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The map label for this gene is ldh [H]

Identifier: 158338134

GI number: 158338134

Start: 5069866

End: 5070804

Strand: Reverse

Name: ldh [H]

Synonym: AM1_5026

Alternate gene names: 158338134

Gene position: 5070804-5069866 (Counterclockwise)

Preceding gene: 158338136

Following gene: 158338133

Centisome position: 77.97

GC content: 50.37

Gene sequence:

>939_bases
ATGAAAATTTCTATAATCGGCATTGGCAAAGTAGGTTCAACCATCAGCTTTATCCTGGCGAAAGAAGGGTTAGCCTCCGA
GTTAGTTCTCTATAACCGCACTAGGGAGATTGCCCATGCCGAGGCCATTGATATTCAGCAAGCCGTCGCACTGACGCCCT
ATCGGCTAATGGTTCGGGATGGCGATCTTGAGGACACCGCTGGGTCCGACATTATCGTCATTGCTGCGAGTGCTCCTATG
CCCAAGCAGATGCAGGCCCGCAGTGCCTTGCTGGCGAAGAACATTCAGATCATGAACACCTTAATCCCGCCTCTTCTCCA
ACACAGTCCGAATGCCATCTTTATCAATATCAGCAACCCCGTTGACGCCCTAAACTACGAAATTCTGCAAATTATCAGGC
AGCACACCCATCTCAACCCTTGGCAACGCGTCATCGGTACCGGCACATTGATAGACTCTGCCCGGTTTCGGGATCTGTTA
TCTGCCCAGTTGGGTATCCATTCCTCTGATATCAACGCCTATATTCTGGGAGAGCATGGGGACAGCCAGTTTGCCGCCCT
CAGTTCCGCCATGATCGGGGGTGAATTAATTGATGCCAACCCCTTACGCCAACAGATGGTCGAAGATGCCAAGCGGTCTG
CCTGGACCATCTTCCAAGCCAAAGGCTATACCAACTACACCGTAGCGTTGGCCGTAGAGATGATTGTGTTTAGCATCGTC
GAGGATCTGCGACATACCCTACCTGTTAGTGTTTTGATTGACGGGTATTGTGATGTATCAGATTGCTGTCTTAGCGTTCC
TTGTATCGTGGGCCGAGACGGGGTGCATCGTCGGATAAAAACCCAACTCAATGCCGAAGAAATCCTGGCTTTTCAAAAGT
GCGCCCATCACGTTAAACAGCAAATCCAAGCGTGTTACCAACCTTCAGCAGAAGATTGA

Upstream 100 bases:

>100_bases
GCTTCGATCCCCTCTATCAATTCATCATCTTCCCATTGAAGAATTATGCAGTTAACGAATCAAGCAGATATACAATCCAT
TTCCATCCCAGCGTCGTAAT

Downstream 100 bases:

>100_bases
ACGGCCTCTAGCCAGAACGCCTATTGGGGAGAAATGACCATGGAAATTACCACTTTTCTCACCCTGCCGGATCAGCGACA
GTTAGCCTACGCTGAATATG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKISIIGIGKVGSTISFILAKEGLASELVLYNRTREIAHAEAIDIQQAVALTPYRLMVRDGDLEDTAGSDIIVIAASAPM
PKQMQARSALLAKNIQIMNTLIPPLLQHSPNAIFINISNPVDALNYEILQIIRQHTHLNPWQRVIGTGTLIDSARFRDLL
SAQLGIHSSDINAYILGEHGDSQFAALSSAMIGGELIDANPLRQQMVEDAKRSAWTIFQAKGYTNYTVALAVEMIVFSIV
EDLRHTLPVSVLIDGYCDVSDCCLSVPCIVGRDGVHRRIKTQLNAEEILAFQKCAHHVKQQIQACYQPSAED

Sequences:

>Translated_312_residues
MKISIIGIGKVGSTISFILAKEGLASELVLYNRTREIAHAEAIDIQQAVALTPYRLMVRDGDLEDTAGSDIIVIAASAPM
PKQMQARSALLAKNIQIMNTLIPPLLQHSPNAIFINISNPVDALNYEILQIIRQHTHLNPWQRVIGTGTLIDSARFRDLL
SAQLGIHSSDINAYILGEHGDSQFAALSSAMIGGELIDANPLRQQMVEDAKRSAWTIFQAKGYTNYTVALAVEMIVFSIV
EDLRHTLPVSVLIDGYCDVSDCCLSVPCIVGRDGVHRRIKTQLNAEEILAFQKCAHHVKQQIQACYQPSAED
>Mature_312_residues
MKISIIGIGKVGSTISFILAKEGLASELVLYNRTREIAHAEAIDIQQAVALTPYRLMVRDGDLEDTAGSDIIVIAASAPM
PKQMQARSALLAKNIQIMNTLIPPLLQHSPNAIFINISNPVDALNYEILQIIRQHTHLNPWQRVIGTGTLIDSARFRDLL
SAQLGIHSSDINAYILGEHGDSQFAALSSAMIGGELIDANPLRQQMVEDAKRSAWTIFQAKGYTNYTVALAVEMIVFSIV
EDLRHTLPVSVLIDGYCDVSDCCLSVPCIVGRDGVHRRIKTQLNAEEILAFQKCAHHVKQQIQACYQPSAED

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI9257228, Length=308, Percent_Identity=32.4675324675325, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4504973, Length=308, Percent_Identity=32.4675324675325, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI15082234, Length=305, Percent_Identity=33.7704918032787, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI47059044, Length=306, Percent_Identity=34.640522875817, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI221136809, Length=306, Percent_Identity=34.640522875817, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI291575128, Length=309, Percent_Identity=32.3624595469256, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI4557032, Length=309, Percent_Identity=32.3624595469256, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI260099723, Length=305, Percent_Identity=32.7868852459016, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI5031857, Length=305, Percent_Identity=32.7868852459016, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI260099725, Length=214, Percent_Identity=31.3084112149533, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI260099727, Length=214, Percent_Identity=31.3084112149533, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI207028494, Length=205, Percent_Identity=34.6341463414634, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI103472011, Length=307, Percent_Identity=25.4071661237785, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI21735621, Length=286, Percent_Identity=23.7762237762238, Blast_Score=65, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI17535107, Length=292, Percent_Identity=30.8219178082192, Blast_Score=147, Evalue=6e-36,
Organism=Drosophila melanogaster, GI17136226, Length=310, Percent_Identity=29.3548387096774, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45550422, Length=287, Percent_Identity=32.404181184669, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 34265; Mature: 34265

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISIIGIGKVGSTISFILAKEGLASELVLYNRTREIAHAEAIDIQQAVALTPYRLMVRD
CEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GDLEDTAGSDIIVIAASAPMPKQMQARSALLAKNIQIMNTLIPPLLQHSPNAIFINISNP
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDALNYEILQIIRQHTHLNPWQRVIGTGTLIDSARFRDLLSAQLGIHSSDINAYILGEHG
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
DSQFAALSSAMIGGELIDANPLRQQMVEDAKRSAWTIFQAKGYTNYTVALAVEMIVFSIV
CCHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHH
EDLRHTLPVSVLIDGYCDVSDCCLSVPCIVGRDGVHRRIKTQLNAEEILAFQKCAHHVKQ
HHHHHHCCEEEEEECCCCHHHHHHHCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
QIQACYQPSAED
HHHHHCCCCCCC
>Mature Secondary Structure
MKISIIGIGKVGSTISFILAKEGLASELVLYNRTREIAHAEAIDIQQAVALTPYRLMVRD
CEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
GDLEDTAGSDIIVIAASAPMPKQMQARSALLAKNIQIMNTLIPPLLQHSPNAIFINISNP
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
VDALNYEILQIIRQHTHLNPWQRVIGTGTLIDSARFRDLLSAQLGIHSSDINAYILGEHG
HHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCC
DSQFAALSSAMIGGELIDANPLRQQMVEDAKRSAWTIFQAKGYTNYTVALAVEMIVFSIV
CCHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHH
EDLRHTLPVSVLIDGYCDVSDCCLSVPCIVGRDGVHRRIKTQLNAEEILAFQKCAHHVKQ
HHHHHHCCEEEEEECCCCHHHHHHHCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
QIQACYQPSAED
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA