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The map label for this gene is pkn1 [H]

Identifier: 158338577

GI number: 158338577

Start: 5536574

End: 5538100

Strand: Reverse

Name: pkn1 [H]

Synonym: AM1_5479

Alternate gene names: 158338577

Gene position: 5538100-5536574 (Counterclockwise)

Preceding gene: 158338578

Following gene: 158338571

Centisome position: 85.15

GC content: 52.65

Gene sequence:

>1527_bases
ATGGAAATCAAACGCAGGGACTTTCTATTATTTGGTGGAACCTTATTGTCCGTCGGATTTTGGCAGCGCTCGCTCCTAGC
CCAAGACCGGCGAACCCTGAAAGATTTAGCTAAAAAAATCACCGTACGAGTAGTGACCCAAGGCACTTCTGGCTCTGGAG
TATTGATTCGTAAAGCTGGAAATACTTACTATGCCTTAACGGCTGGCCATGTCCTCAAAGACACCAATCCTGGGGAAGAA
GCATACATCGAAACCTTTGATGGTCAGCAACATCCCATTGACACGTCAGGGATTCAGTCGGGGGGGAACGTCGACTTGGC
TTTGTTCACTATCAATAGCAAAAACACTTATGCCGTGGCTCAGCTGGCCGGGAAGAATGCCTTAAGCGAACTCGATGAAG
TGTTTGTAGCCGGATTCCCCTTGCCAGGACTAGCGATTACTCAGCCCCAATATACGATTTCCCCGGGACAAGTAACCTCC
GTCGGGACCCAGGCGGGAGGCTATGGCATTACCTATACGGCTGTTACCCAACCGGGCATGAGTGGTGGACCTGTTCTTAA
CCGCTCAGGTCAAGTCGCGGGCATTCATGGTCGGGCAGAAGGCCAAACCGTGGGCAATGTCGCCGTCAAGTCTGGCTTTA
ATTTAGCCATTCCCATTGACACAGCCGTGTCTTTGTTTTCGCTGGAGCAACTGTCATCGGACCAGACGGCAACCGTCTCC
GCCTTGGATAGCGCATTTGCCTATGTGCAAGTTAATCCCCAAGGCAAAATTGTGAAGCGGACGGAGGGGAAAGCCTCAGT
TTTTCAAGAGCGTTTGAGCGATAGCGTCACCCTAGAGATGGTCAGTATCCCCGGTGGAAACTTCACTATGGGGTCTCCTG
ATCGAGAGTCTGATCGGGAGAGCCACGAAGGACCCCAGCGCCAGGTGACGGTTCCGGCGTTTGCCATGGGTAAATTTGAA
GTGACTCAGGCCCAATGGCGGGCCATTATGGGCTCTAATCCTTCACGGGAGAAAGCCTTAAGTCGCCCCGTAGATAATGT
GTCCTGGGAAGATGCTGTTGCCTTTTGCAAAAGACTGTCTCAGAAAACCGGGCGGGATTATCGCTTACCCAGCGAGGCCG
AATGGGAATATGCCTGTCGTGCGGAGACGACAACCCCCTTTCATATGGGAGAAACCATTACACCAGAGTTAGCCAATTAC
TGGGGAGTCCATGCCTATGGCGACGGTCCCAGGGGACAATACCGTAAAAAGACTGTAGGGGTGGGCAGTTTCCCTGCCAA
TGCCTTTGGCCTCCATGATATGCATGGCAATGTGAGCGAGTGGTGCCAGGATACTTGGCATGAGACCTATCAGGGCGCAC
CAACTAATGGTCAGGCCTGGGAGCAAGAAGGGACTGCCCGTCGAGTCATGCGGGGGGGCTCTATGTCGTCTAACCCCAAG
CTTTGTCGGTCTGCGTCTCGCACCTACAACACCTCTGGATTTTTCACCTATGATGTGGGATTTCGAGTAGTTTGCTCAGC
TCTGTAG

Upstream 100 bases:

>100_bases
TGTTGGGAGATTCGCAAAAGGTTGGCATAGAATAGTGGAGCCGCAATCGAGACCGCATCACGCCCGAGGTCTACCGGCAG
TCACCCTTCAACTCAGGAAT

Downstream 100 bases:

