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Identifier: 15834774

GI number: 15834774

Start: 186157

End: 187197

Strand: Direct

Name: Not Available

Synonym: TC0154

Alternate gene names: 15834774

Gene position: 186157-187197 (Clockwise)

Preceding gene: 15834772

Following gene: 15834776

Centisome position: 17.35

GC content: 43.32

Gene sequence:

>1041_bases
ATGAAATACTCTTTGCAAATAGAAGACCTTCATATTGAAGGATTCGAACAGGTTTTGAAAATTAGTTGTGAGTCTGTGCA
GTTGGTGGCTGTAATTGCTATTCATCAGACGAAAGTAGGACCTGCTTTGGGGGGAATTCGTGCTTTTAATTACTCTCAAT
TTGATGATGGATTACAGGATGCTTTGCGTTTGTCAAAAGCAATGACATATAAGGCTCTTCTTAGTAGTACAGGAACCGGT
GGAGGGAAAAGTGTGATTTTCTTACCGGAGGGGCTCTCTAGCCCTACAGAAGGAATGTTAAGAGCTTTTGGTCAAGCTGT
GGACTCTTTGCAAGGGAAATATATTGCAGCTGAGGATGTAGGGATCTCGGTTCAGGACATGACGATCATTCATGAGGAGA
CTCCTTACGTTTGTGGGCTAGCGTCAATAAGCGGAGACCCCTCCATATACACAGCACATGGAGTGTTTTTATGCATTCAA
GAGACGGTTGATTACCTGTGGAATGAGGGTATAAAAGGGAAGCGAGTTGCTGTACAGGGGTTGGGTTCTGTTGGGCGTAA
GCTGGTGCATGAGCTATTCTTTGCAGGGGCTGATTTAATCGTCTATGACACACGAAAACATCTTCTTGATGAAGTAGTGA
CTTTATATGGGGCTCAAGTTGATGAAAACATTATCTCGGTAGATTGCGATGTTTTGTGTCCTTGCGCCTTAGGAGGGGTT
ATTAACGCGTGCAGTGTCGATCAGCTTCGATGTCGAGCGATTGTTGGGGCAGCCAATAACCAGCTTGAAAATACTTCCAT
AGGGAAAGAGTTAGCAATTCGAGAGATTCTTTATGCGCCAGATTATCTTGCTAATGCAGGAGGCCTATTGAATGTTGCTA
GTTCTGTGGGACAGACCTATGCACCTAAAGAAGTCTTAAAAAAAGTAGAGAGTCTACCAAAAACTCTACGACGTCTGTAT
GAGAAAAGCATTCAAGAGAGCATCGATACAGGGACTCTTGCTAACACTATAGTTGAAGAGCGCTTAGCTGCTTATTCTTA
G

Upstream 100 bases:

>100_bases
AAAAATGCTGAAAAGTTCCTTGCAAAAATCCTCTCAGAAGGTTTTTTGGCAACAAACAAGTGTTTCTGTATTGCAGAATG
ATATAGGCTGAACATAGAAT

Downstream 100 bases:

>100_bases
TGAAGGAAGACTGCTCTTCTGGAGATAGTCTGTTTAAAGTAGACCGGTGACGGAGTCTATATAGAGTTTCCAGGATAGTG
TTGTGGATGCGTTCGTTAGC

Product: Glu/Leu/Phe/Val dehydrogenase family protein

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKYSLQIEDLHIEGFEQVLKISCESVQLVAVIAIHQTKVGPALGGIRAFNYSQFDDGLQDALRLSKAMTYKALLSSTGTG
GGKSVIFLPEGLSSPTEGMLRAFGQAVDSLQGKYIAAEDVGISVQDMTIIHEETPYVCGLASISGDPSIYTAHGVFLCIQ
ETVDYLWNEGIKGKRVAVQGLGSVGRKLVHELFFAGADLIVYDTRKHLLDEVVTLYGAQVDENIISVDCDVLCPCALGGV
INACSVDQLRCRAIVGAANNQLENTSIGKELAIREILYAPDYLANAGGLLNVASSVGQTYAPKEVLKKVESLPKTLRRLY
EKSIQESIDTGTLANTIVEERLAAYS

Sequences:

>Translated_346_residues
MKYSLQIEDLHIEGFEQVLKISCESVQLVAVIAIHQTKVGPALGGIRAFNYSQFDDGLQDALRLSKAMTYKALLSSTGTG
GGKSVIFLPEGLSSPTEGMLRAFGQAVDSLQGKYIAAEDVGISVQDMTIIHEETPYVCGLASISGDPSIYTAHGVFLCIQ
ETVDYLWNEGIKGKRVAVQGLGSVGRKLVHELFFAGADLIVYDTRKHLLDEVVTLYGAQVDENIISVDCDVLCPCALGGV
INACSVDQLRCRAIVGAANNQLENTSIGKELAIREILYAPDYLANAGGLLNVASSVGQTYAPKEVLKKVESLPKTLRRLY
EKSIQESIDTGTLANTIVEERLAAYS
>Mature_346_residues
MKYSLQIEDLHIEGFEQVLKISCESVQLVAVIAIHQTKVGPALGGIRAFNYSQFDDGLQDALRLSKAMTYKALLSSTGTG
GGKSVIFLPEGLSSPTEGMLRAFGQAVDSLQGKYIAAEDVGISVQDMTIIHEETPYVCGLASISGDPSIYTAHGVFLCIQ
ETVDYLWNEGIKGKRVAVQGLGSVGRKLVHELFFAGADLIVYDTRKHLLDEVVTLYGAQVDENIISVDCDVLCPCALGGV
INACSVDQLRCRAIVGAANNQLENTSIGKELAIREILYAPDYLANAGGLLNVASSVGQTYAPKEVLKKVESLPKTLRRLY
EKSIQESIDTGTLANTIVEERLAAYS

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids. Catalyzes the reversible deamination of these branched-chain L-amino acids to their oxo analogs [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 37253; Mature: 37253

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYSLQIEDLHIEGFEQVLKISCESVQLVAVIAIHQTKVGPALGGIRAFNYSQFDDGLQD
CCEEEEEEEECHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCHHCCHHCCCCHHHHHHHHH
ALRLSKAMTYKALLSSTGTGGGKSVIFLPEGLSSPTEGMLRAFGQAVDSLQGKYIAAEDV
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCC
GISVQDMTIIHEETPYVCGLASISGDPSIYTAHGVFLCIQETVDYLWNEGIKGKRVAVQG
CCEEEEEEEEECCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LGSVGRKLVHELFFAGADLIVYDTRKHLLDEVVTLYGAQVDENIISVDCDVLCPCALGGV
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCHHCCCEEEECCCEECHHHHHHH
INACSVDQLRCRAIVGAANNQLENTSIGKELAIREILYAPDYLANAGGLLNVASSVGQTY
HCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCC
APKEVLKKVESLPKTLRRLYEKSIQESIDTGTLANTIVEERLAAYS
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYSLQIEDLHIEGFEQVLKISCESVQLVAVIAIHQTKVGPALGGIRAFNYSQFDDGLQD
CCEEEEEEEECHHHHHHHHHHHCCCEEEEEEEEHHHHHCCCHHCCHHCCCCHHHHHHHHH
ALRLSKAMTYKALLSSTGTGGGKSVIFLPEGLSSPTEGMLRAFGQAVDSLQGKYIAAEDV
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCEEEECCC
GISVQDMTIIHEETPYVCGLASISGDPSIYTAHGVFLCIQETVDYLWNEGIKGKRVAVQG
CCEEEEEEEEECCCCCEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LGSVGRKLVHELFFAGADLIVYDTRKHLLDEVVTLYGAQVDENIISVDCDVLCPCALGGV
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCHHCCCEEEECCCEECHHHHHHH
INACSVDQLRCRAIVGAANNQLENTSIGKELAIREILYAPDYLANAGGLLNVASSVGQTY
HCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCC
APKEVLKKVESLPKTLRRLYEKSIQESIDTGTLANTIVEERLAAYS
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020469 [H]