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The map label for this gene is thrB [H]

Identifier: 158337973

GI number: 158337973

Start: 4903950

End: 4904879

Strand: Direct

Name: thrB [H]

Synonym: AM1_4860

Alternate gene names: 158337973

Gene position: 4903950-4904879 (Clockwise)

Preceding gene: 158337970

Following gene: 158337982

Centisome position: 75.4

GC content: 51.4

Gene sequence:

>930_bases
ATGTCGAATACTCAAACATTAACCATCCAAGTCCCGGCAACAACCGCCAATATTGGTCCAGGCTTCGACTGTTTAGGAGC
AGCCCTCTCCCTCTACAATCGCTTTCAATTTACCCGTCTTGCAGATGATGCTGAAGCACCCATCATCCAGGCAACTGGAC
AGGGGGCCGAGCAACTGCCTACGGATGACAAAAATCTGGTTTACCGAGCGTTTGTGTCTACCTACCAACACCTGGGACAA
ACGCCCCCCGCCATCAAAATTGATATCCATTTGGATATTCCCCAAGCGAGAGGGTTAGGTAGCTCAGCCACGGCCATCAT
TGCGGGCCTGATAGGCGCTAATCAATTCGCCAACCAACCGTTAGACCCAGCGGATTTGTTGCAGCTGGCCATTGACCTGG
AAGGCCATCCTGACAATGTGGTCCCTGCCATGGTAGGAGGTTGCTGTCTTGCGGCTAAAGACCTAGCCGGCAAATGGCAG
ATTTGCCCTATCGATTGGTCCCCTGAGGTGGTTCCCATTGTCGCGATACCGGATTTTGAACTCAAGACCGATCTAGCTCG
CAATGCTCTACCCGATACCTGTGGATATGGGGATGCGATTTTTAATATGGCTCACCTTGGTTTTTTGATCAAAGGTTTAG
AGCAAGCTGATCCAGCCCTTCTCAAAACAGCCCTTGATGATAAATTGCACCAACCCTATCGGCTTCAGCTGATTGCTGGA
TTTGCAGAGGCTTACCAAGCGGCCCTAAAGGCTGGAGCCTACGGCCTCGTGATTAGCGGTGCTGGCCCGACCCTTTTGGC
TTTGGGTGATCGTGAATCGGCAGGTGCGATCGCATCTGCCATTCGCAATCAATGGCAAACAGCCAATCGGTCAGTAGAGA
CTCAGGTACTCAAGATAGATAGACAAGGGGCTATCGCTCAATTCACCTAA

Upstream 100 bases:

>100_bases
TTTCTGTGAGAAGTTACTATATACCTTTAGTCTACTAGACGGCTGGAAGTCCCGTACTTCAGCCCCTTTCTATCTTTCAC
CTTCTCGGCGCTCCCGACTC

Downstream 100 bases:

>100_bases
AGTCATTGCCCTCAGCCTCTACCCTCTAAAGGCGCTACTAGGTACTGCTTAGTTCTTAATGCCGTTGGCAACAACACCCA
GGATAGGAATCTGAGCAATT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSNTQTLTIQVPATTANIGPGFDCLGAALSLYNRFQFTRLADDAEAPIIQATGQGAEQLPTDDKNLVYRAFVSTYQHLGQ
TPPAIKIDIHLDIPQARGLGSSATAIIAGLIGANQFANQPLDPADLLQLAIDLEGHPDNVVPAMVGGCCLAAKDLAGKWQ
ICPIDWSPEVVPIVAIPDFELKTDLARNALPDTCGYGDAIFNMAHLGFLIKGLEQADPALLKTALDDKLHQPYRLQLIAG
FAEAYQAALKAGAYGLVISGAGPTLLALGDRESAGAIASAIRNQWQTANRSVETQVLKIDRQGAIAQFT

Sequences:

>Translated_309_residues
MSNTQTLTIQVPATTANIGPGFDCLGAALSLYNRFQFTRLADDAEAPIIQATGQGAEQLPTDDKNLVYRAFVSTYQHLGQ
TPPAIKIDIHLDIPQARGLGSSATAIIAGLIGANQFANQPLDPADLLQLAIDLEGHPDNVVPAMVGGCCLAAKDLAGKWQ
ICPIDWSPEVVPIVAIPDFELKTDLARNALPDTCGYGDAIFNMAHLGFLIKGLEQADPALLKTALDDKLHQPYRLQLIAG
FAEAYQAALKAGAYGLVISGAGPTLLALGDRESAGAIASAIRNQWQTANRSVETQVLKIDRQGAIAQFT
>Mature_308_residues
SNTQTLTIQVPATTANIGPGFDCLGAALSLYNRFQFTRLADDAEAPIIQATGQGAEQLPTDDKNLVYRAFVSTYQHLGQT
PPAIKIDIHLDIPQARGLGSSATAIIAGLIGANQFANQPLDPADLLQLAIDLEGHPDNVVPAMVGGCCLAAKDLAGKWQI
CPIDWSPEVVPIVAIPDFELKTDLARNALPDTCGYGDAIFNMAHLGFLIKGLEQADPALLKTALDDKLHQPYRLQLIAGF
AEAYQAALKAGAYGLVISGAGPTLLALGDRESAGAIASAIRNQWQTANRSVETQVLKIDRQGAIAQFT

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=311, Percent_Identity=31.8327974276527, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321814, Length=332, Percent_Identity=31.0240963855422, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 32737; Mature: 32605

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQTLTIQVPATTANIGPGFDCLGAALSLYNRFQFTRLADDAEAPIIQATGQGAEQLP
CCCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCC
TDDKNLVYRAFVSTYQHLGQTPPAIKIDIHLDIPQARGLGSSATAIIAGLIGANQFANQP
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHCCCCCHHHHHHHHHHCCHHHHCCC
LDPADLLQLAIDLEGHPDNVVPAMVGGCCLAAKDLAGKWQICPIDWSPEVVPIVAIPDFE
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCH
LKTDLARNALPDTCGYGDAIFNMAHLGFLIKGLEQADPALLKTALDDKLHQPYRLQLIAG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHH
FAEAYQAALKAGAYGLVISGAGPTLLALGDRESAGAIASAIRNQWQTANRSVETQVLKID
HHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEE
RQGAIAQFT
CCCCCCCCC
>Mature Secondary Structure 
SNTQTLTIQVPATTANIGPGFDCLGAALSLYNRFQFTRLADDAEAPIIQATGQGAEQLP
CCCEEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHCC
TDDKNLVYRAFVSTYQHLGQTPPAIKIDIHLDIPQARGLGSSATAIIAGLIGANQFANQP
CCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHCCCCCHHHHHHHHHHCCHHHHCCC
LDPADLLQLAIDLEGHPDNVVPAMVGGCCLAAKDLAGKWQICPIDWSPEVVPIVAIPDFE
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCH
LKTDLARNALPDTCGYGDAIFNMAHLGFLIKGLEQADPALLKTALDDKLHQPYRLQLIAG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEHHHHH
FAEAYQAALKAGAYGLVISGAGPTLLALGDRESAGAIASAIRNQWQTANRSVETQVLKID
HHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEE
RQGAIAQFT
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2838727 [H]