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The map label for this gene is msrA [H]

Identifier: 158338454

GI number: 158338454

Start: 5413453

End: 5414064

Strand: Direct

Name: msrA [H]

Synonym: AM1_5356

Alternate gene names: 158338454

Gene position: 5413453-5414064 (Clockwise)

Preceding gene: 158338451

Following gene: 158338460

Centisome position: 83.24

GC content: 47.55

Gene sequence:

>612_bases
ATGATCAAACGTTGGTTTGCGATCGCACTATTGTCTCTAATCACTTGGCTAGGCCCCGTCAGTATGGCGGCTCAGGCCCA
AGACCTCGCCAAGGCCACCTTTGCGGGCGGTTGTTTCTGGTGTATGGAGAAGCCCTTTGATGTGATTGATGGTGTCGTTT
CCACCACATCAGGATATACTGGCGGCAAAAAATTGAATCCTACCTATAAAGAGGTATCGTCCGGAAAAACCGGTCATGCG
GAATCCGTACAGGTGGAATATGACCCTAGTAAAGTCAGCTATGAAACCCTACTAGAGGCATTTTGGACCAATGTTGATCC
ATTGGATGCTGGGGGACAATTTTGCGATCGCGGTGACCAATACCGCACCAATGTCTTCTACCATTCAGACGAGCAAAAAG
CCCTCGCCGAAAAATCTAAAGCTGAAATAGATAACTCTGGTAAATTTGCCACGCCCATCGTCACGGAAATTGTCGCCGCT
GAGACCTTTTATCCTGCAGAAGACTATCACCAAAACTATTACCAAACCAACTCTAATTGGTATCGCTTTTACCGGTACAG
CTGTGGCCGAGATCAGCGACTCGCTAAACTCTGGGGAGAAGAAAATAGCTAA

Upstream 100 bases:

>100_bases
GATACCAGTATCAGTCGGTGATTGAGGATCTCAGGCCAAAATTGTGTTGCTTGTGTCAGTTCTGATTACGATAGATAAGG
CATGACGAATGGAATAAAAG

Downstream 100 bases:

>100_bases
TCCAAATTCCCCTATCGAAGCAAGCTAGACATCTGCAGTCAGTCCAAGAAATTCAGAGAATCGTGCATAGGTTGTATCGA
TACTCCTATCGATCTCACTC

Product: methionine-S-sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MIKRWFAIALLSLITWLGPVSMAAQAQDLAKATFAGGCFWCMEKPFDVIDGVVSTTSGYTGGKKLNPTYKEVSSGKTGHA
ESVQVEYDPSKVSYETLLEAFWTNVDPLDAGGQFCDRGDQYRTNVFYHSDEQKALAEKSKAEIDNSGKFATPIVTEIVAA
ETFYPAEDYHQNYYQTNSNWYRFYRYSCGRDQRLAKLWGEENS

Sequences:

>Translated_203_residues
MIKRWFAIALLSLITWLGPVSMAAQAQDLAKATFAGGCFWCMEKPFDVIDGVVSTTSGYTGGKKLNPTYKEVSSGKTGHA
ESVQVEYDPSKVSYETLLEAFWTNVDPLDAGGQFCDRGDQYRTNVFYHSDEQKALAEKSKAEIDNSGKFATPIVTEIVAA
ETFYPAEDYHQNYYQTNSNWYRFYRYSCGRDQRLAKLWGEENS
>Mature_203_residues
MIKRWFAIALLSLITWLGPVSMAAQAQDLAKATFAGGCFWCMEKPFDVIDGVVSTTSGYTGGKKLNPTYKEVSSGKTGHA
ESVQVEYDPSKVSYETLLEAFWTNVDPLDAGGQFCDRGDQYRTNVFYHSDEQKALAEKSKAEIDNSGKFATPIVTEIVAA
ETFYPAEDYHQNYYQTNSNWYRFYRYSCGRDQRLAKLWGEENS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=152, Percent_Identity=47.3684210526316, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI208609995, Length=152, Percent_Identity=47.3684210526316, Blast_Score=128, Evalue=4e-30,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=44.4444444444444, Blast_Score=85, Evalue=5e-17,
Organism=Escherichia coli, GI1790665, Length=160, Percent_Identity=46.25, Blast_Score=130, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=155, Percent_Identity=36.1290322580645, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=36.3057324840764, Blast_Score=85, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=39.5833333333333, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=38.6861313868613, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=38.8888888888889, Blast_Score=98, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 22908; Mature: 22908

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRWFAIALLSLITWLGPVSMAAQAQDLAKATFAGGCFWCMEKPFDVIDGVVSTTSGYT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCC
GGKKLNPTYKEVSSGKTGHAESVQVEYDPSKVSYETLLEAFWTNVDPLDAGGQFCDRGDQ
CCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
YRTNVFYHSDEQKALAEKSKAEIDNSGKFATPIVTEIVAAETFYPAEDYHQNYYQTNSNW
EEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCE
YRFYRYSCGRDQRLAKLWGEENS
EEEEEECCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MIKRWFAIALLSLITWLGPVSMAAQAQDLAKATFAGGCFWCMEKPFDVIDGVVSTTSGYT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHCCCCC
GGKKLNPTYKEVSSGKTGHAESVQVEYDPSKVSYETLLEAFWTNVDPLDAGGQFCDRGDQ
CCCCCCCHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHCCCCC
YRTNVFYHSDEQKALAEKSKAEIDNSGKFATPIVTEIVAAETFYPAEDYHQNYYQTNSNW
EEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHEECCCCE
YRFYRYSCGRDQRLAKLWGEENS
EEEEEECCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]