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The map label for this gene is hisC [H]

Identifier: 158338820

GI number: 158338820

Start: 5813036

End: 5814136

Strand: Reverse

Name: hisC [H]

Synonym: AM1_5733

Alternate gene names: 158338820

Gene position: 5814136-5813036 (Counterclockwise)

Preceding gene: 158338821

Following gene: 158338819

Centisome position: 89.4

GC content: 49.95

Gene sequence:

>1101_bases
ATGACCCTAAATCTAGATACCCTCGAACAGTGGGTAAGCCCCTCTATTCGCAGCCTCGCCTCCAAAACGGTAGGTCCCCA
TAAAGATGACCAAGCGATTCGTCTGGACAAAGGCGAGTTACCCTATCCCCCTTCCCCCAAAGTGGTGGAGGCCATTACCC
AAGTTGCCACCACTTGTAATCGGTATCCCGCTGTCCTAGGAGGGGTTTTACGAGAGAGACTCGCTACCTACACCGGGGCC
TCTCCTGAGCAGCTCATTATCAGCAATGGATCTGATGATCTGATTGAGCTGATTATCAAGGTCTTTGTTCAACCTGGGCA
GCAAGTGCTTTTGCCCGTGCCCAGCTTTTTTGTCTATTGGCATGCAACCCAGGTGATGGGAGGTGTACCGGTCTTTGTCC
AACGGACCCCTGATTTTGGCCTGGATGTAGATGCCTTGGTAGCCAAAGTCGCCCCCGACACCAAAGTGTTGTACATTGCC
AATCCCAATAATCCCACCGCGAATTTAGTGGCCCGTGAAACCTTGGTGGAGGTGCTGAATCGAGTCAACTGCATGGTCGT
GGTGGATGAATGTTACTTTGAGCTATGCCAAACCACAATCGCGGATCTCGTGGATACCTATCCCCATCTAATTGTGCTGC
GTAGCCTTTCCAAGAGTTTTGGACTAGCTGGTTTGCGCATTGGCTATGGGATTGCCAATACCCAAGTGGTGGATTACCTC
TACCGGGCCGCCCAGTTGTTTCCGGTGAATAAAGTTGCGATCTCAGCTGGTATTGCTGCCCTCAAAGATCAGGCGTATGT
TGAGGCTAATATCCAGAAAATTCTGGCAGAGAAACCTCGATTACAGCAGGCATTAACGGATCTAGGATTGAAGGTCCATC
CCAGCGAAACCAATTTCCTCTTAGTGGATACCCAGCCATTAAACCTGCAGTCAAAAGTTTTAGTTAAAGCGCTCCAAGAA
CAAAATATCTGGGTTGCAGATTTTGGCTCTAAGCCTGGATTAGGAGATCATTATTTCCGCACAGCCGTGGGGACACCGGC
TGAGAATCAAGCCTTGCTCAAGGGATTGGAAGTCGCGATCTCTCAATCCACCTCTGTGTAA

Upstream 100 bases:

>100_bases
GGGCCAAGGCCGAACAGGTGCAAATGTTCTCGAATCTTGGCTGTGACCGAGTGATTGAGAGTATCCAAGCTTTGCCTCAA
GTGTTAGGAATTGAGCCGAC

Downstream 100 bases:

>100_bases
TGCTTTCTGTGATCAAGATCACTGGGAACTTCCGTCATCATCACCGCGACAATTGAATAAACCGGGCATACTCGGAAGTG
TGATGGGTGATGAGGTCAGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTLNLDTLEQWVSPSIRSLASKTVGPHKDDQAIRLDKGELPYPPSPKVVEAITQVATTCNRYPAVLGGVLRERLATYTGA
SPEQLIISNGSDDLIELIIKVFVQPGQQVLLPVPSFFVYWHATQVMGGVPVFVQRTPDFGLDVDALVAKVAPDTKVLYIA
NPNNPTANLVARETLVEVLNRVNCMVVVDECYFELCQTTIADLVDTYPHLIVLRSLSKSFGLAGLRIGYGIANTQVVDYL
YRAAQLFPVNKVAISAGIAALKDQAYVEANIQKILAEKPRLQQALTDLGLKVHPSETNFLLVDTQPLNLQSKVLVKALQE
QNIWVADFGSKPGLGDHYFRTAVGTPAENQALLKGLEVAISQSTSV

Sequences:

>Translated_366_residues
MTLNLDTLEQWVSPSIRSLASKTVGPHKDDQAIRLDKGELPYPPSPKVVEAITQVATTCNRYPAVLGGVLRERLATYTGA
SPEQLIISNGSDDLIELIIKVFVQPGQQVLLPVPSFFVYWHATQVMGGVPVFVQRTPDFGLDVDALVAKVAPDTKVLYIA
NPNNPTANLVARETLVEVLNRVNCMVVVDECYFELCQTTIADLVDTYPHLIVLRSLSKSFGLAGLRIGYGIANTQVVDYL
YRAAQLFPVNKVAISAGIAALKDQAYVEANIQKILAEKPRLQQALTDLGLKVHPSETNFLLVDTQPLNLQSKVLVKALQE
QNIWVADFGSKPGLGDHYFRTAVGTPAENQALLKGLEVAISQSTSV
>Mature_365_residues
TLNLDTLEQWVSPSIRSLASKTVGPHKDDQAIRLDKGELPYPPSPKVVEAITQVATTCNRYPAVLGGVLRERLATYTGAS
PEQLIISNGSDDLIELIIKVFVQPGQQVLLPVPSFFVYWHATQVMGGVPVFVQRTPDFGLDVDALVAKVAPDTKVLYIAN
PNNPTANLVARETLVEVLNRVNCMVVVDECYFELCQTTIADLVDTYPHLIVLRSLSKSFGLAGLRIGYGIANTQVVDYLY
RAAQLFPVNKVAISAGIAALKDQAYVEANIQKILAEKPRLQQALTDLGLKVHPSETNFLLVDTQPLNLQSKVLVKALQEQ
NIWVADFGSKPGLGDHYFRTAVGTPAENQALLKGLEVAISQSTSV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:
GO:0000105: Histidinol-phosphate aminotransferase
GO:0003824: Histidinol-phosphate aminotransferase
GO:0004400: Histidinol-phosphate aminotransferase
GO:0008483: Histidinol-phosphate aminotransferase
GO:0008652: Histidinol-phosphate aminotransferase
GO:0009058: Histidinol-phosphate aminotransferase
GO:0016740: Histidinol-phosphate aminotransferase
GO:0016769: Histidinol-phosphate aminotransferase
GO:0030170: Histidinol-phosphate aminotransferase

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=308, Percent_Identity=34.0909090909091, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1788627, Length=163, Percent_Identity=30.0613496932515, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=267, Percent_Identity=24.3445692883895, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=153, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=153, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=27.7333333333333, Blast_Score=112, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39915; Mature: 39784

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNLDTLEQWVSPSIRSLASKTVGPHKDDQAIRLDKGELPYPPSPKVVEAITQVATTCN
CCCCHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RYPAVLGGVLRERLATYTGASPEQLIISNGSDDLIELIIKVFVQPGQQVLLPVPSFFVYW
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHH
HATQVMGGVPVFVQRTPDFGLDVDALVAKVAPDTKVLYIANPNNPTANLVARETLVEVLN
HHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
RVNCMVVVDECYFELCQTTIADLVDTYPHLIVLRSLSKSFGLAGLRIGYGIANTQVVDYL
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
YRAAQLFPVNKVAISAGIAALKDQAYVEANIQKILAEKPRLQQALTDLGLKVHPSETNFL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCEE
LVDTQPLNLQSKVLVKALQEQNIWVADFGSKPGLGDHYFRTAVGTPAENQALLKGLEVAI
EEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHH
SQSTSV
HCCCCC
>Mature Secondary Structure 
TLNLDTLEQWVSPSIRSLASKTVGPHKDDQAIRLDKGELPYPPSPKVVEAITQVATTCN
CCCHHHHHHHHCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RYPAVLGGVLRERLATYTGASPEQLIISNGSDDLIELIIKVFVQPGQQVLLPVPSFFVYW
HHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCHHHHHH
HATQVMGGVPVFVQRTPDFGLDVDALVAKVAPDTKVLYIANPNNPTANLVARETLVEVLN
HHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
RVNCMVVVDECYFELCQTTIADLVDTYPHLIVLRSLSKSFGLAGLRIGYGIANTQVVDYL
CCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
YRAAQLFPVNKVAISAGIAALKDQAYVEANIQKILAEKPRLQQALTDLGLKVHPSETNFL
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCEE
LVDTQPLNLQSKVLVKALQEQNIWVADFGSKPGLGDHYFRTAVGTPAENQALLKGLEVAI
EEECCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHH
SQSTSV
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]