>100_bases
AGGCAGCTCCAGAGAAATGCCCGCCAAGGCCGGGTTGGGATAGGTCTTGAGATAAACCTGACTCATTTGTTGCAGGGCTT
CGGAATAGCTAAAGGCATAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MEIKRRDFLLFGGTLLSVGFWQRSLLAQDRRTLKDLAKKITVRVVTQGTSGSGVLIRKAGNTYYALTAGHVLKDTNPGEE
AYIETFDGQQHPIDTSGIQSGGNVDLALFTINSKNTYAVAQLAGKNALSELDEVFVAGFPLPGLAITQPQYTISPGQVTS
VGTQAGGYGITYTAVTQPGMSGGPVLNRSGQVAGIHGRAEGQTVGNVAVKSGFNLAIPIDTAVSLFSLEQLSSDQTATVS
ALDSAFAYVQVNPQGKIVKRTEGKASVFQERLSDSVTLEMVSIPGGNFTMGSPDRESDRESHEGPQRQVTVPAFAMGKFE
VTQAQWRAIMGSNPSREKALSRPVDNVSWEDAVAFCKRLSQKTGRDYRLPSEAEWEYACRAETTTPFHMGETITPELANY
WGVHAYGDGPRGQYRKKTVGVGSFPANAFGLHDMHGNVSEWCQDTWHETYQGAPTNGQAWEQEGTARRVMRGGSMSSNPK
LCRSASRTYNTSGFFTYDVGFRVVCSAL

Sequences:

>Translated_508_residues
MEIKRRDFLLFGGTLLSVGFWQRSLLAQDRRTLKDLAKKITVRVVTQGTSGSGVLIRKAGNTYYALTAGHVLKDTNPGEE
AYIETFDGQQHPIDTSGIQSGGNVDLALFTINSKNTYAVAQLAGKNALSELDEVFVAGFPLPGLAITQPQYTISPGQVTS
VGTQAGGYGITYTAVTQPGMSGGPVLNRSGQVAGIHGRAEGQTVGNVAVKSGFNLAIPIDTAVSLFSLEQLSSDQTATVS
ALDSAFAYVQVNPQGKIVKRTEGKASVFQERLSDSVTLEMVSIPGGNFTMGSPDRESDRESHEGPQRQVTVPAFAMGKFE
VTQAQWRAIMGSNPSREKALSRPVDNVSWEDAVAFCKRLSQKTGRDYRLPSEAEWEYACRAETTTPFHMGETITPELANY
WGVHAYGDGPRGQYRKKTVGVGSFPANAFGLHDMHGNVSEWCQDTWHETYQGAPTNGQAWEQEGTARRVMRGGSMSSNPK
LCRSASRTYNTSGFFTYDVGFRVVCSAL
>Mature_508_residues
MEIKRRDFLLFGGTLLSVGFWQRSLLAQDRRTLKDLAKKITVRVVTQGTSGSGVLIRKAGNTYYALTAGHVLKDTNPGEE
AYIETFDGQQHPIDTSGIQSGGNVDLALFTINSKNTYAVAQLAGKNALSELDEVFVAGFPLPGLAITQPQYTISPGQVTS
VGTQAGGYGITYTAVTQPGMSGGPVLNRSGQVAGIHGRAEGQTVGNVAVKSGFNLAIPIDTAVSLFSLEQLSSDQTATVS
ALDSAFAYVQVNPQGKIVKRTEGKASVFQERLSDSVTLEMVSIPGGNFTMGSPDRESDRESHEGPQRQVTVPAFAMGKFE
VTQAQWRAIMGSNPSREKALSRPVDNVSWEDAVAFCKRLSQKTGRDYRLPSEAEWEYACRAETTTPFHMGETITPELANY
WGVHAYGDGPRGQYRKKTVGVGSFPANAFGLHDMHGNVSEWCQDTWHETYQGAPTNGQAWEQEGTARRVMRGGSMSSNPK
LCRSASRTYNTSGFFTYDVGFRVVCSAL

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=276, Percent_Identity=30.7971014492754, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI38202250, Length=301, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI257470977, Length=294, Percent_Identity=27.5510204081633, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI194248088, Length=298, Percent_Identity=28.1879194630872, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI226437577, Length=196, Percent_Identity=33.1632653061224, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130397, Length=292, Percent_Identity=27.7397260273973, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 54962; Mature: 54962

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKRRDFLLFGGTLLSVGFWQRSLLAQDRRTLKDLAKKITVRVVTQGTSGSGVLIRKAG
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCEEEEECC
NTYYALTAGHVLKDTNPGEEAYIETFDGQQHPIDTSGIQSGGNVDLALFTINSKNTYAVA
CEEEEEEECCEEECCCCCCCCEEEECCCCCCCCCHHCCCCCCCEEEEEEEECCCCCEEEE
QLAGKNALSELDEVFVAGFPLPGLAITQPQYTISPGQVTSVGTQAGGYGITYTAVTQPGM
EHHCCHHHHHHHHHHCCCCCCCCEEECCCCEEECCCCEEECCCCCCCCEEEEEEEECCCC
SGGPVLNRSGQVAGIHGRAEGQTVGNVAVKSGFNLAIPIDTAVSLFSLEQLSSDQTATVS
CCCCEECCCCCEEEECCCCCCCEECCEEEECCCEEEEEHHHHHHHHHHHHHCCCCHHHHH
ALDSAFAYVQVNPQGKIVKRTEGKASVFQERLSDSVTLEMVSIPGGNFTMGSPDRESDRE
HHHCEEEEEEECCCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHH
SHEGPQRQVTVPAFAMGKFEVTQAQWRAIMGSNPSREKALSRPVDNVSWEDAVAFCKRLS
HCCCCCCEEEECEEECCCEEECHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
QKTGRDYRLPSEAEWEYACRAETTTPFHMGETITPELANYWGVHAYGDGPRGQYRKKTVG
HHCCCCCCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHCCEEEECCCCCCCCHHHCCC
VGSFPANAFGLHDMHGNVSEWCQDTWHETYQGAPTNGQAWEQEGTARRVMRGGSMSSNPK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHCCCCCCCCCH
LCRSASRTYNTSGFFTYDVGFRVVCSAL
HHHHHHCCCCCCCEEEEECCHHHHEECC
>Mature Secondary Structure
MEIKRRDFLLFGGTLLSVGFWQRSLLAQDRRTLKDLAKKITVRVVTQGTSGSGVLIRKAG
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCEEEEECC
NTYYALTAGHVLKDTNPGEEAYIETFDGQQHPIDTSGIQSGGNVDLALFTINSKNTYAVA
CEEEEEEECCEEECCCCCCCCEEEECCCCCCCCCHHCCCCCCCEEEEEEEECCCCCEEEE
QLAGKNALSELDEVFVAGFPLPGLAITQPQYTISPGQVTSVGTQAGGYGITYTAVTQPGM
EHHCCHHHHHHHHHHCCCCCCCCEEECCCCEEECCCCEEECCCCCCCCEEEEEEEECCCC
SGGPVLNRSGQVAGIHGRAEGQTVGNVAVKSGFNLAIPIDTAVSLFSLEQLSSDQTATVS
CCCCEECCCCCEEEECCCCCCCEECCEEEECCCEEEEEHHHHHHHHHHHHHCCCCHHHHH
ALDSAFAYVQVNPQGKIVKRTEGKASVFQERLSDSVTLEMVSIPGGNFTMGSPDRESDRE
HHHCEEEEEEECCCCCEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHH
SHEGPQRQVTVPAFAMGKFEVTQAQWRAIMGSNPSREKALSRPVDNVSWEDAVAFCKRLS
HCCCCCCEEEECEEECCCEEECHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHH
QKTGRDYRLPSEAEWEYACRAETTTPFHMGETITPELANYWGVHAYGDGPRGQYRKKTVG
HHCCCCCCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHCCEEEECCCCCCCCHHHCCC
VGSFPANAFGLHDMHGNVSEWCQDTWHETYQGAPTNGQAWEQEGTARRVMRGGSMSSNPK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHCCCCCCCCCH
LCRSASRTYNTSGFFTYDVGFRVVCSAL
HHHHHHCCCCCCCEEEEECCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]