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The map label for this gene is mraY

Identifier: 158338874

GI number: 158338874

Start: 5869687

End: 5870802

Strand: Direct

Name: mraY

Synonym: AM1_5787

Alternate gene names: 158338874

Gene position: 5869687-5870802 (Clockwise)

Preceding gene: 158338873

Following gene: 158338876

Centisome position: 90.25

GC content: 50.54

Gene sequence:

>1116_bases
ATGGTCCTTGCAAATAAGACCACTGCGTCAACTCGATCTGGGGCTGGCCGTAATTTGTATTGGTTATTACTCCTGTGTCT
CAGTGGAGTCGCTTTAGCCACGGATATTTACTCCGGCCGTATTGACACCCCTGCTTTAACGATTGTGGCCCCTCTGTGGA
CTAGTACCCTTGTGGTTACGCTATTGGGATTTTGGGCAGTTCCAATGTTGCGATCGCTCAAAGCATCCCAAGTCATCCAA
GAAGACGGTCCCCAGAGTCACCTAAAAAAGGCAGGCACCCCCACCATGGGCGGCATTTTCTTTATGCCGGTGGCTTTGGT
ATTAGGTTGGGCTTGGGTCGCCGCCAATAGCGTTAATTTACTCGAAGTATCTGCAGCAGTCCTCCTTACCCTCTGTTTAG
GTTTGGTGGGCTGGTTTGATGACTGGCAAATCCTGCGCAAAAAATCTAACAAGGGTATCTCGGCAAAGTTGAGATTGGGC
ATCGAATTAGGCAGTGGTCTGATCTTTGGATTGTGGCTCTTTTTAACCCGCTCAGACATTAGTGGGTTGGCTTTACCCTT
TGGGCTTAGCCTTCCAATCGGCGTGCTGTTTTTAGCTATCTCTACCTTCGTTGTGGCAGCAGAAAGTAACGCCGTTAACT
TAACGGATGGTATGGATGGATTAGCGGCGGGCACTAGTGCGATCGCATTCCTCGGACTCGCCCTTGTGGTTGCACCGAGT
TGGCCAGGACTGATGATCTTCTGTGCCTGCTTTTCAGGAAGCTGTTTAGGATTTTTGGCCCACAACCATAATCCGGCCCA
AGTCTTTATGGGTGATACCGGATCGTTAGCTTTGGGCGGTGCTCTAGCGGCTGTAGGATTAATTACCAATACCTTATGGG
CATTACTGATTTTGAGTGGACTCTTTCTAGTAGAGTCCCTATCCGTAATTGCCCAAGTGACCTACTACAAAGCCACTAAG
GGGCCTGATGGGGTGGGCAAACGCCTTTTCAAAATGTCCCCCATTCACCACCATTTCGAGCAATCTGGCTGGCCCGAAGT
CCGGGTTGTATCCACCTTTTACGCTTGCGTTGCCGTTTTAGCGGTGGCGGCCTGCGGCCTGAATGCCCTCAGCTAG

Upstream 100 bases:

>100_bases
CGGGCCAAAACGGTCTTAGAAGAAGAGGAAAGCGAAGAAATCAATGCCCTGATGGGGGGCGATGACGATGCGGATGACGA
TGAGGAATAAGTAAAAAAAC

Downstream 100 bases:

>100_bases
TTTCTCTATTACACCTATTAAAACTGATCTTTCATACCCCGTAGCCGTGCAAAACACTGGACCGGGGTATTGCTTTTGGT
ATGGATAATTAAATGGGGCT

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MVLANKTTASTRSGAGRNLYWLLLLCLSGVALATDIYSGRIDTPALTIVAPLWTSTLVVTLLGFWAVPMLRSLKASQVIQ
EDGPQSHLKKAGTPTMGGIFFMPVALVLGWAWVAANSVNLLEVSAAVLLTLCLGLVGWFDDWQILRKKSNKGISAKLRLG
IELGSGLIFGLWLFLTRSDISGLALPFGLSLPIGVLFLAISTFVVAAESNAVNLTDGMDGLAAGTSAIAFLGLALVVAPS
WPGLMIFCACFSGSCLGFLAHNHNPAQVFMGDTGSLALGGALAAVGLITNTLWALLILSGLFLVESLSVIAQVTYYKATK
GPDGVGKRLFKMSPIHHHFEQSGWPEVRVVSTFYACVAVLAVAACGLNALS

Sequences:

>Translated_371_residues
MVLANKTTASTRSGAGRNLYWLLLLCLSGVALATDIYSGRIDTPALTIVAPLWTSTLVVTLLGFWAVPMLRSLKASQVIQ
EDGPQSHLKKAGTPTMGGIFFMPVALVLGWAWVAANSVNLLEVSAAVLLTLCLGLVGWFDDWQILRKKSNKGISAKLRLG
IELGSGLIFGLWLFLTRSDISGLALPFGLSLPIGVLFLAISTFVVAAESNAVNLTDGMDGLAAGTSAIAFLGLALVVAPS
WPGLMIFCACFSGSCLGFLAHNHNPAQVFMGDTGSLALGGALAAVGLITNTLWALLILSGLFLVESLSVIAQVTYYKATK
GPDGVGKRLFKMSPIHHHFEQSGWPEVRVVSTFYACVAVLAVAACGLNALS
>Mature_371_residues
MVLANKTTASTRSGAGRNLYWLLLLCLSGVALATDIYSGRIDTPALTIVAPLWTSTLVVTLLGFWAVPMLRSLKASQVIQ
EDGPQSHLKKAGTPTMGGIFFMPVALVLGWAWVAANSVNLLEVSAAVLLTLCLGLVGWFDDWQILRKKSNKGISAKLRLG
IELGSGLIFGLWLFLTRSDISGLALPFGLSLPIGVLFLAISTFVVAAESNAVNLTDGMDGLAAGTSAIAFLGLALVVAPS
WPGLMIFCACFSGSCLGFLAHNHNPAQVFMGDTGSLALGGALAAVGLITNTLWALLILSGLFLVESLSVIAQVTYYKATK
GPDGVGKRLFKMSPIHHHFEQSGWPEVRVVSTFYACVAVLAVAACGLNALS

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:
GO:0005886: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0007047: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0007049: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0008360: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0008963: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0009252: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0016020: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0016021: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0016740: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0051301: Phospho-N-acetylmuramoyl-pentapeptide-transferase
GO:0051992: Phospho-N-acetylmuramoyl-pentapeptide-transferase

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=331, Percent_Identity=35.9516616314199, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_ACAM1 (B0BZI7)

Other databases:

- EMBL:   CP000828
- RefSeq:   YP_001520051.1
- GeneID:   5684574
- GenomeReviews:   CP000828_GR
- KEGG:   amr:AM1_5787
- HOGENOM:   HBG708263
- OMA:   TFWQFRN
- BioCyc:   AMAR329726:AM1_5787-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 38993; Mature: 38993

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x14b48480)-; HASH(0x11dd3a0c)-; HASH(0xe113a1c)-; HASH(0x1398ba50)-; HASH(0x1398bb70)-; HASH(0x11dd2650)-; HASH(0x14fbd22c)-; HASH(0x13ae9944)-; HASH(0x12c4cd44)-;

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLANKTTASTRSGAGRNLYWLLLLCLSGVALATDIYSGRIDTPALTIVAPLWTSTLVVT
CEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LLGFWAVPMLRSLKASQVIQEDGPQSHLKKAGTPTMGGIFFMPVALVLGWAWVAANSVNL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
LEVSAAVLLTLCLGLVGWFDDWQILRKKSNKGISAKLRLGIELGSGLIFGLWLFLTRSDI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCC
SGLALPFGLSLPIGVLFLAISTFVVAAESNAVNLTDGMDGLAAGTSAIAFLGLALVVAPS
CCEECCCCCCHHHHHHHHHHHHHHHEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCC
WPGLMIFCACFSGSCLGFLAHNHNPAQVFMGDTGSLALGGALAAVGLITNTLWALLILSG
CCHHHHHHHHHCCCCEEEHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLVESLSVIAQVTYYKATKGPDGVGKRLFKMSPIHHHFEQSGWPEVRVVSTFYACVAVL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
AVAACGLNALS
HHHHHCCCCCH
>Mature Secondary Structure
MVLANKTTASTRSGAGRNLYWLLLLCLSGVALATDIYSGRIDTPALTIVAPLWTSTLVVT
CEECCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LLGFWAVPMLRSLKASQVIQEDGPQSHLKKAGTPTMGGIFFMPVALVLGWAWVAANSVNL
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
LEVSAAVLLTLCLGLVGWFDDWQILRKKSNKGISAKLRLGIELGSGLIFGLWLFLTRSDI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHCCC
SGLALPFGLSLPIGVLFLAISTFVVAAESNAVNLTDGMDGLAAGTSAIAFLGLALVVAPS
CCEECCCCCCHHHHHHHHHHHHHHHEECCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCC
WPGLMIFCACFSGSCLGFLAHNHNPAQVFMGDTGSLALGGALAAVGLITNTLWALLILSG
CCHHHHHHHHHCCCCEEEHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LFLVESLSVIAQVTYYKATKGPDGVGKRLFKMSPIHHHFEQSGWPEVRVVSTFYACVAVL
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHH
AVAACGLNALS
HHHHHCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA