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The map label for this gene is clpP

Identifier: 15834704

GI number: 15834704

Start: 92153

End: 92764

Strand: Reverse

Name: clpP

Synonym: TC0079

Alternate gene names: 15834704

Gene position: 92764-92153 (Counterclockwise)

Preceding gene: 15834705

Following gene: 15834703

Centisome position: 8.65

GC content: 44.61

Gene sequence:

>612_bases
ATGACGTTGGTACCATACGTTGTTGAAGACACGGGTCGCGGCGAACGAGCTATGGATATTTATTCTCGGCTGCTAAAGGA
CCGTATAGTCATGATTGGGCAAGAAATTACCGAGCCTTTGGCAAATACGGTCATAGCCCAGCTTCTATTTCTGATGTCCG
AGGACCCTACAAAAGACATCCAAATTTTCATCAATTCCCCAGGAGGGTATATCACAGCAGGGTTAGCGATCTACGATACC
ATTCGTTTTCTGGGTTGTGATGTAAATACCTACTGTATCGGTCAAGCAGCTTCCATGGGAGCTCTTCTGCTTTCTGCAGG
GACGAAAGGGAAACGTTATGCCTTACCTCACAGCCGCATGATGATCCACCAGCCTTCTGGGGGAATCATTGGAACCTCTG
CAGATATTCAGCTACAAGCTGCTGAGATTTTAACATTGAAAAAACACCTTTCTAATATTCTAGCTGAATGTACTGGTCAG
CCAGTAGAAAAAATTATTGAAGACTCAGAGCGAGACTTCTTTATGGGAGCGGAAGAGGCTATTGCTTACGGGCTAATCGA
CAAGGTTGTCTCTTCAGCAAAAGAGACAAAAGATAAGAACATTGTGTCTTAG

Upstream 100 bases:

>100_bases
GGTGTATTTTTAATTAGATGGGATCCCTCCCTTCTATGGGTCAAGAGTAGATATGACGTACGCACACCTGTAACCAAATG
ATTTGAGAGGAAGCACACAT

Downstream 100 bases:

>100_bases
AGAAGTATTATGACAAAAAAAAATCTTGCGATCTGTTCTTTTTGTGGGCGATCTGAGAAGGATGTTGAGAAACTCATCGC
TGGTCCATCGGTCTACATTT

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDIQIFINSPGGYITAGLAIYDT
IRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQ
PVEKIIEDSERDFFMGAEEAIAYGLIDKVVSSAKETKDKNIVS

Sequences:

>Translated_203_residues
MTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDIQIFINSPGGYITAGLAIYDT
IRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQ
PVEKIIEDSERDFFMGAEEAIAYGLIDKVVSSAKETKDKNIVS
>Mature_202_residues
TLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDIQIFINSPGGYITAGLAIYDTI
RFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRMMIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQP
VEKIIEDSERDFFMGAEEAIAYGLIDKVVSSAKETKDKNIVS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=56.3157894736842, Blast_Score=215, Evalue=2e-56,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=54.4502617801047, Blast_Score=231, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.6881720430108, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=52.0408163265306, Blast_Score=213, Evalue=9e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22101; Mature: 21970

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDI
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
QIFINSPGGYITAGLAIYDTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRM
EEEEECCCCEEEHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHEECCCCCCEEECCCCCE
MIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQPVEKIIEDSERDFFMGAEEA
EEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHH
IAYGLIDKVVSSAKETKDKNIVS
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLVPYVVEDTGRGERAMDIYSRLLKDRIVMIGQEITEPLANTVIAQLLFLMSEDPTKDI
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
QIFINSPGGYITAGLAIYDTIRFLGCDVNTYCIGQAASMGALLLSAGTKGKRYALPHSRM
EEEEECCCCEEEHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHEECCCCCCEEECCCCCE
MIHQPSGGIIGTSADIQLQAAEILTLKKHLSNILAECTGQPVEKIIEDSERDFFMGAEEA
EEECCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCHHHH
IAYGLIDKVVSSAKETKDKNIVS
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA