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The map label for this gene is pyrH [H]

Identifier: 158338602

GI number: 158338602

Start: 5556198

End: 5556926

Strand: Direct

Name: pyrH [H]

Synonym: AM1_6422

Alternate gene names: 158338602

Gene position: 5556198-5556926 (Clockwise)

Preceding gene: 158338596

Following gene: 158338603

Centisome position: 85.43

GC content: 49.93

Gene sequence:

>729_bases
ATGGGGAATACCTATCAACGGGTCCTATTAAAGCTTAGTGGCGAAGCCCTAATGGGAACTTTGCCCTATGGTATCGACCC
CACCATTGTTCAGGGAATTGCCGAAGAAATCTCTGATGTCGCCAGTCGAGGCATTCAGGTCGCTATTGTGGTCGGAGGGG
GCAATATCTTTCGCGGCGTGAAAGGTGCAGCCGCAGGCATGGATCGAGCAACTGCCGACTATATTGGCATGATTGCAACG
GTGATGAATGCCATGACCCTGCAAGATGCCCTTGAACAAATGAATGTACCGACTCGGGTACAAACCGCTATTTCCATGCA
GGAATTAGCAGAACCCTACATTCGTCGTCGCGCCATGCGCCATCTCGAGAAAGGCCGGGTGGTTATTTTTGGTGCAGGGT
CTGGCAATCCGTTCTTTACGACAGACACCACGGCAGCGTTGCGGGCGGCTGAAATCGATGCAGACATCATCATGAAAGCC
ACCAAGGTAGATGGGGTGTACGACTCAGATCCTAAAATAAATCCCGATGCCAAGCGATTTCAAAGTTTAACCTACGGACA
TGTCCTCACCCATGATCTGAAAGTGATGGACAGCACTGCGATCGCATTGTGCAAAGACAACGATATTCCTATTTTGGTCT
TTGACCTTTCCGTTTCTGGAAATATTCGACGGGCCCTATTGGGCGAATCTATTGGCACTATTGTGGGAGGTTCTTGTGGA
GTTAGCTGA

Upstream 100 bases:

>100_bases
GCAGTGATTCAAAATCTGAATTAAATCATTTTAGCCAACCTCCTGATCCCTAATCCTGCTATCTTAATTGGGGAGCAATT
TTCGTAGCAGTTATCATTGC

Downstream 100 bases:

>100_bases
GGCCGAGACTTTAATGCAAAAGTCCATTGAGGCCATGAAGCGGTCCCTCAACACCATTCGGACGGGGCGGGCCAATGCTT
CTTTATTAGACCGAATTACG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MGNTYQRVLLKLSGEALMGTLPYGIDPTIVQGIAEEISDVASRGIQVAIVVGGGNIFRGVKGAAAGMDRATADYIGMIAT
VMNAMTLQDALEQMNVPTRVQTAISMQELAEPYIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDADIIMKA
TKVDGVYDSDPKINPDAKRFQSLTYGHVLTHDLKVMDSTAIALCKDNDIPILVFDLSVSGNIRRALLGESIGTIVGGSCG
VS

Sequences:

>Translated_242_residues
MGNTYQRVLLKLSGEALMGTLPYGIDPTIVQGIAEEISDVASRGIQVAIVVGGGNIFRGVKGAAAGMDRATADYIGMIAT
VMNAMTLQDALEQMNVPTRVQTAISMQELAEPYIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDADIIMKA
TKVDGVYDSDPKINPDAKRFQSLTYGHVLTHDLKVMDSTAIALCKDNDIPILVFDLSVSGNIRRALLGESIGTIVGGSCG
VS
>Mature_241_residues
GNTYQRVLLKLSGEALMGTLPYGIDPTIVQGIAEEISDVASRGIQVAIVVGGGNIFRGVKGAAAGMDRATADYIGMIATV
MNAMTLQDALEQMNVPTRVQTAISMQELAEPYIRRRAMRHLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDADIIMKAT
KVDGVYDSDPKINPDAKRFQSLTYGHVLTHDLKVMDSTAIALCKDNDIPILVFDLSVSGNIRRALLGESIGTIVGGSCGV
S

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:
GO:0000166: Uridylate kinase
GO:0005524: Uridylate kinase
GO:0005737: Uridylate kinase
GO:0006221: Uridylate kinase
GO:0008652: Uridylate kinase
GO:0009041: Uridylate kinase
GO:0016301: Uridylate kinase
GO:0016310: Uridylate kinase
GO:0016740: Uridylate kinase
GO:0033862: Uridylate kinase

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=48.4848484848485, Blast_Score=236, Evalue=1e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 25749; Mature: 25618

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTYQRVLLKLSGEALMGTLPYGIDPTIVQGIAEEISDVASRGIQVAIVVGGGNIFRGV
CCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCC
KGAAAGMDRATADYIGMIATVMNAMTLQDALEQMNVPTRVQTAISMQELAEPYIRRRAMR
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDADIIMKATKVDGVYDSDPKINPDAKRF
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHHEEEHHCCCEECCCCCCCCHHHHH
QSLTYGHVLTHDLKVMDSTAIALCKDNDIPILVFDLSVSGNIRRALLGESIGTIVGGSCG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
VS
CC
>Mature Secondary Structure 
GNTYQRVLLKLSGEALMGTLPYGIDPTIVQGIAEEISDVASRGIQVAIVVGGGNIFRGV
CCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCHHHHCC
KGAAAGMDRATADYIGMIATVMNAMTLQDALEQMNVPTRVQTAISMQELAEPYIRRRAMR
CHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
HLEKGRVVIFGAGSGNPFFTTDTTAALRAAEIDADIIMKATKVDGVYDSDPKINPDAKRF
HHHCCCEEEEECCCCCCEEECCHHHHHHHHHCCHHHHEEEHHCCCEECCCCCCCCHHHHH
QSLTYGHVLTHDLKVMDSTAIALCKDNDIPILVFDLSVSGNIRRALLGESIGTIVGGSCG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
VS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA