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The map label for this gene is prkC [H]

Identifier: 158338623

GI number: 158338623

Start: 5573961

End: 5575499

Strand: Direct

Name: prkC [H]

Synonym: AM1_5527

Alternate gene names: 158338623

Gene position: 5573961-5575499 (Clockwise)

Preceding gene: 158338622

Following gene: 158338626

Centisome position: 85.7

GC content: 50.03

Gene sequence:

>1539_bases
TTGCTGCCCCTTGGAACACTCTTACAAAAAGGAACCTATCGCTTAGAGCAGCTGGTCCGGCATCAGGGCTTGCAGTTAAC
TTATGAGGGCACGCATTTACCCAGTCAGCAGACTGTTCTGATCAATACCCTTAATCCATCCCGTCAAAATCCTAAAAAAA
TTGTTCTACATCGCGATGCTTTTATACAAGAGGCCCAAGCCTGGCAGAACTTAAAACATCCTTCTCTAGAATCCATCCGA
GACATTTTTGTAGATTCCGTTCTCCCCTTTCTAGTCAGGGAAAAGCTATCAGGACAAACTTGGGCCACAAAAGCAAAAAA
ACAGCCTCTACCAGAGGTGGAGGCGATTGCCCAAATTACCCAAATTGCGGATGGCTTGAATCAGGCCCATCAGCAGCAGC
TTCTCCATAGGGATATTCAACCCAAAAATATCTTTATCCACCCCCAAACAAATCATCCAGTTCTAGGAAATTGGGTTTGG
CAACCCAGTGCTCTGGGGGGCTCTTCTTCCCTTCTTCATGCCTATACAGCTCCTGAAGTCGCTCAAGGTCAACAAACTGT
TACAACCGATATCTACGGATTAGCGGCAACTTTATACACCTTGGTGACGGGAAAAATTCCGATAGCAGCCTCCCAGCGGC
AGCATATTCGCTTGGAGATCCGTCACCCAGACTTAAGCCAGGCAACGATTGTTGCCCTACTCCGGGGAATGGCCATGCAA
CCTCAGCACCGTCCCCAATCTATCTCGGAGTGGTTGAAACTCCTACCCAAAGCCCCTTCTCCTCCTGTATCATTCCCAAT
AAAATCGGGTAACATAGGCGCAGCTTCCCTTTCCTCGACTGAGGCAGTGCCTCAACCCTCAGCAAAATCCACTACCCCAG
AGAGCTCTTCTCTCCCCGATTCAGACCCTTCAGATCCAGAAATTTCTTCCCCTTCAGAGGAATTATCTTTAGCTCCCGAG
GCTGAGGATCTTCCTACAGCATCAACAGTCCCTCGCCAGGAGCCCAGTCAGACTGTGTCAACCACTCGCCTTCAACCCTA
TTCCGTGCCTCCTAGATTTCCCTACCGAGCACTACTCATTTGTTCCGTGCTCTCAGGGGTTGTAGGAATTGCCTTTGGTC
TGTTGCTCCGATTTCATTATCAGAATCAGTTTACGAACCCACAAGTGCCTGCAAAGGCCCCCCCAGTTCAAAATGAAGAT
TTTCTACCAAAGCCAGGAACAACCAGAAGACAATTAGAAACGCTGCCGACTCCGGCGGAAACACCCCTTGAGTCTCCCGA
AACCTCGCCTCTAGAAGAACCGACGGTTGATCCTCAGTTTGAGCAGGGTGATATTGGGCCAGATCCCACTCTTCAAGATC
CCGTCCCTCTTAGCCCTGTCCCCGCCGATCCCTTAGACCCGGATCCTGTCCTACAAACGCCAATAGAATCCTATCCTGAT
AGCCTGGCTCCCAGCCCAGAGCCATCTCCCTTCGATCCCTTTGCTCAGCCTGATTTTTCCACACCGCCTCCCTCTGAATC
TCCAGAAAGCTTCCAGTAA

Upstream 100 bases:

>100_bases
GGAATTAGCCAGGAACCTGAGGAATTTTCCCAGCATCTTCATGATCTAACCCTTCCCTCTGTCGTTAGCTCCCATGCGCC
CCCCTCTGCCAACAATGGTT

Downstream 100 bases:

>100_bases
GCCCAGGAGCTAGCCTCAAAGTATCGTATGTCCTCTACTCTGCTGCGGTAGAGTTGTTGAGTATGTGTAACAGTGACGAT
ACTTCTGAAAGTTCAGTGCT

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: Ser/Thr-protein kinase PrkC [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MLPLGTLLQKGTYRLEQLVRHQGLQLTYEGTHLPSQQTVLINTLNPSRQNPKKIVLHRDAFIQEAQAWQNLKHPSLESIR
DIFVDSVLPFLVREKLSGQTWATKAKKQPLPEVEAIAQITQIADGLNQAHQQQLLHRDIQPKNIFIHPQTNHPVLGNWVW
QPSALGGSSSLLHAYTAPEVAQGQQTVTTDIYGLAATLYTLVTGKIPIAASQRQHIRLEIRHPDLSQATIVALLRGMAMQ
PQHRPQSISEWLKLLPKAPSPPVSFPIKSGNIGAASLSSTEAVPQPSAKSTTPESSSLPDSDPSDPEISSPSEELSLAPE
AEDLPTASTVPRQEPSQTVSTTRLQPYSVPPRFPYRALLICSVLSGVVGIAFGLLLRFHYQNQFTNPQVPAKAPPVQNED
FLPKPGTTRRQLETLPTPAETPLESPETSPLEEPTVDPQFEQGDIGPDPTLQDPVPLSPVPADPLDPDPVLQTPIESYPD
SLAPSPEPSPFDPFAQPDFSTPPPSESPESFQ

Sequences:

>Translated_512_residues
MLPLGTLLQKGTYRLEQLVRHQGLQLTYEGTHLPSQQTVLINTLNPSRQNPKKIVLHRDAFIQEAQAWQNLKHPSLESIR
DIFVDSVLPFLVREKLSGQTWATKAKKQPLPEVEAIAQITQIADGLNQAHQQQLLHRDIQPKNIFIHPQTNHPVLGNWVW
QPSALGGSSSLLHAYTAPEVAQGQQTVTTDIYGLAATLYTLVTGKIPIAASQRQHIRLEIRHPDLSQATIVALLRGMAMQ
PQHRPQSISEWLKLLPKAPSPPVSFPIKSGNIGAASLSSTEAVPQPSAKSTTPESSSLPDSDPSDPEISSPSEELSLAPE
AEDLPTASTVPRQEPSQTVSTTRLQPYSVPPRFPYRALLICSVLSGVVGIAFGLLLRFHYQNQFTNPQVPAKAPPVQNED
FLPKPGTTRRQLETLPTPAETPLESPETSPLEEPTVDPQFEQGDIGPDPTLQDPVPLSPVPADPLDPDPVLQTPIESYPD
SLAPSPEPSPFDPFAQPDFSTPPPSESPESFQ
>Mature_512_residues
MLPLGTLLQKGTYRLEQLVRHQGLQLTYEGTHLPSQQTVLINTLNPSRQNPKKIVLHRDAFIQEAQAWQNLKHPSLESIR
DIFVDSVLPFLVREKLSGQTWATKAKKQPLPEVEAIAQITQIADGLNQAHQQQLLHRDIQPKNIFIHPQTNHPVLGNWVW
QPSALGGSSSLLHAYTAPEVAQGQQTVTTDIYGLAATLYTLVTGKIPIAASQRQHIRLEIRHPDLSQATIVALLRGMAMQ
PQHRPQSISEWLKLLPKAPSPPVSFPIKSGNIGAASLSSTEAVPQPSAKSTTPESSSLPDSDPSDPEISSPSEELSLAPE
AEDLPTASTVPRQEPSQTVSTTRLQPYSVPPRFPYRALLICSVLSGVVGIAFGLLLRFHYQNQFTNPQVPAKAPPVQNED
FLPKPGTTRRQLETLPTPAETPLESPETSPLEEPTVDPQFEQGDIGPDPTLQDPVPLSPVPADPLDPDPVLQTPIESYPD
SLAPSPEPSPFDPFAQPDFSTPPPSESPESFQ

