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The map label for this gene is pqqL [C]

Identifier: 158337972

GI number: 158337972

Start: 4902414

End: 4903721

Strand: Reverse

Name: pqqL [C]

Synonym: AM1_4859

Alternate gene names: 158337972

Gene position: 4903721-4902414 (Counterclockwise)

Preceding gene: 158337974

Following gene: 158337971

Centisome position: 75.4

GC content: 49.77

Gene sequence:

>1308_bases
ATGTGGTTTGATCCCAATCCTGCGAAGCATTGGCAGCCTGCCCAGACCCTAGGGGCAGCCCATCCCGTTCATCAAACGCG
TTTGGAGAATGGATTAACGGTTGTGCATCAATACCTACCGTTTACGCCAGTCGTAACCGTTGATATTTGGGTTAATGCAG
GGGTTACTCAGGAACCCAATACCATACCTGGGTTAGCTCATGTTTTAGAGCATATGATTTTCAAGGGGACTGAAACTATT
TCTCCCCAAGAATTTGATCGGCTGCTGGAGCGCCAGGGCGGAATGGTCAATGCCTCCACAGGCTATGATTACGCTCATTT
CTATATGGTGACCCTAGCAGATCAGCTTGGCCCCTGCTTTGCACATCTGGCTGAACTCTTAATCCATGCAGCAGTTCCTG
AAACGGAATTTTTACAGGAACAGGACATCATCCGTACTGAAATTGATCAAGCCTACGACAATCCCGATTGGGTGGTTTAT
CAGTCGGTGCGCCAGCTCATATTTCCGAACCATCCCTATGGGCGTCCAGTGCTTGGTTTGGCAGAACTGCCTCCCTTTCT
ATCTGCAGACCATGTGCGGAATTTTCACCATCAGCTTTATCAGCCAGAGAATATGACGATCGTCTTGGTGGGCGATCTGA
CCCATGAACAAGCGATGGATCTAGTCCATCGGCATTGTGATTGGCCCCCTGCCTCGGGTTCTAGGAAACCTCTGTCGACG
CCAAGTCCTTTAACCCCTTTGGGTCAACGCTGTTACCATGCCATGGAAACTCCAGGTATTGATCAAGCCCGGTTGACCAT
GGCCTGGCTAGGACCAGGGGTAACGGAAAAAGAGCAGGGGTACGGATTTGATCTGTTGTCGGTGCTATTAACGGGAGGAC
GCACGTCCCGATTAGTCTCGGATTTATTAGAACAACGCGGCTGGATTTATGATGTCCACAGCGAATTTTTTCTGCAGCGA
GAAGGGGGATGTTTCACCATCTCTGTCTGGCTAGATCCGAAGTATCTAGAGGTGGCGGAGACGGTGATTCGTGAGCATAT
GTATCAATTGGGGGAAACCTCCATTCCAGAGGCTGAGTTGCATCGATGCCAACAACTGGTAGTCAACGACTTTATTTTTG
GGACAGAAATGGTGAATCAGTTGGCTGGCTTATATGGGTATTACAGTATATTGGGCGAATTGGGGCAAGCTTCTGCCTAT
CCACAGCTCATTCAGGCCCTTGAGCCCCCAACCTTGCAACATCTCGTTCACCAGTACTTGTCCCCAAGTCACTACGCCAT
CACCACCTTGCAACCCTGCTCTTATTGA

Upstream 100 bases:

>100_bases
ATTTCCCCTCCAGTTCGGCATCCCCTTTTATACTCTCGTTATTGAATACAGACCTTTAAAACCATCTATTTCCTTATCCC
TCCTGTCTTAACCCTCGTTG

Downstream 100 bases:

>100_bases
TCTGAATGCTGTCTCTCCCTGCTCCCACCGCTTCGGTTCCCGTTACTTCAGGATTACTCTGCCAGAAGTTTGAGTTAGCC
AATGGGCTGACGGTACTAAT

Product: M16 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MWFDPNPAKHWQPAQTLGAAHPVHQTRLENGLTVVHQYLPFTPVVTVDIWVNAGVTQEPNTIPGLAHVLEHMIFKGTETI
SPQEFDRLLERQGGMVNASTGYDYAHFYMVTLADQLGPCFAHLAELLIHAAVPETEFLQEQDIIRTEIDQAYDNPDWVVY
QSVRQLIFPNHPYGRPVLGLAELPPFLSADHVRNFHHQLYQPENMTIVLVGDLTHEQAMDLVHRHCDWPPASGSRKPLST
PSPLTPLGQRCYHAMETPGIDQARLTMAWLGPGVTEKEQGYGFDLLSVLLTGGRTSRLVSDLLEQRGWIYDVHSEFFLQR
EGGCFTISVWLDPKYLEVAETVIREHMYQLGETSIPEAELHRCQQLVVNDFIFGTEMVNQLAGLYGYYSILGELGQASAY
PQLIQALEPPTLQHLVHQYLSPSHYAITTLQPCSY

Sequences:

>Translated_435_residues
MWFDPNPAKHWQPAQTLGAAHPVHQTRLENGLTVVHQYLPFTPVVTVDIWVNAGVTQEPNTIPGLAHVLEHMIFKGTETI
SPQEFDRLLERQGGMVNASTGYDYAHFYMVTLADQLGPCFAHLAELLIHAAVPETEFLQEQDIIRTEIDQAYDNPDWVVY
QSVRQLIFPNHPYGRPVLGLAELPPFLSADHVRNFHHQLYQPENMTIVLVGDLTHEQAMDLVHRHCDWPPASGSRKPLST
PSPLTPLGQRCYHAMETPGIDQARLTMAWLGPGVTEKEQGYGFDLLSVLLTGGRTSRLVSDLLEQRGWIYDVHSEFFLQR
EGGCFTISVWLDPKYLEVAETVIREHMYQLGETSIPEAELHRCQQLVVNDFIFGTEMVNQLAGLYGYYSILGELGQASAY
PQLIQALEPPTLQHLVHQYLSPSHYAITTLQPCSY
>Mature_435_residues
MWFDPNPAKHWQPAQTLGAAHPVHQTRLENGLTVVHQYLPFTPVVTVDIWVNAGVTQEPNTIPGLAHVLEHMIFKGTETI
SPQEFDRLLERQGGMVNASTGYDYAHFYMVTLADQLGPCFAHLAELLIHAAVPETEFLQEQDIIRTEIDQAYDNPDWVVY
QSVRQLIFPNHPYGRPVLGLAELPPFLSADHVRNFHHQLYQPENMTIVLVGDLTHEQAMDLVHRHCDWPPASGSRKPLST
PSPLTPLGQRCYHAMETPGIDQARLTMAWLGPGVTEKEQGYGFDLLSVLLTGGRTSRLVSDLLEQRGWIYDVHSEFFLQR
EGGCFTISVWLDPKYLEVAETVIREHMYQLGETSIPEAELHRCQQLVVNDFIFGTEMVNQLAGLYGYYSILGELGQASAY
PQLIQALEPPTLQHLVHQYLSPSHYAITTLQPCSY

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=226, Percent_Identity=26.1061946902655, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI46593007, Length=246, Percent_Identity=23.5772357723577, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI24308013, Length=376, Percent_Identity=22.0744680851064, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1787770, Length=240, Percent_Identity=28.75, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI2367164, Length=346, Percent_Identity=23.121387283237, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI72001443, Length=333, Percent_Identity=24.3243243243243, Blast_Score=78, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71999683, Length=274, Percent_Identity=21.8978102189781, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994338, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI32566665, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25146563, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25146566, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557500, Length=206, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533970, Length=363, Percent_Identity=23.1404958677686, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=255, Percent_Identity=27.0588235294118, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321813, Length=204, Percent_Identity=23.0392156862745, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323421, Length=291, Percent_Identity=21.9931271477663, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21357875, Length=242, Percent_Identity=26.0330578512397, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646943, Length=242, Percent_Identity=26.0330578512397, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221513245, Length=332, Percent_Identity=25.3012048192771, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49153; Mature: 49153

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFDPNPAKHWQPAQTLGAAHPVHQTRLENGLTVVHQYLPFTPVVTVDIWVNAGVTQEPN
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCHHHHHHHCCCCCEEEEEEEEECCCCCCCC
TIPGLAHVLEHMIFKGTETISPQEFDRLLERQGGMVNASTGYDYAHFYMVTLADQLGPCF
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCHHH
AHLAELLIHAAVPETEFLQEQDIIRTEIDQAYDNPDWVVYQSVRQLIFPNHPYGRPVLGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AELPPFLSADHVRNFHHQLYQPENMTIVLVGDLTHEQAMDLVHRHCDWPPASGSRKPLST
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCC
PSPLTPLGQRCYHAMETPGIDQARLTMAWLGPGVTEKEQGYGFDLLSVLLTGGRTSRLVS
CCCCCHHHHHHHHHHCCCCCCHHHEEHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
DLLEQRGWIYDVHSEFFLQREGGCFTISVWLDPKYLEVAETVIREHMYQLGETSIPEAEL
HHHHHCCCEEEECHHHHEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHH
HRCQQLVVNDFIFGTEMVNQLAGLYGYYSILGELGQASAYPQLIQALEPPTLQHLVHQYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHC
SPSHYAITTLQPCSY
CCCCEEEEECCCCCC
>Mature Secondary Structure
MWFDPNPAKHWQPAQTLGAAHPVHQTRLENGLTVVHQYLPFTPVVTVDIWVNAGVTQEPN
CCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCHHHHHHHCCCCCEEEEEEEEECCCCCCCC
TIPGLAHVLEHMIFKGTETISPQEFDRLLERQGGMVNASTGYDYAHFYMVTLADQLGPCF
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCHHH
AHLAELLIHAAVPETEFLQEQDIIRTEIDQAYDNPDWVVYQSVRQLIFPNHPYGRPVLGL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
AELPPFLSADHVRNFHHQLYQPENMTIVLVGDLTHEQAMDLVHRHCDWPPASGSRKPLST
HHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCC
PSPLTPLGQRCYHAMETPGIDQARLTMAWLGPGVTEKEQGYGFDLLSVLLTGGRTSRLVS
CCCCCHHHHHHHHHHCCCCCCHHHEEHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
DLLEQRGWIYDVHSEFFLQREGGCFTISVWLDPKYLEVAETVIREHMYQLGETSIPEAEL
HHHHHCCCEEEECHHHHEEECCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHH
HRCQQLVVNDFIFGTEMVNQLAGLYGYYSILGELGQASAYPQLIQALEPPTLQHLVHQYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHC
SPSHYAITTLQPCSY
CCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA