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The map label for this gene is pkn1 [H]

Identifier: 158338779

GI number: 158338779

Start: 5757342

End: 5758640

Strand: Direct

Name: pkn1 [H]

Synonym: AM1_5690

Alternate gene names: 158338779

Gene position: 5757342-5758640 (Clockwise)

Preceding gene: 158338778

Following gene: 158338780

Centisome position: 88.52

GC content: 52.35

Gene sequence:

>1299_bases
ATGCCCTCTAAGGAACTATTTTCTGGAACAGAACCGCTGCAATTAGAGATTAAGGACACCTTGACCCAATCCCGCGCCCG
CACCCTCCAGCTTTTTGAAGGCGTTAGTGAGGAGACGTTTCGCCTGCAAGCCAATTCTGACTTTAGCCCGGTGGGGTGGC
ATTTGGGACATATTGGCTTTACCGAAGGACTGTGGCTTTTAGAACATGAAGCTGGATATGCCCCCCTGTTTCCAGAGTAT
CGGCGGTTATTTGCGGCGGATGGCTTACCTAAGGCTGAGCGCCAAAACCTGCCCTCCTTTGCGGAAATATGTGCCTATCT
AGAGCAAATCCGGAATCAAGTTTGGGACTATTTGCTAGAAGCCCCTTTAGACACTCGGGCTTGGCTATGGCATTGGTTAG
TCCAGCACGAAAGCCAGCATTGCGAGACCATCACCTGGGTGCTCCAACTGCATCGCCGACAATCCCAACCCGTTTCGTTT
GTGGCCAAGGAAAAGCCATGGCCTGCTGCCCTTGTCAGTACCTCTAAAGAGAAGCCCACCCTGCCAGATCATCAAGACAT
GGTTCCCATTGAAGGGGGGCAGTTTCTCTTAGGCAATGACGGTTTGGAAGCCCTCGATAACGAAAGAAAAGCCCATTGGG
TTCAGGTGGATTCATTTTGGATCGATCGATTTCCCGTGACTCAAGGCCAGTATCAACAGTTCATTGAAGCGGGGGGATAT
CGTCAGTCCCAATTTTGGTCAGATGAGGGATGGCAATGGTTACAAGAGAATCCCGTTAACCATCCCACCCATTGGCTTGC
CGAGGGGGGAGCTGATCATCCCGTCTGTGGGGTGAGCTGGTATGAAGCAGATGCCTATGCTCGGTTTGTGGGCAAACGAC
TACCGACGGAGGCGGAATGGGAGAAGGCAGCCTGTTGGCAGCCTAGACCTCAGGATCCACCCACCAAGCGAATCTATCCT
TGGGGCAACCAGACCCCGGACAACCACCACTGTAATCATGGGGGCTTGCATTGGGGGACGACCCCCGTTCATCAGTATGC
AAACGGGCAAAGCGCCTTTGGTTGTTTCGATTTACTAGGCAATGTTTGGGAATGGACCAATACCTGGTTCCATCCCTTTC
CTGATTTCGATCCCTATCCCTACAAAGGCTATTCCATGGTTTATTTTGATCACCAGCATCGCATCTTAAAAGGGGGGAGT
TGGGCGACCCAGGCCCCGGTTCTTAGGGGGGCCTTCCGTAACTGGTATGAGCCTCGGATTCGAATTCATTTTGCAGGGTT
TCGCTGTGCCTATGGGTGA

Upstream 100 bases:

>100_bases
GATGCCGATGCAGAGATGCGATCGCAATTTGGGGAGCGTTGGCAATCCATTCCAGCCAACTGTTTGTTAACCATCAATCC
CAGGAGAGAAGTTGCCACCC

Downstream 100 bases:

>100_bases
TTGTGCGGGTTTGTTGGGGATGGTTTACAGTGGTTGGGAACCTAAGGCGACCCCTGTGTTGCCTCCCTGTTGGAGACCTC
TCACCCATGCTTGAGTCTGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MPSKELFSGTEPLQLEIKDTLTQSRARTLQLFEGVSEETFRLQANSDFSPVGWHLGHIGFTEGLWLLEHEAGYAPLFPEY
RRLFAADGLPKAERQNLPSFAEICAYLEQIRNQVWDYLLEAPLDTRAWLWHWLVQHESQHCETITWVLQLHRRQSQPVSF
VAKEKPWPAALVSTSKEKPTLPDHQDMVPIEGGQFLLGNDGLEALDNERKAHWVQVDSFWIDRFPVTQGQYQQFIEAGGY
RQSQFWSDEGWQWLQENPVNHPTHWLAEGGADHPVCGVSWYEADAYARFVGKRLPTEAEWEKAACWQPRPQDPPTKRIYP
WGNQTPDNHHCNHGGLHWGTTPVHQYANGQSAFGCFDLLGNVWEWTNTWFHPFPDFDPYPYKGYSMVYFDHQHRILKGGS
WATQAPVLRGAFRNWYEPRIRIHFAGFRCAYG

Sequences:

>Translated_432_residues
MPSKELFSGTEPLQLEIKDTLTQSRARTLQLFEGVSEETFRLQANSDFSPVGWHLGHIGFTEGLWLLEHEAGYAPLFPEY
RRLFAADGLPKAERQNLPSFAEICAYLEQIRNQVWDYLLEAPLDTRAWLWHWLVQHESQHCETITWVLQLHRRQSQPVSF
VAKEKPWPAALVSTSKEKPTLPDHQDMVPIEGGQFLLGNDGLEALDNERKAHWVQVDSFWIDRFPVTQGQYQQFIEAGGY
RQSQFWSDEGWQWLQENPVNHPTHWLAEGGADHPVCGVSWYEADAYARFVGKRLPTEAEWEKAACWQPRPQDPPTKRIYP
WGNQTPDNHHCNHGGLHWGTTPVHQYANGQSAFGCFDLLGNVWEWTNTWFHPFPDFDPYPYKGYSMVYFDHQHRILKGGS
WATQAPVLRGAFRNWYEPRIRIHFAGFRCAYG
>Mature_431_residues
PSKELFSGTEPLQLEIKDTLTQSRARTLQLFEGVSEETFRLQANSDFSPVGWHLGHIGFTEGLWLLEHEAGYAPLFPEYR
RLFAADGLPKAERQNLPSFAEICAYLEQIRNQVWDYLLEAPLDTRAWLWHWLVQHESQHCETITWVLQLHRRQSQPVSFV
AKEKPWPAALVSTSKEKPTLPDHQDMVPIEGGQFLLGNDGLEALDNERKAHWVQVDSFWIDRFPVTQGQYQQFIEAGGYR
QSQFWSDEGWQWLQENPVNHPTHWLAEGGADHPVCGVSWYEADAYARFVGKRLPTEAEWEKAACWQPRPQDPPTKRIYPW
GNQTPDNHHCNHGGLHWGTTPVHQYANGQSAFGCFDLLGNVWEWTNTWFHPFPDFDPYPYKGYSMVYFDHQHRILKGGSW
ATQAPVLRGAFRNWYEPRIRIHFAGFRCAYG

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI194248087, Length=274, Percent_Identity=32.4817518248175, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI194248088, Length=287, Percent_Identity=31.3588850174216, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI257470975, Length=276, Percent_Identity=30.7971014492754, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI38202250, Length=296, Percent_Identity=30.0675675675676, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI257470977, Length=227, Percent_Identity=31.2775330396476, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226437577, Length=175, Percent_Identity=35.4285714285714, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194248090, Length=165, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20130397, Length=298, Percent_Identity=26.8456375838926, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 50200; Mature: 50069

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKELFSGTEPLQLEIKDTLTQSRARTLQLFEGVSEETFRLQANSDFSPVGWHLGHIGF
CCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCCCC
TEGLWLLEHEAGYAPLFPEYRRLFAADGLPKAERQNLPSFAEICAYLEQIRNQVWDYLLE
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
APLDTRAWLWHWLVQHESQHCETITWVLQLHRRQSQPVSFVAKEKPWPAALVSTSKEKPT
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCC
LPDHQDMVPIEGGQFLLGNDGLEALDNERKAHWVQVDSFWIDRFPVTQGQYQQFIEAGGY
CCCCCCEEECCCCEEEECCCCHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCC
RQSQFWSDEGWQWLQENPVNHPTHWLAEGGADHPVCGVSWYEADAYARFVGKRLPTEAEW
CCHHCCCCCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCH
EKAACWQPRPQDPPTKRIYPWGNQTPDNHHCNHGGLHWGTTPVHQYANGQSAFGCFDLLG
HHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
NVWEWTNTWFHPFPDFDPYPYKGYSMVYFDHQHRILKGGSWATQAPVLRGAFRNWYEPRI
HHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHCCCCEE
RIHFAGFRCAYG
EEEEECEEECCC
>Mature Secondary Structure 
PSKELFSGTEPLQLEIKDTLTQSRARTLQLFEGVSEETFRLQANSDFSPVGWHLGHIGF
CCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCCCC
TEGLWLLEHEAGYAPLFPEYRRLFAADGLPKAERQNLPSFAEICAYLEQIRNQVWDYLLE
CCCEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
APLDTRAWLWHWLVQHESQHCETITWVLQLHRRQSQPVSFVAKEKPWPAALVSTSKEKPT
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCCCCCC
LPDHQDMVPIEGGQFLLGNDGLEALDNERKAHWVQVDSFWIDRFPVTQGQYQQFIEAGGY
CCCCCCEEECCCCEEEECCCCHHHHCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHCCC
RQSQFWSDEGWQWLQENPVNHPTHWLAEGGADHPVCGVSWYEADAYARFVGKRLPTEAEW
CCHHCCCCCCCHHHHCCCCCCCCHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCH
EKAACWQPRPQDPPTKRIYPWGNQTPDNHHCNHGGLHWGTTPVHQYANGQSAFGCFDLLG
HHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
NVWEWTNTWFHPFPDFDPYPYKGYSMVYFDHQHRILKGGSWATQAPVLRGAFRNWYEPRI
HHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEECCCCCHHHHHHHHHHHHCCCCEE
RIHFAGFRCAYG
EEEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]