Specific function: Protein kinase that is responsible for triggering spore germination in response to muropeptides, signaling bacteria to exit dormancy. PrkC is thus a germination receptor that binds peptidoglycan fragments containing m-Dpm (meso-diaminopimelate), which act

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Spore core membrane; Single-pass type II membrane protein. Note=Is associated with the inner membrane of the spore [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI33636756, Length=216, Percent_Identity=23.1481481481481, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI46852166, Length=216, Percent_Identity=21.7592592592593, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI193083129, Length=216, Percent_Identity=21.7592592592593, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI193083125, Length=216, Percent_Identity=21.7592592592593, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI193083127, Length=216, Percent_Identity=21.7592592592593, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI153791472, Length=216, Percent_Identity=21.7592592592593, Blast_Score=74, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45552739, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363794, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552743, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363796, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471747, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552741, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552747, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552745, Length=216, Percent_Identity=22.2222222222222, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363800, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552751, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45552749, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45552731, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45552735, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45552737, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45552733, Length=216, Percent_Identity=22.2222222222222, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI62471745, Length=216, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI62471749, Length=216, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281363798, Length=216, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR005543
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271
- InterPro:   IPR002290 [H]

Pfam domain/function: PF03793 PASTA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 55993; Mature: 55993

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPLGTLLQKGTYRLEQLVRHQGLQLTYEGTHLPSQQTVLINTLNPSRQNPKKIVLHRDA
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEHHH
FIQEAQAWQNLKHPSLESIRDIFVDSVLPFLVREKLSGQTWATKAKKQPLPEVEAIAQIT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
QIADGLNQAHQQQLLHRDIQPKNIFIHPQTNHPVLGNWVWQPSALGGSSSLLHAYTAPEV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEECCCHH
AQGQQTVTTDIYGLAATLYTLVTGKIPIAASQRQHIRLEIRHPDLSQATIVALLRGMAMQ
HCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
PQHRPQSISEWLKLLPKAPSPPVSFPIKSGNIGAASLSSTEAVPQPSAKSTTPESSSLPD
CCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDPSDPEISSPSEELSLAPEAEDLPTASTVPRQEPSQTVSTTRLQPYSVPPRFPYRALLI
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
CSVLSGVVGIAFGLLLRFHYQNQFTNPQVPAKAPPVQNEDFLPKPGTTRRQLETLPTPAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
TPLESPETSPLEEPTVDPQFEQGDIGPDPTLQDPVPLSPVPADPLDPDPVLQTPIESYPD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCC
SLAPSPEPSPFDPFAQPDFSTPPPSESPESFQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLPLGTLLQKGTYRLEQLVRHQGLQLTYEGTHLPSQQTVLINTLNPSRQNPKKIVLHRDA
CCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEHHH
FIQEAQAWQNLKHPSLESIRDIFVDSVLPFLVREKLSGQTWATKAKKQPLPEVEAIAQIT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHH
QIADGLNQAHQQQLLHRDIQPKNIFIHPQTNHPVLGNWVWQPSALGGSSSLLHAYTAPEV
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEECCCHH
AQGQQTVTTDIYGLAATLYTLVTGKIPIAASQRQHIRLEIRHPDLSQATIVALLRGMAMQ
HCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
PQHRPQSISEWLKLLPKAPSPPVSFPIKSGNIGAASLSSTEAVPQPSAKSTTPESSSLPD
CCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
SDPSDPEISSPSEELSLAPEAEDLPTASTVPRQEPSQTVSTTRLQPYSVPPRFPYRALLI
CCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHH
CSVLSGVVGIAFGLLLRFHYQNQFTNPQVPAKAPPVQNEDFLPKPGTTRRQLETLPTPAE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
TPLESPETSPLEEPTVDPQFEQGDIGPDPTLQDPVPLSPVPADPLDPDPVLQTPIESYPD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHCCC
SLAPSPEPSPFDPFAQPDFSTPPPSESPESFQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]