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The map label for this gene is pncB [H]

Identifier: 158338009

GI number: 158338009

Start: 4943929

End: 4945311

Strand: Direct

Name: pncB [H]

Synonym: AM1_4896

Alternate gene names: 158338009

Gene position: 4943929-4945311 (Clockwise)

Preceding gene: 158338005

Following gene: 158338010

Centisome position: 76.02

GC content: 50.83

Gene sequence:

>1383_bases
ATGTTAGAACTGGTTACGCCCCCTGAGGTAGCTGATCAATCTTTAAACCTCTCTGCCAGTGACTATAATCTCTTGACTGA
TTTATATCAAGCCACCATGTCTGCTTGCTATTTAAATGAGAATCTGGCGGAAATACCGGCAAGCTTCGAGTTAACGGTTC
GGCGCTTACCTGACAAGTTCGGCTATTTAGTCGCCATGGGTTTAGCACAGGTTTTAGATTACCTACAAAACCTAAAATTT
ACGGCTCGGCAAATTCAGTATCTTCAAGAAACCGATTTATTTAGTCATGCCCCTACTCAGTTTTGGCGCATGTTAGAAGA
AGGAAAATTTACTGGTGACGTGTGGGCGGTCCCGGAAGGAACAACCATCTTTGCCAACGAACCCTTTTTGAGGATTGAAG
CGCCGTTGTGGCAAGCCCAGTGGGTAGAAACGTTTATCCTCAATACCATCAACTATCAAACCTTAATCGCCACTCGTGCG
GCTCGGTTGCGAGATGTGGCCGGTCCTGATGCCACAGTTTTAGAATTTGGAACCCGCCGAGCATTTGGGCCGCAGGCGTC
TGTATGGGCGGCCCGAGCTGCCTTGGCTGCCGGATTAAATGCCACATCGAATGTCTTAGCGGCCCAACTTTTGGGCCGAC
AGCCCAGTGGAACGATGGCCCATGCGTTAGTCATGGCCATGACGGCCACTCAAGGTACTGAACTTCAGGCTTTTACCGCT
TTTCACCGCACCTTTCCTCAGGCGGCGCTGTTGATTGATACCTATGACACCCTCGCAGCAGCCCAAACTCTGGCGGAGAA
GGTTAACGCGGGGGAACTAGAAGTACCGGCGATTCGCCTAGATTCAGGGGATTTAGTGGAATTATCCCAACAGATTCATC
AGCTCTTGCCGGAAGCCAAAATTGTGGTCAGTGGAGATTTGGATGAACCAGAAATCCTCCGACTCCGCCAAGCGGGAACC
CATATCCATGGCTATGGCGTCGGGACAAAGCTGGTGACGGGCAGCCCTGTCAACGGGGTATATAAGCTCGTCGACATCGA
CGGCAAGCCCGTGATGAAGGAGGCCAATGGCAAGATTACCTATCCGGGGCGCAAACAAATTTTTCGCCAGTTTCATCACG
GGCATGTGAGTCAAGATCACCTGGGATTAGTCAACGATTCGGCTCCAGGGGGTCAACCTCTCTTGCAGCTCATGATGAAA
GCAGGGCAACGACTCAAAACCCCAGAATCTCTAGAAACCATTGCCCAGCGAACCTTAGACTCTGTGCAGAGCTTACCAGC
AGACGTCCGTTCTGTGGTTAATCCAGTTTCTTTACCTATGCAGTTATCGACCGATTTACAAGCCCTAACGGCGGCGACTC
GCCGGACATCAAAGGCTGCTTAG

Upstream 100 bases:

>100_bases
ATTAAGGCAAGCGCTTCTAAATCAATTGAAAATTGTTTTTTGCTCAGCGCTGATTCCTGGCTGTGCAGGAATTTTATGGA
TATTTACTAGGAGTCCAGTG

Downstream 100 bases:

>100_bases
CCCTTAACTTCTTGCCCAGTTCGCTCAGATGATTCGATCTATGACAAAAATTGCACTTTTTGGCACCAGTGCTGATCCGC
CCACCGTGGGACATCAATCC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MLELVTPPEVADQSLNLSASDYNLLTDLYQATMSACYLNENLAEIPASFELTVRRLPDKFGYLVAMGLAQVLDYLQNLKF
TARQIQYLQETDLFSHAPTQFWRMLEEGKFTGDVWAVPEGTTIFANEPFLRIEAPLWQAQWVETFILNTINYQTLIATRA
ARLRDVAGPDATVLEFGTRRAFGPQASVWAARAALAAGLNATSNVLAAQLLGRQPSGTMAHALVMAMTATQGTELQAFTA
FHRTFPQAALLIDTYDTLAAAQTLAEKVNAGELEVPAIRLDSGDLVELSQQIHQLLPEAKIVVSGDLDEPEILRLRQAGT
HIHGYGVGTKLVTGSPVNGVYKLVDIDGKPVMKEANGKITYPGRKQIFRQFHHGHVSQDHLGLVNDSAPGGQPLLQLMMK
AGQRLKTPESLETIAQRTLDSVQSLPADVRSVVNPVSLPMQLSTDLQALTAATRRTSKAA

Sequences:

>Translated_460_residues
MLELVTPPEVADQSLNLSASDYNLLTDLYQATMSACYLNENLAEIPASFELTVRRLPDKFGYLVAMGLAQVLDYLQNLKF
TARQIQYLQETDLFSHAPTQFWRMLEEGKFTGDVWAVPEGTTIFANEPFLRIEAPLWQAQWVETFILNTINYQTLIATRA
ARLRDVAGPDATVLEFGTRRAFGPQASVWAARAALAAGLNATSNVLAAQLLGRQPSGTMAHALVMAMTATQGTELQAFTA
FHRTFPQAALLIDTYDTLAAAQTLAEKVNAGELEVPAIRLDSGDLVELSQQIHQLLPEAKIVVSGDLDEPEILRLRQAGT
HIHGYGVGTKLVTGSPVNGVYKLVDIDGKPVMKEANGKITYPGRKQIFRQFHHGHVSQDHLGLVNDSAPGGQPLLQLMMK
AGQRLKTPESLETIAQRTLDSVQSLPADVRSVVNPVSLPMQLSTDLQALTAATRRTSKAA
>Mature_460_residues
MLELVTPPEVADQSLNLSASDYNLLTDLYQATMSACYLNENLAEIPASFELTVRRLPDKFGYLVAMGLAQVLDYLQNLKF
TARQIQYLQETDLFSHAPTQFWRMLEEGKFTGDVWAVPEGTTIFANEPFLRIEAPLWQAQWVETFILNTINYQTLIATRA
ARLRDVAGPDATVLEFGTRRAFGPQASVWAARAALAAGLNATSNVLAAQLLGRQPSGTMAHALVMAMTATQGTELQAFTA
FHRTFPQAALLIDTYDTLAAAQTLAEKVNAGELEVPAIRLDSGDLVELSQQIHQLLPEAKIVVSGDLDEPEILRLRQAGT
HIHGYGVGTKLVTGSPVNGVYKLVDIDGKPVMKEANGKITYPGRKQIFRQFHHGHVSQDHLGLVNDSAPGGQPLLQLMMK
AGQRLKTPESLETIAQRTLDSVQSLPADVRSVVNPVSLPMQLSTDLQALTAATRRTSKAA

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=534, Percent_Identity=31.8352059925094, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71997952, Length=447, Percent_Identity=31.5436241610738, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997947, Length=447, Percent_Identity=31.5436241610738, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997955, Length=209, Percent_Identity=37.799043062201, Blast_Score=138, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24581587, Length=513, Percent_Identity=30.0194931773879, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161076680, Length=209, Percent_Identity=37.799043062201, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24581595, Length=209, Percent_Identity=37.799043062201, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574709, Length=209, Percent_Identity=37.799043062201, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24581593, Length=209, Percent_Identity=37.799043062201, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24581591, Length=209, Percent_Identity=37.799043062201, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 50255; Mature: 50255

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELVTPPEVADQSLNLSASDYNLLTDLYQATMSACYLNENLAEIPASFELTVRRLPDKF
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHCCHHH
GYLVAMGLAQVLDYLQNLKFTARQIQYLQETDLFSHAPTQFWRMLEEGKFTGDVWAVPEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCC
TTIFANEPFLRIEAPLWQAQWVETFILNTINYQTLIATRAARLRDVAGPDATVLEFGTRR
CEEEECCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
AFGPQASVWAARAALAAGLNATSNVLAAQLLGRQPSGTMAHALVMAMTATQGTELQAFTA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
FHRTFPQAALLIDTYDTLAAAQTLAEKVNAGELEVPAIRLDSGDLVELSQQIHQLLPEAK
HHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCEECCEEEECCCCHHHHHHHHHHHCCCCE
IVVSGDLDEPEILRLRQAGTHIHGYGVGTKLVTGSPVNGVYKLVDIDGKPVMKEANGKIT
EEEECCCCCHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCCHHHCCCEEE
YPGRKQIFRQFHHGHVSQDHLGLVNDSAPGGQPLLQLMMKAGQRLKTPESLETIAQRTLD
CCCHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SVQSLPADVRSVVNPVSLPMQLSTDLQALTAATRRTSKAA
HHHHCCHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLELVTPPEVADQSLNLSASDYNLLTDLYQATMSACYLNENLAEIPASFELTVRRLPDKF
CCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHCCHHH
GYLVAMGLAQVLDYLQNLKFTARQIQYLQETDLFSHAPTQFWRMLEEGKFTGDVWAVPEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCC
TTIFANEPFLRIEAPLWQAQWVETFILNTINYQTLIATRAARLRDVAGPDATVLEFGTRR
CEEEECCCEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCC
AFGPQASVWAARAALAAGLNATSNVLAAQLLGRQPSGTMAHALVMAMTATQGTELQAFTA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
FHRTFPQAALLIDTYDTLAAAQTLAEKVNAGELEVPAIRLDSGDLVELSQQIHQLLPEAK
HHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCEECCEEEECCCCHHHHHHHHHHHCCCCE
IVVSGDLDEPEILRLRQAGTHIHGYGVGTKLVTGSPVNGVYKLVDIDGKPVMKEANGKIT
EEEECCCCCHHHHHHHHCCCEEEEECCCCEEEECCCCCCEEEEEECCCCCCHHHCCCEEE
YPGRKQIFRQFHHGHVSQDHLGLVNDSAPGGQPLLQLMMKAGQRLKTPESLETIAQRTLD
CCCHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SVQSLPADVRSVVNPVSLPMQLSTDLQALTAATRRTSKAA
HHHHCCHHHHHHHCHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]