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The map label for this gene is fabF

Identifier: 15834771

GI number: 15834771

Start: 183497

End: 184753

Strand: Direct

Name: fabF

Synonym: TC0151

Alternate gene names: 15834771

Gene position: 183497-184753 (Clockwise)

Preceding gene: 15834770

Following gene: 15834772

Centisome position: 17.1

GC content: 44.39

Gene sequence:

>1257_bases
ATGAACAAAAAACGTGTAGTCGTTACGGGAATGGGGATAGTCTCCTGCCTTGGGAATGAAGTAGAATCTTTCTATGATAG
CCTGTTGGCTGGAATTAGTGGGGTGCGGACAATCACATCTTTCCCCTGCGATGATTATGCTACGCGTTTTGCAGGTTGGA
TAGAGGAATTTAACTCGGAGCCTTATTTAGATAAAAAACAAGCTCGACGAGTAGACCCTTTTATTACATATGCTGTTGTG
GCTGCAAAGAAAGCAATAGCTATGTCTCGTTGGGATCAAGAGACTCTTCCTGCGAATCCTCATCGTTGCGGAGTGATCAT
TGGATCTGGGATGGGGGGGCTTCGGACCCTTGATGAGGGGATCGAAAAATTATCAGCAGGGAATAGAAAACTGTCTCCAT
TCTTTATTCCTTATATCATTACTAATATGGCTCCTGCCTTGATCGCTATGGATTATGGTTTAATGGGGCCAAACTATTCT
ATTTCAACAGCCTGTGCAACGGCCAACTATTGTATTGATGCTGCTTATCAACATCTCGTTGAAGGGCGTGCGGATGTCAT
CGTTTGTGGAGGGACTGAGGCTGCCATTAATCGTGTTGGCTTGGCTGGATTTATTGCTAATCGCGCATTGTCGGAAAGAA
ATGATGCTCCTGAACAGGCATCGCGTCCCTGGGACCGGGATCGGGATGGTTTTGTGCTAGGAGAAGGGGCTGGCGTCCTG
GTCTTAGAAACCCTGGATAATGCTTTAAAAAGAGGGGCTCCAATTTTTGCTGAAGTGCTTGGAACCTATACAACGTGCGA
CGCTTTTCATATTACTGCTCCTAGAGATGATGGTGAAGGAATCACTGCCTGTATACTAGGAGCTTTGAATAAAGCTGGTA
TTCCTAAAGAACGGGTGAATTACATTAATGCGCACGGAACTTCCACTCCATTAGGAGATCTGTCAGAGGTATTGGCTTTG
AAAAAGGCTTTTGGAAGTCATATCAAAAACTTGCGCATGAATTCGACCAAGTCTTTGATAGGGCACTGCTTAGGAGCTGC
AGGTGGGGTAGAAGCTGTTGCGACTATTCAAGCCATTCAGACAGGGAAGTTGCACCCAACAATCAATATAGAAAATCCTA
TAGCAGAAATAGAAGAGTTTGATGTAGTTGCGAATAAATCCCAGGATTGGGATGTGGATGTTGCTATGTCGAATTCCTTT
GGTTTCGGCGGACATAATTCAACGATATTATTTTCGAGGTATGAACCTTCATTATGA

Upstream 100 bases:

>100_bases
TTGTTTGTCTCTTCTGTTCGGGAACAGTATTGCCTAGAAGAACTGTGGAAAGACGGAGCAATCATTACGTCCGATTGTCT
AGCTTCTTAAAGGAGAAAGT

Downstream 100 bases:

>100_bases
TGAAAACTAAGCACGAATATTCTTTTGGCGTTATTCCTATCCGATTTTTTGGTACTCCAGATAGAAGTACCTTAAAGGCT
TGTTTTATCTGCCATACAGA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MNKKRVVVTGMGIVSCLGNEVESFYDSLLAGISGVRTITSFPCDDYATRFAGWIEEFNSEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDQETLPANPHRCGVIIGSGMGGLRTLDEGIEKLSAGNRKLSPFFIPYIITNMAPALIAMDYGLMGPNYS
ISTACATANYCIDAAYQHLVEGRADVIVCGGTEAAINRVGLAGFIANRALSERNDAPEQASRPWDRDRDGFVLGEGAGVL
VLETLDNALKRGAPIFAEVLGTYTTCDAFHITAPRDDGEGITACILGALNKAGIPKERVNYINAHGTSTPLGDLSEVLAL
KKAFGSHIKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINIENPIAEIEEFDVVANKSQDWDVDVAMSNSF
GFGGHNSTILFSRYEPSL

Sequences:

>Translated_418_residues
MNKKRVVVTGMGIVSCLGNEVESFYDSLLAGISGVRTITSFPCDDYATRFAGWIEEFNSEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDQETLPANPHRCGVIIGSGMGGLRTLDEGIEKLSAGNRKLSPFFIPYIITNMAPALIAMDYGLMGPNYS
ISTACATANYCIDAAYQHLVEGRADVIVCGGTEAAINRVGLAGFIANRALSERNDAPEQASRPWDRDRDGFVLGEGAGVL
VLETLDNALKRGAPIFAEVLGTYTTCDAFHITAPRDDGEGITACILGALNKAGIPKERVNYINAHGTSTPLGDLSEVLAL
KKAFGSHIKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINIENPIAEIEEFDVVANKSQDWDVDVAMSNSF
GFGGHNSTILFSRYEPSL
>Mature_418_residues
MNKKRVVVTGMGIVSCLGNEVESFYDSLLAGISGVRTITSFPCDDYATRFAGWIEEFNSEPYLDKKQARRVDPFITYAVV
AAKKAIAMSRWDQETLPANPHRCGVIIGSGMGGLRTLDEGIEKLSAGNRKLSPFFIPYIITNMAPALIAMDYGLMGPNYS
ISTACATANYCIDAAYQHLVEGRADVIVCGGTEAAINRVGLAGFIANRALSERNDAPEQASRPWDRDRDGFVLGEGAGVL
VLETLDNALKRGAPIFAEVLGTYTTCDAFHITAPRDDGEGITACILGALNKAGIPKERVNYINAHGTSTPLGDLSEVLAL
KKAFGSHIKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQTGKLHPTINIENPIAEIEEFDVVANKSQDWDVDVAMSNSF
GFGGHNSTILFSRYEPSL

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=41.3461538461538, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=46.5753424657534, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI41872631, Length=432, Percent_Identity=24.537037037037, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=45.7831325301205, Blast_Score=327, Evalue=1e-90,
Organism=Escherichia coli, GI1788663, Length=416, Percent_Identity=35.8173076923077, Blast_Score=236, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=34.1981132075472, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=38.2575757575758, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=353, Percent_Identity=26.628895184136, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI212642053, Length=358, Percent_Identity=23.1843575418994, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=34.8314606741573, Blast_Score=240, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24644341, Length=424, Percent_Identity=40.8018867924528, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI221330659, Length=372, Percent_Identity=23.9247311827957, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19920632, Length=372, Percent_Identity=23.9247311827957, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24581345, Length=431, Percent_Identity=23.4338747099768, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44858; Mature: 44858

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE ; PS00205 TRANSFERRIN_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKRVVVTGMGIVSCLGNEVESFYDSLLAGISGVRTITSFPCDDYATRFAGWIEEFNSE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PYLDKKQARRVDPFITYAVVAAKKAIAMSRWDQETLPANPHRCGVIIGSGMGGLRTLDEG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
IEKLSAGNRKLSPFFIPYIITNMAPALIAMDYGLMGPNYSISTACATANYCIDAAYQHLV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGRADVIVCGGTEAAINRVGLAGFIANRALSERNDAPEQASRPWDRDRDGFVLGEGAGVL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLETLDNALKRGAPIFAEVLGTYTTCDAFHITAPRDDGEGITACILGALNKAGIPKERVN
EEHHHHHHHHCCCCHHHHHHCCHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHH
YINAHGTSTPLGDLSEVLALKKAFGSHIKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQ
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINIENPIAEIEEFDVVANKSQDWDVDVAMSNSFGFGGHNSTILFSRYEPSL
CCCCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MNKKRVVVTGMGIVSCLGNEVESFYDSLLAGISGVRTITSFPCDDYATRFAGWIEEFNSE
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
PYLDKKQARRVDPFITYAVVAAKKAIAMSRWDQETLPANPHRCGVIIGSGMGGLRTLDEG
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
IEKLSAGNRKLSPFFIPYIITNMAPALIAMDYGLMGPNYSISTACATANYCIDAAYQHLV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGRADVIVCGGTEAAINRVGLAGFIANRALSERNDAPEQASRPWDRDRDGFVLGEGAGVL
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCCEEEECCCCEE
VLETLDNALKRGAPIFAEVLGTYTTCDAFHITAPRDDGEGITACILGALNKAGIPKERVN
EEHHHHHHHHCCCCHHHHHHCCHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHH
YINAHGTSTPLGDLSEVLALKKAFGSHIKNLRMNSTKSLIGHCLGAAGGVEAVATIQAIQ
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHH
TGKLHPTINIENPIAEIEEFDVVANKSQDWDVDVAMSNSFGFGGHNSTILFSRYEPSL
CCCCCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]