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Identifier: 15834741

GI number: 15834741

Start: 139262

End: 140557

Strand: Reverse

Name: Not Available

Synonym: TC0116

Alternate gene names: 15834741

Gene position: 140557-139262 (Counterclockwise)

Preceding gene: 15834742

Following gene: 29337301

Centisome position: 13.1

GC content: 40.12

Gene sequence:

>1296_bases
ATGTCTTGGCTTTCAAGCCTGTACCCTATTTTTATTGCTTCTACCGCATTTTGTGCTTTAGGCCTTCTTCTTGTAGCCAT
CATCCTTCTTTCCAGGAAATTTCTTATCAAAGTGCATCCCTGTAAACTGAGAATCAATAATGATGACTCTCTTACTAAAA
CTGTAGATAGCGGAAAAACGCTCCTTTCCTCTTTGCTTGATTCTGGGATTGCTATCCCTTCTCCTTGCGGAGGAAAAGCC
GCATGCAAGCAATGTAAAATTCGCATTACAAAAAATGTCGATGAGCCATTAGAAACGGATCGCTCTACCTTCTCAAAGCA
ACAGTTGGAACAAGGCTGGCGACTTTCCTGCCAAACGAAAGTACAACATGATATGAACTTAGAAATTGAAGAACGTTATT
TCAATGCTTCATCCTGGGAAGGCACAGTTGTATCAAACGAGAATGTTGCGACCTTCATTAAAGAACTTGTTCTGTCTGTA
GATCCCGCACGTCCTATTCCTTTCAAACCTGGGGGATATCTGCAAATTACCGTTCCCTCCTATAAAACTAATACCTCTGA
CTGGAAACAGACTATGGATCCCCAATATTATAGTGATTGGGAAACCTTCCACCTCTTTGATAAAGTGATTGATCACCAAT
CTTTGGATGCCAACTCTGCAAATAAAGCATATTCTCTAGCTTCTTATCCAGCAGAGCTCCCTCTTATCAAATTTAATATC
CGTATCGCAACGCCTCCATTTATAAATAAATCCCCTGATCCAACGATTCCATGGGGAGTCTGTTCCTCCTATATATTCTC
CCTCAAGCCAGGTGATAAGGTAACTGTATCTGGTCCTTATGGCGAATCATTCATGAAAGAAGATAACCGTCCTGTTATCT
TCCTAATTGGAGGAGCTGGCTCCTCTTTTGGAAGAAGCCATATTCTTGATTTATTATTAAGCAAACATACAAACCGAGAG
CTTACGTTATGGTATGGTGCCCGCTCTCTTAAGGAAAATATTTATCAAGAAGAGTATGAGAAATTAGAAAAGGAATTTCC
TAACTTTCACTACCATCTTGTTCTATCTCAACCTTTGCAGGAAGACTTAGATAAAGGATGGGACAGTAAAGACCCAATCA
AAACGAACTTTTTGTTTAAAGCTTTTGAGCTCGGACAACTGAGCAAGCTTCCCAATCCAGAAGACTATCTATACTATGTT
TGTGGTCCAGCACTTCACAACAGCAGTATTCTTACTTTACTTGATAACTACGGAGTTGAGCGGTCTTCTATTATCCTGGA
TGATTTTGGAAGCTAA

Upstream 100 bases:

>100_bases
TTCCTAGTAATAAAACTCTAAAAAACTCCATTGATTTTTTATGAAGTAAACTATAAGTTGACGCTACAGTCTCGTTGAAA
TTCCAGGGATTCTTATAATT

Downstream 100 bases:

>100_bases
TCTTCCTTGTGGCAATCCTAGCCCCCCATCTTGATATCCCTAAAGTACCAATAAGATATCCTTTCCCCCTGCATAGAGTT
CTTCTAGTTTTCATTCTTTC

Product: Na(+)-translocating NADH-quinone reductase subunit F

Products: NAD(P); FMNH2; 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: Na(+)-NQR subunit F; Na(+)-translocating NQR subunit F; NQR complex subunit F; NQR-1 subunit F

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSWLSSLYPIFIASTAFCALGLLLVAIILLSRKFLIKVHPCKLRINNDDSLTKTVDSGKTLLSSLLDSGIAIPSPCGGKA
ACKQCKIRITKNVDEPLETDRSTFSKQQLEQGWRLSCQTKVQHDMNLEIEERYFNASSWEGTVVSNENVATFIKELVLSV
DPARPIPFKPGGYLQITVPSYKTNTSDWKQTMDPQYYSDWETFHLFDKVIDHQSLDANSANKAYSLASYPAELPLIKFNI
RIATPPFINKSPDPTIPWGVCSSYIFSLKPGDKVTVSGPYGESFMKEDNRPVIFLIGGAGSSFGRSHILDLLLSKHTNRE
LTLWYGARSLKENIYQEEYEKLEKEFPNFHYHLVLSQPLQEDLDKGWDSKDPIKTNFLFKAFELGQLSKLPNPEDYLYYV
CGPALHNSSILTLLDNYGVERSSIILDDFGS

Sequences:

>Translated_431_residues
MSWLSSLYPIFIASTAFCALGLLLVAIILLSRKFLIKVHPCKLRINNDDSLTKTVDSGKTLLSSLLDSGIAIPSPCGGKA
ACKQCKIRITKNVDEPLETDRSTFSKQQLEQGWRLSCQTKVQHDMNLEIEERYFNASSWEGTVVSNENVATFIKELVLSV
DPARPIPFKPGGYLQITVPSYKTNTSDWKQTMDPQYYSDWETFHLFDKVIDHQSLDANSANKAYSLASYPAELPLIKFNI
RIATPPFINKSPDPTIPWGVCSSYIFSLKPGDKVTVSGPYGESFMKEDNRPVIFLIGGAGSSFGRSHILDLLLSKHTNRE
LTLWYGARSLKENIYQEEYEKLEKEFPNFHYHLVLSQPLQEDLDKGWDSKDPIKTNFLFKAFELGQLSKLPNPEDYLYYV
CGPALHNSSILTLLDNYGVERSSIILDDFGS
>Mature_430_residues
SWLSSLYPIFIASTAFCALGLLLVAIILLSRKFLIKVHPCKLRINNDDSLTKTVDSGKTLLSSLLDSGIAIPSPCGGKAA
CKQCKIRITKNVDEPLETDRSTFSKQQLEQGWRLSCQTKVQHDMNLEIEERYFNASSWEGTVVSNENVATFIKELVLSVD
PARPIPFKPGGYLQITVPSYKTNTSDWKQTMDPQYYSDWETFHLFDKVIDHQSLDANSANKAYSLASYPAELPLIKFNIR
IATPPFINKSPDPTIPWGVCSSYIFSLKPGDKVTVSGPYGESFMKEDNRPVIFLIGGAGSSFGRSHILDLLLSKHTNREL
TLWYGARSLKENIYQEEYEKLEKEFPNFHYHLVLSQPLQEDLDKGWDSKDPIKTNFLFKAFELGQLSKLPNPEDYLYYVC
GPALHNSSILTLLDNYGVERSSIILDDFGS

Specific function: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by nqrF, which accepts electrons from NADH and reduces

COG id: COG2871

COG function: function code C; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF

Gene ontology:

Cell location: Cell inner membrane (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NQRF_CHLMU (Q9PLI3)

Other databases:

- EMBL:   AE002160
- PIR:   H81738
- RefSeq:   NP_296500.1
- ProteinModelPortal:   Q9PLI3
- GeneID:   1245650
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0116
- TIGR:   TC_0116
- HOGENOM:   HBG680293
- OMA:   HKAPEDC
- ProtClustDB:   PRK05464
- BioCyc:   CMUR243161:TC_0116-MONOMER
- HAMAP:   MF_00430
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR010205
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938
- Gene3D:   G3DSA:3.10.20.30
- TIGRFAMs:   TIGR01941

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1; SSF54292 Ferredoxin; SSF63380 Riboflavin_synthase_like_b-brl

EC number: 1.5.1.29 [C]

Molecular weight: Translated: 48639; Mature: 48508

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x403a3350)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWLSSLYPIFIASTAFCALGLLLVAIILLSRKFLIKVHPCKLRINNDDSLTKTVDSGKT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEECCCCCHHHHHHHHHH
LLSSLLDSGIAIPSPCGGKAACKQCKIRITKNVDEPLETDRSTFSKQQLEQGWRLSCQTK
HHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VQHDMNLEIEERYFNASSWEGTVVSNENVATFIKELVLSVDPARPIPFKPGGYLQITVPS
CCCCCCCEEHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
YKTNTSDWKQTMDPQYYSDWETFHLFDKVIDHQSLDANSANKAYSLASYPAELPLIKFNI
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEHHCCCCCCCEEEEEE
RIATPPFINKSPDPTIPWGVCSSYIFSLKPGDKVTVSGPYGESFMKEDNRPVIFLIGGAG
EECCCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEEECCCCHHHHHCCCCCEEEEEECCC
SSFGRSHILDLLLSKHTNRELTLWYGARSLKENIYQEEYEKLEKEFPNFHYHLVLSQPLQ
CCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
EDLDKGWDSKDPIKTNFLFKAFELGQLSKLPNPEDYLYYVCGPALHNSSILTLLDNYGVE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEHHHCCCC
RSSIILDDFGS
CCEEEECCCCH
>Mature Secondary Structure 
SWLSSLYPIFIASTAFCALGLLLVAIILLSRKFLIKVHPCKLRINNDDSLTKTVDSGKT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECEEEEECCCCCHHHHHHHHHH
LLSSLLDSGIAIPSPCGGKAACKQCKIRITKNVDEPLETDRSTFSKQQLEQGWRLSCQTK
HHHHHHHCCCCCCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VQHDMNLEIEERYFNASSWEGTVVSNENVATFIKELVLSVDPARPIPFKPGGYLQITVPS
CCCCCCCEEHHHCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
YKTNTSDWKQTMDPQYYSDWETFHLFDKVIDHQSLDANSANKAYSLASYPAELPLIKFNI
CCCCCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEHHCCCCCCCEEEEEE
RIATPPFINKSPDPTIPWGVCSSYIFSLKPGDKVTVSGPYGESFMKEDNRPVIFLIGGAG
EECCCCCCCCCCCCCCCHHHHHHHEEEECCCCEEEEECCCCHHHHHCCCCCEEEEEECCC
SSFGRSHILDLLLSKHTNRELTLWYGARSLKENIYQEEYEKLEKEFPNFHYHLVLSQPLQ
CCCHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
EDLDKGWDSKDPIKTNFLFKAFELGQLSKLPNPEDYLYYVCGPALHNSSILTLLDNYGVE
HHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEHHHCCCC
RSSIILDDFGS
CCEEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD(P)H2; FMN [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD(P)H2; FMN; 2 2-octaprenylphenol; O2 [C]

Specific reaction: NAD(P)H2 + FMN = NAD(P) + FMNH2 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10684935