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The map label for this gene is phoR [H]

Identifier: 158338635

GI number: 158338635

Start: 5587253

End: 5588659

Strand: Reverse

Name: phoR [H]

Synonym: AM1_5539

Alternate gene names: 158338635

Gene position: 5588659-5587253 (Counterclockwise)

Preceding gene: 158338636

Following gene: 158338628

Centisome position: 85.93

GC content: 43.85

Gene sequence:

>1407_bases
ATGGTTTTGGCTATCGTCTTAAACAGGTTTCGTAATCCTCTCTTTCAAGGATTACGGTGGCGTTTACTGCTGTCTTACCT
CTTGGTTATGGCAGCAATATTGGCCGTTTTTAGCGTACAAGTCTATGTTTTCGTTAGTCGACGACTTTACGCTCAAATTG
ATGCAGAATTACAAACTTTAGCCCAATCTGCAGCCCTTTCTCTCTCTGATATTAAACAGGAAGGTAAACCCTATCTCGAT
AAAGTAGATAAAGTGCCGTGGCGCGATATCTTTAATCGAGACCGCCATAGTTTGGAATGGTTTACAGCAGATGGCCGATT
ATTGGCTCGGAAAGGGGCGATTACCCTTCATTTGCCACCAAAACTGAGAGAACAAAATATAGTCGTCCGAGTCATAAGAG
AAGAGAAGTCTTTTCAGGTTCGTGCCTTTACTATTTCAGTTCATAGCGATGCCGATGCGTTAAAACGTCCCTTACTAGAA
GGGTATATCCGGGCAAGTCAGTCCATTGCACCTGTTGAAAAAGCTCAGCTTAGACTGCTGTGGGGATTAGGTGTAGGAGG
AACAATTGCGCTAGGTTTAGTTGGGATAGGAGGGCTGTGGCTAACGGAATATTCACTCAAGCCGGTTGAGCAAAGCTTTT
TGAGGCTGAAGCAGTTTACCGCTGATGCTTCCCATGAATTACGCACTCCTCTAACAGTAATCAAAACATCTGTTGAGGTG
ATGATGAATCATCCAGAAAGGGTTCATCCTAAAGATGCTAAAAAACTTGCAGCTATTTCCAGTGCAACTGCACAAATGAA
CCGCTTAGTTGAAGATCTACTCTTTTTGGCGAGAACAGATACATCTGTACCCACTGCCCGACGCGAATGGACTAGGGTGG
CTTTAGATGAAGTCCTCAAAGACCTAGTCGACTTTTTAGATCCTTCCGCCCAAACGCAAGGGGTTACATTAGTAACCCAA
GGCATAGTTCCAATGACATTAGTTGGAGATGCCATGCAATTGGCTCGATTATTCTCAAACTTGTTAAGGAATGCTGTAGC
ATACACCCCTTCTGGAGGGACAGTTACTCTATCCGTAGCTCGGACTAACCAGGTCACTATTATCAGTGTGGAAGATACTG
GAATAGGCATCTCTAAAGAGCAAATTCCATATATCTTTAACCGCTTTTATCGTGTGGATAAACACCGAGCCCGCAGGCAA
GGAGGCTTAGGCCTTGGGTTGGCTATCGCTCAATCCATTGCTCAACTCCATAAAGGCAAAATTACTATTCAGAGTCAAGT
TGGAGTAGGTAGTTGTTTCCGAGTCCATTTGCCAACGGTACAAATGGGTGTTGTGACTGAAGTATCTAATAACTCTATTC
AACTAGCTTCGAGGAGCACTCAATTAGTATCTCCGGAGGTTAAATAA

Upstream 100 bases:

>100_bases
GAAGTTTTACCTGAAGAAGATACGGTGAAAGCCCATATCAAAGGGTTACGGCATAAATTGAAAGGGGCAGGAGCCCCCAA
TGATTTAATTCAAACGGTCT

Downstream 100 bases:

>100_bases
AGTATTACAAATTCTCGAAACGGATTTTTTCCCAAAAGCGCAGTTTAGTCTTGTTGATTGGAGAACTGGTGAGCTCCAAT
TATGGCAAGGATCAAGGCCA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MVLAIVLNRFRNPLFQGLRWRLLLSYLLVMAAILAVFSVQVYVFVSRRLYAQIDAELQTLAQSAALSLSDIKQEGKPYLD
KVDKVPWRDIFNRDRHSLEWFTADGRLLARKGAITLHLPPKLREQNIVVRVIREEKSFQVRAFTISVHSDADALKRPLLE
GYIRASQSIAPVEKAQLRLLWGLGVGGTIALGLVGIGGLWLTEYSLKPVEQSFLRLKQFTADASHELRTPLTVIKTSVEV
MMNHPERVHPKDAKKLAAISSATAQMNRLVEDLLFLARTDTSVPTARREWTRVALDEVLKDLVDFLDPSAQTQGVTLVTQ
GIVPMTLVGDAMQLARLFSNLLRNAVAYTPSGGTVTLSVARTNQVTIISVEDTGIGISKEQIPYIFNRFYRVDKHRARRQ
GGLGLGLAIAQSIAQLHKGKITIQSQVGVGSCFRVHLPTVQMGVVTEVSNNSIQLASRSTQLVSPEVK

Sequences:

>Translated_468_residues
MVLAIVLNRFRNPLFQGLRWRLLLSYLLVMAAILAVFSVQVYVFVSRRLYAQIDAELQTLAQSAALSLSDIKQEGKPYLD
KVDKVPWRDIFNRDRHSLEWFTADGRLLARKGAITLHLPPKLREQNIVVRVIREEKSFQVRAFTISVHSDADALKRPLLE
GYIRASQSIAPVEKAQLRLLWGLGVGGTIALGLVGIGGLWLTEYSLKPVEQSFLRLKQFTADASHELRTPLTVIKTSVEV
MMNHPERVHPKDAKKLAAISSATAQMNRLVEDLLFLARTDTSVPTARREWTRVALDEVLKDLVDFLDPSAQTQGVTLVTQ
GIVPMTLVGDAMQLARLFSNLLRNAVAYTPSGGTVTLSVARTNQVTIISVEDTGIGISKEQIPYIFNRFYRVDKHRARRQ
GGLGLGLAIAQSIAQLHKGKITIQSQVGVGSCFRVHLPTVQMGVVTEVSNNSIQLASRSTQLVSPEVK
>Mature_468_residues
MVLAIVLNRFRNPLFQGLRWRLLLSYLLVMAAILAVFSVQVYVFVSRRLYAQIDAELQTLAQSAALSLSDIKQEGKPYLD
KVDKVPWRDIFNRDRHSLEWFTADGRLLARKGAITLHLPPKLREQNIVVRVIREEKSFQVRAFTISVHSDADALKRPLLE
GYIRASQSIAPVEKAQLRLLWGLGVGGTIALGLVGIGGLWLTEYSLKPVEQSFLRLKQFTADASHELRTPLTVIKTSVEV
MMNHPERVHPKDAKKLAAISSATAQMNRLVEDLLFLARTDTSVPTARREWTRVALDEVLKDLVDFLDPSAQTQGVTLVTQ
GIVPMTLVGDAMQLARLFSNLLRNAVAYTPSGGTVTLSVARTNQVTIISVEDTGIGISKEQIPYIFNRFYRVDKHRARRQ
GGLGLGLAIAQSIAQLHKGKITIQSQVGVGSCFRVHLPTVQMGVVTEVSNNSIQLASRSTQLVSPEVK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=34.8936170212766, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1786600, Length=225, Percent_Identity=35.1111111111111, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=229, Percent_Identity=30.5676855895196, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=28.8793103448276, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=31.7307692307692, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=31.4814814814815, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=28.3842794759825, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1789149, Length=242, Percent_Identity=31.8181818181818, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=28.2511210762332, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI48994928, Length=258, Percent_Identity=26.7441860465116, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=320, Percent_Identity=27.8125, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=29.5546558704453, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=32.8947368421053, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082128, Length=286, Percent_Identity=26.5734265734266, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=32.5242718446602, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=27.0386266094421, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=232, Percent_Identity=24.5689655172414, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=27.5229357798165, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=217, Percent_Identity=28.110599078341, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51985; Mature: 51985

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLAIVLNRFRNPLFQGLRWRLLLSYLLVMAAILAVFSVQVYVFVSRRLYAQIDAELQTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSAALSLSDIKQEGKPYLDKVDKVPWRDIFNRDRHSLEWFTADGRLLARKGAITLHLPP
HHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCCCEEEEECCCEEEEECCEEEEECCC
KLREQNIVVRVIREEKSFQVRAFTISVHSDADALKRPLLEGYIRASQSIAPVEKAQLRLL
CCCCCCEEEEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEE
WGLGVGGTIALGLVGIGGLWLTEYSLKPVEQSFLRLKQFTADASHELRTPLTVIKTSVEV
EECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHH
MMNHPERVHPKDAKKLAAISSATAQMNRLVEDLLFLARTDTSVPTARREWTRVALDEVLK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DLVDFLDPSAQTQGVTLVTQGIVPMTLVGDAMQLARLFSNLLRNAVAYTPSGGTVTLSVA
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEE
RTNQVTIISVEDTGIGISKEQIPYIFNRFYRVDKHRARRQGGLGLGLAIAQSIAQLHKGK
ECCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
ITIQSQVGVGSCFRVHLPTVQMGVVTEVSNNSIQLASRSTQLVSPEVK
EEEEECCCCCCEEEEECCEEEEEEEEEECCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVLAIVLNRFRNPLFQGLRWRLLLSYLLVMAAILAVFSVQVYVFVSRRLYAQIDAELQTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSAALSLSDIKQEGKPYLDKVDKVPWRDIFNRDRHSLEWFTADGRLLARKGAITLHLPP
HHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHCCCCCCEEEEECCCEEEEECCEEEEECCC
KLREQNIVVRVIREEKSFQVRAFTISVHSDADALKRPLLEGYIRASQSIAPVEKAQLRLL
CCCCCCEEEEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHEEEE
WGLGVGGTIALGLVGIGGLWLTEYSLKPVEQSFLRLKQFTADASHELRTPLTVIKTSVEV
EECCCCHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHH
MMNHPERVHPKDAKKLAAISSATAQMNRLVEDLLFLARTDTSVPTARREWTRVALDEVLK
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
DLVDFLDPSAQTQGVTLVTQGIVPMTLVGDAMQLARLFSNLLRNAVAYTPSGGTVTLSVA
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEE
RTNQVTIISVEDTGIGISKEQIPYIFNRFYRVDKHRARRQGGLGLGLAIAQSIAQLHKGK
ECCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
ITIQSQVGVGSCFRVHLPTVQMGVVTEVSNNSIQLASRSTQLVSPEVK
EEEEECCCCCCEEEEECCEEEEEEEEEECCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]