BacMap

Definition	Acaryochloris marina MBIC11017 chromosome, complete genome.
Accession	NC_009925
Length	6,503,724

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The map label for this gene is gmk [H]

Identifier: 158338593

GI number: 158338593

Start: 5549160

End: 5549717

Strand: Reverse

Name: gmk [H]

Synonym: AM1_5497

Alternate gene names: 158338593

Gene position: 5549717-5549160 (Counterclockwise)

Preceding gene: 158338595

Following gene: 158338592

Centisome position: 85.33

GC content: 50.18

Gene sequence:

>558_bases
ATGACAAAAACGGGTAAGCTGATCGTCCTAACTGGACCCAGCGGTGTCGGCAAAGGCACTCTTTTGCAGCAGCTCTTACA
AGCCTGCCCAGATTTATACCTTGCGGTTTCCGCCACGACTCGTTCTCCCCGAGAGGGAGAAGTGGATGGCAAACACTACT
ACTTTTTGACCAAAGACCAATTTCAAACCCGCATTGATCAAAATCAGCTCTTGGAATGGGCAGAGTATGCAGGTAATTTC
TACGGAACGCTACGGGCTCCCGTGATGCGGGAAATTACCCAAGGAAAAAAAGTGATTTTGGAAATTGAACTGGTTGGGGC
TCGTCAAATCCGAGATCAGGTTGCCGATGCCTTTCAAATCTTTGTCAGCCCCCCTTCTGTGGCCGATTTAGAGGCTCGGA
TTCGGGGGCGAGGCCAGGATTCAGAAGAAGCCATTGCCCGCCGTTTAGACCAGGCCAAGGTCGAGCTTGCCGCCGCCGAT
GAATTTGATTTTCAGCTGGTCAATGATGATCTAGATGCAGCCTTTCAAACCCTTAAGTCTAAGGTGTTGTCCCTATGA

Upstream 100 bases:

>100_bases
AACTCCTTTATTTCTTCATATAAAAAGTTCAAACCAGGCTTAACCCGAACTGGCGTTAAAATGAGGTGTTTTCCCCCTAT
AAGACGCAAGGTCCCAGGAA

Downstream 100 bases:

>100_bases
TGCTTCGTCGTCTAATCACCCTATTGCTATTGCTGCTCAGTCTGACTGCATATCCCCTGCCCGTTCAGGCCGAGACCCAT
CTTTACCAAGAGAAACCGGG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MTKTGKLIVLTGPSGVGKGTLLQQLLQACPDLYLAVSATTRSPREGEVDGKHYYFLTKDQFQTRIDQNQLLEWAEYAGNF
YGTLRAPVMREITQGKKVILEIELVGARQIRDQVADAFQIFVSPPSVADLEARIRGRGQDSEEAIARRLDQAKVELAAAD
EFDFQLVNDDLDAAFQTLKSKVLSL

Sequences:

>Translated_185_residues
MTKTGKLIVLTGPSGVGKGTLLQQLLQACPDLYLAVSATTRSPREGEVDGKHYYFLTKDQFQTRIDQNQLLEWAEYAGNF
YGTLRAPVMREITQGKKVILEIELVGARQIRDQVADAFQIFVSPPSVADLEARIRGRGQDSEEAIARRLDQAKVELAAAD
EFDFQLVNDDLDAAFQTLKSKVLSL
>Mature_184_residues
TKTGKLIVLTGPSGVGKGTLLQQLLQACPDLYLAVSATTRSPREGEVDGKHYYFLTKDQFQTRIDQNQLLEWAEYAGNFY
GTLRAPVMREITQGKKVILEIELVGARQIRDQVADAFQIFVSPPSVADLEARIRGRGQDSEEAIARRLDQAKVELAAADE
FDFQLVNDDLDAAFQTLKSKVLSL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:
GO:0000166: Guanylate kinase
GO:0004385: Guanylate kinase
GO:0005524: Guanylate kinase
GO:0005737: Guanylate kinase
GO:0006163: Guanylate kinase
GO:0016301: Guanylate kinase
GO:0016310: Guanylate kinase
GO:0016740: Guanylate kinase

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=176, Percent_Identity=39.7727272727273, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI226874833, Length=176, Percent_Identity=39.7727272727273, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4504221, Length=176, Percent_Identity=39.7727272727273, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=31.6091954022989, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=30.8571428571429, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=30.8571428571429, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=30.8571428571429, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=30.8571428571429, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=29.0155440414508, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI21361598, Length=189, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI186972120, Length=179, Percent_Identity=26.8156424581006, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI186700629, Length=179, Percent_Identity=26.8156424581006, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI186700627, Length=179, Percent_Identity=26.8156424581006, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI52630447, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI21536464, Length=184, Percent_Identity=29.3478260869565, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1790080, Length=180, Percent_Identity=45.5555555555556, Blast_Score=168, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=43.1034482758621, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=43.1034482758621, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=31.1475409836066, Blast_Score=89, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=31.1475409836066, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17557440, Length=187, Percent_Identity=29.9465240641711, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17556244, Length=123, Percent_Identity=29.2682926829268, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71984092, Length=142, Percent_Identity=28.8732394366197, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=176, Percent_Identity=44.8863636363636, Blast_Score=162, Evalue=4e-41,
Organism=Drosophila melanogaster, GI21356141, Length=189, Percent_Identity=41.2698412698413, Blast_Score=140, Evalue=4e-34,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281362230, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648808, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362232, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161078485, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648810, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161078487, Length=181, Percent_Identity=28.1767955801105, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221330166, Length=191, Percent_Identity=30.8900523560209, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330162, Length=191, Percent_Identity=30.8900523560209, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330164, Length=191, Percent_Identity=30.8900523560209, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI85816106, Length=129, Percent_Identity=31.7829457364341, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85816281, Length=129, Percent_Identity=31.7829457364341, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551002, Length=129, Percent_Identity=31.7829457364341, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 20562; Mature: 20430

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTGKLIVLTGPSGVGKGTLLQQLLQACPDLYLAVSATTRSPREGEVDGKHYYFLTKDQ
CCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHH
FQTRIDQNQLLEWAEYAGNFYGTLRAPVMREITQGKKVILEIELVGARQIRDQVADAFQI
HHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHH
FVSPPSVADLEARIRGRGQDSEEAIARRLDQAKVELAAADEFDFQLVNDDLDAAFQTLKS
EECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCHHHHHHHHHHH
KVLSL
HHHCC
>Mature Secondary Structure 
TKTGKLIVLTGPSGVGKGTLLQQLLQACPDLYLAVSATTRSPREGEVDGKHYYFLTKDQ
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEEEHHH
FQTRIDQNQLLEWAEYAGNFYGTLRAPVMREITQGKKVILEIELVGARQIRDQVADAFQI
HHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCHHHHHHHHHHHHHH
FVSPPSVADLEARIRGRGQDSEEAIARRLDQAKVELAAADEFDFQLVNDDLDAAFQTLKS
EECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEECCCCCEEEECCHHHHHHHHHHH
KVLSL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA