKVTLQEVLKHPIWDMGPKITVDSSTLVNKGLEIIEAFWLFGLQAVEIEAVIHPQ
SLIHGMVEFCDGTILSVMNPPSMLFPIQHVLTFPDRYPSIISGLNFLTNQTLEFLPIDDERFPSIRLAKDVLREGGSMGC
FFNGANEALVQRFLSGEIAWYQIVSKLQTLMDKYVVRSCLSLEDILQVDSEARALASEC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=390, Percent_Identity=37.9487179487179, Blast_Score=263, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHLMU (Q9PKW8)

Other databases:

- EMBL:   AE002160
- PIR:   G81712
- RefSeq:   NP_296721.1
- ProteinModelPortal:   Q9PKW8
- SMR:   Q9PKW8
- GeneID:   1246386
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0343
- TIGR:   TC_0343
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q9PKW8
- ProtClustDB:   PRK05447
- BioCyc:   CMUR243161:TC_0343-MONOMER
- BRENDA:   1.1.1.267
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41811; Mature: 41811

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: BINDING 122-122 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLALIGSTGSIGKQVLQVIREIPDAFVIETLAAYGRNRESLISQIREFSPRVVAVRDE
CCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECC
TTYKELRKLFPHIEILSGEEGLIAVATAASVDMTIVASSGIDALPAVMASIQERKTIALA
HHHHHHHHHCCCEEEECCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHEEEE
NKESLVAAGELVTTLAKKNHVQILPIDSEHNALFQCLEGRDPSTIKKLILTASGGPLRNK
CCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
SKEELQKVTLQEVLKHPIWDMGPKITVDSSTLVNKGLEIIEAFWLFGLQAVEIEAVIHPQ
CHHHHHHHHHHHHHHCCHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCHHEEEEEEECHH
SLIHGMVEFCDGTILSVMNPPSMLFPIQHVLTFPDRYPSIISGLNFLTNQTLEFLPIDDE
HHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCC
RFPSIRLAKDVLREGGSMGCFFNGANEALVQRFLSGEIAWYQIVSKLQTLMDKYVVRSCL
CCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
SLEDILQVDSEARALASEC
CHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MKRLALIGSTGSIGKQVLQVIREIPDAFVIETLAAYGRNRESLISQIREFSPRVVAVRDE
CCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECC
TTYKELRKLFPHIEILSGEEGLIAVATAASVDMTIVASSGIDALPAVMASIQERKTIALA
HHHHHHHHHCCCEEEECCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHEEEE
NKESLVAAGELVTTLAKKNHVQILPIDSEHNALFQCLEGRDPSTIKKLILTASGGPLRNK
CCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCC
SKEELQKVTLQEVLKHPIWDMGPKITVDSSTLVNKGLEIIEAFWLFGLQAVEIEAVIHPQ
CHHHHHHHHHHHHHHCCHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCHHEEEEEEECHH
SLIHGMVEFCDGTILSVMNPPSMLFPIQHVLTFPDRYPSIISGLNFLTNQTLEFLPIDDE
HHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCC
RFPSIRLAKDVLREGGSMGCFFNGANEALVQRFLSGEIAWYQIVSKLQTLMDKYVVRSCL
CCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
SLEDILQVDSEARALASEC
CHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935