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The map label for this gene is prk [H]

Identifier: 158338026

GI number: 158338026

Start: 4959537

End: 4960541

Strand: Direct

Name: prk [H]

Synonym: AM1_4913

Alternate gene names: 158338026

Gene position: 4959537-4960541 (Clockwise)

Preceding gene: 158338025

Following gene: 158338028

Centisome position: 76.26

GC content: 47.66

Gene sequence:

>1005_bases
ATGACCACTAAACCAGACCGTGTTGTTCTAATCGGCGTTGCCGGTGACTCTGGATGCGGTAAATCTACTTTCCTGCGCCG
ACTGGAGGATCTGTTTGGGGAGCAATTCATCACGGTTATTTGCCTAGATGATTACCACAGCTTGGATCGTTATCAACGGA
AGGAAACGGGGATTACTGCTCTAGACCCTAGAGCGAATAATTTTGATTTGATGTACGAGCAAATCAAAACCCTCAAAGGT
GGTCAATCAATCGATAAGCCCATTTACAACCACGAAACAGGTCTCATTGATCCCCCTGAACGCATCGACCCCAACCACGT
AATTGTGATTGAAGGTCTGCACCCTCTCCACGATGAGCGGGTTCGGGGGTTGATTGATTTCAGTGTCTATTTGGACATCA
GCGATGAAGTCAAAATTGCCTGGAAGATTCAGCGAGACATGGCAGAGCGGGGTCATACCTATGAAGACGTTCTGGCCTCT
ATCAATGCTCGTCGTCCTGACTTTGAGGCTTATATTGATCCGCAAAAACAACATGCTGATGTTGTGATTCAGATCTTGCC
GACACAACTGCTGAAGGAAGAGAAGCCCGGCAGCATTCTGCGGGTCCGACTGATTCAAAAAGACGGTGTGCCTGATTTTG
CCCCGGTCTATCTCTTTGATGAAGGATCAACTATCAATTGGGTGCCCTGTGGTCGCAAGTTAACTTGTTCTTACCCCGGT
ATTCGGATGGCCTATGGTCCTGACGATTACTACGGTAACGCCGTATCTGTTCTAGAAGTAGACGGTCAATTCGAGAAGCT
GGATGAGGTCATCTATATTGAAGGTCATCTCAGTAATACCTCTACTAAGTTTGAAGGTGAGATGACGGAGTTGCTGCTCA
AGCATCGGGATTACCCCGGATCTAACAATGGCTCTGGCTTGTTCCAGGTTATTGCTGGATTAAAGATGCGGGCGACCTAT
GAGAAGTTGACTGCAACCAAGACGTCAGAAACGGTTGGCGTGTAA

Upstream 100 bases:

>100_bases
GGAGCAATTTAATGCTCTATCTGTGCAAACCCCCTCTCATACGGGTTGGTGCCTGGGGTTAGTTGCTGTTGAGATAGGAT
TTATAAAGGAAATCGTAGTT

Downstream 100 bases:

>100_bases
CACATTCCTATCTATAGATTTCTATATTCAGGTGTTGGGGCTGCTCTCAACGCCTGATTTTTTTATGGGTTAACTAGACA
TTGGCATTGATAGTGTGTCC

Product: phosphoribulokinase

Products: NA

Alternate protein names: PRK; PRKase; Phosphopentokinase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTTKPDRVVLIGVAGDSGCGKSTFLRRLEDLFGEQFITVICLDDYHSLDRYQRKETGITALDPRANNFDLMYEQIKTLKG
GQSIDKPIYNHETGLIDPPERIDPNHVIVIEGLHPLHDERVRGLIDFSVYLDISDEVKIAWKIQRDMAERGHTYEDVLAS
INARRPDFEAYIDPQKQHADVVIQILPTQLLKEEKPGSILRVRLIQKDGVPDFAPVYLFDEGSTINWVPCGRKLTCSYPG
IRMAYGPDDYYGNAVSVLEVDGQFEKLDEVIYIEGHLSNTSTKFEGEMTELLLKHRDYPGSNNGSGLFQVIAGLKMRATY
EKLTATKTSETVGV

Sequences:

>Translated_334_residues
MTTKPDRVVLIGVAGDSGCGKSTFLRRLEDLFGEQFITVICLDDYHSLDRYQRKETGITALDPRANNFDLMYEQIKTLKG
GQSIDKPIYNHETGLIDPPERIDPNHVIVIEGLHPLHDERVRGLIDFSVYLDISDEVKIAWKIQRDMAERGHTYEDVLAS
INARRPDFEAYIDPQKQHADVVIQILPTQLLKEEKPGSILRVRLIQKDGVPDFAPVYLFDEGSTINWVPCGRKLTCSYPG
IRMAYGPDDYYGNAVSVLEVDGQFEKLDEVIYIEGHLSNTSTKFEGEMTELLLKHRDYPGSNNGSGLFQVIAGLKMRATY
EKLTATKTSETVGV
>Mature_333_residues
TTKPDRVVLIGVAGDSGCGKSTFLRRLEDLFGEQFITVICLDDYHSLDRYQRKETGITALDPRANNFDLMYEQIKTLKGG
QSIDKPIYNHETGLIDPPERIDPNHVIVIEGLHPLHDERVRGLIDFSVYLDISDEVKIAWKIQRDMAERGHTYEDVLASI
NARRPDFEAYIDPQKQHADVVIQILPTQLLKEEKPGSILRVRLIQKDGVPDFAPVYLFDEGSTINWVPCGRKLTCSYPGI
RMAYGPDDYYGNAVSVLEVDGQFEKLDEVIYIEGHLSNTSTKFEGEMTELLLKHRDYPGSNNGSGLFQVIAGLKMRATYE
KLTATKTSETVGV

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoribulokinase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=187, Percent_Identity=26.7379679144385, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI57863312, Length=187, Percent_Identity=26.7379679144385, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI18699734, Length=187, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13899253, Length=190, Percent_Identity=24.7368421052632, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI87082034, Length=191, Percent_Identity=33.5078534031414, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17539892, Length=180, Percent_Identity=29.4444444444444, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17539894, Length=180, Percent_Identity=29.4444444444444, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71981181, Length=194, Percent_Identity=31.4432989690722, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324339, Length=125, Percent_Identity=30.4, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28573516, Length=180, Percent_Identity=26.1111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573514, Length=180, Percent_Identity=26.1111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573512, Length=180, Percent_Identity=26.1111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45550449, Length=180, Percent_Identity=26.1111111111111, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221458995, Length=188, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24649624, Length=188, Percent_Identity=27.6595744680851, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006082
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.19 [H]

Molecular weight: Translated: 37697; Mature: 37566

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00567 PHOSPHORIBULOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKPDRVVLIGVAGDSGCGKSTFLRRLEDLFGEQFITVICLDDYHSLDRYQRKETGITA
CCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEE
LDPRANNFDLMYEQIKTLKGGQSIDKPIYNHETGLIDPPERIDPNHVIVIEGLHPLHDER
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHH
VRGLIDFSVYLDISDEVKIAWKIQRDMAERGHTYEDVLASINARRPDFEAYIDPQKQHAD
HCEEEEEEEEEEECCCEEEEEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCCCCCC
VVIQILPTQLLKEEKPGSILRVRLIQKDGVPDFAPVYLFDEGSTINWVPCGRKLTCSYPG
EEEEEECHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCEEEECCCC
IRMAYGPDDYYGNAVSVLEVDGQFEKLDEVIYIEGHLSNTSTKFEGEMTELLLKHRDYPG
EEEEECCCCCCCCEEEEEEECCCHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
SNNGSGLFQVIAGLKMRATYEKLTATKTSETVGV
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TTKPDRVVLIGVAGDSGCGKSTFLRRLEDLFGEQFITVICLDDYHSLDRYQRKETGITA
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEE
LDPRANNFDLMYEQIKTLKGGQSIDKPIYNHETGLIDPPERIDPNHVIVIEGLHPLHDER
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCEEEEECCCCCCCHHH
VRGLIDFSVYLDISDEVKIAWKIQRDMAERGHTYEDVLASINARRPDFEAYIDPQKQHAD
HCEEEEEEEEEEECCCEEEEEEEEHHHHHCCCCHHHHHHHHCCCCCCCCEEECCCCCCCC
VVIQILPTQLLKEEKPGSILRVRLIQKDGVPDFAPVYLFDEGSTINWVPCGRKLTCSYPG
EEEEEECHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEECCCEEEEEECCCEEEECCCC
IRMAYGPDDYYGNAVSVLEVDGQFEKLDEVIYIEGHLSNTSTKFEGEMTELLLKHRDYPG
EEEEECCCCCCCCEEEEEEECCCHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
SNNGSGLFQVIAGLKMRATYEKLTATKTSETVGV
CCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1660882; 8905231 [H]