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The map label for this gene is capL [H]

Identifier: 158338848

GI number: 158338848

Start: 5841049

End: 5842383

Strand: Direct

Name: capL [H]

Synonym: AM1_5761

Alternate gene names: 158338848

Gene position: 5841049-5842383 (Clockwise)

Preceding gene: 158338846

Following gene: 158338849

Centisome position: 89.81

GC content: 44.19

Gene sequence:

>1335_bases
ATGGGAAATTTTGAGAACTTCAACCACTTCTCCCAACTTCAAGACAGCATTCTCAATCGAAAAGCAGTTGTCTGTGTGAT
TGGATTAGGCTATGTTGGTCTCCCGTTTGCTGTAGAGAAAGCGAAAGCAGGATTCGATGTCGTTGGTGTTGAACAGAATC
CAGCGAGAGCGGGACAGGTGAATCAGTCGGACAGCTACATTGATGATATCAGTTCTGCAGAACTGGGGGCTGCTGTGAGC
GCCGGTAAGCTGAGGGCTTCAACTGATTTTGATGAGATCCGGAATGCTGATGTGATCGTTATCTGTGTCCCCACTCCGCT
AACAAAAAATCTAACTCCCGATTTAAGTTATATCGAAAGTGTCACCACAGAAATTTCACATCGGTTGAAACCTGGACAAT
TAATTGCATTGGAGTCTACGACGTATCCAGGCACAACTGATGAGGTGATGCGACCTATTCTGGAAAAAAATAGTGGATTA
GTTCAGGGAAAAGATTTCTTTCTAGCTCATTCCCCAGAACGGGTTGATCCTGGTAACCAGCGTTATACCACTCAGAATAC
AAATAAGGTTGTGGGCGCATCTGATGCACAATCCTTGGAAATAGCATTGTGTTTTTACCAACAAACCATTCAACATGTTG
TCCCGGTAAGCAGTGCGAAGGCTGCAGAATTGGTAAAGGTATTTGAGAATACTTTTCGTGCGGTCAATATTGCCTTGGTA
AATGAGCTGGCATTGTTGTGCGATCGCATTGACTTAGATGTATGGGAAGTGCTAGATGCCGCTAACACTAAACCTTTTGG
GATTATGCCCTTCTACCCTGGCCCAGGGGTAGGTGGTCATTGTATTCCTATTGATCCACATTATTTGGAGTGGAAAGCGA
AAGAAGTCAATTTTAATACGCGCTTTATTGCTTTAGCAGGTGAGATTAATCGCCGTATGCCCTCTTTTGTGAGGAGTAAA
GCTTTTAGAGTACTGAATCAGTTGGGAATAGCGCCTTCTAAAGCCCAAGTTTTAGTTTTGGGTGCCACCTACAAAAAAGA
CTTGGCGGATTGGAGAGAGTCCCCTGCGATCGAGGTGATGACAGCCTTAAAAAGAGATCAGGTTAACCTGTCCTATCACG
ATCTATATATTCCTGAAATTCAAGTGGATGGACAAGTTCTGAACAGTATTGAGTTGACCCCAGAAACATTAGCCCAGATG
GATCTGGTGCTCATTGCAACAGACCATAGTTGTGTTGACTACCCCTACGTAGTGCAGCATGCTAAAGCAGTTTTGGATAC
CCGTGGTATTACTCGCACATTGGACTGCGATCACACTAAAGTAACATTGCTCTGA

Upstream 100 bases:

>100_bases
TAAATATCTGCCCAATATTTCTACTCAGGATTCACAGAAATAGAAACAAAATCATTATTTTTTTAGGTATCTTTTGATGG
TCCAGGCTTCTTTACCTGAA

Downstream 100 bases:

>100_bases
TTCTTAAGGGTGCTTACTGAATGTTCTAAGAGAATTAATCAGCAATGGAAAAACAGGTAAAAATTAGCCTGCATTCAATC
TGTTTAAGTCCTCTTCAAAT

Product: UDP-N-acetyl-D-mannosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MGNFENFNHFSQLQDSILNRKAVVCVIGLGYVGLPFAVEKAKAGFDVVGVEQNPARAGQVNQSDSYIDDISSAELGAAVS
AGKLRASTDFDEIRNADVIVICVPTPLTKNLTPDLSYIESVTTEISHRLKPGQLIALESTTYPGTTDEVMRPILEKNSGL
VQGKDFFLAHSPERVDPGNQRYTTQNTNKVVGASDAQSLEIALCFYQQTIQHVVPVSSAKAAELVKVFENTFRAVNIALV
NELALLCDRIDLDVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEVNFNTRFIALAGEINRRMPSFVRSK
AFRVLNQLGIAPSKAQVLVLGATYKKDLADWRESPAIEVMTALKRDQVNLSYHDLYIPEIQVDGQVLNSIELTPETLAQM
DLVLIATDHSCVDYPYVVQHAKAVLDTRGITRTLDCDHTKVTLL

Sequences:

>Translated_444_residues
MGNFENFNHFSQLQDSILNRKAVVCVIGLGYVGLPFAVEKAKAGFDVVGVEQNPARAGQVNQSDSYIDDISSAELGAAVS
AGKLRASTDFDEIRNADVIVICVPTPLTKNLTPDLSYIESVTTEISHRLKPGQLIALESTTYPGTTDEVMRPILEKNSGL
VQGKDFFLAHSPERVDPGNQRYTTQNTNKVVGASDAQSLEIALCFYQQTIQHVVPVSSAKAAELVKVFENTFRAVNIALV
NELALLCDRIDLDVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEVNFNTRFIALAGEINRRMPSFVRSK
AFRVLNQLGIAPSKAQVLVLGATYKKDLADWRESPAIEVMTALKRDQVNLSYHDLYIPEIQVDGQVLNSIELTPETLAQM
DLVLIATDHSCVDYPYVVQHAKAVLDTRGITRTLDCDHTKVTLL
>Mature_443_residues
GNFENFNHFSQLQDSILNRKAVVCVIGLGYVGLPFAVEKAKAGFDVVGVEQNPARAGQVNQSDSYIDDISSAELGAAVSA
GKLRASTDFDEIRNADVIVICVPTPLTKNLTPDLSYIESVTTEISHRLKPGQLIALESTTYPGTTDEVMRPILEKNSGLV
QGKDFFLAHSPERVDPGNQRYTTQNTNKVVGASDAQSLEIALCFYQQTIQHVVPVSSAKAAELVKVFENTFRAVNIALVN
ELALLCDRIDLDVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEVNFNTRFIALAGEINRRMPSFVRSKA
FRVLNQLGIAPSKAQVLVLGATYKKDLADWRESPAIEVMTALKRDQVNLSYHDLYIPEIQVDGQVLNSIELTPETLAQMD
LVLIATDHSCVDYPYVVQHAKAVLDTRGITRTLDCDHTKVTLL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=378, Percent_Identity=26.1904761904762, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI296040438, Length=287, Percent_Identity=25.4355400696864, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI48994968, Length=432, Percent_Identity=32.4074074074074, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1788340, Length=394, Percent_Identity=23.3502538071066, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560350, Length=394, Percent_Identity=25.3807106598985, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136908, Length=393, Percent_Identity=25.9541984732824, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 48871; Mature: 48740

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNFENFNHFSQLQDSILNRKAVVCVIGLGYVGLPFAVEKAKAGFDVVGVEQNPARAGQV
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
NQSDSYIDDISSAELGAAVSAGKLRASTDFDEIRNADVIVICVPTPLTKNLTPDLSYIES
CCCCHHHHCCCCHHHCCHHCCCCEECCCCHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
VTTEISHRLKPGQLIALESTTYPGTTDEVMRPILEKNSGLVQGKDFFLAHSPERVDPGNQ
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCC
RYTTQNTNKVVGASDAQSLEIALCFYQQTIQHVVPVSSAKAAELVKVFENTFRAVNIALV
EEECCCCCEEECCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEHHHHH
NELALLCDRIDLDVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEVNFNT
HHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEEEEECCCE
RFIALAGEINRRMPSFVRSKAFRVLNQLGIAPSKAQVLVLGATYKKDLADWRESPAIEVM
EEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHH
TALKRDQVNLSYHDLYIPEIQVDGQVLNSIELTPETLAQMDLVLIATDHSCVDYPYVVQH
HHHHHCCCCCEEEEEECCEEEECCHHHCCEECCHHHHHHCEEEEEEECCCCCCCHHHHHH
AKAVLDTRGITRTLDCDHTKVTLL
HHHHHHCCCCEEEECCCCCEEEEC
>Mature Secondary Structure 
GNFENFNHFSQLQDSILNRKAVVCVIGLGYVGLPFAVEKAKAGFDVVGVEQNPARAGQV
CCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHCCCCEEEECCCCCCCCCCC
NQSDSYIDDISSAELGAAVSAGKLRASTDFDEIRNADVIVICVPTPLTKNLTPDLSYIES
CCCCHHHHCCCCHHHCCHHCCCCEECCCCHHHHCCCCEEEEEECCCCCCCCCCCHHHHHH
VTTEISHRLKPGQLIALESTTYPGTTDEVMRPILEKNSGLVQGKDFFLAHSPERVDPGNQ
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEECCEEEEECCCCCCCCCCC
RYTTQNTNKVVGASDAQSLEIALCFYQQTIQHVVPVSSAKAAELVKVFENTFRAVNIALV
EEECCCCCEEECCCCCCCEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEHHHHH
NELALLCDRIDLDVWEVLDAANTKPFGIMPFYPGPGVGGHCIPIDPHYLEWKAKEVNFNT
HHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCEEEECCCCEEEEEEEEECCCE
RFIALAGEINRRMPSFVRSKAFRVLNQLGIAPSKAQVLVLGATYKKDLADWRESPAIEVM
EEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCHHHHH
TALKRDQVNLSYHDLYIPEIQVDGQVLNSIELTPETLAQMDLVLIATDHSCVDYPYVVQH
HHHHHCCCCCEEEEEECCEEEECCHHHCCEECCHHHHHHCEEEEEEECCCCCCCHHHHHH
AKAVLDTRGITRTLDCDHTKVTLL
HHHHHHCCCCEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]