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The map label for this gene is ispA [C]

Identifier: 158337967

GI number: 158337967

Start: 4898776

End: 4899681

Strand: Reverse

Name: ispA [C]

Synonym: AM1_4854

Alternate gene names: 158337967

Gene position: 4899681-4898776 (Counterclockwise)

Preceding gene: 158337969

Following gene: 158337966

Centisome position: 75.34

GC content: 51.88

Gene sequence:

>906_bases
TTGTCTGCTCCAACCCCCTCCAACTTTAACCTTGTAGACTATCTCTCTCAGCGGCGAGAACTTGTGGAGGCCGCCTTAGA
TGCCTCTATTCCCGTGGTTTACCCGGAAAAAATTTATGAGGCCATGCGCTACTCCTTACTGGCAGGAGGGAAGCGCCTTC
GTCCGATTTTGTGCTTGGCGGCTTGTGAACTGGCTGGCGGCACCATTGAGATGGCAATGCCTACGGCCTGTGCCCTAGAA
ATGATCCATACTATGTCCCTGATTCATGACGATTTGCCCGCCATGGACAACGATGACTTCCGCCGAGGCAAGCCCACCAA
CCACAAAAAATATGGGGAAGACATTGCTATTCTGGCCGGGGATGGATTATTAGCCTATGCCTATGAGCATGTGGCAATTG
AGACGCAGCAGGTTCCGCCCGAACAGGTTCTGAAAGTTGTTGCTCGCCTGGGGCATGCGGTGGCTGCGACAGGTCTAGTG
GGCGGTCAGGTCGTCGATCTAGAGTCGGAAGGCGCAGAAGATGTCACCCTCTCGACTTTGAATTTTATCCATGCCCATAA
AACCGGGGCATTGCTAGAAGCATCGGTTTTATCGGGAGCTGAGCTGGCAGGGGCGAGTCAAGACCTCTTGAATCGGTGCT
CTAAATTTGCGCGTAATATCGGTCTGGCCTTCCAAATTATTGATGATGTATTGGATGTGACGGCCACTAGCGAAAAGCTA
GGCAAAACTGCGGGTAAAGATGTGGCGGCTCAAAAAGCGACTTATCCCAGTCTGTGGGGCATTCCAGAGTCTAAACGACA
AGCCCAGCATTTAATCGAAGAAGCGAAAGCAGAGTTAGCGGTTTACGGAGAGCAGTCAGCCCCGTTACAGGCCCTCGCTG
ATTTTATTACGTCTCGTCAATCTTAG

Upstream 100 bases:

>100_bases
TTTGCCCGACTTAGGGTGACCATTTCATCGTCAAAGATCACGAAGGATCAACAGGATGATATCCGCTGAAAACCCTCAGA
AAACCTCATCGACTCAAGAT

Downstream 100 bases:

>100_bases
ATGCTGTCAATGCTCTCCTGGTTTAAGTTTCGACAATAGATATGCAGGATTTTGGCAATATTCTCAACAACCAGGTCTTG
CTGGTTTCCCTTGCGGCGAG

Product: geranylgeranyl diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSAPTPSNFNLVDYLSQRRELVEAALDASIPVVYPEKIYEAMRYSLLAGGKRLRPILCLAACELAGGTIEMAMPTACALE
MIHTMSLIHDDLPAMDNDDFRRGKPTNHKKYGEDIAILAGDGLLAYAYEHVAIETQQVPPEQVLKVVARLGHAVAATGLV
GGQVVDLESEGAEDVTLSTLNFIHAHKTGALLEASVLSGAELAGASQDLLNRCSKFARNIGLAFQIIDDVLDVTATSEKL
GKTAGKDVAAQKATYPSLWGIPESKRQAQHLIEEAKAELAVYGEQSAPLQALADFITSRQS

Sequences:

>Translated_301_residues
MSAPTPSNFNLVDYLSQRRELVEAALDASIPVVYPEKIYEAMRYSLLAGGKRLRPILCLAACELAGGTIEMAMPTACALE
MIHTMSLIHDDLPAMDNDDFRRGKPTNHKKYGEDIAILAGDGLLAYAYEHVAIETQQVPPEQVLKVVARLGHAVAATGLV
GGQVVDLESEGAEDVTLSTLNFIHAHKTGALLEASVLSGAELAGASQDLLNRCSKFARNIGLAFQIIDDVLDVTATSEKL
GKTAGKDVAAQKATYPSLWGIPESKRQAQHLIEEAKAELAVYGEQSAPLQALADFITSRQS
>Mature_300_residues
SAPTPSNFNLVDYLSQRRELVEAALDASIPVVYPEKIYEAMRYSLLAGGKRLRPILCLAACELAGGTIEMAMPTACALEM
IHTMSLIHDDLPAMDNDDFRRGKPTNHKKYGEDIAILAGDGLLAYAYEHVAIETQQVPPEQVLKVVARLGHAVAATGLVG
GQVVDLESEGAEDVTLSTLNFIHAHKTGALLEASVLSGAELAGASQDLLNRCSKFARNIGLAFQIIDDVLDVTATSEKLG
KTAGKDVAAQKATYPSLWGIPESKRQAQHLIEEAKAELAVYGEQSAPLQALADFITSRQS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=29.7872340425532, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1786623, Length=267, Percent_Identity=43.8202247191011, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1789578, Length=238, Percent_Identity=31.5126050420168, Blast_Score=107, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17505681, Length=188, Percent_Identity=29.7872340425532, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319475, Length=230, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24651612, Length=225, Percent_Identity=28.4444444444444, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32283; Mature: 32152

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTPSNFNLVDYLSQRRELVEAALDASIPVVYPEKIYEAMRYSLLAGGKRLRPILCLA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHHH
ACELAGGTIEMAMPTACALEMIHTMSLIHDDLPAMDNDDFRRGKPTNHKKYGEDIAILAG
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEC
DGLLAYAYEHVAIETQQVPPEQVLKVVARLGHAVAATGLVGGQVVDLESEGAEDVTLSTL
CCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEHHHH
NFIHAHKTGALLEASVLSGAELAGASQDLLNRCSKFARNIGLAFQIIDDVLDVTATSEKL
HHHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTAGKDVAAQKATYPSLWGIPESKRQAQHLIEEAKAELAVYGEQSAPLQALADFITSRQ
HHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCC
S
C
>Mature Secondary Structure 
SAPTPSNFNLVDYLSQRRELVEAALDASIPVVYPEKIYEAMRYSLLAGGKRLRPILCLA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHCCCHHHHHHHHH
ACELAGGTIEMAMPTACALEMIHTMSLIHDDLPAMDNDDFRRGKPTNHKKYGEDIAILAG
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHCCCCEEEEEC
DGLLAYAYEHVAIETQQVPPEQVLKVVARLGHAVAATGLVGGQVVDLESEGAEDVTLSTL
CCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEHHHH
NFIHAHKTGALLEASVLSGAELAGASQDLLNRCSKFARNIGLAFQIIDDVLDVTATSEKL
HHHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTAGKDVAAQKATYPSLWGIPESKRQAQHLIEEAKAELAVYGEQSAPLQALADFITSRQ
HHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]