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The map label for this gene is hemA

Identifier: 15834658

GI number: 15834658

Start: 38542

End: 39543

Strand: Direct

Name: hemA

Synonym: TC0033

Alternate gene names: 15834658

Gene position: 38542-39543 (Clockwise)

Preceding gene: 15834655

Following gene: 15834659

Centisome position: 3.59

GC content: 43.71

Gene sequence:

>1002_bases
ATGGTTAGGGAAGGGGAAGAGCACATAGACGAGGAGTTTTCGTTGGGTGTTATCGGCGTAAGTTATCGCGAGACTGCGTT
GCAGCAGCGAGAACAAGTCCTCCAATTCTTACAACAAGCTCAGCTTTCTTTTTATCCAAAATTTCCCCAGGAAGAAGGGC
GTAGCGTTTTGTTATCTACTTGTCATCGTGTGGAGCTATACGGCATGGCTACCGAGGCGATCTTTTCTACTTTGGAGAAA
GAAATTCGGGAAATGGGAGCTATCCCCTACTTTTATCGGAATCAGGATTGTTTTTCACATTTGTTTTGTGTAGTAGGAGG
TATGGATAGCTTAGTCCTTGGAGAGACTGAAATTCAAGGGCAGGTGAAGCGAGCCTATTTACAAGCTATTGAAGAGCAAA
AGCTTGCATTTGCTCTTCATTTTCTCTTTCAAAAAGCACTGAAAGAGGGGAAAGTTTTCCGAACAAAAAGAAGCTCGCCT
TCTACAGAAATTACCATTCCAGCTTTTGTACAGCACGAGTTGCAGAAACAAAAGATGGCAAGGAGCGCATCTTTGCTGTT
TATGGGATATTCTGAAATCAATCGTTCTGTAGCCTATTATCTACAAAAGCAAGGGTTCTCTCGCATTACATTTTGTTCTC
GTCAGCCACTTTCGCTTCGATCTATGGATCAAGTATTGCGAGAAGAGGTGTGTTTTCAAGATCCTTATCATGTGATATTT
TTGGGTTCTTCTGAACTGCGGCATGCTTTTCCTAGATCGCTCTGGGAAGGTGTGTGGGATTTTCCTGGACGGCTGGTTTT
TGATTTTGCAGTTCCTCGTGCTCTCCCTGTACAGCCAGCTTGCCGTGATCGTTATATCGATATGGAACAGATTAGCGATT
GGTTGAGACAGCATCAAAAAGAAGTCTTCCCATTGCAACTCGATAGTTTGAGAGAGGTGGGTTATCGTTATTGGGAATCT
TTGAATAGAAGGCTTGCACGGCGTCGTTATGCAAGCGTGTGA

Upstream 100 bases:

>100_bases
GGTAACGCGAGAGCTATCAAAAATATTGGTATAAAATTAAGAAACTAAGAGAGAATAGGCCAACCAAGAGAGGAAGCTGA
AGGAGCAAAGCGGAACCGCA

Downstream 100 bases:

>100_bases
GCCTAATCTCGGATGATTACAATGCAGGTTTTTCCCCCGAAAAGAATGCCGATATGTTAAAGGTCTGTAACTGACCTTTC
AATGGAAATCACAAACTTCT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVREGEEHIDEEFSLGVIGVSYRETALQQREQVLQFLQQAQLSFYPKFPQEEGRSVLLSTCHRVELYGMATEAIFSTLEK
EIREMGAIPYFYRNQDCFSHLFCVVGGMDSLVLGETEIQGQVKRAYLQAIEEQKLAFALHFLFQKALKEGKVFRTKRSSP
STEITIPAFVQHELQKQKMARSASLLFMGYSEINRSVAYYLQKQGFSRITFCSRQPLSLRSMDQVLREEVCFQDPYHVIF
LGSSELRHAFPRSLWEGVWDFPGRLVFDFAVPRALPVQPACRDRYIDMEQISDWLRQHQKEVFPLQLDSLREVGYRYWES
LNRRLARRRYASV

Sequences:

>Translated_333_residues
MVREGEEHIDEEFSLGVIGVSYRETALQQREQVLQFLQQAQLSFYPKFPQEEGRSVLLSTCHRVELYGMATEAIFSTLEK
EIREMGAIPYFYRNQDCFSHLFCVVGGMDSLVLGETEIQGQVKRAYLQAIEEQKLAFALHFLFQKALKEGKVFRTKRSSP
STEITIPAFVQHELQKQKMARSASLLFMGYSEINRSVAYYLQKQGFSRITFCSRQPLSLRSMDQVLREEVCFQDPYHVIF
LGSSELRHAFPRSLWEGVWDFPGRLVFDFAVPRALPVQPACRDRYIDMEQISDWLRQHQKEVFPLQLDSLREVGYRYWES
LNRRLARRRYASV
>Mature_333_residues
MVREGEEHIDEEFSLGVIGVSYRETALQQREQVLQFLQQAQLSFYPKFPQEEGRSVLLSTCHRVELYGMATEAIFSTLEK
EIREMGAIPYFYRNQDCFSHLFCVVGGMDSLVLGETEIQGQVKRAYLQAIEEQKLAFALHFLFQKALKEGKVFRTKRSSP
STEITIPAFVQHELQKQKMARSASLLFMGYSEINRSVAYYLQKQGFSRITFCSRQPLSLRSMDQVLREEVCFQDPYHVIF
LGSSELRHAFPRSLWEGVWDFPGRLVFDFAVPRALPVQPACRDRYIDMEQISDWLRQHQKEVFPLQLDSLREVGYRYWES
LNRRLARRRYASV

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=234, Percent_Identity=29.0598290598291, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CHLMU (Q9PLR2)

Other databases:

- EMBL:   AE002160
- PIR:   E81748
- RefSeq:   NP_296417.1
- ProteinModelPortal:   Q9PLR2
- GeneID:   1245558
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0033
- TIGR:   TC_0033
- HOGENOM:   HBG413932
- OMA:   IFFGSSE
- ProtClustDB:   PRK00676
- BioCyc:   CMUR243161:TC_0033-MONOMER
- BRENDA:   1.2.1.70
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015895
- InterPro:   IPR018214

Pfam domain/function: PF05201 GlutR_N; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 39016; Mature: 39016

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 61-61 BINDING 110-110 BINDING 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREGEEHIDEEFSLGVIGVSYRETALQQREQVLQFLQQAQLSFYPKFPQEEGRSVLLST
CCCCCHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
CHRVELYGMATEAIFSTLEKEIREMGAIPYFYRNQDCFSHLFCVVGGMDSLVLGETEIQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCHHEECCHHHHH
QVKRAYLQAIEEQKLAFALHFLFQKALKEGKVFRTKRSSPSTEITIPAFVQHELQKQKMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHH
RSASLLFMGYSEINRSVAYYLQKQGFSRITFCSRQPLSLRSMDQVLREEVCFQDPYHVIF
HHHHHHEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEE
LGSSELRHAFPRSLWEGVWDFPGRLVFDFAVPRALPVQPACRDRYIDMEQISDWLRQHQK
ECCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHH
EVFPLQLDSLREVGYRYWESLNRRLARRRYASV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVREGEEHIDEEFSLGVIGVSYRETALQQREQVLQFLQQAQLSFYPKFPQEEGRSVLLST
CCCCCHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
CHRVELYGMATEAIFSTLEKEIREMGAIPYFYRNQDCFSHLFCVVGGMDSLVLGETEIQG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHCCCCHHEECCHHHHH
QVKRAYLQAIEEQKLAFALHFLFQKALKEGKVFRTKRSSPSTEITIPAFVQHELQKQKMA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCEEEHHHHHHHHHHHHHHH
RSASLLFMGYSEINRSVAYYLQKQGFSRITFCSRQPLSLRSMDQVLREEVCFQDPYHVIF
HHHHHHEEEHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEE
LGSSELRHAFPRSLWEGVWDFPGRLVFDFAVPRALPVQPACRDRYIDMEQISDWLRQHQK
ECCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHH
EVFPLQLDSLREVGYRYWESLNRRLARRRYASV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10684935